1,537
Views
56
CrossRef citations to date
0
Altmetric
Reviews

Stem cells in clinical trials for treatment of retinal degeneration

, MD PhD (Associate Professor)

Bibliography

  • Björklund A, Stenevi U, Dunnett SB, Iversen SD. Functional reactivation of the deafferented neostriatum by nigral transplants. Nature 1981;289(5797):497-9
  • Klassen H, Lund R. Retinal transplants can drive a pupillary reflex in host rat brains. Proc Natl Acad Sci USA 1987;84:6958-60
  • Sheedlo HJ, Li LX, Turner JE. Functional and structural characteristics of photoreceptor cells rescued in RPE-cell grafted retinas of RCS dystrophic rats. Exp Eye Res 1989;48(6):841-54
  • Lopez R, Gouras P, Kjeldbye H, et al. Transplanted retinal pigment epithelium modifies the retinal degeneration in the RCS rat. Invest Ophthalmol Vis Sci 1989;30(3):586-8
  • Silverman MS, Hughes SE. Photoreceptor rescue in the RCS rat without pigment epithelium transplantation. Curr Eye Res 1990;9(2):183-91
  • Aramant R, Seiler M, Ehinger B, et al. Transplantation of human embryonic retina to adult rat retina. Restor Neurol Neurosci 1990;2(1):9-22
  • Algvere PV, Berglin L, Gouras P, et al. Transplantation of RPE in age-related macular degeneration: observations in disciform lesions and dry RPE atrophy. Graefes Arch Clin Exp Ophthalmol 1997;235(3):149-58
  • Algvere PV, Gouras P, Dafgård Kopp E. Long-term outcome of RPE allografts in non-immunosuppressed patients with AMD. Eur J Ophthalmol 1999;9(3):217-30
  • Kaplan HJ, Tezel TH, Berger AS, et al. Human photoreceptor transplantation in retinitis pigmentosa. A safety study. Arch Ophthalmol 1997;115(9):1168-72
  • Das T, del Cerro M, Jalali S, et al. The transplantation of human fetal neuroretinal cells in advanced retinitis pigmentosa patients: results of a long-term safety study. Exp Neurol 1999;157(1):58-68
  • Humayun MS, de Juan EJr, del Cerro M, et al. Human neural retinal transplantation. Invest Ophthalmol Vis Sci 2000;41(10):3100-6
  • Radtke ND, Aramant RB, Seiler M, Petry HM. Preliminary report: indications of improved visual function after retinal sheet transplantation in retinitis pigmentosa patients. Am J Ophthalmol 1999;128(3):384-7
  • Radtke ND, Seiler MJ, Aramant RB, et al. Transplantation of intact sheets of fetal neural retina with its retinal pigment epithelium in retinitis pigmentosa patients. Am J Ophthalmol 2002;133(4):544-50
  • Radtke ND, Aramant RB, Petry HM, et al. Vision improvement in retinal degeneration patients by implantation of retina together with retinal pigment epithelium. Am J Ophthalmol 2008;146(2):172-82
  • Tao W, Wen R, Goddard MB, et al. Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa. Invest Ophthalmol Vis Sci 2002;43(10):3292-8
  • Tao W. Application of encapsulated cell technology for retinal degenerative diseases. Expert Opin Biol Ther 2006;6(7):717-26
  • Kauper K, McGovern C, Sherman S, et al. Two-year intraocular delivery of ciliary neurotrophic factor by encapsulated cell technology implants in patients with chronic retinal degenerative diseases. Invest Ophthalmol Vis Sci 2012;53(12):7484-91
  • ECT Pipeline. Neurotech. ECT treatment of retinal diseases. 2005. Available from: www.neurotechusa.com/ect-pipeline.html [Last accessed 28 July 2015]
  • Takahashi M, Palmer TD, Takahashi J, Gage FH. Widespread integration and survival of adult-derived neural progenitor cells in the developing optic retina. Mol Cell Neurosci 1998;12(6):340-8
  • Young M, Ray J, Whiteley S, et al. Neuronal differentiation and morphological integration of hippocampal progenitor cells transplanted to the retina of immature and mature dystropic rats. Mol Cell Neurosci 2000;16(3):1997-2005
  • Klassen H, Ng TF, Kurimoto Y, et al. Multipotent progenitor cells express developmental markers, differentiate into retinal neurons, and preserve light-mediated behavior. Invest Ophthalmol Vis Sci 2004;45:4167-73
  • Klassen H, Ziaeian B, Kirov I, et al. Isolation of retinal progenitor cells from postmortem human tissue with comparison to autologous brain progenitors. J Neurosci Res 2004;77(3):334-43
