Tyrosine kinase inhibitors to treat liver cancer

Bibliography

• Global Cancer facts and Figures 2007. American Cancer Society, 2007. Available from: http://www.cancer.org/docroot/home/index.asp
   Google Scholar
• Edmondson HA, Peters RL. Tumors of the liver: pathologic features. Semin Roentgenol 1983;18:75-83
   PubMed Web of Science ®Google Scholar
• Donato F, Gelatti U, Limina RM, Fattovich G. Southern Europe as an example of interaction between various environmental factors: a systematic review of the epidemiologic evidence. Oncogene 2006;25:3756-70
   PubMed Web of Science ®Google Scholar
• Seeff LB, Hoofnagle JH. Epidemiology of hepatocellular carcinoma in areas of low hepatitis B and hepatitis C endemicity. Oncogene 2006;25:3771-7
   PubMed Web of Science ®Google Scholar
• Okuda K, Ohtsuki T, Obata H, Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients. Cancer 1985;56:918-28
   PubMed Web of Science ®Google Scholar
• Huguet C, Stipa F, Gavelli A. Primary hepatocellular cancer: western experience. In: L.Blumgart, editor, Surgery of the liver and billary tract. Churchill Livingstone, London; 2000. p. 1365-69
   Google Scholar
• Colombo M. Hepatocellular carcinoma. J Hepatol 1992;15:225-36
   PubMed Web of Science ®Google Scholar
• Simonetti RG, Liberati A, Angiolini C, Pagliaro L. Treatment of hepatocellular carcinoma: a systematic review of randomized controlled trials. Ann Oncol 1997;8:117-36
   PubMed Web of Science ®Google Scholar
• Poon RT, Fan ST, Lo CM, Improving survival results after resection of hepatocellular carcinoma: a prospective study of 377 patients over 10 years. Ann Surg 2001;234:63-70
   PubMed Web of Science ®Google Scholar
• Abdalla EK, Denys A, Hasegawa K, Treatment of large and advanced hepatocellular carcinoma. Ann Surg Oncol 2007;15:979-85
   Web of Science ®Google Scholar
• Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet 2003;362:1907-17
   PubMed Web of Science ®Google Scholar
• Thomas M. Molecular targeted therapy for hepatocellular carcinoma. J Gastroenterol 2009;44(Suppl 19):136-41
   PubMed Web of Science ®Google Scholar
• Zhu AX, Raymond E. Early development of sunitinib in hepatocellular carcinoma. Expert Rev Anticancer Ther 2009;9:143-50
   PubMed Web of Science ®Google Scholar
• Yeo W, Mok TS, Zee B, A randomized phase III study of doxorubicin versus cisplatin/interferon alpha-2b/doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinoma. J Natl Cancer Inst 2005;97:1532-8
   PubMed Web of Science ®Google Scholar
• Wilhelm SM, Carter C, Tang L, BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004;64:7099-109
   PubMed Web of Science ®Google Scholar
• Wilhelm SM, Carter C, Lynch M, Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nat Rev 2006;5:835-44
   Google Scholar
• Huynh H, Ngo VC, Koong HN, Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. J Cell Mol Med 2009:1-12. In press
   Google Scholar
• Liu L, Cao Y, Chen C, Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res 2006;66:11851-8
   PubMed Web of Science ®Google Scholar
• Llovet JM, Ricci S, Mazzaferro V, Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008;359:378-90
   PubMed Web of Science ®Google Scholar
• Cheng AL, Kang YK, Chen Z, Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 2009;10:25-34
   PubMed Web of Science ®Google Scholar
• Roberts LR. Sorafenib in liver cancer–just the beginning. N Engl J Med 2008;359:420-2
   PubMed Web of Science ®Google Scholar
• Olive KP, Jacobetz MA, Davidson CJ, Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009;324:1457-61
   PubMed Web of Science ®Google Scholar
• Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005;23:1011-27
