354
Views
18
CrossRef citations to date
0
Altmetric
Reviews

Recent considerations in the use of recombinant interferon gamma for biological therapy of atopic dermatitis

&
Pages 507-514 | Received 13 Nov 2015, Accepted 21 Dec 2015, Published online: 03 Mar 2016

References

  • Leung DYM, Guttman-Yassky E. Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches. J Allergy Clin Immunol. 2014;134:769–779. DOI:10.1016/j.jaci.2014.08.008.
  • Leung DYM. Atopic dermatitis: age and race do matter! J Allergy Clin Immunol. 2015;136:1265–1267. DOI:10.1016/j.jaci.2015.09.011.
  • Gao PS, Rafaels NM, Hand T, et al. Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum. J Allergy Clin Immunol. 2009;124:507–513. DOI:10.1016/j.jaci.2009.07.034.
  • Cai SC, Chen H, Koh WP, et al. Filaggrin mutations are associated with recurrent skin infection in Singaporean Chinese patients with atopic dermatitis. Br J Dermatol. 2012;166:200–203. DOI:10.1111/j.1365-2133.2011.10541.x.
  • Van Drongelen V, Haisma EM, Out-Luiting JJ, et al. Reduced filaggrin expression is accompanied by increased Staphylococcus aureus colonization of epidermal skin models. Clin Exp Allergy. 2014;44(12):1515–1524. DOI:10.1111/cea.12443.
  • Brauweiler AM, Bin L, Kim BE, et al. Filaggrin-dependent secretion of sphingomyelinase protects against staphylococcal α-toxin-induced keratinocyte death. J Allergy Clin Immunol. 2013;131(2):421–422. DOI:10.1016/j.jaci.2012.10.030.
  • Beck LA, Thaçi D, et al. Dupilumab treatment in adults with moderate-to-severe atopic dermatitis. N Engl J Med. 2014;371:130–139. DOI:10.1056/NEJMoa1314768.
  • Hamilton JD, Suárez-Fariñas M, Dhingra N, et al. Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis. J Allergy Clin Immunol. 2014;134:1293–1300. DOI:10.1016/j.jaci.2014.10.013.
  • Farrar MA, Schreiber RD. The molecular cell biology of interferon-gamma and its receptor. Annu Rev Immunol. 1993;11:571–611. DOI:10.1146/annurev.iy.11.040193.003035
  • The International Chronic Granulomatous Disease Cooperative Study Group. A controlled trial of interferon gamma to prevent infection in chronic gramulomatous disease. N Engl J Med. 1991;324:509–516. DOI:10.1056/NEJM199102213240801.
  • Marciano BE, Wesley R, De Carlo ES, et al. Long-term interferon-γ therapy for patients with chronic granulomatous disease. Clin Infect Dis. 2004;39:692–699. DOI:10.1086/422993.
  • Leung DY, Gao PS, Grigoryev DN, et al. Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-gamma response. J Allergy Clin Immunol. 2011;127:965–973. DOI:10.1016/j.jaci.2011.02.010.
  • Machura E, Mazur B, Golemiec E, et al. Staphylococcus aureus skin colonization in atopic dermatitis children is associated with decreased IFN-gamma production by peripheral blood CD4+ and CD8+ T cells. Pediatr Allergy Immunol. 2008;19:37–45. DOI:10.1111/j.1399-3038.2007.00586.x.
  • Leyva-Castillo JM, et al. TSLP produced by keratinocytes promotes allergen sensitization through skin and thereby triggers atopic march in mice. J Invest Dermatol. 2013;133:154–163. DOI:10.1038/jid.2012.239.
  • Van Der Velden VH, Laan MP, Baert MR, et al. Selective development of a strong Th2 cytokine profile in high-risk children who develop atopy: risk factors and regulatory role of IFN-gamma, IL-4 and IL-10. Clin Exp Allergy. 2001;31:997–1006.
  • Herberth G, Heinrich J, Roder S, et al. Reduced IFN-gamma- and enhanced IL-4-producing CD41 cord blood T cells are associated with a higher risk for atopic dermatitis during the first 2 years of life. Pediatr Allergy Immunol. 2010;21:5–13. DOI:10.1111/j.1399-3038.2009.00890.x.
  • Warner JA, Miles EA, Jones AC, et al. Is deficiency of interferon gamma production by allergen triggered cord blood cells a predictor of atopic eczema? Clin Exp Allergy. 1994;24:423–430.
  • Akkoc T, De Koning PJ, Rückert B, et al. Increased activation-induced cell death of high IFN-γ–producing TH1 cells as a mechanism of TH2 predominance in atopic diseases. J Allergy Clin Immunol. 2008;121:652–658. DOI:10.1016/j.jaci.2007.12.1171.
  • Czarnowicki T, Gonzalez J, Shemer A, et al. Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing T-cell population. J Allergy Clin Immunol. 2015;136:104–115. DOI:10.1016/j.jaci.2015.01.020.
  • Park H, Ahn K, Park MH, et al. The HLA-DRB1 polymorphism is associated with atopic dermatitis, but not egg allergy in Korean children. Allergy Asthma Immunol Res. 2012;4:143–149. DOI:10.4168/aair.2012.4.3.143.
