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Expert Opinion on Biological Therapy Volume 16, 2016 - Issue 2
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Drug Evaluations

Ixekizumab: a new anti-IL-17A monoclonal antibody therapy for moderate-to severe plaque psoriasis

Andrew BlauveltOregon Medical Research Center, Portland, OR, USACorrespondence[email protected]
Pages 255-263 | Received 23 Sep 2015, Accepted 14 Dec 2015, Published online: 25 Jan 2016

References

  • Papers of special note have been highlighted as either of interest (•) or of considerable interest (••) to readers.
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•• Key phase III ixekizumab study.

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•• Key phase I ixekizumab study.

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  • Leonardi C, Matheson R, Zachariae C, et al. Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N Engl J Med. 2012;366:1190–1199.

•• Key phase II ixekizumab study.

  • Rich P, Sigurgeirsson B, Thaci D, et al. Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study. Br J Dermatol. 2013;168:402–411.
  • Papp KA, Langley RG, Sigurgeirsson B, et al. Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study. Br J Dermatol. 2013;168:412–421.
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• First demonstration of systemic anti-inflammatory effect of ixekizumab.

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  • Langley RG, Rich P, Menter A, et al. Improvement of scalp and nail lesions with ixekizumab in a phase 2 trial in patients with chronic plaque psoriasis. J Eur Acad Dermatol Venereol. 2015;29:1763–1770.
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• Quality of life improvements with clear or near clear skin.

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•• Key phase II ixekizumab study: long-term results.

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• Open-label ixekizumab study, including erythrodermic and generalized pustular psoriasis patients.

  • Takeshita J, Callis Duffin K, Shin DB, et al. Patient-reported outcomes for psoriasis patients with clear versus almost clear skin in the clinical setting. J Am Acad Dermatol. 2014;71:633–641.

• Quality of life improvements with clear or near clear skin.

  • Papp KA, Griffiths CE, Gordon K, et al. Long-term safety of ustekinumab in patients with moderate-to-severe psoriasis: final results from 5 years of follow-up. Br J Dermatol. 2013;168:844–854.

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