CpG DNA: immunomodulation and remodelling of the asthmatic airway

Bibliography

• JAMES AL, PARE PD, HOGG JC: The mechanics of airway narrowing in asthma. Am. Rev. Respir: Dis. (1989) 139:242–246.
   PubMed Web of Science ®Google Scholar
• WILSON JW, LI X, PAIN MC: The lack of distensibility of asthmatic airways. Am. Rev Respir: Dis. (1993) 148:806–809.
   PubMed Web of Science ®Google Scholar
• KIBE A, INOUE H, FUKUYAMA S et al: Differential regulation by glucocorticoid of interleukin-13-induced eosinophilia, hyperresponsiveness, and goblet cell hyperplasia in mouse airways. Am. .1. Respir: Crit. Care Med. (2003) 167:50–56.
   Google Scholar
• DORSCHEID DR, LOW E, CONFORTI A et al: Corticosteroid-induced apoptosis in mouse airway epithelium: effect in normal airways and after allergen-induced airway inflammation. Allergy Clin. Immune] (2003) 111:360–366.
   PubMed Web of Science ®Google Scholar
• LEWIS CC, SUTHERLAND ER, MOSS TA et al.: Interleukin-4 and interleukin-13 augment the proliferative effect of dexamethasone on distal lung fibroblasts. Chest (2003) 123:356S.
   PubMed Web of Science ®Google Scholar
• WARSHAMANA GS, MARTINEZ S, LASKY JA, CORTI M, BRODY AR: Dexamethasone activates expression of the PDGF-alpha receptor and induces lung fibroblast proliferation. Am. Physic] (1998) 274:L499–L507.
   PubMed Web of Science ®Google Scholar
• KLINE JN, WALDSCHMIDT TJ, BUSINGA TR et al.: Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. .1 Immune]. (1998) 160:2555–2559.
   Google Scholar
• KLINE JN, KITAGAKI K, BUSINGA TR, JAIN VV: Treatment of established asthma in a murine model using CpG oligonucleotides. Am. j Physiol Lung Cell. Physiol (2002) 283:L170–L179.
   Google Scholar
• HUSSAIN I, JAIN VV, KITAGAKI K et al.: Modulation of murine allergic rhinosinusitis by CpG oligodeoxynucleotides. Laryngoscope (2002) 112:1819–1826.
   PubMed Web of Science ®Google Scholar
• JAIN VV, KITAGAKI K, BUSINGA T et al.: CpG-oligodeoxynucleotides inhibit airway remodeling in a murine model of chronic asthma. I Allergy Clin. Immunol. (2002) 110:867–872.
   PubMed Web of Science ®Google Scholar
• JAIN VV, BUSINGA TR, KITAGAKI KK et al: Mucosal administration of CpG oligodeoxynucleotides reverses a murine model of chronic asthma. Am. Physiol Lung Cell. MM. Physiol (2003) 285:L1137–L1146.
   PubMed Web of Science ®Google Scholar
• KRIEG AM: From A to Z on CpG. Trends Immunol (2002) 23:64–65.
   PubMedGoogle Scholar
• KRIEG AM: CpG motifs: The active ingredient in bacterial extracts? Nat. Med. (2003) 9:831–835.
   Web of Science ®Google Scholar
• ••An excellent update on cellularmechanisms of CpG DNA.
   Google Scholar
• KRIEG AM: An innate immune defense mechanism based on the recognition of CpG motifs in microbial DNA. I Lab. Clin. Med. (1996) 128:128–133.
   PubMed Web of Science ®Google Scholar
• LAMBRECHT BN, SALOMON B, KLATZMANN D, PAUVVELS RA: Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice. J Immunol (1998) 160:4090–4097.
   PubMed Web of Science ®Google Scholar
• HEMMI H, TAKEUCHI O, KAWAI T et al: A toll-like receptor recognizes bacterial DNA. Nature (2000) 408:740–745.
   PubMed Web of Science ®Google Scholar
• KRUG A, TOWAROWSKI A, BRITSCH S et al.: Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur. Immunol (2001) 31:3026–3037.
   PubMed Web of Science ®Google Scholar
• BAUER S, KIRSCHNING CJ, HACKER H et al.: Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc. Nati Acad. Sci. USA (2001) 98:9237–9242.
   PubMed Web of Science ®Google Scholar
• HORNUNG V, ROTHENFUSSER S, BRITSCH S et al.: Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol (2002) 168:4531–4537.
   PubMed Web of Science ®Google Scholar
• KRIEG AM: CpG motifs in bacterial DNAand their immune effects. Annu. Rev. Immunol (2002) 20:709–760.
   PubMed Web of Science ®Google Scholar
• HEMMI H, KAISHO T, TAKEDA K, AKIRA S: The roles of toll-like receptor 9, myd88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J Immunol (2003) 170:3059–3064.
