Reprogramming cancer cells: overview & current progress

References

• Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131:861–872. doi:10.1016/j.cell.2007.11.019.
   PubMed Web of Science ®Google Scholar
• Kumar SM, Liu S, Lu H, et al. Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation. Oncogene. 2012;31:4898–4911. doi:10.1038/onc.2011.627.
   PubMed Web of Science ®Google Scholar
• Miyoshi N, Ishii H, Nagai K, et al. Defined factors induce reprogramming of gastrointestinal cancer cells. Proc Natl Acad Sci U S A. 2010;107:40–45. doi:10.1073/pnas.0910097107.
   PubMed Web of Science ®Google Scholar
• Zhang X, Cruz FD, Terry M, et al. Terminal differentiation and loss of tumorigenicity of human cancers via pluripotency-based reprogramming. Oncogene. 2013;32:2249–2260, 2260.e1–2260.e21. doi:10.1038/onc.2012.322.
   Web of Science ®Google Scholar
• Vêncio E, Nelson A, Cavanaugh C Reprogramming of prostate cancer‐associated stromal cells to embryonic stem‐like [Internet]; 2012 [cited 2014]. Available from: http://onlinelibrary.wiley.com/doi/10.1002/pros.22497/full
   Google Scholar
• Kim J, Hoffman JP, Alpaugh RK, et al. An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression. Cell Rep. 2013;3:2088–2099. doi:10.1016/j.celrep.2013.02.004.
   PubMed Web of Science ®Google Scholar
• Utikal J, Maherali N, Kulalert W, et al. Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells. J Cell Sci. 2009;122:3502–3510. doi:10.1242/jcs.054783.
   PubMed Web of Science ®Google Scholar
• Carette JE, Pruszak J, Varadarajan M, et al. Generation of iPSCs from cultured human malignant cells. Blood. 2010;115:4039–4042. doi:10.1182/blood-2009-12-255992.
   PubMed Web of Science ®Google Scholar
• Kim JB, Sebastiano V, Wu G, et al. Oct4-induced pluripotency in adult neural stem cells. Cell. 2009;136:411–419. doi:10.1016/j.cell.2009.01.023.
   PubMed Web of Science ®Google Scholar
• Wernig M, Meissner A, Cassady JP, et al. c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell. 2008;2:10–12. doi:10.1016/j.stem.2007.12.001.
   PubMed Web of Science ®Google Scholar
• Nakagawa M, Koyanagi M, Tanabe K, et al. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol. 2008;26:101–106. doi:10.1038/nbt1374.
   PubMed Web of Science ®Google Scholar
• Choong PF, Teh HX, Teoh HK, et al. Heterogeneity of osteosarcoma cell lines led to variable responses in reprogramming. Int J Med Sci. 2014;11:1154–1160. doi:10.7150/ijms.8281.
   PubMed Web of Science ®Google Scholar
• Hu K, Yu J, Suknuntha K, et al. Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells. Blood. 2011;117:e109–e119. doi:10.1182/blood-2010-07-298331.
   PubMed Web of Science ®Google Scholar
• Choi SM, Liu H, Chaudhari P, et al. Reprogramming of EBV-immortalized B-lymphocyte cell lines into induced pluripotent stem cells. Blood. 2011;118:1801–1805. doi:10.1182/blood-2011-02-334870.
   PubMed Web of Science ®Google Scholar
• Allegrucci C, Rushton MD, Dixon JE, et al. Epigenetic reprogramming of breast cancer cells with oocyte extracts. Mol Cancer. 2011;10:7. doi:10.1186/1476-4598-10-93.
   PubMed Web of Science ®Google Scholar
• Stricker SH, Feber A, Engström PG, et al. Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner. Genes Dev. 2013;27:654–669.
   PubMed Web of Science ®Google Scholar
• Lin S-L, Chang DC, Chang-Lin S, et al. Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state. RNA. 2008;14:2115–2124. doi:10.1261/rna.1162708.
   PubMed Web of Science ®Google Scholar
• Eminli S, Utikal J, Arnold K, et al. Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression. Stem Cells. 2008;26:2467–2474. doi:10.1634/stemcells.2008-0317.
   PubMed Web of Science ®Google Scholar
• Kim JB, Zaehres H, Wu G, et al. Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature. 2008;454:646–650. doi:10.1038/nature07061.
   PubMed Web of Science ®Google Scholar
• Silva J, Barrandon O, Nichols J, et al. Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol. 2008;6:e253. doi:10.1371/journal.pbio.0060098.
   PubMed Web of Science ®Google Scholar
• Hochedlinger K, Blelloch R, Brennan C, et al. Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev. 2004;18:1875–1885. doi:10.1101/gad.1213504.
