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Review

Emerging drugs for chemotherapy-induced mucositis

, MBBS MD FRACP, , DMD DMSc & , PhD
Pages 511-522 | Published online: 02 Sep 2008

Bibliography

  • Pico J, Avila-Garavito A, Naccache P. Mucositis: its occurrence, consequences and treatment in the oncology setting. Oncologist 1998;3:446-51
  • Keefe DM. Gastrointestinal mucositis: a new biological model. Support Care Cancer 2004;12:6-9
  • Sonis ST, Oster G, Fuchs H, et al. Oral mucositis and the clinical and economic outcomes of hematopoietic stem-cell transplantation. J Clin Oncol 2001;19:2201-5
  • Sonis ST. A biological approach to mucositis. J Support Oncol 2004;2:21-32; discussion 5-6
  • Sonis ST, Elting LS, Keefe D, et al. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 2004;100(Suppl 9):1995-2025
  • Scully C, Sonis S, Diz PD. Oral mucositis. Oral Dis 2006;12:229-41
  • Anthony L, Bowen J, Garden A, et al. New thoughts on the pathobiology of regimen-related mucosal injury. Support Care Cancer 2006;14:516-8
  • Sonis ST. The pathobiology of mucositis. Nat Rev Cancer 2004;4(4):277-84
  • Sonis ST, Scherer J, Phelan S, et al. The gene expression sequence of radiated mucosa in an animal mucositis model. Cell Prolif 2002;35(Suppl 1):93-102
  • Sonis ST. The biologic role for nuclear factor-kappaB in disease and its potential involvement in mucosal injury associated with anti-neoplastic therapy. Crit Rev Oral Biol Med 2002;13:380-9
  • Sonis S, Haddad R, Posner M, et al. Gene expression changes in peripheral blood cells provide insight into the biological mechanisms associated with regimen-related toxicities in patients being treated for head and neck cancers. Oral Oncol 2007;43(3):289-300
  • Keefe DM, Gibson RJ, Hauer-Jensen M. Gastrointestinal mucositis. Semin Oncol Nurs 2004;20(1):38-47
  • Logan RM, Gibson RJ, Bowen JM, et al. Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis. Cancer Chemother Pharmacol 2008;62(1):33-41
  • Keefe DM. Intestinal mucositis: mechanisms and management. Curr Opin Oncol 2007;19(4):323-7
  • Sonis ST. Pathobiology of mucositis. Semin Oncol Nurs 2004;20(1):11-5
  • Sonis ST. Mucositis as a biological process: a new hypothesis for the development of chemotherapy-induced stomatotoxicity. Oral Oncol 1998;34(1):39-43
  • Duncan M, Grant G. Oral and intestinal mucositis – causes and possible treatments. Aliment Pharmacol Ther 2003;18(9):853-74
  • Logan RM, Stringer AM, Bowen JM, et al. Is the pathobiology of chemotherapy-induced alimentary tract mucositis influenced by the type of mucotoxic drug administered? Cancer Chemother Pharmacol 2008 [Epub ahead of print] PMID: 18351341
  • Sonis ST. Pathobiology of oral mucositis: novel insights and opportunities. J Support Oncol 2007;5(9 Suppl 4):3-11
  • Sonis ST, Fey EG. Oral complications of cancer therapy. Oncology (Huntingt) 2002;16(5):680-6; discussion 6, 91-2, 95
  • Keefe DM, Cummins AG, Dale BM, et al. Effect of high-dose chemotherapy on intestinal permeability in humans. Clin Sci (Lond) 1997;92(4):385-9
  • Blijlevens NM, Donnelly JP, Yakar D, et al. Determining mucosal barrier injury to the oesophagus using CT scan. Support Care Cancer 2007;15(9):1105-8
  • Gibson RJ, Keefe DM. Cancer chemotherapy-induced diarrhoea and constipation: mechanisms of damage and prevention strategies. Support Care Cancer 2006;14(9):890-900
  • Peterson DE, Cariello A. Mucosal damage: a major risk factor for severe complications after cytotoxic therapy. Semin Oncol 2004;31(3 Suppl 8):35-44
  • Sartori S, Trevisani L, Nielsen I, et al. Randomized trial of omeprazole or ranitidine versus placebo in the prevention of chemotherapy-induced gastroduodenal injury. J Clin Oncol 2000;18(3):463-7
  • Stringer AM, Gibson RJ, Logan RM, et al. Chemotherapy-induced diarrhea is associated with changes in the luminal environment in the DA rat. Exp Biol Med (Maywood) 2007;232(1):96-106
  • Mothersill C, Moriarty MJ, Seymour CB. Bystander and other delayed effects and multi-organ involvement and failure following high dose exposure to ionising radiation. BJR Suppl 2005;27:128-31
  • Keefe DM, Gibson RJ. Mucosal injury from targeted anti-cancer therapy. Support Care Cancer 2006;15(5):483-90
  • Aprile G, Ramoni M, Keefe D, Sonis S. Application of distance matrices to define associations between acute toxicities in colorectal cancer patients receiving chemotherapy. Cancer 2008;112(2):284-92