   PubMed Web of Science ®Google Scholar
• TAKESHITA F, LEIFER CA, GURSEL I et al.: Cutting edge: role of toll-like receptor 9 in CpG DNA-induced activation of human cells. I Immunol (2001) 167:3555–3558.
   PubMed Web of Science ®Google Scholar
• CHIANG DJ, YE YL, CHEN WL et al: Ribavirin or CpG DNA sequence-modulated dendritic cells decrease the IgE level and airway inflammation. Am. J. Respic Grit. Care Med. (2003) 168:575–580.
   PubMed Web of Science ®Google Scholar
• •This study provides evidence for benefit from dendritic cell-based irnmunotherapy using CpG DNA in airway inflammation.
   Google Scholar
• HATTON RD, WEAVER CT: Immunology. T-bet or not T-bet. Science (2003) 302:993–994.
   Google Scholar
• FINOTTO S, NEURATH ME GLICKMAN JN et al.: Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science (2002) 295:336–338.
   Google Scholar
• ••T-bet, a Thl-inducing transcriptionfactor, is critical in suppressing asthmatic phenotype.
   Google Scholar
• LIU N, OHNISHI N, NI L, AKIRA S, BACON KB: CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells. Nat. Immunol (2003) 4:687–693.
   PubMed Web of Science ®Google Scholar
• KLINE JN, KRIEG AM, WALDSCHMIDT TJ et al.: CpG oligodeoxynucleotides do not require Thl cytokines to prevent eosinophilic airway inflammation in a murine model of asthma. Allergy Clin. Immunol (1999) 104:1258–1264.
   Google Scholar
• BROIDE D, SCHWARZE J, TIGHE H et al.: Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice. Immunol (1998) 161:7054–7062.
   Web of Science ®Google Scholar
• SUR S, WILD JS, CHOUDHURY BK et al.: Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides. I Immunol (1999) 162:6284–6293.
   PubMed Web of Science ®Google Scholar
• SHIROTA H, SANO K, KIKUCHI T, TAMURA G, SHIRATO K: Regulation of murine airway eosinophilia and Th2 cells by antigen-conjugated CpG oligodeoxynucleotides as a novel antigen-specific immunomodulator. I Immunol (2000) 164:5575–5582.
   PubMed Web of Science ®Google Scholar
• SHIROTA H, SANO K, KIKUCHI T, TAMURA G, SHIRATO K: Regulation of T-helper type 2 cell and airway eosinophilia by transmucosal coadministration of antigen and oligodeoxynucleotides containing CpG motifs. Am. I Respic Cell MM. Biol. (2000) 22:176–182.
   PubMed Web of Science ®Google Scholar
• SEREBRISKY D, TEPER AA, HUANG CK et al: CpG oligodeoxynucleotides can reverse Th2-associated allergic airway responses and alter the b7.1167.2 expression in a murine model of asthma. I Immunol (2000) 165:5906–5912.
   Google Scholar
• SANTELIZ JV, NEST GV, TRAQUINA P,LARSEN E, WILLS-KARP M: Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma. I Allergy Clin. Immunol. (2002) 109:455–462.
   PubMed Web of Science ®Google Scholar
• YI AK, CHANG M, PECKHAM DW, KRIEG AM, ASHMAN RF: CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry. I Immunol (1998) 160:5898–5906.
   PubMed Web of Science ®Google Scholar
• YI AK, HORNBECK P, LAFRENZ DE, KRIEG AM: CpG DNA rescue of murine B lymphoma cells from anti-IgM-induced growth arrest and programmed cell death is associated with increased expression of c-myc and bc1-xL. I Immunol (1996) 157:4918–4925.
   PubMed Web of Science ®Google Scholar
• YI AK, PECKHAM DW, ASHMAN RF, KRIEG AM: CpG DNA rescues B cells from apoptosis by activating NFkappaB and preventing mitochondrial membrane potential disruption via a chloroquine-sensitive pathway. Int. Immunol (1999) 11:2015–2024.
   PubMed Web of Science ®Google Scholar
• SCHWARTZ DA, WOHLFORD-LENANE CL, QUINN TJ, KRIEG AM: Bacterial DNA or oligonucleotides containing unmethylated CpG motifs can minimize lipopolysaccharide-induced inflammation in the lower respiratory tract through an IL-12-dependent pathway. I Immunol (1999) 163:224–231.
   PubMed Web of Science ®Google Scholar
• BOULET LP, LAVIOLETTE M, TURCOTTE H et al.: Bronchial subepithelial fibrosis correlates with airway responsiveness to methacholine. Chest (1997) 112:45–52.
   PubMed Web of Science ®Google Scholar
• BOUSQUET J, JEFFERY PK, BUSSE WW, JOHNSON M, VIGNOLA AM: Asthma. From bronchoconstriction to airways inflammation and remodeling. Am. Respit: Crit. Care Med. (2000) 161:1720–1745.
