Tissue engineering and microRNAs: future perspectives in regenerative medicine

Bibliography

• Langer R, Vacanti JP. Tissue engineering. Science 1993;260:920-6
   PubMed Web of Science ®Google Scholar
• Jopling C, Boue S, Izpisua Belmonte JC. Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration. Nat Rev Mol Cell Biol 2011;12:79-89
   PubMed Web of Science ®Google Scholar
• Poss KD. Advances in understanding tissue regenerative capacity and mechanisms in animals. Nat Rev Genet 2010;11:710-22
   PubMed Web of Science ®Google Scholar
• Carthew RW, Sontheimer EJ. Origins and Mechanisms of miRNAs and siRNAs. Cell 2009;136:642-55
   PubMed Web of Science ®Google Scholar
• Andersen MØ. The role of micrornas in natural tissue development and application in regenerative medicine. In: Howard KA, Editor. RNA interference from biology to therapeutics. Springer, New York Heidelberg Dordrecht London; 2013. p. 57-78
   Google Scholar
• Zoldan J, Lytton-Jean AK, Karagiannis ED, et al. Directing human embryonic stem cell differentiation by non-viral delivery of siRNA in 3D culture. Biomaterials 2011;32:7793-800
   PubMed Web of Science ®Google Scholar
• Levi B, Hyun JS, Nelson ER, et al. Nonintegrating knockdown and customized scaffold design enhances human adipose-derived stem cells in skeletal repair. Stem Cells 2011;29:2018-29
   PubMed Web of Science ®Google Scholar
• Low WC, Rujitanaroj PO, Lee DK, et al. Nanofibrous scaffold-mediated REST knockdown to enhance neuronal differentiation of stem cells. Biomaterials 2013;34:3581-90
   PubMed Web of Science ®Google Scholar
• Chang TC, Mendell JT. microRNAs in vertebrate physiology and human disease. Annu Rev Genomics Hum Genet 2007;8:215-39
   PubMed Web of Science ®Google Scholar
• Gusev Y. Computational methods for analysis of cellular functions and pathways collectively targeted by differentially expressed microRNA. Methods 2008;44:61-72
   PubMed Web of Science ®Google Scholar
• Liu N, Williams AH, Maxeiner JM, et al. microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice. J Clin Invest 2012;122:2054-65
   PubMed Web of Science ®Google Scholar
• Motohashi N, Alexander MS, Shimizu-Motohashi Y, et al. Regulation of IRS1/Akt insulin signaling by microRNA-128a during myogenesis. J Cell Sci 2013;126:2678-91
   PubMed Web of Science ®Google Scholar
• Zhou J, Ju W, Wang D, et al. Down-regulation of microRNA-26a promotes mouse hepatocyte proliferation during liver regeneration. PLoS One 2012;7:e33577
   PubMed Web of Science ®Google Scholar
• Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004;116:281-97
   PubMed Web of Science ®Google Scholar
• Murata K, Yoshitomi H, Tanida S, et al. Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis. Arthritis Res Ther 2010;12:R86
   PubMed Web of Science ®Google Scholar
• Cermelli S, Ruggieri A, Marrero JA, et al. Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease. PLoS One 2011;6:e23937
   PubMed Web of Science ®Google Scholar
• Gori M, Arciello M, Balsano C. MicroRNAs in nonalcoholic fatty liver disease: novel biomarkers and prognostic tools during the transition from steatosis to hepatocarcinoma. Biomed Res Int 2014;2014:741465
   Web of Science ®Google Scholar
• Sayed D, Abdellatif M. MicroRNAs in development and disease. Physiol Rev 2011;91:827-87
   PubMed Web of Science ®Google Scholar
• Lim LP, Lau NC, Garrett-Engele P, et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 2005;433:769-73
   PubMed Web of Science ®Google Scholar
• Krek A, Grün D, Poy MN, et al. Combinatorial microRNA target predictions. Nat Genet 2005;37:495-500
   PubMed Web of Science ®Google Scholar
• Houbaviy HB, Murray MF, Sharp PA. Embryonic stem cell-specific MicroRNAs. Dev Cell 2003;5:351-8
   PubMed Web of Science ®Google Scholar
• Mineno J, Okamoto S, Ando T, et al. The expression profile of microRNAs in mouse embryos. Nucleic Acids Res 2006;34:1765-71
   PubMed Web of Science ®Google Scholar
• Kanellopoulou C, Muljo SA, Kung AL, et al. Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev 2005;19:489-501
   PubMed Web of Science ®Google Scholar
• Murchison EP, Partridge JF, Tam OH, et al. Characterization of Dicer-deficient murine embryonic stem cells. Proc Natl Acad Sci USA 2005;102:12135-40