  • Aprile G, Ramoni M, Keefe D, Sonis S. Network analyses to define chemotherapy toxicity clusters in patients with colorectal cancer (CRC) [abstract]. J Clin Oncol 2007;25(18S):9045
  • Lima MV, Ferreira FV, Macedo FY, et al. Histological changes in bladders of patients submitted to ifosfamide chemotherapy even with mesna prophylaxis. Cancer Chemother Pharmacol 2007;59(5):643-50
  • Chaves AP, Gomes JA, Hofling-Lima AL. Ocular changes induced by chemotherapy. Arq Bras Oftalmol 2007;70(4):718-25
  • Barasch A, Peterson DE. Risk factors for ulcerative oral mucositis in cancer patients: unanswered questions. Oral Oncol 2003;39(2):91-100
  • Sloan JA, Goldberg RM, Sargent DJ, et al. Women experience greater toxicity with fluorouracil-based chemotherapy for colorectal cancer. J Clin Oncol 2002;20(6):1491-8
  • Vera-Llonch M, Oster G, et al. Oral mucositis in patients undergoing radiation treatment for head and neck carcinoma. Cancer 2006;106(2):329-36
  • Schwab M, Zanger UM, Marx C, et al. Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: A Prospective Clinical Trial by the German 5-FU Toxicity Study Group. J Clin Oncol 2008;26(13):2131-8
  • Miller CR, McLeod HL. Pharmacogenomics of cancer chemotherapy-induced toxicity. J Support Oncol 2007;5(1):9-14
  • Bogunia-Kubik K, Polak M, Lange A. TNF polymorphisms are associated with toxic but not with aGVHD complications in the recipients of allogeneic sibling haematopoietic stem cell transplantation. Bone Marrow Transplant 2003;32(6):617-22
  • Sakamoto K, Oka M, Yoshino S, et al. Relation between cytokine promoter gene polymorphism and toxicity of 5-fluorouracil plus cisplatin chemotherapy. Oncol Rep 2006;16(2):381-7
  • Keefe DM, Brealey J, Goland GJ, Cummins AG. Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humans. Gut 2000;47(5):632-7
  • Rubenstein EB, Peterson DE, Schubert M, et al. Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis. Cancer 2004;100(9 Suppl):2026-46
  • Fanning SR, Rybicki L, Kalaycio M, et al. Severe mucositis is associated with reduced survival after autologous stem cell transplantation for lymphoid malignancies. Br J Haematol 2006;135(3):374-81
  • Keefe DM. The effect of cytotoxic chemotherapy on the mucosa of the small intestine. Unpublished MD thesis, University of Adelaide, Australia; 1998
  • Keefe DM, Schubert MM, Elting LS, et al. Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer 2007;109(5):820-31
  • Elting LS, Cooksley C, Chambers M, et al. The burdens of cancer therapy. Clinical and economic outcomes of chemotherapy-induced mucositis. Cancer 2003;98(7):1531-9
  • Elting LS, Cooksley CD, Chambers MS, Garden AS. Risk, outcomes, and costs of radiation-induced oral mucositis among patients with head-and-neck malignancies. Int J Radiat Oncol Biol Phys 2007;68(4):1110-20
  • Niscola P, Romani C, Cupelli L, et al. Mucositis in patients with hematologic malignancies: an overview. Haematologica 2007;92(2):222-31
  • Stiff P. Mucositis associated with stem cell transplantation: current status and innovative approaches to management. Bone Marrow Transplant 2001;27(Suppl 2):S3-11
  • Elting L, Calais G, Selva N, et al. Patient-reported burden of mucosal injury (MUI): comparison of clinician-rated MUI and patient-reported outcomes [abstract]. J Clin Oncol 2007;25(18S):9117
  • Grunberg S, Hesketh P, Randolph-Jackson P, et al. Risk and quality of life impact of mucosal injury among colorectal cancer patients receiving FOLFOX chemotherapy [abstract]. Support Care Cancer 2007;15(6):704
  • Keefe D, Garden A, Barasch A, et al. Oral mucositis (OM) is associated with increased resource use among patients receiving treatment for cancers of the head and neck (HN) [abstract]. Support Care Cancer 2007;15(6):695
  • Leiper K, Morris AI. Treatment of radiation proctitis. Clin Oncol (Royal Coll Radiol) 2007;19(9):724-9
  • Bensadoun RJ, Schubert MM, Lalla RV, Keefe D. Amifostine in the management of radiation-induced and chemo-induced mucositis. Support Care Cancer 2006;14(6):566-72
  • Werner-Wasik M. Treatment-related esophagitis. Semin Oncol 2005;32(2 Suppl 3):S60-6
  • Jones JA, Avritscher EB, Cooksley CD, et al. Epidemiology of treatment-associated mucosal injury after treatment with newer regimens for lymphoma, breast, lung, or colorectal cancer. Support Care Cancer 2006;14(6):505-15
  • Epstein JB, Klasser GD. Emerging approaches for prophylaxis and management of oropharyngeal mucositis in cancer therapy. Expert Opin Emerging Drugs 2006;11(2):353-73
