Bibliography
- American Cancer Society. Cancer Facts and Figures 2006. Atlanta: American Cancer Society; 2006
- Leaf C. Why we're losing the war on cancer (and how to win it). Fortune Magazine 2004;14:76-86
- Stupp R, Mason WP, van den Bent MJ, Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352(10):987-96
- Pastorelli D, Cartei G, Zustovich F, Gemcitabine and liposomal doxorubicin in biliary and hepatic carcinoma (HCC) chemotherapy: preliminary results and review of the literature. Ann Oncol 2006;17(Suppl 5):v153-7
- Pardal R, Clarke MF, Morrison SJ. Applying the principles of stem-cell biology to cancer. Nat Rev 2003;3(12):895-902
- Lobo NA, Shimono Y, Qian D, Clarke MF. The biology of cancer stem cells. Annu Rev Cell Dev Biol 2007;23:675-99
- Al-Hajj M, Wicha MS, Benito-Hernandez A, Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003;100(7):3983-8
- Singh SK, Hawkins C, Clarke ID, Identification of human brain tumour initiating cells. Nature 2004;432(7015):396-401
- Maitland NJ, Collins A. A tumour stem cell hypothesis for the origins of prostate cancer. BJU Int 2005;96(9):1219-23
- Clarke MF, Dick JE, Dirks PB, Cancer stem cells–perspectives on current status and future directions: AACR workshop on cancer stem cells. Cancer Res 2006;66(19):9339-44
- Dahlstrand J, Collins VP, Lendahl U. Expression of the class VI intermediate filament nestin in human central nervous system tumors. Cancer Res 1992;52(19):5334-41
- Almqvist PM, Mah R, Lendahl U, Immunohistochemical detection of nestin in pediatric brain tumors. J Histochem Cytochem 2002;50(2):147-58
- Lapidot T, Sirard C, Vormoor J, A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994;367(6464):645-8
- Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997;3(7):730-7
- Hope KJ, Jin L, Dick JE. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat Immunol 2004;5(7):738-43
- Dalerba P, Cho RW, Clarke MF. Cancer stem cells: models and concepts. Annu Rev Med 2007;58:267-84
- Ponti D, Costa A, Zaffaroni N, Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res 2005;65(13):5506-11
- Read TA, Hegedus B, Wechsler-Reya R, Gutmann DH. The neurobiology of neurooncology. Ann Neurol 2006;60(1):3-11
- Ignatova TN, Kukekov VG, Laywell ED, Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia 2002;39(3):193-206
- Singh SK, Clarke ID, Terasaki M, Identification of a cancer stem cell in human brain tumors. Cancer Res 2003; 63(18):5821-8
- Dirks PB. Cancer: stem cells and brain tumours. Nature 2006;444(7120):687-8
- Singh SK, Clarke ID, Hide T, Dirks PB. Cancer stem cells in nervous system tumors. Oncogene 2004;23(43):7267-73
- Galli R, Binda E, Orfanelli U, Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 2004;64(19):7011-21
- Pomeroy SL, Tamayo P, Gaasenbeek M, Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 2002;415(6870):436-42
- Lee J, Kotliarova S, Kotliarov Y, Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 2006;9(5):391-403
- O'Brien CA, Pollett A, Gallinger S, Dick JE. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007;445(7123):106-10
- Ricci-Vitiani L, Lombardi DG, Pilozzi E, Identification and expansion of human colon-cancer-initiating cells. Nature 2007;445(7123):111-5
- Dean M, Fojo T, Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer 2005;5(4):275-84
- Blagosklonny MV. Target for cancer therapy: proliferating cells or stem cells. Leukemia 2006;20(3):385-91
- Kruger GM, Morrison SJ. Brain repair by endogenous progenitors. Cell 2002;110(4):399-402
- Lou H, Dean M. Targeted therapy for cancer stem cells: the patched pathway and ABC transporters. Oncogene 2007;26(9):1357-60
- Bao S, Wu Q, McLendon RE, Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006;444(7120):756-60
- Diehn M, Cho RW, Lobo NA, Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 2009;458(7239):780-3
- Chakravarti A, Chakladar A, Delaney MA, The epidermal growth factor receptor pathway mediates resistance to sequential administration of radiation and chemotherapy in primary human glioblastoma cells in a RAS-dependent manner. Cancer Res 2002;62(15):4307-15