   PubMed Web of Science ®Google Scholar
• Suh MR, Lee Y, Kim JY, et al. Human embryonic stem cells express a unique set of microRNAs. Dev Biol 2004;270:488-98
   PubMed Web of Science ®Google Scholar
• Marson A, Levine SS, Cole MF, et al. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell 2008;134:521-33
   PubMed Web of Science ®Google Scholar
• Gruber AJ, Grandy WA, Balwierz PJ, et al. Embryonic stem cell-specific microRNAs contribute to pluripotency by inhibiting regulators of multiple differentiation pathways. Nucleic Acids Res 2014;42:9313-26
   PubMed Web of Science ®Google Scholar
• Judson RL, Babiarz JE, Venere M, Blelloch R. Embryonic stem cell-specific microRNAs promote induced pluripotency. Nat Biotechnol 2009;27:459-61
   PubMed Web of Science ®Google Scholar
• Melton C, Judson RL, Blelloch R. Opposing microRNA families regulate self-renewal in mouse embryonic stem cells. Nature 2010;463:621-6
   PubMed Web of Science ®Google Scholar
• Anokye-Danso F, Trivedi CM, Juhr D, et al. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell 2011;8:376-88
   PubMed Web of Science ®Google Scholar
• Li Z, Dang J, Chang KY, Rana TM. MicroRNA-mediated regulation of extracellular matrix formation modulates somatic cell reprogramming. RNA 2014;20:1900-15
   PubMed Web of Science ®Google Scholar
• Shaer A, Azarpira N, Karimi MH. Differentiation of human induced pluripotent stem cells into insulin-like cell clusters with miR-186 and miR-375 by using chemical transfection. Appl Biochem Biotechnol 2014;174:242-58
   PubMed Web of Science ®Google Scholar
• Greene WA, Muñiz A, Plamper ML, et al. MicroRNA expression profiles of human iPS cells, retinal pigment epithelium derived from iPS, and fetal retinal pigment epithelium. J Vis Exp 2014(88):e51589
   Google Scholar
• Chen CY, Liao W, Lou YL, et al. Inhibition of Notch signaling facilitates the differentiation of human-induced pluripotent stem cells into neural stem cells. Mol Cell Biochem 2014;395:291-8
   PubMed Web of Science ®Google Scholar
• Simeonov KP, Uppal H. Direct reprogramming of human fibroblasts to hepatocyte-like cells by synthetic modified mRNAs. PLoS One 2014;9:e100134
   PubMed Web of Science ®Google Scholar
• Eskildsen T, Taipaleenmäki H, Stenvang J, et al. MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo. Proc Natl Acad Sci USA 2011;108:6139-44
   PubMed Web of Science ®Google Scholar
• Gao J, Yang T, Han J, et al. MicroRNA expression during osteogenic differentiation of human multipotent mesenchymal stromal cells from bone marrow. J Cell Biochem 2011;112:1844-56
   PubMed Web of Science ®Google Scholar
• Zhang Y, Xie RL, Croce CM, et al. A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2. Proc Natl Acad Sci USA 2011;108:9863-8
   PubMed Web of Science ®Google Scholar
• Li H, Xie H, Liu W, et al. A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans. J Clin Invest 2009;119:3666-77
   PubMed Web of Science ®Google Scholar
• Kapinas K, Kessler CB, Delany AM. miR-29 suppression of osteonectin in osteoblasts: regulation during differentiation and by canonical Wnt signaling. J Cell Biochem 2009;108:216-24
   PubMed Web of Science ®Google Scholar
• Kapinas K, Kessler C, Ricks T, et al. miR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop. J Biol Chem 2010;285:25221-31
   PubMed Web of Science ®Google Scholar
• Reddi AH. Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nat Biotechnol 1998;16:247-52
   PubMed Web of Science ®Google Scholar
• Toh WS, Spector M, Lee EH, Cao T. Biomaterial-mediated delivery of microenvironmental cues for repair and regeneration of articular cartilage. Mol Pharm 2011;8:994-1001
   PubMed Web of Science ®Google Scholar
• Hong E, Reddi AH. MicroRNAs in chondrogenesis, articular cartilage, and osteoarthritis: implications for tissue engineering. Tissue Eng Part B Rev 2012;18:445-53
   PubMed Web of Science ®Google Scholar
• Tuddenham L, Wheeler G, Ntounia-Fousara S, et al. The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells. FEBS Lett 2006;580:4214-17
   PubMed Web of Science ®Google Scholar