   PubMed Web of Science ®Google Scholar
• Wada H, Nagano H, Yamamoto H, Expression pattern of angiogenic factors and prognosis after hepatic resection in hepatocellular carcinoma: importance of angiopoietin-2 and hypoxia-induced factor-1 alpha. Liver Int 2006;26:414-23
   PubMed Web of Science ®Google Scholar
• Tugues S, Fernandez-Varo G, Munoz-Luque J, Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats. Hepatology 2007;46:1919-26
   PubMed Web of Science ®Google Scholar
• Miura H, Miyazaki T, Kuroda M, Increased expression of vascular endothelial growth factor in human hepatocellular carcinoma. J Hepatol 1997;27:854-61
   PubMed Web of Science ®Google Scholar
• Poon RT, Ho JW, Tong CS, Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma. Br J Surg 2004;91:1354-60
   PubMed Web of Science ®Google Scholar
• Thomas MB, Abbruzzese JL. Opportunities for targeted therapies in hepatocellular carcinoma. J Clin Oncol 2005;23:8093-108
   PubMed Web of Science ®Google Scholar
• Zhang T, Sun HC, Xu Y, Overexpression of platelet-derived growth factor receptor alpha in endothelial cells of hepatocellular carcinoma associated with high metastatic potential. Clin Cancer Res 2005;11:8557-63
   PubMed Web of Science ®Google Scholar
• Conway EM, Collen D, Carmeliet P. Molecular mechanisms of blood vessel growth. Cardiovasc Res 2001;49:507-21
   PubMed Web of Science ®Google Scholar
• Pietras K, Hanahan D. A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J Clin Oncol 2005;23:939-52
   PubMed Web of Science ®Google Scholar
• Abou-Alfa G, Johnson P, Knox J, Preliminary results from a phase II, randomized, double-blind study of sorafenib plus doxorubicin versus placebo plus doxorubicin in patients with advanced hepatocellular carcinoma. Proceedings of the 14th European Cancer Conference; 23 – 27 September 2007; Barcelona, Spain
   Google Scholar
• Kim DW, Jo YS, Jung HS, An orally administered multitarget tyrosine kinase inhibitor, SU11248, is a novel potent inhibitor of thyroid oncogenic RET/papillary thyroid cancer kinases. J Clin Endocrinol Metab 2006;91:4070-6
   PubMed Web of Science ®Google Scholar
• Chow LQ, Eckhardt SG. Sunitinib: from rational design to clinical efficacy. J Clin Oncol 2007;25:884-96
   PubMed Web of Science ®Google Scholar
• Motzer RJ, Hutson TE, Tomczak P, Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007;356:115-24
   PubMed Web of Science ®Google Scholar
• Demetri G, Van Oosterom A, Garrett C, Efficacy and safety of Sunitinib in patients with advanced GISTs after failure of imatinib: a randomized controlled trial. Lancet 2006;368:1329-38
   PubMed Web of Science ®Google Scholar
• Huynh H, Ngo VC, Choo SP, Sunitinib (SUTENT, SU11248) suppresses tumor growth and induces apoptosis in xenograft models of human hepatocellular carcinoma. Curr Cancer Drug Targets 2009;9:738-47
   PubMed Web of Science ®Google Scholar
• Zhu AX, Sahani DV, di Tomaso E, A phase II study of sunitinib in patients with advanced hepatocellular carcinoma. ASCO 2007: Proceedings of the 2007 ASCO Annual Meeting; June 1 – 5 2007; Chicago, USA. J Clin Oncol 2007;25:18S
   Google Scholar
• Faivre SJ, Raymond E, Douillard J, Phase II trial investigating the efficacy and safety of sunitinib in patients with unresectable hepatocellular carcinoma (HCC). Eur J Cancer Suppl 2007;5(4):270
   Web of Science ®Google Scholar
• Zhu AX, Duda DG, Sahani DV, Jain RK. Development of sunitinib in hepatocellular carcinoma: rationale, early clinical experience, and correlative studies. Cancer J 2009;15:263-8
   PubMed Web of Science ®Google Scholar
• Faivre SJ, Raymond E, Douillard JBE, Assessment of safety and drug-induced tumor necrosis with sunitinib in patients (pts) with unresectable hepatocellular carcinoma (HCC). J Clin Oncol 2007;25:18S
