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Review

Anti-idiotype antibody vaccine therapy for cancer

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Pages 869-881 | Published online: 23 Feb 2005

Bibliography

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  • ••Certain anti-Id antibodies carry the internal image of antigens because their idiotypes cross react with antigen. Lindemann called these antibodies homobodies.
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  • •The development of anti-tumour antibodies after anti-Id immunisation was associated with disease stabilisation.
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  • ••Results suggest that anti-IdTriGem
  • ••mimicking GD2 may have a beneficial effect on the clinical course of melanoma.
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  • •Anti-Id vaccine was useful in some metastatic breast cancer patients in the transplant setting.
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  • •Linear peptides derived from hepatitis B surface antigen and anti-Id hybridoma share amino acid sequence homology.
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  • ••Cloning of both antigen and anti-Id showsthe molecular basis of their mimicry.
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