- Donnenberg VS, Donnenberg AD. Multiple drug resistance in cancer revisited: the cancer stem cell hypothesis. J Clin Pharmacol 2005;45(8):872-7
- Hermann DM, Kilic E, Spudich A, Role of drug efflux carriers in the healthy and diseased brain. Ann Neurol 2006;60(5):489-98
- Clark PA, Treisman DM, Ebben J, Kuo JS. Developmental signaling pathways in brain tumor-derived stem-like cells. Dev Dyn 2007;236(12):3297-308
- Sharif A, Legendre P, Prevot V, Transforming growth factor alpha promotes sequential conversion of mature astrocytes into neural progenitors and stem cells. Oncogene 2007;26(19):2695-706
- Piccirillo SG, Reynolds BA, Zanetti N, Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 2006;444(7120):761-5
- Purow BW, Haque RM, Noel MW, Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer Res 2005;65(6):2353-63
- Kanamori M, Kawaguchi T, Nigro JM, Contribution of Notch signaling activation to human glioblastoma multiforme. J Neurosurg 2007;106(3):417-27
- Fan X, Matsui W, Khaki L, Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res 2006;66(15):7445-52
- Corcoran RB, Scott MP. A mouse model for medulloblastoma and basal cell nevus syndrome. J Neurooncol 2001;53(3):307-18
- Karhadkar SS, Bova GS, Abdallah N, Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 2004;431(7009):707-12
- Bar EE, Chaudhry A, Lin A, Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. Stem Cells 2007;25(10):2524-33
- Berman DM, Karhadkar SS, Hallahan AR, Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 2002;297(5586):1559-61
- Clement V, Sanchez P, de Tribolet N, HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr Biol 2007;17(2):165-72
- Rudin CM, Hann CL, Laterra J, Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med 2009;361(12):1173-8
- Yauch RL, Dijkgraaf GJ, Alicke B, Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma. Science 2009;326(5952):572-4
- Vibhakar R, Foltz G, Yoon JG, Dickkopf-1 is an epigenetically silenced candidate tumor suppressor gene in medulloblastoma. Neuro-oncol 2007;9(2):135-44
- Niimi H, Pardali K, Vanlandewijck M, Notch signaling is necessary for epithelial growth arrest by TGF-beta. J Cell Biol 2007;176(5):695-707
- Attisano L, Labbe E. TGFbeta and Wnt pathway cross-talk. Cancer Metastasis Rev 2004;23(1-2):53-61
- Bhardwaj G, Murdoch B, Wu D, Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat Immunol 2001;2(2):172-80
- Alexson TO, Hitoshi S, Coles BL, Notch signaling is required to maintain all neural stem cell populations–irrespective of spatial or temporal niche. Dev Neurosci 2006;28(1-2):34-48
- Machold R, Hayashi S, Rutlin M, Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron 2003;39(6):937-50
- Palma V, Lim DA, Dahmane N, Sonic hedgehog controls stem cell behavior in the postnatal and adult brain. Development 2005;132(2):335-44
- Williams DA, Cancelas JA. Leukaemia: niche retreats for stem cells. Nature 2006;444(7121):827-8
- Jin L, Hope KJ, Zhai Q, Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med 2006;12(10):1167-74
- Krause DS, Lazarides K, von Andrian UH, Van Etten RA. Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells. Nat Med 2006;12(10):1175-80
- Tran CP, Lin C, Yamashiro J, Reiter RE. Prostate stem cell antigen is a marker of late intermediate prostate epithelial cells. Mol Cancer Res 2002;1(2):113-21
- Kim KJ, Li B, Winer J, Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993;362(6423):841-4
- Plate KH, Breier G, Weich HA, Risau W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 1992;359(6398):845-8
- Li Q, Ford MC, Lavik EB, Madri JA. Modeling the neurovascular niche: VEGF- and BDNF-mediated cross-talk between neural stem cells and endothelial cells: an in vitro study. J Neurosci Res 2006;84(8):1656-68
- Bao S, Wu Q, Sathornsumetee S, Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res 2006;66(16):7843-8
- Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005;434(7035):843-50
