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Review

Pharmacological treatments for restenosis

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Pages 29-72 | Published online: 24 Feb 2005

Bibliography

  • GRÜ NTZIG A: A transluminal dilatation of coronary artery stenosis. Lancet (1978) 1:263.
  • ECCLESTON D, TOPOL EJ: Clinical trials of restenosis. In: Coronary Restenosis: from Genetics to Therapeutics. Marcel Dekker, New York, NY (1996):333–381.
  • CLOWES AW, REIDY MA, CLOWES MM: Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium. Lab. Invest. (1983) 49:327–333.
  • BLOCK PC, BAUGHMAN KL, PASTERNAK RC, FALLON JT: Transluminal angioplasty: correlation of morphologic and angiographic findings in an experimental model. Circulation (1980) 61:778–785.
  • SCHWARTZ RS, HUBER KC, MURPHY JG, et al.: Restenosis and the proportional response to coronary artery injury: results in a porcine model. J. Am. Coll. Cardiol. (1992) 19:267–274.
  • SCHEINOWITZ M, SHOU M, BANAI S, et al.: Neointimal proliferation in canine coronary arteries: a model of restenosis permitting local and continuous drug delivery. Lab. Invest. (1994) 71:813–819.
  • DZAU VJ: Vascular renin-angiotensin system and vascular protection. J. Cardiovasc. Pharmacol.(1993) 22\(Suppl. 5):S1–59.
  • HUCKLE WR, EARP HS: Regulation of cell proliferation and growth by angiotensin II. Frog. Growth Factor Res. (1994) 5:177–194.
  • SUNG CP, ARLETH AJ, STORER BL, OHLSTEIN EH: Angiotensin type 1 receptors mediate smooth muscle proliferation and endothelin biosynthesis in rat vascular smooth muscle. J. Pharmacol. Exp. Ther. (1994) 271:429–437.
  • DAEMON MJAP, LOMBARDI DM, BOSMAN FT, SCHWARTZ SM: Angiotensin 11 induces smooth muscle proliferation in the normal and injured rat arterial wall. Circ. Res. (1991) 68:450–456.
  • POWELL JS, CLOZEL JP, WILLER RKM, et al.: Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury. Science (1989) 245:186–188.
  • JANIAK P, LIBERT 0, VILAINE JP: The role of the renin-angiotensin system in neointima formation after injury in rabbits. Hypertension (1994) 24:671–678.
  • HIRATA Y, UMEMURA K, KONDOH K, UEMATSU T, NAKASHIMA M: Experimental intimal thickening studies using the photochemically induced thrombosis model in the guinea-pig femoral artery. Atherosclerosis (1994) 107:117–124.
  • HUBER KC, SCHWARTZ RS, EDWARDS WD, et al.: Effects of angiotensin converting enzyme inhibition on neointimal proliferation in a porcine coronary injury model. Am. Heart J. (1993) 125:695–701.
  • TAGUCHI J, ABE J, OHNO M, SCHWARTZ SM, KUROKAWA K: Topical application of AT1 receptor antagonists prevents medial and neointimal proliferation after balloon injury. Blood Pressure (1994) 5:S38–S42.
  • MUNRO E, PATEL M, CHAN P, et al.: Effect of calcium channel blockers on the growth of human vascular smooth muscle cells derived from saphenous vein and vascular graft stenosis. Cardiovasc. Pharmacol. (1994) 23:779–784.
  • JACKSON CL, BUSH RC, BOWYER DE: Inhibitory effect of calcium antagonists on balloon catheter-induced arterial smooth muscle cell proliferation and lesion size. Atherosclerosis (1988) 69:115–122.
  • POWELL JS, MULLER RK, ROUGE M, et al.: The proliferative response to vascular injury is suppressed by angiotensin-converting enzyme inhibition. J. Cardiovasc. Pharmacol. (1990) 16\(Suppl. 4):542–549.
  • SASO Y, OHTANI A, ODAWARA A, et al.: Inhibitory effect of clentiazem (TA-3090), a new calcium antagonist, on balloon catheter-induced intimal thickening of rabbit aorta. Cardiovasc. Drugs Ther. (1993) 7:257–264.
  • HILLEGASS WB, OHMAN EM, LEIMBERGER JD, CALIFF RM: A meta-analysis of randomized trials of calcium antagonists to reduce restenosis after coronary angioplasty. Am. J. Cardiol. (1994) 73:835–839.
  • KURIYAMA S, NAKANIURA K, KAGUCHI Y, et al.: The effects of vasoactive agents on the proliferation of vascular smooth muscle cells grown in vitro. J. Hypertens. (1988) 6\(Suppl. 4):S154–S156.
  • BLAES N, BOISSEL JP: Growth-stimulating effect of catecholamines on rat smooth muscle cells in culture. J. Cell Physiol. (1983) 116:167–172.
