403
Views
50
CrossRef citations to date
0
Altmetric
Reviews

VEGF as an inhibitor of tumor vessel maturation: implications for cancer therapy

& , PhD
Pages 1347-1356 | Published online: 18 Sep 2009

Bibliography

  • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285(21):1182-6
  • Auerbach R, Kubai L, Knighton D, A simple procedure for the long-term cultivation of chicken embryos. Dev Biol 1974;41:391-4
  • Folkman J, Klagsburn M. Angiogenic factors. Science 1987;235:442-7
  • Leung DW, Cachianes G, Kuang WJ, Vascular endothelial growth factor is a secreted angiogenic molecule. Science 1989;246:1306-9
  • Senger DR, Galli SJ, Dvorak AM, Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983;219:983-5
  • Heldin CH, Wasteson A, Westermark B. Partial purification and characterization of platelet factors stimulating the multiplication of normal human glial cells. Exp Cell Res 1977;109(2):429-37
  • Kim KJ, Li B, Winer J, Inhibition of vascular endothelial growth factor in induced angiogenesis suppresses tumour growth in vivo. Nature 1993;362:841-4
  • Fukumura D, Xavier R, Sugiura T. Tumor induction of VEGF promoter activity in stromal cells. Cell 1998;94(6):715-25
  • Levy AP, Levy NS, Wegner S, Goldberg MA. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem 1995;270:13333-40
  • Tischer E, Mitchell R, Hartman T, The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 1991;266(18):11947-54
  • Millauer B, Wizigmann-Voos S, Schnurch H. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 1993;72:835-46
  • Kroll J, Waltenberger J. The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. J Biol Chem 1997;272(51):32521-7
  • Dougher-Vermazen M, Hulmes JD, Böhlen P, Biological activity and phosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGF receptor. Biochem Biophys Res Commun 1994;205:728-38
  • Eliceiri BP, Paul R, Schwartzberg PL, Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol Cell 1999;4:915-24
  • Jiang BH, Zheng JZ, Aoki M, Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc Natl Acad Sci USA 2000;97:1749-53
  • Henkemeyer M, Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Nature 1995;377:695-701
  • Shalaby F, Rossant J, Yamaguchi TP, Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 1995;376:62-6
  • Fong GH, Rossant J, Gertsenstein M, Breitman ML. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995;376:66-70
  • Autiero M, Waltenberger J, Communi D, Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nat Med 2003;9:936-43
  • Stalmans I, Ng YS, Rohan R, Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J Clin Invest 2002;109(3):327-36
  • D'Amore PA. Vascular endothelial cell growth factor-a: not just for endothelial cells anymore. Am J Pathol 2007;171(1):1
  • Grosskreutz CL, Anand-Apte B, Dupláa C, Vascular endothelial growth factor-induced migration of vascular smooth muscle cells in vitro. Microvasc Res 1999;58(2):128-36
  • Couper LL, Bryant SR, Eldrup-Jorgenson J, Vascular endothelial growth factor increases the mitogenic response to fibroblast growth factor-2 in vascular smooth muscle cells in vivo via expression of fms-like tyrosine kinase-1. Circ Res 1997;81:932-9
  • Fredriksson L, Li H, Eriksson U. The PDGF family: four gene products form five dimeric isoforms. Cytokine Growth Factor Rev 2004;15(4):197-204
  • Tallquist M, Kazlauskas A. PDGF signaling in cells and mice. Cytokine Growth Factor Rev 2004;15(4):205-13
  • Heldin CH, Ostman A. PDGF receptors as cancer drug targets. Cancer Cell 2003;3:439
  • Heldin CH, Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 1999;79(4):1283-316
  • Hwang RF, Yokoi K, Bucana CD, Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model. Clin Cancer Res 2003;9(17):6534-44
  • Bergers G, Song S, Meyer-Morse N, Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 2003111(9):1287-95
  • Sennino B, Falcón BL, McCauley D, Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102. Cancer Res 2007;67(15):7358-67
  • Darland DC, Massingham LJ, Smith SR, Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival. Dev Biol 2003;264:275-88
  • Reinmuth N, Liu W, Jung YD, Induction of VEGF in perivascular cells defines a potential paracrine mechanism for endothelial cell survival. FASEB J 2001;15:1239-41
  • Shih SC, Ju M, Liu N, Transforming growth factor ß1 induction of vascular endothelial growth factor receptor 1: mechanism of pericyte-induced vascular survival in vivo. Proc Natl Acad Sci 2003;100:15859-64
  • von Tell D, Armulik A, Betsholtz C. Pericytes and vascular stability. Exp Cell Res 2006;312:623-9