- Son MJ, Woolard K, Nam DH, SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma. Cell Stem Cell 2009;4(5):440-52
- Gunther HS, Schmidt NO, Phillips HS, Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria. Oncogene 2008;27(20):2897-909
- Beier D, Hau P, Proescholdt M, CD133+ and CD133- glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles. Cancer Res 2007;67(9):4010-5
- Ward RJ, Lee L, Graham K, Multipotent CD15+ cancer stem cells in patched-1-deficient mouse medulloblastoma. Cancer Res 2009;69(11):4682-90
- Mao XG, Zhang X, Xue XY, Brain tumor stem-like cells identified by neural stem cell marker CD15. Transl Oncol 2009;2(4):247-57
- Charafe-Jauffret E, Ginestier C, Iovino F, Aldehyde dehydrogenase 1-positive cancer stem cells mediate metastasis and poor clinical outcome in inflammatory breast cancer. Clin Cancer Res 2010;16(1):45-55
- Hwang-Verslues WW, Kuo WH, Multiple lineages of human breast cancer stem/progenitor cells identified by profiling with stem cell markers. PLoS One 2009;4(12):e8377
- Croker AK, Goodale D, Chu J, High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability. J Cell Mol Med 2009;13(8B):2236-52
- Magnifico A, Albano L, Campaner S, Tumor-initiating cells of HER2-positive carcinoma cell lines express the highest oncoprotein levels and are sensitive to trastuzumab. Clin Cancer Res 2009;15(6):2010-21
- Li F, Tiede B, Massague J, Kang Y. Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res 2007;17(1):3-14
- Hermann PC, Huber SL, Herrler T, Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 2007;1(3):313-23
- Dittmar T, Nagler C, Schwitalla S, Recurrence cancer stem cells–made by cell fusion? Med Hypotheses 2009;73(4):542-7
- Shackleton M, Quintana E, Fearon ER, Morrison SJ. Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 2009;138(5):822-9
- Zhou BB, Zhang H, Damelin M, Tumour-initiating cells: challenges and opportunities for anticancer drug discovery. Nat Rev Drug Discov 2009;8(10):806-23
- Shiras A, Chettiar ST, Shepal V, Spontaneous transformation of human adult nontumorigenic stem cells to cancer stem cells is driven by genomic instability in a human model of glioblastoma. Stem Cells 2007;25(6):1478-89
- Rubio D, Garcia-Castro J, Martin MC, Spontaneous human adult stem cell transformation. Cancer Res 2005;65(8):3035-9
- Perez-Caro M, Cobaleda C, Gonzalez-Herrero I, Cancer induction by restriction of oncogene expression to the stem cell compartment. EMBO J 2009;28(1):8-20
- Alcantara Llaguno S, Chen J, Kwon CH, Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell 2009;15(1):45-56
- Jaiswal S, Traver D, Miyamoto T, Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias. Proc Natl Acad Sci USA 2003;100(17):10002-7
- Krivtsov AV, Twomey D, Feng Z, Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature 2006;442(7104):818-22
- Jamieson CH, Ailles LE, Dylla SJ, Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med 2004;351(7):657-67
- Joseph NM, Mosher JT, Buchstaller J, The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell 2008;13(2):129-40
- Takahashi K, Tanabe K, Ohnuki M, Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131(5):861-72
- Yu J, Vodyanik MA, Smuga-Otto K, Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318(5858):1917-20
- Zhou Q, Brown J, Kanarek A, In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008;455(7213):627-32
- Hong D, Gupta R, Ancliff P, Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia. Science 2008;319(5861):336-9
- Kelly PN, Dakic A, Adams JM, Tumor growth need not be driven by rare cancer stem cells. Science 2007;317(5836):337
- Quintana E, Shackleton M, Sabel MS, Efficient tumour formation by single human melanoma cells. Nature 2008;456(7222):593-8
- Li T, Su Y, Mei Y, ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome. Lab Invest 2010;90(2):234-44
- Liu G, Yuan X, Zeng Z, Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer 2006;5:67