   Google Scholar
• Huynh H, Ngo VC, Fargnoli J, Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma. Clin Cancer Res 2008;14:6146-53
   PubMed Web of Science ®Google Scholar
• Kanai F, Yoshida H, Tateishi R, Final result of a phase I/II trial of the oral anti-angiogenesis inhibitor TSU-68 in patients with advanced hepatocellular carcinoma. ASCO 2008: Proceedings of the 2008 ASCO Annual Meeting; May 30 – June 6 2008; Chicago,USA. J Clin Oncol 2008;26. Abstract 4589
   Web of Science ®Google Scholar
• Batchelor T, Sorensen G, di Tomaso E, A multidisciplinary phase II study of AZD2171 (cediranib), an oral pan-VEGF receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. ASCO 2008: Proceedings of the 2008 ASCO Annual Meeting; May 30 – June 3 2008; Chicago, USA. J Clin Oncol 2008;26. Abstract LB-247
   Google Scholar
• Goss G, Shepherd FA, Laurie S, A phase I and pharmacokinetic study of daily oral cediranib, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer. A study of the National Cancer Institute of Canada Clinical Trials Group. Eur J Cancer 2009;45(5):782-8
   PubMed Web of Science ®Google Scholar
• Robertson JD, Botwood NA, Rothenberg ML, Schmoll HJ. Phase III trial of FOLFOX plus bevacizumab or cediranib (AZD2171) as first-line treatment of patients with metastatic colorectal cancer: HORIZON III. Clin Colorectal Cancer 2009;8:59-60
   PubMed Web of Science ®Google Scholar
• Fiedler W, Mesters R, Heuser M, An open-label, phase I study of cediranib (RECENTIN™) in patients with acute myeloid leukemia. Leukemia Res 2009. In press
   Google Scholar
• Huynh H, Chow PK, Palanisamy N, Bevacizumab and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. J Hepatol 2008;49:52-60
   PubMed Web of Science ®Google Scholar
• Mise M, Arii S, Higashituji H, Clinical significance of vascular endothelial growth factor and basic fibroblast growth factor gene expression in liver tumor. Hepatology 1996;23:455-64
   PubMed Web of Science ®Google Scholar
• Ingber D. Extracellular matrix and cell shape: potential control points for inhibition of angiogenesis. J Cell Biochem 1991;47:236-41
   PubMed Web of Science ®Google Scholar
• El Assal ON, Yamanoi A, Ono T, The clinicopathological significance of heparanase and basic fibroblast growth factor expressions in hepatocellular carcinoma. Clin Cancer Res 2001;7:1299-305
   PubMed Web of Science ®Google Scholar
• Poon RT, Ng IO, Lau C, Correlation of serum basic fibroblast growth factor levels with clinicopathological features and postoperative recurrence in hepatocellular carcinoma. Am J Surg 2001;182:298-304
   PubMed Web of Science ®Google Scholar
• Yoshiji H, Kuriyama S, Yoshii J, Synergistic effect of basic fibroblast growth factor and vascular endothelial growth factor in murine hepatocellular carcinoma. Hepatology 2002;35:834-42
   PubMed Web of Science ®Google Scholar
• Kin M, Sata M, Ueno T, Basic fibroblast growth factor regulates proliferation and motility of human hepatoma cells by an autocrine mechanism. J Hepatol 1997;27:677-87
   PubMed Web of Science ®Google Scholar
• Bhide RS, Cai ZW, Zhang YZ, Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol- 5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor. J Med Chem 2006;49:2143-6
   PubMed Web of Science ®Google Scholar
• Lee SH, Lopes DM, Vora J, In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models. Clin Cancer Res 2005;11:3633-41
   PubMed Web of Science ®Google Scholar
• Harada K, Shiota G, Kawasaki H. Transforming growth factor-alpha and epidermal growth factor receptor in chronic liver disease and hepatocellular carcinoma. Liver 1999;19:318-25
