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Editorial

Antibody-drug conjugates for non-oncological indications

, &
Pages 591-593 | Received 29 Jan 2016, Accepted 01 Mar 2016, Published online: 21 Mar 2016

References

  • Ehrlich P. Zur Kenntnis der Antitoxinwirkung. Fortschr Med. 1897;15:41–43.
  • Kamath AV, Iyer S. Preclinical pharmacokinetic considerations for the development of antibody drug conjugates. Pharm Res. 2015;32:3470–3479.
  • Sassoon I, Blanc V. Antibody-drug conjugate (ADC) clinical pipeline: a review. Methods Mol Biol. 2013;1045:1–27.
  • Graversen JH, Svendsen P, Dagnaes-Hansen F, et al. Targeting the hemoglobin scavenger receptor CD163 in macrophages highly increases the anti-inflammatory potency of dexamethasone. Mol Ther. 2012;20:1550−8.
  • Talpaz M, Shah NP, Kantarjian H, et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med. 2006;354:2531–2541.
  • Giles FJ, O’Dwyer M, Swords R. Class effects of tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia. Leukemia. 2009;23:1698–1707.
  • Wang RE, Liu T, Wang Y, et al. An immunosuppressive antibody-drug conjugate. J Am Chem Soc. 2015;137:3229−32.
  • Liu T, Liu Y, Wang Y, et al. Rational design of CXCR4 specific antibodies with elongated CDRs. J Am Chem Soc. 2014;136:10557–10560.
  • Junutula JR, Raab H, Clark S, et al. Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index. Nat Biotechnol. 2008;26:925−32.
  • Axup JY, Bajjuri KM, Ritland M, et al. Synthesis of site-specific antibody-drug conjugates using unnatural amino acids. Proc Natl Acad Sci U S A. 2012;109:16101–16106.
  • Lim RKV, Yu S, Cheng B, et al. Targeted delivery of LXR agonist using a site-specific antibody−drug conjugate. Bioconjugate Chem. 2015;26:2216–2222.
  • Lehar SM, Pillow T, Xu M, et al. Novel antibody–antibiotic conjugate eliminates intracellular S. aureus. Nature. 2015;527:323–328.
  • Perez HL, Cardarelli PM, Deshpande S, et al. Antibody-drug conjugates: current status and future directions. Drug Discov Today. 2014;19:869–881.

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