Bibliography
- ANDRE F, SCHARTZ NE, MOVASSAGH M et al.: Malignant effusions and immunogenic tumour-derived exosomes. Lancet (2002) 360(9329):295–305.
- ••First observation describing that tumour cell-derived exosomes are founded in vivo in cancer-bearing patients. These TEX could be used as a novel source of tumour antigens.
- DENZER K, KLEIJMEER MJ, HEIJNEN HF et al.: Exosome: from internal vesicle of the multivesicular body to intercellular signaling device./ Cell Sci. (2000) 113(Pt 19):3365–3374.
- DENZER K, VAN EIJK M, KLEIJMEER MJ et al.: Follicular dendritic cells carry MHC class II-expressing microvesicles at their surface. J. ImmunoL (2000) 165(3):1259–1265.
- QUAH B, O'NEILL HC: Review: the application of dendritic cell-derived exosomes in tumour immunotherapy. Cancer Biother. Radiopharm. (2000) 15(2):185–194.
- WOLFERS J, LOZIER A, RAPOSO G et al.: Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat. Med. (2001) 7(3):297–303.
- ••This work was the first to demonstrate thatexosomes secreted by tumour cell lines can have immunological bioactivity in vitro and in vivo.
- ZITVOGEL L, REGNAULT A, LOZIER A et al.: Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat. Med. (1998) 4(5):594–600.
- ••This is the reference article of DEX thathighlights the potential antitumour activity of these vesicles.
- JOHNSTONE RM, ADAM M, HAMMOND JR et al.: Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). j Biol. Chem. (1987) 262(19):9412–9420.
- ••This is one of the first descriptions ofexosomes as vesicles secreted by living cells.
- ARNOLD PY, MANNIE MD: Vesicles bearing MHC class II molecules mediate transfer of antigen from antigen-presenting cells to CD4+ T cells. Eur. j Immunol. (1999) 29(4):1363–1373.
- ESCOLA JM, KLEIJMEER MJ, STOORVOGEL Wet al.: Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. j Biol. Chem. (1998) 273(32):20121–20127.
- GEMINARD C, NAULT F, JOHNSTONE RM et al.: Characteristics of the interaction between Hsc70 and the transferrin receptor in exosomes released during reticulocyte maturation. J. Biol. Chem. (2001) 276(13):9910–9916.
- HEIJNEN IA, VAN VUGT MJ, FANGER NA et al.: Antigen targeting to myeloid-specific human Fc gamma RD CD64 triggers enhanced antibody responses in transgenic mice. J. Clin. Invest. (1996) 97(2):331–338.
- HESS C, SADALLAH S, HEFTI A et al.: Ectosomes released by human neutrophils are specialized functional units. J. ImmunoL (1999) 163(8):4564–4573.
- PATEL DM, ARNOLD PY, WHITE GA et al.: Class II MHC/peptide complexes are released from APC and are acquired by T cell responders during specific antigen recognition. J. ImmunoL (1999) 163(10):5201–5210.
- RAPOSO G, TENZA D, MECHERI S et al.: Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation. Mol. Biol. Cell (1997) 8(12):2631–2645.
- SKOKOS D, LE PANSE S, VILLA I et al.: Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes. ImmunoL (2001) 166(2):868–876.
- THERY C, ZITVOGEL L, AMIGORENA S: Exosomes: composition, biogenesis and function. Nat. Rev. ImmunoL (2002) 2(8):569–579.
- BLANCHARD N, LANKAR D, FAURE F et al.: TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex. J. ImmunoL (2002) 168(7):3235–3241.
- LAULAGNIER K, GRAND D, DUJARDIN A et al.: PLD2 is enriched on exosomes and its activity is correlated to the release of exosomes. FEBS Lett. (2004) 572(1-3):11–14.
- •This work suggests that exosome formation is a regulated mechanism.
- SAVINA A, VIDAL M, COLOMBO MI: The exosome pathway in K562 cells is regulated by Rab11. J. Cell Sci. (2002) 115(Pt 12):2505–2515.