  • Lamba DA, Karl MO, Ware CB, Reh TA. Efficient generation of retinal progenitor cells from human embryonic stem cells. Proc Natl Acad Sci USA 2006;103(34):12769-74
  • Osakada F, Ikeda H, Mandai M, et al. Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells. Nat Biotechnol 2008;26(2):215-24
  • Osakada F, Ikeda H, Mandai M, et al. Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells. Nat Biotechnol 2008;26(2):215-24
  • Vugler A, Carr AJ, Lawrence J, et al. Elucidating the phenomenon of HESC-derived RPE: anatomy of cell genesis, expansion and retinal transplantation. Exp Neurol 2008;214(2):347-61
  • Hirami Y, Osakada F, Takahashi K, et al. Generation of retinal cells from mouse and human induced pluripotent stem cells. Neurosci Lett 2009;458(3):126-31
  • Buchholz DE, Hikita ST, Rowland TJ, et al. Derivation of functional retinal pigmented epithelium from induced pluripotent stem cells. Stem Cells 2009;27(10):2427-34
  • Lund RD, Wang S, Klimanskaya I, et al. Human embryonic stem cell-derived cells rescue visual function in dystrophic RCS rats. Cloning Stem Cells 2006;8(3):189-99
  • Diniz B, Thomas P, Thomas B, et al. Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer. Invest Ophthalmol Vis Sci 2013;54(7):5087-96
  • Stanzel BV, Liu Z, Somboonthanakij S, et al. Human RPE stem cells grown into polarized RPE monolayers on a polyester matrix are maintained after grafting into rabbit subretinal space. Stem Cell Rep 2014;2(1):64-77
  • Blenkinsop TA, Salero E, Stern JH, Temple S. The culture and maintenance of functional retinal pigment epithelial monolayers from adult human eye. Methods Mol Biol 2013;945:45-65
  • Lund RD, Wang S, Lu B, et al. Cells Isolated from Umbilical Cord Tissue Rescue Photoreceptors and Visual Functions in a Rodent Model of Retinal Disease. Stem Cells 2007;25(3):602-11
  • Otani A, Dorrell MI, Kinder K, et al. Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells. J Clin Invest 2004;114(6):765-74
  • Park SS, Caballero S, Bauer G, et al. Long-term effects of intravitreal injection of GMP-grade bone-marrow-derived CD34+ cells in NOD-SCID mice with acute ischemia-reperfusion injury. Invest Ophthalmol Vis Sci 2012;53(2):986-94
  • ClinicalTrials.gov A service of the National Institutes of Health. Sub-retinal Transplantation of hESC Derived RPE (MA09-hRPE) Cells in Patients With Stargardt’s Macular Dystrophy. 2015. Available from: https://clinicaltrials.gov/ct2/show/NCT01345006?term=NCT01345006&rank=1 [Last accessed 28 July 2015]
  • ClinicalTrials.gov A service of the National Institutes of Health. Safety and Tolerability of Sub-retinal Transplantation of hESC Derived RPE (MA09-hRPE) Cells in Patients With Advanced Dry Age Related Macular Degeneration (Dry AMD). 2015. Available from: https://clinicaltrials.gov/ct2/show/NCT01344993?term=rpe+advanced+cell+technology&rank=1 [Last accessed on 28 July 2015]
  • Schwartz SD, Hubschman JP, Heilwell G, et al. Embryonic stem cell trials for macular degeneration: a preliminary report. Lancet 2012;379(9817):713-20
  • ClinicalTrials.gov A service of the National Institutes of Health. Research with retinal cells derived from stem cells for myopic macular degeneration. 2015. Available from: https://clinicaltrials.gov/ct2/show/NCT02122159?term=myopic+macular&rank=1 [Last accessed 28 July 2015]
  • BioTime’s Subsidiary Cell Cure Neurosciences Ltd. Awarded $1.6 Million Grant From Israel’s Office of the Chief Scientist. BusinessWire. 2015. Available from: www.businesswire.com/news/home/20150513005362/en/BioTime’s-Subsidiary-Cell-Cure-Neurosciences-Ltd.-Awarded#.Va2z_CRRqS0 [Last accessed 28 July 2015]
  • Kamao H, Mandai M, Okamoto S, et al. Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application. Stem Cell Rep 2014;2(2):205-18
  • News. Nature. Japanese woman is first recipient of next-generation stem cells. 2014. Available from: www.nature.com/news/japanese-woman-is-first-recipient-of-next-generation-stem-cells-1.15915 [Last accessed 28 July 2015]
