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Drug Evaluation

Pexelizumab – a C5 complement inhibitor for use in both acute myocardial infarction and cardiac surgery with cardiopulmonary bypass

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Pages 833-839 | Published online: 24 Nov 2005

Bibliography

  • AMERICAN HEART ASSOCIATION: Heart Disease and Stroke Statistics, 2004 update. (2004).
  • NIAN M, LEE P, KHAPER N, LIU P: Inflammatory cytokines and postmyocardial infarction remodeling. Circ. Res. (2004) 94(12):1543–1553.
  • MONSINJON T, RICHARD V, FONTAINE M: Complement and its implications in cardiac ischaemia/ reperfusion: strategies to inhibit complement. Fundam. Clin. Pharmacol. (2001) 15(5):293–306.
  • WAN S, LECLERC JL, VINCENT JL: Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies. Chest (1997) 112(3):676–692.
  • LEVY JH, TANAKA KA: Inflammatory response to cardiopulmonary bypass. Ann. Thorac. Surg. (2003) 75(2):5715–5720.
  • BRAUNWALD E, FAUCI AS, KASPER DL, HAUSER SL, LONGO DL, JAMESON JL: Harrison's Principles of Internal Medicine (15th edition). Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL (Eds), McGraw-Hill, New York, USA (2001).
  • JOHANSSON-SYNNERGREN M, NILSSON F, BENGTSSON A. JEPPSSON A, WIKLUND L: Off-pump CABG reduces complement activation but does not significantly affect peripheral endothelial function: a prospective randomized study. Scand. Cardiovasc. (2004) 38(1):53–58.
  • VAKEVA AP, AGAH A, ROLLINS SA, MATIS LA, LI L, STAHL GL: Myocardial infarction and apoptosis after myocardial ischaemia and reperfusion: role of the terminal complement components and inhibition by anti-05 therapy. Circulation (1998) 97(22):2259–2267.
  • FITCH JC, ROLLINS S, MATIS Let al.: Pharmacology and biological efficacy of a recombinant, humanized, single-chain antibody C5 complement inhibitor in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass. Circulation (1999) 100(25):2499–2506.
  • MAHAFFEY KW, GRANGER CB, NICOLAU JC et al.: Effect of pexelizumab, an anti-05 complement antibody, as adjunctive therapy to fibrinolysis in acute myocardial infarction: the COMPlement inhibition in myocardial infarction treated with thromboLYtics (COMPLY) trial. COMPLY Investigators. Circulation (2003) 108(141176–1183.
  • GRANGER CB, MAHAFFEY KW, WEAVER WD et al.: Pexelizumab, an anti-C5 complement antibody, as adjunctive therapy to primary percutaneous coronary intervention in acute myocardial infarction: the COMplement inhibition in Myocardial infarction treated with Angioplasty (COMMA) trial. COMMA Investigators. Circulation (2003) 108(10):1184–1190.
  • KONG DF, HASSELBLAD HARRINGTON RA et al.: Meta-analysis of survival with platelet glycoprotein IIb/ IIIa antagonists for percutaneous coronary interventions. Am. J. CardioL (2003) 92(6):651–655.
  • BERANEK JT: Why did the anti-05 complement antibody pexelizumab not reduce infarct size but influence clinical outcomes positively when applied as adjunctive therapy to primary percutaneous coronary intervention? Circulation (2004) 109(16):e195–e196; author reply e195–e196.
  • SHERNAN SK, FITCH JC, NUSSMEIER NA et al.: Impact of pexelizumab, an anti-05 complement antibody, on total mortality and adverse cardiovascular outcomes in cardiac surgical patients undergoing cardiopulmonary bypass. Pexelizumab Study Investigators. Ann. Thorac. Surg. (2004) 77(3):942–949; discussion 949–950.
  • MATHEW JP, SHERNAN SK, WHITE WD et al.: Preliminary report of the effects of complement suppression with pexelizumab on neurocognitive decline after coronary artery bypass graft surgery. Stroke (2004) 35(10):2335–2339.
  • VERRIER ED, SHERNAN SK, TAYLOR KM et al.: Terminal complement blockade with pexelizumab during coronary artery bypass graft surgery requiring cardiopulmonary bypass: a randomized trial. PRIMO-CABG Investigators. JAMA (2004) 291(19):2319–2327.

Websites

  • http://www.who.int World Health Report 2003 — shaping the world, WHO 2003.

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