• Han J, Yang T, Gao J, et al. Specific microRNA expression during chondrogenesis of human mesenchymal stem cells. Int J Mol Med 2010;25:377-84
   PubMed Web of Science ®Google Scholar
• Yang B, Guo H, Zhang Y, et al. MicroRNA-145 regulates chondrogenic differentiation of mesenchymal stem cells by targeting Sox9. PLoS One 2011;6:e21679
   PubMed Web of Science ®Google Scholar
• Ham O, Song BW, Lee SY, et al. The role of microRNA-23b in the differentiation of MSC into chondrocyte by targeting protein kinase A signaling. Biomaterials 2012;33:4500-7
   PubMed Web of Science ®Google Scholar
• Dudek KA, Lafont JE, Martinez-Sanchez A, Murphy CL. Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes. J Biol Chem 2010;285:24381-7
   PubMed Web of Science ®Google Scholar
• Guan YJ, Yang X, Wei L, Chen Q. MiR-365: a mechanosensitive microRNA stimulates chondrocyte differentiation through targeting histone deacetylase 4. FASEB J 2011;25:4457-66
   PubMed Web of Science ®Google Scholar
• Ohgawara T, Kubota S, Kawaki H, et al. Regulation of chondrocytic phenotype by micro RNA 18a: involvement of Ccn2/Ctgf as a major target gene. FEBS Lett 2009;583:1006-10
   PubMed Web of Science ®Google Scholar
• Martinez-Sanchez A, Dudek KA, Murphy CL. Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145). J Biol Chem 2012;287:916-24
   PubMed Web of Science ®Google Scholar
• Kim D, Song J, Jin EJ. MicroRNA-221 regulates chondrogenic differentiation through promoting proteosomal degradation of slug by targeting Mdm2. J Biol Chem 2010;285:26900-7
   PubMed Web of Science ®Google Scholar
• Bork S, Horn P, Castoldi M, et al. Adipogenic differentiation of human mesenchymal stromal cells is down-regulated by microRNA-369-5p and up-regulated by microRNA-371. J Cell Physiol 2011;226:2226-34
   PubMed Web of Science ®Google Scholar
• Sun J, Wang Y, Li Y, Zhao G. Downregulation of PPARγ by miR-548d-5p suppresses the adipogenic differentiation of human bone marrow mesenchymal stem cells and enhances their osteogenic potential. J Transl Med 2014;12:168
   PubMed Web of Science ®Google Scholar
• Kang H, Hata A. The role of microRNAs in cell fate determination of mesenchymal stem cells: balancing adipogenesis and osteogenesis. BMB Rep 2015;48:6-319-23
   PubMed Web of Science ®Google Scholar
• Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002;13:4279-95
   PubMed Web of Science ®Google Scholar
• Rodriguez AM, Elabd C, Amri EZ, et al. The human adipose tissue is a source of multipotent stem cells. Biochimie 2005;87:125-8
   PubMed Web of Science ®Google Scholar
• Gimble JM, Guilak F. Differentiation potential of adipose derived adult stem (ADAS) cells. Curr Top Dev Biol 2003;58:137-60
   PubMed Web of Science ®Google Scholar
• Kim YJ, Bae SW, Yu SS, et al. miR-196a regulates proliferation and osteogenic differentiation in mesenchymal stem cells derived from human adipose tissue. J Bone Miner Res 2009;24:816-25
   PubMed Web of Science ®Google Scholar
• Kim YJ, Hwang SH, Cho HH, et al. MicroRNA 21 regulates the proliferation of human adipose tissue-derived mesenchymal stem cells and high-fat diet-induced obesity alters microRNA 21 expression in white adipose tissues. J Cell Physiol 2012;227:183-93
   PubMed Web of Science ®Google Scholar
• Kim JY, Shin KK, Lee AL, et al. MicroRNA-302 induces proliferation and inhibits oxidant-induced cell death in human adipose tissue-derived mesenchymal stem cells. Cell Death Dis 2014;5:e1385
   PubMed Web of Science ®Google Scholar
• Sato T, Yamamoto T, Sehara-Fujisawa A. miR-195/497 induce postnatal quiescence of skeletal muscle stem cells. Nat Commun 2014;5:4597
   PubMed Web of Science ®Google Scholar
• Nakasa T, Ishikawa M, Shi M, et al. Acceleration of muscle regeneration by local injection of muscle-specific microRNAs in rat skeletal muscle injury model. J Cell Mol Med 2010;14:2495-505
   PubMed Web of Science ®Google Scholar
• Eulalio A, Mano M, Dal Ferro M, et al. Functional screening identifies miRNAs inducing cardiac regeneration. Nature 2012;492:376-81
   PubMed Web of Science ®Google Scholar
• Chen J, Huang ZP, Seok HY, et al. mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts. Circ Res 2013;112:1557-66