- Bleau AM, Hambardzumyan D, Ozawa T, PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell 2009;4(3):226-35
- Armstrong F, Brunet de la Grange P, Gerby B, NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity. Blood 2009;113(8):1730-40
- Espada J, Calvo MB, Diaz-Prado S, Medina V. Wnt signalling and cancer stem cells. Clin Transl Oncol 2009;11(7):411-27
- He S, Iwashita T, Buchstaller J, Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo. Dev Biol 2009;328(2):257-72
- Ito K, Bernardi R, Morotti A, PML targeting eradicates quiescent leukaemia-initiating cells. Nature 2008;453(7198):1072-8
- Fan X, Khaki L, Zhu TS, NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells 2010;28(1):5-16
- Korkaya H, Wicha MS. HER-2, notch, and breast cancer stem cells: targeting an axis of evil. Clin Cancer Res 2009;15(6):1845-7
- Soeda A, Inagaki A, Oka N, Epidermal growth factor plays a crucial role in mitogenic regulation of human brain tumor stem cells. J Biol Chem 2008;283(16):10958-66
- Hambardzumyan D, Becher OJ, Rosenblum MK, PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo. Genes Dev 2008;22(4):436-48
- Francipane MG, Alea MP, Lombardo Y, Crucial role of interleukin-4 in the survival of colon cancer stem cells. Cancer Res 2008;68(11):4022-5
- Phillips HS, Kharbanda S, Chen R, Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 2006;9(3):157-73
- Liu R, Wang X, Chen GY, The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med 2007;356(3):217-26
- Okamoto OK, Carvalho AC, Marti LC, Common molecular pathways involved in human CD133+/CD34+ progenitor cell expansion and cancer. Cancer Cell Int 2007;7:11
- Pollard SM, Yoshikawa K, Clarke ID, Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell 2009;4(6):568-80
- Gal H, Makovitzki A, Amariglio N, A rapid assay for drug sensitivity of glioblastoma stem cells. Biochem Biophys Res Commun 2007;358(3):908-13
- Kelly JJ, Stechishin O, Chojnacki A, Proliferation of human glioblastoma stem cells occurs independently of exogenous mitogens. Stem Cells 2009;27(8):1722-33
- Chaichana K, Zamora-Berridi G, Camara-Quintana J, Neurosphere assays: growth factors and hormone differences in tumor and nontumor studies. Stem Cells 2006;24(12):2851-7
- Kong Y, Yoshida S, Saito Y, CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL. Leukemia 2008;22(6):1207-13
- Ginestier C, Hur MH, Charafe-Jauffret E, ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007;1(5):555-67
- Hemmati HD, Nakano I, Lazareff JA, Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci USA 2003;100(25):15178-83
- Fang D, Nguyen TK, Leishear K, A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res 2005;65(20):9328-37
- Schatton T, Murphy GF, Frank NY, Identification of cells initiating human melanomas. Nature 2008;451(7176):345-9
- Dalerba P, Dylla SJ, Park IK, Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci USA 2007; 104(24):10158-63
- Huang EH, Hynes MJ, Zhang T, Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res 2009;69(8):3382-9
- Ho MM, Ng AV, Lam S, Hung JY. Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells. Cancer Res 2007;67(10):4827-33
- Eramo A, Lotti F, Sette G, Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ 2008;15(3):504-14
- Gibbs CP, Kukekov VG, Reith JD, Stem-like cells in bone sarcomas: implications for tumorigenesis. Neoplasia 2005;7(11):967-76
- Prince ME, Sivanandan R, Kaczorowski A, Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci USA 2007;104(3):973-8
- Ma S, Chan KW, Hu L, Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology 2007;132(7):2542-56
- Yang ZF, Ho DW, Ng MN, Significance of CD90+ cancer stem cells in human liver cancer. Cancer Cell 2008;13(2):153-66
- Xu Q, Yuan X, Tunici P, Isolation of tumour stem-like cells from benign tumours. Br J Cancer 2009;101(2):303-11
- Li C, Heidt DG, Dalerba P, Identification of pancreatic cancer stem cells. Cancer Res 2007;67(3):1030-7
- Hermann PC, Huber SL, Herrler T, Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 2007;1:313-23