  • Clarke SJ, Abdi E, Davis D. Recombinant human keratinocyte growth factor (rHuKGF) prevents chemotherapy-induced mucositis in patients with advanced colorectal cancer: a randomized phase II trial [abstract]. Proc Am Soc Clin Oncol 2001;20:383a
  • Durrant S, Pico JL, Schultz N. A phase 1 study of recombinant keratinocyte growth factor (rHuKGF) in lymphoma patients receiving high-dose chemotherapy with autologous peripheral blood progenitor cell transplantation [abstract]. Blood 1999;94(Suppl 1):708a
  • Speilberger RT, Stiff P, Emmanoulides C. Efficacy of recombinant human keratinocyte growth factor (rHuKGF) in reducing mucositis in patients with hematologic malignancies undergoing autologous peripheral blood progenitor cell transplantation (auto-PBPCT) after radiation-based conditioning-results of a phase 2 trial [abstract]. Proc Am Soc Clin Oncol 2001;20:7a
  • Spielberger R, Stiff P, Bensinger W, et al. Palifermin for oral mucositis after intensive therapy for hematologic cancers. N Engl J Med 2004;351(25):2590-8
  • Aisa Y, Mori T, Kudo M, et al. Oral cryotherapy for the prevention of high-dose melphalan-induced stomatitis in allogeneic hematopoietic stem cell transplant recipients. Support Care Cancer 2005;13(4):266-9
  • Rocke LK, Loprinzi CL, Lee JK, et al. A randomized clinical trial of two different durations of oral cryotherapy for prevention of 5-fluorouracil-related stomatitis. Cancer 1993;72(7):2234-8
  • Stern J, Ippoliti C. Management of acute cancer treatment-induced diarrhea. Semin Oncol Nurs 2003;19(4 Suppl 3):11-6
  • Storr M, Meining A, Allescher HD. Pathophysiology and pharmacological treatment of gastroesophageal reflux disease. Dig Dis 2000;18(2):93-102
  • Chan A, Ignoffo RJ. Survey of topical oral solutions for the treatment of chemo-induced oral mucositis. J Oncol Pharm Pract 2005;11(4):139-43
  • Dodd MJ, Dibble SL, Miaskowski C, et al. Randomized clinical trial of the effectiveness of 3 commonly used mouthwashes to treat chemotherapy-induced mucositis. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 2000;90(1):39-47
  • Naidu MU, Ramana GV, Ratnam SV, et al. A randomised, double-blind, parallel, placebo-controlled study to evaluate the efficacy of MF 5232 (Mucotrol), a concentrated oral gel wafer, in the treatment of oral mucositis. Drugs R&D 2005;6(5):291-8
  • Redding SW, Haveman CW. Treating the discomfort of oral ulceration resulting from cancer chemotherapy. Compend Contin Educ Dent 1999;20(4):389-92, 94, 96.
  • Smith T. Gelclair: managing the symptoms of oral mucositis. Hosp Med 2001;62(10):623-6
  • Barber C, Powell R, Ellis A, Hewett J. Comparing pain control and ability to eat and drink with standard therapy vs Gelclair: a preliminary, double centre, randomised controlled trial on patients with radiotherapy-induced oral mucositis. Support Care Cancer 2007;15(4):427-40
  • Papas AS, Clark RE, Martuscelli G, O'Loughlin KT, Johansen E, Miller KB. A prospective, randomized trial for the prevention of mucositis in patients undergoing hematopoietic stem cell transplantation. Bone Marrow Transplant 2003;31(8):705-12
  • Harris DJ. Cancer treatment-induced mucositis pain: strategies for assessment and management. Ther Clin Risk Manag 2006;2(3):251-8
  • Krissansen GW. Emerging health properties of whey proteins and their clinical implications. J Am Coll Nutr 2007;26(6):S713-23
  • Peterson DE, Jones JB, Petit RG 2nd. Randomized, placebo-controlled trial of Saforis for prevention and treatment of oral mucositis in breast cancer patients receiving anthracycline-based chemotherapy. Cancer 2007;109(2):322-31
  • Gibson RJ, Bowen JM, Keefe DMK. Technological advances in mucositis research: new insights and new issues. Cancer Treat Rev 2008; In press
  • Worthington HV, Clarkson JE, Eden OB. Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database syst Rev (Online) 2007;(4):CD000978. Available from: http://mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD000978/frame.html [Last accessed 3 July 2008]
  • Clarkson JE, Worthington HV, Eden OB. Interventions for treating oral mucositis for patients with cancer receiving treatment. Cochrane Database syst Rev (Online) 2007;(2):CD001973. Available from: http://mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD001973/frame.html [Last accessed 3 July 2008]
  • Blijlevens N, Sonis S. Palifermin (recombinant keratinocyte growth factor-1): a pleiotropic growth factor with multiple biological activities in preventing chemotherapy- and radiotherapy-induced mucositis. Ann Oncol 2007;18(5):817-26

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