   PubMed Web of Science ®Google Scholar
• Li X, Wang J, Jia Z, et al. MiR-499 regulates cell proliferation and apoptosis during late-stage cardiac differentiation via Sox6 and cyclin D1. PLoS One 2013;8:e74504
   PubMedGoogle Scholar
• Porrello ER, Johnson BA, Aurora AB, et al. MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes. Circ Res 2011;109:670-9
   PubMed Web of Science ®Google Scholar
• Porrello ER, Mahmoud AI, Simpson E, et al. Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family. Proc Natl Acad Sci USA 2013;110:187-92
   PubMed Web of Science ®Google Scholar
• Hullinger TG, Montgomery RL, Seto AG, et al. Inhibition of miR-15 protects against cardiac ischemic injury. Circ Res 2012;110:71-81
   PubMed Web of Science ®Google Scholar
• Schmidt CE, Leach JB. Neural tissue engineering: strategies for repair and regeneration. Annu Rev Biomed Eng 2003;5:293-347
   PubMed Web of Science ®Google Scholar
• Horner PJ, Gage FH. Regenerating the damaged central nervous system. Nature 2000;407:963-70
   PubMed Web of Science ®Google Scholar
• Stroncek JD, Reichert WM. Overview of wound healing in different tissue types, in, indwelling neural implants: strategies for contending with the in vivo environment. CRC Press; Boca Raton (FL): 2008
   Google Scholar
• Yunta M, Nieto-Diaz M, Esteban FJ, et al. MicroRNA dysregulation in the spinal cord following traumatic injury. PLoS One 2012;7:e34534
   PubMed Web of Science ®Google Scholar
• Szulwach KE, Li X, Smrt RD, et al. Cross talk between microRNA and epigenetic regulation in adult neurogenesis. J Cell Biol 2010;189:127-41
   PubMed Web of Science ®Google Scholar
• Visvanathan J, Lee S, Lee B, et al. The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development. Genes Dev 2007;21:744-9
   PubMed Web of Science ®Google Scholar
• Liu XS, Chopp M, Zhang RL, et al. MicroRNA profiling in subventricular zone after stroke: MiR-124a regulates proliferation of neural progenitor cells through Notch signaling pathway. PLoS One 2011;6:e23461
   PubMed Web of Science ®Google Scholar
• Peng C, Li N, Ng YK, et al. A unilateral negative feedback loop between miR-200 microRNAs and Sox2/E2F3 controls neural progenitor cell-cycle exit and differentiation. J Neurosci 2012;32:13292-308
   PubMed Web of Science ®Google Scholar
• Pandey A, Singh P, Jauhari A, et al. Critical role of the miR-200 family in regulating differentiation and proliferation of neurons. J Neurochem 2015;133:640-52
   PubMed Web of Science ®Google Scholar
• Song H, Stevens CF, Gage FH. Astroglia induce neurogenesis from adult neural stem cells. Nature 2002;417:39-44
   PubMed Web of Science ®Google Scholar
• Ota Y, Zanetti AT, Hallock RM. The role of astrocytes in the regulation of synaptic plasticity and memory formation. Neural Plast 2013;2013:185463
   PubMedGoogle Scholar
• Zhao C, Sun G, Li S, Shi Y. A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination. Nat Struct Mol Biol 2009;16:365-71
   PubMed Web of Science ®Google Scholar
• Zhao C, Sun G, Ye P, et al. MicroRNA let-7d regulates the TLX/microRNA-9 cascade to control neural cell fate and neurogenesis. Sci Rep 2013;3:1329
   PubMed Web of Science ®Google Scholar
• Guo L, Zhao RC, Wu Y. The role of microRNAs in self-renewal and differentiation of mesenchymal stem cells. Exp Hematol 2011;39:608-16
   PubMed Web of Science ®Google Scholar
• Lim PK, Patel SA, Gregory LA, Rameshwar P. Neurogenesis: role for microRNAs and mesenchymal stem cells in pathological states. Curr Med Chem 2010;17:2159-67
   PubMed Web of Science ®Google Scholar
• Bianco P, Cao X, Frenette PS, et al. The meaning, the sense and the significance: Translating the science of mesenchymal stem cells into medicine. Nat Med 2013;19:35-42
   PubMed Web of Science ®Google Scholar
• Han R, Kan Q, Sun Y, et al. MiR-9 promotes the neural differentiation of mouse bone marrow mesenchymal stem cells via targeting zinc finger protein 521. Neurosci Lett 2012;515:147-52
   PubMed Web of Science ®Google Scholar
• Zou D, Chen Y, Han Y, et al. Overexpression of microRNA-124 promotes the neuronal differentiation of bone marrow-derived mesenchymal stem cells. Neural Regen Res 2014;9:1241-8