- TOLMACHOVA T, ANDERS R, STINCHCOMBE Jet al.: A general role for Rab27a in secretory cells. MoL Biol. Cell (2004) 15(1):332–344.
- KLEIJMEER M, RAMM G, SCHUURHUIS D et al.: Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells. J. Cell Biol. (2001) 155(1):53–63.
- RAPOSO G, MOORE M, INNES D et al.: Human macrophages accumulate HIV-1 particles in MHC II compartments. Traffic (2002) 3(10):718–729.
- STOORVOGEL W, KLEIJMEER MJ, GEUZE HJ et al.: The biogenesis and functions of exosomes. Traffic (2002) 3(5):321–330.
- THERY C, BOUSSAC M, VERON P et aL:Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. J. ImmunoL (2001) 166(12):7309–7318.
- •This work describes extensively DEX protein composition and demonstrates clearly that they are different from apoptotic bodies.
- LAULAGNIER K, MOTTA C, HAMDI S et al.: Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization. Biochem. J. (2004) 380(Pt 1):161–171.
- •The authors show that lipid composition of exosomes could be used as a specific marker for exosome characterisation.
- THERY C, DUBAN L, SEGURA E et aL: Indirect activation of naive CD4+ T cells by dendritic cell-derived exosomes. Nat. ImmunoL (2002) 3(12):1156–1162.
- •First observation to demonstrate that DEX can activate CD4* T cells in vivo in a murine model.
- LAMPARSKI HG, METHA-DAMANI A, YAO JY et al.: Production and characterization of clinical grade exosomes derived from dendritic cells. J. ImmunoL Methods (2002) 270(2):211–226.
- •This work describes very extensively how to purify DEX for clinical use. This process was used for the first clinical trial using DEX in cancer patients.
- ESCUDIER B, DORVAL T, CHAPUT N, et al.: Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial. J. TransL Med. (2005) 3(1):10.
- ESCUDIER B, DORVAL T, ANGEVIN E et al.: Novel approach to immunotherapy of cancer: Phase I trial of dexosome vaccine for patients with advanced melanoma. Proc. Am. Soc. Clin. Oncol. (2002):A1857.
- HSU DH, PAZ P, VILLAFLOR G et aL: Exosomes as a tumor vaccine: enhancing potency through direct loading of antigenic peptides. J. Immunother. (2003) 26(5):440–450.
- HARDING C, HEUSER J, STAHL P: Endocytosis and intracellular processing of transferrin and colloidal gold-transferrin in rat reticulocytes: demonstration of a pathway for receptor shedding. Eur. Cell Biol. (1984) 35(2):256–263.
- PAN BT, JOHNSTONE RM: Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell (1983) 33(3):967–978.
- ••This was the first description of exosomesas vesicles secreted by living cells.
- RIEU S, GEMINARD C, RABESANDRATANA H et aL: Exosomes released during reticulocyte maturation bind to fibronectin via integrin alpha4betal. Eur. j Biochem. (2000) 267(2):583–590.
- RAPOSO G, NIJMAN HW, STOORVOGEL Wet al.: B lymphocytes secrete antigen-presenting vesicles. J. Exp. Med. (1996) 183(3):1161–1172.
- ••First work to suggest that exosomes canhave immunological activities.
- CLAYTON A, TURKES A, DEWITT S et al.: Adhesion and signaling by B cell-derived exosomes: the role of integrins. EASEB J. (2004) 18(9):977–979.
- SKOKOS D, BOTROS HG, DEMEURE C et al.: Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo. ImmunoL (2003) 170(6):3037–3045.
- VAN NIEL G, RAPOSO G, CANDALH C et al.: Intestinal epithelial cells secrete exosome-like vesicles. Gastroenterology (2001) 121(2):337–349.
- KARLSSON M, LUNDIN S, DAHLGREN U et al.: `Tolerosomes' are produced by intestinal epithelial cells. Eur. j Immunol. (2001) 31(10):2892–2900.
- VAN NIEL G, HEYMAN M: The epithelial cell cytoskeleton and intracellular trafficking. II. Intestinal epithelial cell exosomes: perspectives on their structure and function. Am. J. PhysioL Gastrointest. Liver PhysioL (2002) 283(2):G251–G255.