   PubMedGoogle Scholar
• Huether A, Hopfner M, Baradari V, EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer. Biochem Pharmacol 2005;70:1568-78
   PubMed Web of Science ®Google Scholar
• Hopfner M, Sutter AP, Huether A, Targeting the epidermal growth factor receptor by gefitinib for treatment of hepatocellular carcinoma. J Hepatol 2004;41:1008-16
   PubMed Web of Science ®Google Scholar
• Philip PA, Mahoney MR, Allmer C, Phase II study of erlotinib (OSI-774) in patients with advanced hepatocellular cancer. J Clin Oncol 2005;23:6657-63
   PubMed Web of Science ®Google Scholar
• Thomas MB, Morris JS, Chadha R, Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma. J Clin Oncol 2009;27:843-50
   PubMed Web of Science ®Google Scholar
• Ramanathan RK, Belani CP, Singh DA, A phase II study of lapatinib in patients with advanced biliary tree and hepatocellular cancer. Cancer Chemother Pharmacol 2009;64:777-83
   PubMed Web of Science ®Google Scholar
• O'Dwyer PJ, Giantonio BJ, Levy DE, Gefitinib in advanced unresectable hepatocellular carcinoma: Results from the Eastern Cooperative Oncology Group's Study E1203. ASCO 2006: Proceedings of the 2006 ASCO Annual Meeting; June 2 – 6 2006; Atlanta, USA. J Clin Oncol 2006;24:18S
   Google Scholar
• Hynes NE, Lane HA. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 2005;5:341-54
   PubMed Web of Science ®Google Scholar
• Villanueva A, Newell P, Chiang DY, Genomics and signaling pathways in hepatocellular carcinoma. Semin Liver Dis 2007;27:55-76
   PubMed Web of Science ®Google Scholar
• Mckillop IH, Schmidt CM, Cahill PA, Altered expression of mitogen-activated protein kinases in a rat model of experimental hepatocellular carcinoma. Hepatology 1997;26:1484-91
   PubMed Web of Science ®Google Scholar
• Giambartolomei S, Covone F, Levrero M, Balsano C. Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the Hepatitis C Virus (HCV) core protein. Oncogene 2001;20:2606-10
   PubMed Web of Science ®Google Scholar
• Wentz SC, Wu H, Yip-Schneider MT, Targeting MEK is effective chemoprevention of hepatocellular carcinoma in TGF-alpha-transgenic mice. J Gastrointest Surg 2008;12:30-7
   PubMed Web of Science ®Google Scholar
• Huynh H, Soo KC, Chow PK, Tran E. Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma. Mol Cancer Ther 2007;6:138-46
   PubMed Web of Science ®Google Scholar
• Huynh H. AZD6244 enhances the antitumor activity of rapamycin in mouse models of human HCC. Cancer 2009. In press
   Google Scholar
• Hwang YH, Choi JY, Kim S, Over-expression of c-raf-1 proto-oncogene in liver cirrhosis and hepatocellular carcinoma. Hepatol Res 2004;29:113-21
   PubMed Web of Science ®Google Scholar
• Lee HC, Tian B, Sedivy JM, Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells. Gastroenterology 2006;131:1208-17
   PubMed Web of Science ®Google Scholar
• Huynh H, Ngo VC, Koong HN, AZD6244 enhances the antitumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC). J Hepatol 2010;52:79-87
   PubMed Web of Science ®Google Scholar
• Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002;2:489-501
   PubMed Web of Science ®Google Scholar
• Schmitz KJ, Wohlschlaeger J, Lang H, Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection. J Hepatol 2008;48:83-90
   PubMed Web of Science ®Google Scholar
• Boyault S, Rickman DS, de Reynies A, Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets. Hepatology 2007;45:42-52
   PubMed Web of Science ®Google Scholar
• Sahin F, Kannangai R, Adegbola O, mTOR and P70 S6 kinase expression in primary liver neoplasms. Clin Cancer Res 2004;10:8421-5
   PubMed Web of Science ®Google Scholar