   PubMed Web of Science ®Google Scholar
• Wu R, Tang Y, Zang W, et al. MicroRNA 128 regulates the differentiation of rat bone mesenchymal stem cells into neuron-like cells by Wnt signaling. Mol Cell Biochem 2014;387:151-8
   PubMed Web of Science ®Google Scholar
• Zhang B, Pan X, Cobb GP, Anderson TA. microRNAs as oncogenes and tumor suppressors. Dev Biol 2007;302:1-12
   PubMed Web of Science ®Google Scholar
• Gillies JK, Lorimer IA. Regulation of p27Kip1 by miRNA 221/222 in glioblastoma. Cell Cycle 2007;6:2005-9
   PubMed Web of Science ®Google Scholar
• Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell 2006;126:677-89
   PubMed Web of Science ®Google Scholar
• Forte G, Carotenuto F, Pagliari F, et al. Criticality of the biological and physical stimuli array inducing resident cardiac stem cell determination. Stem Cells 2008;26:2093-103
   PubMed Web of Science ®Google Scholar
• He Y, Huang C, Lin X, Li J. MicroRNA-29 family, a crucial therapeutic target for fibrosis diseases. Biochimie 2013;95:1355-9
   PubMed Web of Science ®Google Scholar
• James EN, Delany AM, Nair LS. Post-transcriptional regulation in osteoblasts using localized delivery of miR-29a inhibitor from nanofibers to enhance extracellular matrix deposition. Acta Biomater 2014;10:3571-80
   PubMed Web of Science ®Google Scholar
• Price KJ, Tsykin A, Giles KM, et al. Matrigel basement membrane matrix influences expression of microRNAs in cancer cell lines. Biochem Biophys Res Commun 2012;427:343-8
   PubMed Web of Science ®Google Scholar
• Edeleva EV, Shcherbata HR. Stress-induced ECM alteration modulates cellular microRNAs that feedback to readjust the extracellular environment and cell behavior. Front Genet 2013;4:305
   PubMedGoogle Scholar
• Cacchiarelli D, Martone J, Girardi E, et al. MicroRNAs involved in molecular circuitries relevant for the Duchenne muscular dystrophy pathogenesis are controlled by the dystrophin/nNOS pathway. Cell Metab 2010;12:341-51
   PubMed Web of Science ®Google Scholar
• Mouw JK, Yui Y, Damiano L, et al. Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression. Nat Med 2014;20:360-7
   PubMed Web of Science ®Google Scholar
• Neth P, Nazari-Jahantigh M, Schober A, Weber C. MicroRNAs in flow-dependent vascular remodelling. Cardiovasc Res 2013;99:294-303
   PubMed Web of Science ®Google Scholar
• Yehya N, Yerrapureddy A, Tobias J, Margulies SS. MicroRNA modulate alveolar epithelial response to cyclic stretch. BMC Genomics 2012;13:154
   PubMed Web of Science ®Google Scholar
• Gerson KD, Shearstone JR, Maddula VSRK, et al. Integrin beta4 regulates SPARC protein to promote invasion. J Biol Chem 2012;287:9835-44
   PubMed Web of Science ®Google Scholar
• Clark CJ, Sage EH. A prototypic matricellular protein in the tumor microenvironment—where there’s SPARC, there’s fire. J Cell Biochem 2008;104:721-32
   PubMed Web of Science ®Google Scholar
• Hergenreider E, Heydt S, Tréguer K, et al. Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat Cell Biol 2012;14:249-56
   PubMed Web of Science ®Google Scholar
• Giannitelli SM, Accoto D, Trombetta M, Rainer A. Current trends in the design of scaffolds for computer-aided tissue engineering. Acta Biomater 2014;10:580-94
   PubMed Web of Science ®Google Scholar
• Little MH. Regrow or repair: potential regenerative therapies for the kidney. J Am Soc Nephrol 2006;17:2390-401
   PubMed Web of Science ®Google Scholar
• Kato M, Arce L, Natarajan R. MicroRNAs and their role in progressive kidney diseases. Clin J Am Soc Nephrol 2009;4:1255-66
   PubMed Web of Science ®Google Scholar
• Chau BN, Xin C, Hartner J, et al. MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Sci Transl Med 2012;4:121ra18
   PubMed Web of Science ®Google Scholar
• Banerjee J, Chan YC, Sen CK. MicroRNAs in skin and wound healing. Physiol Genomics 2011;43:543-56
   PubMed Web of Science ®Google Scholar
• Roy S, Sen CK. miRNA in wound inflammation and angiogenesis. Microcirculation 2012;19:224-32
   PubMed Web of Science ®Google Scholar
• Kato M, Zhang J, Wang M, et al. MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors. Proc Natl Acad Sci USA 2007;104:3432-7
   PubMed Web of Science ®Google Scholar