   PubMed Web of Science ®Google Scholar
• CHU HW, HALLIDAY JL, MARTIN RJ et al.: Collagen deposition in large airways may not differentiate severe asthma from milder forms of the disease. Am. Respir. Grit. Care Med. (1998) 158:1936–1944.
   PubMed Web of Science ®Google Scholar
• BOULET L, BELANGER M, CARRIER G: Airway responsiveness and bronchial-wall thickness in asthma with or without fixed airflow obstruction. Am. Respir. Crit. Care Med. (1995) 152:865–871.
   PubMed Web of Science ®Google Scholar
• OKAZAWA M, MULLER N, MCNAMARA AE et al.: Human airway narrowing measured using high resolution computed tomography. Am. I Respir. Grit. Care Med. (1996) 154:1557–1562.
   PubMed Web of Science ®Google Scholar
• CARROLL N, ELLIOT J, MORTON A, JAMES A: The structure of large and small airways in nonfatal and fatal asthma. Am. Rev. Respir. Dis. (1993) 147:405–410.
   PubMed Web of Science ®Google Scholar
• CHO JY, MILLER M, BAEK KJ et al: Immunostimulatory DNA inhibits transforming growth factor-beta expression and airway remodeling. Am. j Respir. Cell Mol Biol. (2004) 30:651–661.
   PubMed Web of Science ®Google Scholar
• KNIGHT DA, HOLGATE ST: The airway epithelium: Structural and functional properties in health and disease. Respiro/ogy (2003) 8:432–446.
   PubMed Web of Science ®Google Scholar
• •A brief overview of epithelial changes in airway remodelling.
   Google Scholar
• COTTREZ F, HURST SD, COFFMAN RL, GROUX H: T regulatory cells 1 inhibit a Th2-specific response M vivo. Immunol (2000) 165:4848–4853.
   Web of Science ®Google Scholar
• SUTO A, NAKAJIMA H, KAGAMI SI et al.: Role of CD4(+) CD25(-1-) regulatory T cells in T helper 2 cell-mediated allergic inflammation in the airways. Am. I Respir. Grit. Care Med. (2001) 164:680–687.
   PubMed Web of Science ®Google Scholar
• HANSEN G, YEUNG VP, BERRY G, UMETSU DT, DEKRUYFF RH: Vaccination with heat-killed listeria as adjuvant reverses established allergen-induced airway hyperreactivity and inflammation: Role of CD8+ T cells and IL-18. J. Immunol (2000) 164:223–230.
   PubMed Web of Science ®Google Scholar
• •This study demonstrates the inhibitory role of TGF-I3 in allergic airway inflammation.
   Google Scholar
• HANEDA K, SANO K, TAMURA G et al: TGF-beta induced by oral tolerance ameliorates experimental tracheal eosinophilia. j Innnunol. (1997) 159:4484–4490.
   Google Scholar
• HANEDA K, SANO K, TAMURA G et al.: Transforming growth factor-beta secreted from CD4(+) T cells ameliorates antigen-induced eosinophilic inflammation. A novel high-dose tolerance in the trachea. Am. .1. Respir. Cell Ma Biol. (1999) 21:268–274.
   Google Scholar
• NAKAO A, MIIKE S, HATANO M et al: Blockade of transforming growth factor beta/smad signaling in T cells by overexpression of smad7 enhances antigen-induced airway inflammation and airway reactivity. J. Exp. Med. (2000) 192:151–158.
   PubMed Web of Science ®Google Scholar
• •This study provides insight into TGF-I3 downstream signalling, which may mediate its protective effects in airway remodelling.
   Google Scholar
• REDINGTON AE, MADDEN J, FREW AJ et al: Transforming growth factor-beta 1 in asthma. Measurement in bronchoalveolar lavage fluid. Am. J. Respir. Crit. Care Med. (1997) 156:642–647.
   PubMed Web of Science ®Google Scholar
• HOWAT WJ, HOLGATE ST, LACKIE PM: TGF-beta isoform release and activation during M vitro bronchial epithelial wound repair. Am.]: Physiol Lung Cell. Ma Physiol (2002) 282:L115–L123.
   PubMed Web of Science ®Google Scholar
• KUMAR RK, HERBERT C, YANG M et al: Role of interleukin-13 in eosinophil accumulation and airway remodeling in a mouse model of chronic asthma. Clin. Exp. Allergy (2002) 32:1104–1111.
   PubMed Web of Science ®Google Scholar
• •This study reiterates the critical role of IL-13 in chronic asthma.
   Google Scholar
• ZHU Z, HOMER RJ, WANG Z et al.: Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. Clin. Invest. (1999) 103:779–788.