   PubMed Web of Science ®Google Scholar
• Mathieu J, Zhang Z, Zhou W, et al. HIF induces human embryonic stem cell markers in cancer cells. Cancer Res. 2011;71:4640–4652. doi:10.1158/0008-5472.CAN-10-3320.
   PubMed Web of Science ®Google Scholar
• Mahalingam D, Kong CM, Lai J, et al. Reversal of aberrant cancer methylome and transcriptome upon direct reprogramming of lung cancer cells. Sci Rep. 2012. doi:10.1038/srep00592.
   PubMed Web of Science ®Google Scholar
• Kumano K, Arai S, Hosoi M, et al. Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples. Blood. 2012;119:6234–6242. doi:10.1182/blood-2011-10-388512.
   PubMed Web of Science ®Google Scholar
• Zhang S, Zhong B, Chen M, et al. Epigenetic reprogramming reverses the malignant epigenotype of the MMP/TIMP axis genes in tumor cells. Int J Cancer. 2014;134:1583–1594. doi:10.1002/ijc.28487.
   PubMed Web of Science ®Google Scholar
• Millán JL. Alkaline phosphatases : structure, substrate specificity and functional relatedness to other members of a large superfamily of enzymes. Purinergic Signal. 2006;2:335–341. doi:10.1007/s11302-005-5435-6.
   PubMedGoogle Scholar
• O’Connor MD, Kardel MD, Iosfina I, et al. Alkaline phosphatase-positive colony formation is a sensitive, specific, and quantitative indicator of undifferentiated human embryonic stem cells. Stem Cells. 2008;26:1109–1116. doi:10.1634/stemcells.2007-0801.
   PubMed Web of Science ®Google Scholar
• Singh U, Quintanilla RH, Grecian S, et al. Novel live alkaline phosphatase substrate for identification of pluripotent stem cells. Stem Rev Rep. 2012;8:1021–1029. doi:10.1007/s12015-012-9359-6.
   PubMed Web of Science ®Google Scholar
• Pera MF, Reubinoff B, Trounson A. Human embryonic stem cells. J Cell Sci. 2000;113 Pt 1:5–10.
   PubMed Web of Science ®Google Scholar
• Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663–676. doi:10.1016/j.cell.2006.07.024.
   PubMed Web of Science ®Google Scholar
• Martí M, Mulero L, Pardo C, et al. Characterization of pluripotent stem cells. Nat Protoc. 2013;8:223–253. doi:10.1038/nprot.2012.154.
   PubMed Web of Science ®Google Scholar
• Kim K, Doi A, Wen B, et al. Epigenetic memory in induced pluripotent stem cells. Nature. 2010;467:285–290. doi:10.1038/nature09342.
   PubMed Web of Science ®Google Scholar
• Zhao W, Ji X, Zhang F, et al. Embryonic stem cell markers. Molecules. 2012;17:6196–6236. doi:10.3390/molecules17066196.
   PubMed Web of Science ®Google Scholar
• Zaehres H, Lensch MW, Daheron L, et al. High-efficiency RNA interference in human embryonic stem cells. Stem Cells. 2005;23:299–305. doi:10.1634/stemcells.2004-0252.
   PubMed Web of Science ®Google Scholar
• Chambers I, Tomlinson SR. The transcriptional foundation of pluripotency. Development. 2009;136:2311–2322. doi:10.1242/dev.024398.
   PubMed Web of Science ®Google Scholar
• Johansson H, Simonsson S. Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination. Aging (Albany NY). 2010;2:815–822. doi:10.18632/aging.v2i11.
   PubMedGoogle Scholar
• Henderson J, Draper J, Baillie H, et al. Preimplantation human embryos and embryonic stem cells show comparable expression of stage-specific embryonic antigens. Stem Cells. 2002;20:329–337. doi:10.1634/stemcells.20-4-329.
   PubMed Web of Science ®Google Scholar
• Schopperle WM, DeWolf WC. The TRA-1-60 and TRA-1-81 human pluripotent stem cell markers are expressed on podocalyxin in embryonal carcinoma. Stem Cells. 2007;25:723–730.
   PubMed Web of Science ®Google Scholar
• Masaki H, Ishikawa T, Takahashi S, et al. Heterogeneity of pluripotent marker gene expression in colonies generated in human iPS cell induction culture. Stem Cell Res. 2008;1:105–115. doi:10.1016/j.scr.2008.01.001.
   Web of Science ®Google Scholar
• Adewumi O, Aflatoonian B, Ahrlund-Richter L, et al. Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol. 2007;25:803–816. doi:10.1038/nbt1276.