• Long J, Wang Y, Wang W, et al. Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions. J Biol Chem 2010;285:23457-65
   PubMed Web of Science ®Google Scholar
• Zarjou A, Yang S, Abraham E, et al. Identification of a microRNA signature in renal fibrosis: role of miR-21. Am J Physiol Renal Physiol 2011;301:F793-801
   PubMed Web of Science ®Google Scholar
• Liu G, Friggeri A, Yang Y, et al. miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med 2010;207:1589-97
   PubMed Web of Science ®Google Scholar
• Thum T, Gross C, Fiedler J, et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 2008;456:980-4
   PubMed Web of Science ®Google Scholar
• Wang T, Feng Y, Sun H, et al. miR-21 regulates skin wound healing by targeting multiple aspects of the healing process. Am J Pathol 2012;181:1911-20
   PubMed Web of Science ®Google Scholar
• Bowen T, Jenkins RH, Fraser DJ. MicroRNAs, transforming growth factor beta-1, and tissue fibrosis. J Pathol 2013;229:274-85
   PubMed Web of Science ®Google Scholar
• Ochi M, Nakasa T, Kamei G, et al. Regenerative medicine in orthopedics using cells, scaffold, and microRNA. J Orthop Sci 2014;19:521-8
   PubMed Web of Science ®Google Scholar
• Minakuchi Y, Takeshita F, Kosaka N, et al. Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo. Nucleic Acids Res 2004;32:e109
   PubMed Web of Science ®Google Scholar
• Lee F, Chung JE, Kurisawa M. An injectable hyaluronic acid-tyramine hydrogel system for protein delivery. J Control Release 2009;134:186-93
   PubMed Web of Science ®Google Scholar
• Li Z, Qu T, Ding C, et al. Injectable gelatin derivative hydrogels with sustained vascular endothelial growth factor release for induced angiogenesis. Acta Biomater 2015;13:88-100
   PubMed Web of Science ®Google Scholar
• Sakai S, Hirose K, Taguchi K, et al. An injectable, in situ enzymatically gellable, gelatin derivative for drug delivery and tissue engineering. Biomaterials 2009;30:3371-7
   PubMed Web of Science ®Google Scholar
• Xu Y, Patnaik S, Guo X, et al. Cardiac differentiation of cardiosphere-derived cells in scaffolds mimicking morphology of the cardiac extracellular matrix. Acta Biomater 2014;10:3449-62
   PubMed Web of Science ®Google Scholar
• Oteri G, Pizzino G, Pisano M, et al. Polyethylene glycol formulations show different soft tissue remodeling and angiogenesis features. Tissue Eng Part A 2015;21(3-4):580-5
   PubMed Web of Science ®Google Scholar
• Jaikumar D, Sajesh KM, Soumya S, et al. Injectable alginate-O-carboxymethyl chitosan/nano fibrin composite hydrogels for adipose tissue engineering. Int J Biol Macromol 2014;74C:318-26
   Google Scholar
• Toh WS, Loh XJ. Advances in hydrogel delivery systems for tissue regeneration. Mater Sci Eng C Mater Biol Appl 2014;45:690-7
   PubMed Web of Science ®Google Scholar
• Li J, Kooger R, He M, et al. A supramolecular hydrogel as a carrier to deliver microRNA into the encapsulated cells. Chem Commun (Camb) 2014;50:3722-4
   PubMed Web of Science ®Google Scholar
• Andersen MØ, Le DQS, Chen M, et al. Spatially controlled delivery of siRNAs to stem cells in implants generated by multi-component additive manufacturing advanced functional materials. Adv Funct Mater 2013. 23(45):5599-607
   Google Scholar
• Castaño IM, Curtin CM, Shaw G, et al. A novel collagen-nanohydroxyapatite microRNA-activated scaffold for tissue engineering applications capable of efficient delivery of both miR-mimics and antagomiRs to human mesenchymal stem cells. J Control Release 2015;200:42-51
   PubMed Web of Science ®Google Scholar
• Wang S, Aurora AB, Johnson BA, et al. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell 2008;15:261-71
   PubMed Web of Science ®Google Scholar
• Bruchova H, Yoon D, Agarwal AM, et al. Regulated expression of microRNAs in normal and polycythemia vera erythropoiesis. Exp Hematol 2007;35:1657-67
   PubMed Web of Science ®Google Scholar
• Lee DY, Deng Z, Wang CH, Yang BB. MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression. Proc Natl Acad Sci USA 2007;104:20350-5
   PubMed Web of Science ®Google Scholar
• Würdinger T, Tannous BA, Saydam O, et al. miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. Cancer Cell 2008;14:382-93