  • Deryugina EI, Quigley JP. Methods in enzymology angiogenesis: in vivo systems, Part A. Volume 444, 2008, Chapter 2 Chick embryo chorioallantoic membrane models to quantify angiogenesis induced by inflammatory and tumor cells or purified effector molecules. Elsevier; 2008. p. 21-41
  • Eliceiri BP, Paul R, Schwartzberg PL, Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol Cell 1999;4:915-24
  • Alavi AS, Acevedo L, Min W, Chemoresistance of endothelial cells induced by basic fibroblast growth factor depends on Raf-1-mediated inhibition of the proapoptotic kinase, ASK1. Cancer Res 2007;6:2766-72
  • Chen RR, Silva EA, Yuen WW, Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation. Pharm Res 2007;24(2):258-64
  • Levanon K, Varda-Bloom N, Greenberger S, Vascular wall maturation and prolonged angiogenic effect by endothelial-specific platelet-derived growth factor expression. Pathobiology 2006;73(3):149-58
  • Pietras K, Pahler J, Bergers G, Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting. PLoS Med 2008;5(1):e19
  • Cao R, Brakenhielm E, Pawliuk R, Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2. Nat Med 2003;9(5):604-13
  • Kano MR, Morishita Y, Iwata C, VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRbeta signaling. J Cell Sci 2005;118(Pt 16):3759-68
  • Greenberg JI, Shields DJ, Barillas SG, A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature 2008;456(7223):809-13
  • Gerhardt H, Golding M, Fruttiger M, VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol 2003;161(6):1163-77
  • Dvorak HF. Leaky tumor vessels: consequences for tumor stroma generation and for solid tumor therapy. Prog Clin Biol Res 1990;345A:317-30
  • Abramsson A, Berlin O, Papayan H. Paulin, Shani M., and Betsholtz C.. Analysis of mural cell recruitment to tumor vessels. Circulation 2002;105(1):112-7
  • Jain RK, Duda DG, Clark JW, Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol 2006;3:24-40
  • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005;307(5706):58-62
  • Padera TP, Stoll BR, Tooredman JB, Pathology: cancer cells compress intratumour vessels. Nature 2004;427(6976):695
  • Hurwitz H, Fehrenbacher L, Novotny W, Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335-42
  • Sandler A, Gray R, Perry MC, Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006;355:2542-50
  • Hutson TE, Figlin RA, Kuhn JG, Targeted therapies for metastatic renal cell carcinoma: an overview of toxicity and dosing strategies. Oncologist 2008;13:1084-96
  • Miller K, Wang M, Gralow J, Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007;357(26):2666-76
  • Prewett M, Huber J, Li Y, Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Res 1999;59(20):5209-18
  • Hampton T. “Promiscuous” anticancer drugs that hit multiple targets may thwart resistance. J Am Med Assoc 2004;292:419-20
  • Hansen-Algenstaedt N, Stoll BR, Padera TP, Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy. Cancer Res 2000;60:4556-60
  • Willett CG, Boucher Y, di Tomaso E, Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 2004;10(2):145-7
  • Stockmann C, Doedens A, Weidemann A, Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature 2008;456(7223):814-8
  • Klement G, Baruchel S, Rak J, Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J Clin Invest 2000;105(8):15-24
  • Benjamin LE, Golijanin D, Itin A. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 1999;103(2):159-65
  • Winkler F, Kozin SV, Tong RT, Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 2004;6(6):553-63
  • Dorafshar AH, Angle N, Bryer-Ash M, Vascular endothelial growth factor inhibits mitogen-induced vascular smooth muscle cell proliferation. J Surg Res 2003;114(2):179-86
  • Ryan HE, Poloni M, McNulty W, Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth. Cancer Res 2000;60:4010-5
  • Sweeney CJ, Miller KD, Sissons SE, The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors. Cancer Res 2001;61(8):3369-72
  • Weis S, Cui J, Barnes L, Cheresh D. Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis. J Cell Biol 2004;167(2):223-9
  • Jain RK. Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer. Nat Rev Cancer 2008;8(4):309-16
  • Dickson PV, Hamner JB, Sims TL, Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy. Clin Cancer Res 2007;13(13):3942-50
  • Pàez-Ribes M, Allen E, Hudock J, Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009;15(3):220-23
  • Ebos JML, Lee CR, Cruz-Munoz W, Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 2009;15(3):232-9
  • Mazzone M, Dettori D, Leite de Oliveira R, Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 2009;136(5):839-51
  • Jain RK, Duda DG, Willett CG, Biomarkers of response and resistance to antiangiogenic therapy. Nat Clin Pract Oncol 2006;3(12):693-7

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.