• Horie Y, Suzuki A, Kataoka E, Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest 2004;113:1774-83
   PubMed Web of Science ®Google Scholar
• Amaravadi R, Thompson CB. The survival kinases Akt and Pim as potential pharmacological targets. J Clin Invest 2005;115:2618-24
   PubMed Web of Science ®Google Scholar
• Lee TK, Man K, Ho JW, FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation. Carcinogenesis 2004;25:2397-405
   PubMed Web of Science ®Google Scholar
• Semela D, Piguet AC, Kolev M, Vascular remodelling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma. J Hepatol 2007;46:840-8
   PubMed Web of Science ®Google Scholar
• Huynh H, Chow P, Soo KC, RAD001 (everolimus) inhibits tumor growth in xenograft models of human hepatocellular carcinoma. J Cell Mol Med 2008. In press
   Google Scholar
• Dudkin L, Dilling MB, Cheshire PJ, Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition. Clin Cancer Res 2001;7:1758-64
   PubMed Web of Science ®Google Scholar
• Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006;124:471-84
   PubMed Web of Science ®Google Scholar
• Motzer RJ, Escudier B, Oudard S, RAD001 vs placebo in patients with metastatic renal cell carcinoma (RCC) after progression on VEGFr-TKI therapy: Results from a randomized, double-blind, multicenter phase-III study. J Clin Oncol 2008;26. Abstract LBA-5026
   Google Scholar
• Rizell M, Andersson M, Cahlin C, Effects of the mTOR inhibitor sirolimus in patients with hepatocellular and cholangiocellular cancer. Int J Clin Oncol 2008;13:66-70
   PubMed Web of Science ®Google Scholar
• Bromberg JF. Activation of STAT proteins and growth control. Bioessays 2001;23:161-9
   PubMed Web of Science ®Google Scholar
• Riesterer O, Honer M, Jochum W, Ionizing radiation antagonizes tumor hypoxia induced by antiangiogenic treatment. Clin Cancer Res 2006;12:3518-24
   PubMed Web of Science ®Google Scholar
• Yun C, Cho H, Kim SJ, Mitotic aberration coupled with centrosome amplification is induced by hepatitis B virus X oncoprotein via the Ras-mitogen-activated protein/extracellular signal-regulated kinase-mitogen-activated protein pathway. Mol Cancer Res 2004;2:159-69
   PubMed Web of Science ®Google Scholar
• Yoshida T, Hanada T, Tokuhisa T, Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation. J Exp Med 2002;196:641-53
   PubMed Web of Science ®Google Scholar
• Calvisi DF, Ladu S, Gorden A, Ubiquitous activation of Ras and Jak/Stat pathways in human HCC. Gastroenterology 2006;130:1117-28
   PubMed Web of Science ®Google Scholar
• Park WS, Dong SM, Kim SY, Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas. Cancer Res 1999;59:307-10
   PubMed Web of Science ®Google Scholar
• Osada S, Kanematsu M, Imai H, Goshima S. Clinical significance of serum HGF and c-Met expression in tumor tissue for evaluation of properties and treatment of hepatocellular carcinoma. Hepatogastroenterology 2008;55:544-9
   PubMed Web of Science ®Google Scholar
• Therasse P, Arbuck SG, Eisenhauer EA, New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 2000;92:205-16
   PubMed Web of Science ®Google Scholar
• Maione P, Gridelli C, Troiani T, Ciardiello F. Combining targeted therapies and drugs with multiple targets in the treatment of NSCLC. Oncologist 2006;11:274-84
   PubMed Web of Science ®Google Scholar
• Ganslmayer M, Ocker M, Zopf S, A quadruple therapy synergistically blocks proliferation and promotes apoptosis of hepatoma cells. Oncol Rep 2004;11:943-50
   PubMed Web of Science ®Google Scholar
• Herold C, Ganslmayer M, Ocker M, Overadditive anti-proliferative and pro-apoptotic effects of a combination therapy on colorectal carcinoma cells. Int J Oncol 2003;23:751-6
   PubMed Web of Science ®Google Scholar