   PubMed Web of Science ®Google Scholar
• Zhou Q, Gallagher R, Ufret-Vincenty R, et al. Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23∼27∼24 clusters. Proc Natl Acad Sci USA 2011;108:8287-92
   PubMed Web of Science ®Google Scholar
• Li Y, Fan L, Liu S, et al. The promotion of bone regeneration through positive regulation of angiogenic-osteogenic coupling using microRNA-26a. Biomaterials 2013;34:5048-58
   PubMed Web of Science ®Google Scholar
• Shen J, Yang X, Xie B, et al. MicroRNAs regulate ocular neovascularization. Mol Ther 2008;16:1208-16
   PubMed Web of Science ®Google Scholar
• Ivkovic S, Yoon BS, Popoff SN, et al. Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 2003;130:2779-91
   PubMed Web of Science ®Google Scholar
• Ameres SL, Horwich MD, Hung JH, et al. Target RNA-directed trimming and tailing of small silencing RNAs. Science 2010;328:1534-9
   PubMed Web of Science ®Google Scholar
• Zacchigna S, Giacca M. Extra- and intracellular factors regulating cardiomyocyte proliferation in postnatal life. Cardiovasc Res 2014;102:312-20
   PubMed Web of Science ®Google Scholar
• Lennox KA, Behlke MA. A direct comparison of anti-microRNA oligonucleotide potency. Pharm Res 2010;27:1788-99
   PubMed Web of Science ®Google Scholar
• Choi WY, Giraldez AJ, Schier AF. Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430. Science 2007;318:271-4
   PubMed Web of Science ®Google Scholar
• Grünweller A, Hartmann RK. Locked nucleic acid oligonucleotides: the next generation of antisense agents? BioDrugs 2007;21:235-43
   PubMed Web of Science ®Google Scholar
• Lorenz C, Hadwiger P, John M, et al. Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells. Bioorg Med Chem Lett 2004;14:4975-7
   PubMed Web of Science ®Google Scholar
• Ebert MS, Neilson JR, Sharp PA. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat Methods 2007;4:721-6
   PubMed Web of Science ®Google Scholar
• Carè A, Catalucci D, Felicetti F, et al. MicroRNA-133 controls cardiac hypertrophy. Nat Med 2007;13:613-18
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wang Z, Gemeinhart RA. Progress in microRNA delivery. J Control Release 2013;172:962-74
   PubMed Web of Science ®Google Scholar
• Haraguchi T, Ozaki Y, Iba H. Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells. Nucleic Acids Res 2009;37:e43
   PubMed Web of Science ®Google Scholar
• Kost TA, Condreay JP, Jarvis DL. Baculovirus as versatile vectors for protein expression in insect and mammalian cells. Nat Biotechnol 2005;23:567-75
   PubMed Web of Science ®Google Scholar
• Merrihew RV, Clay WC, Condreay JP, et al. Chromosomal integration of transduced recombinant baculovirus DNA in mammalian cells. J Virol 2001;75:903-9
   PubMed Web of Science ®Google Scholar
• Lin CY, Lu CH, Luo WY, et al. Baculovirus as a gene delivery vector for cartilage and bone tissue engineering. Curr Gene Ther 2010;10:242-54
   PubMed Web of Science ®Google Scholar
• Lu CH, Chang YH, Lin SY, et al. Recent progresses in gene delivery-based bone tissue engineering. Biotechnol Adv 2013;31:1695-706
   PubMed Web of Science ®Google Scholar
• Elmén J, Lindow M, Schütz S, et al. LNA-mediated microRNA silencing in non-human primates. Nature 2008;452:896-9
   PubMed Web of Science ®Google Scholar
• Zhang Y, Liu D, Chen X, et al. Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell 2010;39:133-44
   PubMed Web of Science ®Google Scholar
• Turchinovich A, Weiz L, Langheinz A, Burwinkel B. Characterization of extracellular circulating microRNA. Nucleic Acids Res 2011;39:7223-33
   PubMed Web of Science ®Google Scholar
• Zernecke A, Bidzhekov K, Noels H, et al. Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Sci Signal 2009;2:ra81
   PubMed Web of Science ®Google Scholar
• Collino F, Deregibus MC, Bruno S, et al. Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs. PLoS One 2010;5:e11803
   PubMed Web of Science ®Google Scholar
• Mittelbrunn M, Gutierrez-Vazquez C, Villaroya-Beltri C, et al. Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat Commun 2011;2:282
   PubMed Web of Science ®Google Scholar
• Kosaka N, Iguchi H, Yoshioka Y, et al. Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem 2010;285:17442-52