  • ClinicalTrials.gov A service of the National Institutes of Health. Study of Human Central Nervous System Stem Cells (HuCNS-SC) in Age-Related Macular Degeneration (AMD). 2015. Available from: https://clinicaltrials.gov/ct2/show/NCT01632527?term=StemCells%2C+Inc.&rank=1 [Last accessed 28 July 2015]
  • StemCells, Inc. Initiates Phase I/II Clinical Trial in Dry Age-Related Macular Degeneration. News Release. StemCells. 2012. Available from: http://investor.stemcellsinc.com/phoenix.zhtml?c=86230&p=irol-newsArticle&ID=1707300 [Last accessed 28 July 2015]
  • StemCells, Inc. Reports top line results for its Phase I/II study in dry age related macular degeneration. news release. StemCells. 2012. Available from: http://investor.stemcellsinc.com/phoenix.zhtml?c=86230&p=irol-newsArticle&ID=2062904 [Last accessed 28 July 2015]
  • StemCells, Inc, CNN Money. Transplants first patient in Phase II clinical trial for dry age-related macular degeneration. 2015. Available from: http://money.cnn.com/news/newsfeeds/articles/globenewswire/10142035.htm [Last accessed 28 July 2015]
  • ClinicalTrials.gov A service of the National Institutes of Health. Study of HUCNS-SC Subretinal Transplantation in Subjects With GA of AMD (RADIANT). 2015. Available from: https://clinicaltrials.gov/ct2/show/NCT02467634?term=StemCells%2C+Inc.&rank=10 [Last accessed 28 July 2015]
  • ClinicalTrials.gov A service of the National Institutes of Health. Safety of a Single, Intravitreal Injection of Human Retinal Progenitor Cells (jCell) in Retinitis Pigmentosa. 2015. Available from: https://clinicaltrials.gov/ct2/show/NCT02320812?term=jCyte&rank=1 [Last accessed 28 July 2015]
  • ClinicalTrials.gov A service of the National Institutes of Health. A Study to evaluate the safety of CNTO 2476 in patients with advanced retinitis pigmentosa. 2015. Available from: https://clinicaltrials.gov/ct2/show/NCT00458575?term=CNTO+2476&rank=1 [Last accessed 28 July 2015]
  • ClinicalTrials.gov A service of the National Institutes of Health. A Safety Study of CNTO 2476 in Patients With Age-Related Macular Degeneration. 2015. Available from: https://clinicaltrials.gov/ct2/show/NCT01226628?term=CNTO+2476&rank=2 [Last accessed 28 July 2015]
  • Siqueira RC, Messias A, Voltarelli JC, et al. Intravitreal injection of autologous bone marrow-derived mononuclear cells for hereditary retinal dystrophy: a phase I trial. Retina 2011;31(6):1207-14
  • Siqueira RC, Messias A, Voltarelli JC, et al. Resolution of macular oedema associated with retinitis pigmentosa after intravitreal use of autologous BM-derived hematopoietic stem cell transplantation. Bone Marrow Transp 2013;48(4):612-13
  • Siqueira RC, Messias A, Messias K, et al. Quality of life in patients with retinitis pigmentosa submitted to intravitreal use of bone marrow-derived stem cells (Reticell -clinical trial). Stem Cell Res Ther 2015;6:29
  • ClinicalTrials.gov A service of the National Institutes of Health. Clinical trial of autologous intravitreal bone-marrow CD34+ stem cells for retinopathy. 2015. Available from: https://clinicaltrials.gov/ct2/show/NCT01736059?term=stem+cell+retinitis+pigmentosa&rank=7 [Last accessed 28 July 2015]
  • Park SS, Bauer G, Abedi M, et al. Intravitreal autologous bone marrow CD34+ cell therapy for ischemic and degenerative retinal disorders: preliminary phase 1 clinical trial findings. Invest Ophthalmol Vis Sci 2014;56(1):81-9
  • The London Project to Cure Blindness. 2015. Available from: www.thelondonproject.org [Last accessed 28 July 2015]
  • YouTube. Regenerative patch technologies - company presentation. 2014. Available from: www.youtube.com/watch?v=pDQ2SD9aLt0 [Last accessed 28 July 2015]
  • ReNeuron. Phase I/II clinical trial in retinitis pigmentosa. 2015. Available from: www.reneuron.com/clinical-trials/phase-iii-clinical-trial-in-retinitis-pigmentosa/ [Last accessed 28 July 2015]

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.