- VAN NIEL G, MALLEGOL J, BEVILACQUA C et aL: Intestinal epithelial exosomes carry MHC class II/peptides able to inform the immune system in mice. Gut (2003) 52(12):1690–1697.
- HEIJNEN HF, SCHIEL AE, FIJNHEER R et al.: Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules. Blood (1999) 94(11):3791–3799.
- JANISZEWSKI M, DO CARMO AO, PEDRO MA et al.: Platelet-derived exosomes of septic individuals possess proapoptotic NAD(P)H oxidase activity: a novel vascular redox pathway. Crit. Care Med. (2004) 32(3):818–825.
- KELLER R: Dendritic cells: their significance in health and disease. ImmunoL Lett. (2001) 78(3):113–122.
- THERY C, REGNAULT A, GARIN J et aL: Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73. J. Cell BioL (1999) 147(3):599–610.
- BANCHEREAU J, BRIERE F, CAUX C et aL: Immunobiology of dendritic cells. Annu. Rev. Immunol. (2000) 18:767–811.
- PECHE H, HESLAN M, USAL C et aL: Presentation of donor major histocompatibility complex antigens by bone marrow dendritic cell-derived exosomes modulates allograft rejection. Transplantation (2003) 76(10):1503–1510.
- ALTIERI SL, KHAN AN, TOMASI TB: Exosomes from plasmacytoma cells as a tumor vaccine. J. /mmunother. (2004) 27(4):282–288.
- HEGMANS JP, BARD MP, HEMMES A et aL: Proteomic analysis of exosomes secreted by human mesothelioma cells. Am. J. PathoL (2004) 164(5):1807–1815.
- RITEAU B, FAURE F, MENIER C et aL: Exosomes bearing HLA-G are released by melanoma cells. Hum. Immunol. (2003) 64(11):1064–1072.
- ANDRE F, CHAPUT N, SCHARTZ NE et aL: Exosomes as potent cell-free peptide-based vaccine. I. Dendritic cell-derived exosomes transfer functional MHC class I/ peptide complexes to dendritic cells. ImmunoL (2004) 172(4):2126–2136.
- •First work to show that exosomes' MHC class 1/peptide complexes can be transferred to DCs to elicit antigen-specific CM* T cell responses in vitro in normal volunteers and in vivo in a murine model.
- CHAPUT N, SCHARTZ NE, ANDRE F et aL: Exosomes as potent cell-free peptide-based vaccine. II. Exosomes in CpG adjuvants efficiently prime naive Tcl lymphocytes leading to tumor rejection. ImmunoL (2004) 172(4):2137–2146.
- •This work demonstrates that DEX need synthetic adjuvant (TLR-9/3 ligands) to prime naïve CM* T cells leading to tumour regression.
- FIRAT H, COCHET M, ROHRLICH PS et aL: Comparative analysis of the CD8(+) T cell repertoires of H-2 class I wild-type/HLA-A2.1 and H-2 class I knockout/HLA-A2.1 transgenic mice. Int. Immunol (2002) 14(8):925–934.
- CURIEL TJ, COUKOS G, ZOU Let al: Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. (2004) 10(9):942–949.
- SAKAGUCHI S: Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol (2004) 22:531–562.
- VIGUIER M, LEMAITRE F, VEROLA O et al.: Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells. J. Immunol (2004) 173(2):1444–1453.
- GHIRINGHELLI F, LARMONIER N, SCHMITT E et al.: CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative. Eur. J. Immunol (2004) 34(2):336–344.
- ESCUDIER B, ANGEVIN E, LANTZ O et al.: Preclinical and clinical development of dexosome-based immunotherapy for advanced cancer. Annual Meeting of the American Association for Cancer Research (2003):Abstract #2981, p681.
- ALINE F, BOUT D, AMIGORENA S et al.: Toxoplasma gondii antigen-pulsed-dendritic cell-derived exosomes induce a protective immune response against T gondii infection. Infect. Immun. (2004) 72(7):4127–4137.