   PubMed Web of Science ®Google Scholar
• Wehman AM, Poggioli C, Schweinsberg P, et al. The P4-ATPase TAT-5 inhibits the budding of extracellular vesicles in C. elegans embryos. Curr Biol 2011;21:1951-9
   PubMed Web of Science ®Google Scholar
• Pigati L, Yaddanapudi SC, Iyengar R, et al. Selective release of microRNA species from normal and malignant mammary epithelial cells. PLoS One 2010;5:e13515
   PubMed Web of Science ®Google Scholar
• Guduric-Fuchs J, O’Connor A, Camp B, et al. Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types. BMC Genomics 2012;13:357
   PubMed Web of Science ®Google Scholar
• Chapel A, Bertho JM, Bensidhoum M, et al. Mesenchymal stem cells home to injured tissues when co-infused with hematopoietic cells to treat a radiation-induced multi-organ failure syndrome. J Gene Med 2003;5:1028-38
   PubMed Web of Science ®Google Scholar
• Lee HK, Finniss S, Cazacu S, et al. Mesenchymal stem cells deliver synthetic microRNA mimics to glioma cells and glioma stem cells and inhibit their cell migration and self-renewal. Oncotarget 2013;4:346-61
   PubMed Web of Science ®Google Scholar
• Malik R, Roy I. Design and development of antisense drugs. Expert Opin Drug Discov 2008;3:1189-207
   PubMed Web of Science ®Google Scholar
• Chiarantini L, Cerasi A, Fraternale A, et al. Comparison of novel delivery systems for antisense peptide nucleic acids. J Control Release 2005;109:24-36
   PubMed Web of Science ®Google Scholar
• Zuhorn IS, Engberts JB, Hoekstra D. Gene delivery by cationic lipid vectors:overcoming cellular barriers. Eur Biophys J 2007;36:349-62
   PubMed Web of Science ®Google Scholar
• Yano J, Hirabayashi K, Nakagawa S, et al. Antitumor activity of small interfering RNA/cationic liposome complex in mouse models of cancer. Clin Cancer Res 2004;10:7721-6
   PubMed Web of Science ®Google Scholar
• Santel A, Aleku M, Keil O, et al. RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy. Gene Ther 2006;13:1360-70
   PubMed Web of Science ®Google Scholar
• Chirila TV, Rakoczy PE, Garrett KL, et al. The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides. Biomaterials 2002;23:321-42
   PubMed Web of Science ®Google Scholar
• Suh JS, Lee JY, Choi YS, et al. Peptide-mediated intracellular delivery of miRNA-29b for osteogenic stem cell differentiation. Biomaterials 2013;34:4347-59
   PubMed Web of Science ®Google Scholar
• Wu K, Song W, Zhao L, et al. MicroRNA functionalized microporous titanium oxide surface by lyophilization with enhanced osteogenic activity. ACS Appl Mater Interfaces 2013;5:2733-44
   PubMed Web of Science ®Google Scholar
• Sriram M, Sainitya R, Kalyanaraman V, et al. Biomaterials mediated microRNA delivery for bone tissue engineering. Int J Biol Macromol 2015;74:404-12
   PubMed Web of Science ®Google Scholar
• Garzon R, Marcucci G, Croce CM. Targeting MicroRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov 2010;9:775-89
   PubMed Web of Science ®Google Scholar
• Rosi NL, Giljohann DA, Thaxton CS, et al. Oligonucleotide-modified gold nanoparticles for intracellular gene regulation. Science 2006;312:1027-30
   PubMed Web of Science ®Google Scholar
• Tivnan A, Orr WS, Gubala V, et al. Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles. PLoS One 2012;7:e38129
   PubMed Web of Science ®Google Scholar
• Huang Y, Lü X, Qu Y, et al. MicroRNA sequencing and molecular mechanisms analysis of the effects of gold nanoparticles on human dermal fibroblasts. Biomaterials 2014;37C:13-24
   Google Scholar
• Li H, Mu Y, Qian S, et al. Synthesis of fluorescent dye-doped silica nanoparticles for target-cell-specific delivery and intracellular MicroRNA imaging. Analyst 2014;140:567-73
   Web of Science ®Google Scholar
• Schade A, Müller P, Delyagina E, et al. Magnetic Nanoparticle Based Nonviral MicroRNA Delivery into Freshly Isolated CD105(+) hMSCs. Stem Cells Int 2014;2014:197154
   PubMedGoogle Scholar
• Kim VN, Nam JW. Genomics of microRNA. Trends Genet 2006;22:165-73
   PubMed Web of Science ®Google Scholar
• Olena AF, Patton JG. Genomic organization of microRNAs. J Cell Physiol 2010;222:540-5
   PubMed Web of Science ®Google Scholar