   Google Scholar
• WEBB DC, MCKENZIE AN, KOSKINEN AM et al.: Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity. Innnunol. (2000) 165:108–113.
   Google Scholar
• FOSTER PS, MING Y, MATTHEI KI et al: Dissociation of inflammatory and epithelial responses in a murine model of chronic asthma. Lab. Invest. (2000) 80:655–662.
   PubMed Web of Science ®Google Scholar
• OH JW, SEROOGY CM, MEYER EH et al.: CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation. Allergy Clin. Immunol (2002) 110:460–468.
   Google Scholar
• ARAI T, ABE K, MATSUOKA H et al.: Introduction of the interleukin-10 gene into mice inhibited bleomycin-induced lung injury in vivo. Am. I Physiol Lung Cell. Physiol (2000) 278:L914–L922.
   PubMed Web of Science ®Google Scholar
• LEE WT, PASOS G, CECCHINI L, MITTLER JN: Continued antigen stimulation is not required during CD4(+) T cell clonal expansion. Innnunol. (2002) 168:1682–1689.
   Google Scholar
• KITAGAKI K, JAIN V, BUSINGA T, HUSSAIN I, KLINE J: Immunomodulatory effects of CpG oligodeoxynucleotides on established Th2 responses. Clin. Diagn. Lab. Immunol (2002) 9:1260–1269.
   PubMedGoogle Scholar
• CHIARAMONTE MG, HESSE M, CHEEVER A, WYNN TA: CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-induced pathology by an IL-12-independent mechanism. j Innnunol. (2000) 164:973–985.
   Google Scholar
• WALTER MJ, MORTON JD, KAJIWARA N, AGAPOV E, HOLTZMAN MJ: Viral induction of a chronic asthma phenotype and genetic segregation from the acute response. I Gin. Invest. (2002) 110:165–175.
   PubMed Web of Science ®Google Scholar
• HOLTZMAN MJ, MORTON JD, SHORNICK LP et al.: Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigm. Physiol Rev (2002) 82:19–46.
   PubMed Web of Science ®Google Scholar
• SORKNESS RL, CASTLEMAN WL, KUMAR A, KAPLAN MR, LEMANSKE RF JR: Prevention of chronic postbronchiolitis airway sequelae with IFN-gamma treatment in rats. Am. I Respir. Grit. Care Med. (1999) 160:705–710.
   PubMed Web of Science ®Google Scholar
• HANCOCK GE, HEERS KM, PRYHARSKI KS, SMITH JD, TIBERIO L: Adjuvants recognized by Toll-like receptors inhibit the induction of polarized type 2 T cell responses by natural attachment (G) protein of respiratory syncytial virus. Vaccine (2003) 21:4348–4358.
   PubMed Web of Science ®Google Scholar
• PRINCE GA, MOND JJ, PORTER DD et al: Immunoprotective activity and safety of a respiratory syncytial virus vaccine: mucosal delivery of fusion glycoprotein with a CpG oligodeoxynucleotide adjuvant. J. Viral. (2003) 77:13156–13160.
   PubMed Web of Science ®Google Scholar
• HANCOCK GE, HEERS KM, SMITH JD et al: CpG containing oligodeoxynucleotides are potent adjuvants for parenteral vaccination with the fusion (F) protein of respiratory syncytial virus (RSV). Vaccine (2001) 19:4874–4882.
   PubMed Web of Science ®Google Scholar
• ORDONEZ CL, KHASHAYAR R, WONG HH et al.: Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am. .1. Respic Crit. Care Med. (2001) 163:517–523.
   Google Scholar
• FAHY JV: Goblet cell and mucin gene abnormalities in asthma. Chest (2002) 122:320S–326S.
   Google Scholar
• •A review on GC hyperplasia with emphasis on mechanisms.
   Google Scholar
• IKEDA RK, MILLER M, NAYAR J et al: Accumulation of peribronchial mast cells in a mouse model of ovalbumin allergen induced chronic airway inflammation: modulation by immunostimulatory DNA sequences. J. Immune]. (2003) 171:4860–4867.
   PubMed Web of Science ®Google Scholar
• •This study shows that CpG DNA may inhibit IL-9 and mast cell accumulation.
   Google Scholar
• KNOX AJ, PANG L, JOHNSON S, HAMAD A: Airway smooth muscle function in asthma. Clin. Exp. Allergy (2000) 30:606–614.
   PubMed Web of Science ®Google Scholar
• HEARD BE, HOSSAIN S: Hyperplasia of bronchial muscle in asthma. J. Athol (1973) 110:319–331.
   Web of Science ®Google Scholar
• WOODRUFF PG, DOLGANOV GM, FERRANDO RE et al.: Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am. I Respic Crit. Care Med. (2004) 169:1001–1006.
   PubMed Web of Science ®Google Scholar