   PubMed Web of Science ®Google Scholar
• Assou S, Le Carrour T, Tondeur S, et al. A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas. Stem Cells. 2007;25:961–973. doi:10.1634/stemcells.2006-0352.
   PubMed Web of Science ®Google Scholar
• Peerani R, Rao BM, Bauwens C, et al. Niche-mediated control of human embryonic stem cell self-renewal and differentiation. EMBO J. 2007;26:4744–4755. doi:10.1038/sj.emboj.7601806.
   PubMed Web of Science ®Google Scholar
• Burridge PW, Anderson D, Priddle H, et al. Improved human embryonic stem cell embryoid body homogeneity and cardiomyocyte differentiation from a novel V-96 plate aggregation system highlights interline variability. Stem Cells. 2007;25:929–938.
   PubMed Web of Science ®Google Scholar
• Polo JM, Liu S, Figueroa ME, et al. Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol. 2010;28:848–855. doi:10.1038/nbt.1665.
   PubMed Web of Science ®Google Scholar
• Vallier L, Alexander M, Pedersen RA. Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells. J Cell Sci. 2005;118:4495–4509. doi:10.1242/jcs.02391.
   PubMed Web of Science ®Google Scholar
• Smith JR, Vallier L, Lupo G, et al. Inhibition of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectoderm. Dev Biol. 2008;313:107–117. doi:10.1016/j.ydbio.2007.10.003.
   PubMed Web of Science ®Google Scholar
• Brown S, Teo A, Pauklin S, et al. Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors. Stem Cells. 2011;29:1176–1185.
   PubMed Web of Science ®Google Scholar
• Xu X, Browning VL, Odorico JS. Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells. Mech Dev. 2011;128:412–427. doi:10.1016/j.mod.2011.08.001.
   PubMed Web of Science ®Google Scholar
• Ben-Haim N, Lu C, Guzman-Ayala M, et al. The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4. Dev Cell. 2006;11:313–323. doi:10.1016/j.devcel.2006.07.005.
   PubMed Web of Science ®Google Scholar
• Willems E, Leyns L. Patterning of mouse embryonic stem cell-derived pan-mesoderm by Activin A/Nodal and Bmp4 signaling requires fibroblast growth factor activity. Differentiation. 2008;76:745–759. doi:10.1111/j.1432-0436.2007.00257.x.
   PubMed Web of Science ®Google Scholar
• Torres J, Prieto J, Durupt FC, et al. Efficient differentiation of embryonic stem cells into mesodermal precursors by BMP, retinoic acid and Notch signalling. PLoS One. 2012;7:e36405.
   Google Scholar
• Mayshar Y, Ben-David U, Lavon N, et al. Identification and classification of chromosomal aberrations in human induced pluripotent stem cells. Cell Stem Cell. 2010;7:521–531.
   PubMed Web of Science ®Google Scholar
• Teoh H-K, Cheong S-K. Induced pluripotent stem cells in research and therapy. Malays J Pathol. 2012;34:1–13.
   PubMedGoogle Scholar
• Dimos JT, Rodolfa KT, Niakan KK, et al. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science. 2008;321:1218–1221. doi:10.1126/science.1158799.
   PubMed Web of Science ®Google Scholar
• Zhang N, An MC, Montoro D, et al. Characterization of human Huntington’s disease cell model from induced pluripotent stem cells. PLoS Curr. 2010;2:1–113. doi:10.1371/currents.RRN1193.
   Google Scholar
• Hanna J, Wernig M, Markoulaki S, et al. Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science. 2007;318:1920–1923. doi:10.1126/science.1143609.
   PubMed Web of Science ®Google Scholar
• Yusa K, Rashid ST, Strick-Marchand H, et al. Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells. Nature. 2011;478:391–394. doi:10.1038/nature10424.
   PubMed Web of Science ®Google Scholar
• Semi K, Matsuda Y, Ohnishi K, et al. Cellular reprogramming and cancer development. Int J Cancer. 2013;132:1240–1248. doi:10.1002/ijc.27963.
   PubMed Web of Science ®Google Scholar
• Ron-Bigger S, Bar-Nur O, Isaac S, et al. Aberrant epigenetic silencing of tumor suppressor genes is reversed by direct reprogramming. Stem Cells. 2010;28:1349–1354. doi:10.1002/stem.468.
   PubMed Web of Science ®Google Scholar
• Kourtidis A, Ngok SP, Pulimeno P, et al. Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity. Nat Cell Biol. 2015;17:1145–1157. doi:10.1038/ncb3137.
   PubMed Web of Science ®Google Scholar
• Subramanyam D, Lamouille S, Judson RL, et al. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol. 2011;29:443–448. doi:10.1038/nbt.1867.
   PubMed Web of Science ®Google Scholar