  • Giustizieri ML, Mascia F, Frezzolini A, et al. Keratinocytes from patients with atopic dermatitis and psoriasis show a distinct chemokine production profile in response to T cell-derived cytokines. J Allergy Clin Immunol. 2001;107:871–877. DOI:10.1067/mai.2001.114707.
  • Mathes EF, Oza V, Frieden IJ, et al. “Eczema coxsackium” and unusual cutaneous findings in an enterovirus outbreak. Pediatrics. 2013;132:e149–157. DOI:10.1542/peds.2012-3175.
  • Seize MB, Ianhez M, Cestari SC. A study of the correlation between molluscum contagiosum and atopic dermatitis in children. An Bras Dermatol. 2011;86:663–668.
  • Feder HM Jr, Bennett N, Modlin JF. Atypical hand, foot, and mouth disease: a vesiculobullous eruption caused by Coxsackie virus A6. Lancet Infect Dis. 2014;14:83–86. DOI:10.1016/S1473-3099(13)70264-0.
  • Nahmias AJ, Froeschle JE, Feorino PM, et al. Generalized eruption in a child with eczema due to coxsackievirus A16. Arch Dermatol. 1968;97:147–148.
  • Harris PN, Wang AD, Yin M, et al. Atypical hand, foot, and mouth disease: eczema coxsackium can also occur in adults. Lancet Infect Dis. 2014;14:1043. DOI:10.1016/S1473-3099(14)70940-5.
  • Gao P-S, Rafaels NM, Mu D, et al. Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum. J Allergy Clin Immunol. 2010;125:1403–1407. DOI:10.1016/j.jaci.2010.03.016.
  • Gao P-S, Leung DY, Rafaels NM, et al. Genetic variants in interferon regulatory factor 2 (IRF2) are associated with atopic dermatitis and eczema herpeticum. J Invest Dermatol. 2012;132:650–657. DOI:10.1038/jid.2011.374.
  • Bin L, Edwards MG, Heiser R, et al. Identification of novel gene signatures in patients with atopic dermatitis complicated by eczema herpeticum. J Allergy Clin Immunol. 2014;134:848–855. DOI:10.1016/j.jaci.2014.07.018.
  • Dorman SE, Uzel G, Roesler J, et al. Viral infections in interferon-gamma receptor deficiency. J Pediatr. 1999;135:640–643.
  • Gao L, Bin L, Rafaels NM, et al. Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum. J Allergy Clin Immunol. 2015;136:1591–1600. DOI:10.1016/j.jaci.2015.06.047.
  • Boguniewicz M, Jaffe HS, Izu A, et al. Recombinant gamma interferon in treatment of patients with atopic dermatitis and elevated IgE levels. Am J Med. 1990;88:365–370.
  • Hanifin JM, Schneider LC, Leung DY, et al. Recombinant interferon gamma therapy for atopic dermatitis. J Am Acad Dermatol. 1993;28:189–197.
  • Jang IG, Yang JK, Lee HJ, et al. Clinical improvement and immunohistochemical findings in severe atopic dermatitis treated with interferon gamma. J Am Acad Dermatol. 2000;42:1033–1040.
  • Reinhold U, Kukel S, Brzoska J, et al. Systemic interferon gamma treatment in severe atopic dermatitis. J Am Acad Dermatol. 1993;29:58–63.
  • Ellis CN, Stevens SR, Blok BK, et al. Interferon-γ therapy reduces blood leukocyte levels in patients with atopic dermatitis: correlation with clinical improvement. Clin Immunol. 1999;92:49–55. DOI:10.1006/clim.1999.4731.
  • Stevens SR, Hanifin JM, Hamilton T, et al. Long-term effectiveness and safety of recombinant human interferon gamma therapy for atopic dermatitis despite unchanged serum IgE levels. Arch Dermatol. 1998;134:799–804.
  • Schneider LC, Baz Z, Zarcone C, et al. Long-term therapy with recombinant interferon-gamma (rIFN-γ) for atopic dermatitis. Ann Allergy Asthma Immunol. 1998;80:263–268. DOI:10.1016/S1081-1206(10)62968-7.
  • Noda S, Suárez-Fariñas M, Ungar B, et al. The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization. J Allergy Clin Immunol. 2015 Sep 28;136:1254–1264. DOI:10.1016/j.jaci.2015.08.015. Epub ahead of print.
  • Nakajima H, Loegering DA, Kita H, et al. Reactivity of monoclonal antibodies EG1 and EG2 with eosinophils and their granule proteins. J Leukoc Biol. 1999;66:447–454.
  • Sechler JM, Malech HL, White CJ, et al. Recombinant human interferon-gamma reconstitutes defective phagocyte function in patients with chronic granulomatous disease of childhood. Proc Natl Acad Sci U S A. 1988;85:4874–4878.
  • Ezekowitz RA, Orkin SH, Newburger PE. Recombinant interferon gamma augments phagocyte superoxide production and X-chronic granulomatous disease gene expression in X-linked variant chronic granulomatous disease. J Clin Invest. 1987;80:1009–1016. DOI:10.1172/JCI113153.
  • Tang ML, Kemp AS, Thorburn J, et al. Reduced interferon-gamma secretion in neonates and subsequent atopy. Lancet. 1994;344:983–985.
  • Fishbein AB, Vitaterna O, Haugh IM, et al. Nocturnal eczema: review of sleep and circadian rhythms in children with atopic dermatitis and future research directions. J Allergy Clin Immunol. 2015;136:1170–1177. DOI:10.1016/j.jaci.2015.08.028.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.