  • BELL L, MADRI JA: Effect of platelet factors on migration of cultured bovine aortic endothelial and smooth muscle cells. Circ. Res. (1989) 65:1057–1065.
  • NAKAKI T, NAKAYAMA M, YAMAMOTO S, KATO R: ai-adrenergic stimulation and I32-adrenergic inhibition of DNA synthesis in vascular smooth muscle cells. Mol. Pharmacol. (1990) 37:30–36.
  • CAVELLERO C, DI TONDO U, MINGAZZINI PL, PESANDO PC, SPAGNOLI LG: Cell prolif-eration in the atherosclerotic lesions of cholesterol fed rabbits. Atherosclerosis (1973) 17:49–62.
  • BEVAN RD: Effect of sympathetic denervation on smooth muscle cell proliferation in the growing rabbit ear artery. Circ. Res. (1975) 37:14–19.
  • FRONEK K, BLOOR CM, AMIEL D, CHVAPIL M: Effect of long-term sympathectomy on the arterial wall in rabbits and rats. Exp. Ma Pathol. (1978) 28:279–289.
  • FINGERLE J, SANDERS KII, FOTEV Z: Alpha 1 receptor antagonists urapidil and prazosin inhibit neointima formation in the rat carotid artery induced by balloon catheter injury. Basic Res. Cardiol. (1991) 86\(Suppl. 1):75–81.
  • OHLSTEIN EH, DOUGLAS SA, SUNG CP, et al.: Carvedilol, a cardiovascular drug, prevents smooth muscle cell proliferation, migration and neointimal formation following vascular injury. Proc. Natl. Acad. Sci. USA (1993) 90:6189–6193.
  • PATEL MK, CHAN P, BETTERIDGE LJ, SCHACHTER M, SEVER PS: Inhibition of human smooth muscle cell proliferation by the novel multiple-action antihypertensive agent carvedilol. Cardiovasc. Pharmacol. (1995) 25:652–657.
  • BENNETT MR, LITTLEWOOD TD, HANCOCK DC, EVAN GI, NEWBY AC: Down-regulation of the c-myc proto-oncogene in inhibition of vascular smooth muscle cell proliferation: a signal for growth arrest. Biochem. J. (1994) 302:701–708.
  • SOYOMBO AA, ANGELINI GD, NEWBY AC: Neointima formation is promoted by surgical preparation and inhibited by cyclic nucleotides in human saphenous vein organ cultures. J. Thoracic Cardiovasc. Surg. (1995) 109:2–12.
  • GUIEU R, PAGANELLI F, SAMPIERI F, et al. : The use of HPLC to evaluate the variations of blood coronary adenosine levels during percutaneous transluminal angioplasty. Clin. Chim. Acta (1994) 230:63–68.
  • TAKIGUCHI Y, NAGANO M, IKEDA Y, NAKASHIMA M: Early administration of YT-146, an adenosine A2 receptor agonist, inhibits neointimal thickening after rat femoral artery endothe-lium injury. Eur. I Pharmacol. (1995) 281:205–207.
  • HARKER LA, ROSS R, SLICHTER SJ, SCOTT CR: Homocysteine-induced atherosclerosis: the role of endothelial cell injury and platelet response in its genesis. J. Clin. Invest. (1976) 58:731–741.
  • BOMBERGER RA, WILBURN J, DEPALMA RG: Aspirin and dipyridamole increase intimal thickening after injury. Surg. Forum (1983) 34:475–477.
  • KOSTER JK, TRYKA AF, H'DOUBLER P, COLLINS JJ: The effect of low dose aspirin and dipyridamole upon atherosclerosis in the rabbit. Artery (1981) 9:405–413.
  • ROGERS GP, MINOR ST, ROBINSON K, et al.: Adjuvant therapy for intracoronary stents: investigations in atherosclerotic swine. Circulation (1990) 82:560–569.
  • SCHWARTZ L, BOURASSA MG, LESPERANCE J. ALDRIDGE HE, KAZIM F: Aspirin and dipyridamole in the prevention of restenosis after percutaneous transluminal coronary angioplasty. New Engl. J. Med. (1988) 318:1714–1719.
  • MCNAMARA DB, BEDI B, AURORA H, et al.: L-arginine inhibits balloon catheter-induced intimal hyperplasia. Biochem. Biophys. Res. Commun. (1993) 193:291–296.
  • GUO JP, MILHOAN KA, TUAN JS, LEFER AM: Beneficial effect of SPM-5185, a cysteine-con-taining nitric oxide donor, in rat carotid artery intimal injury. Circ. Res. (1994) 75:77–84.
  • VON DER LEYEN HE, GIBBONS GH, MORISHITA R, et al.: Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. Proc. Natl. Acad. Sci. USA (1995) 92:1137–41.
  • OHLSTEIN EH, DOUGLAS SA: Endothelin modulates vascular smooth muscle structure and vasomotion: implications in cardiovascular pathology. Drug Dev Res (1993) 29:108–128.
  • Ruffolo RR, Jr. (Ed.), CRC Press, Boca Raton (1995):109–185.
  • LERMAN A, EDWARDS BS, HALLETT JVV, et al.: Circulating and tissue endothelin immunore-activity in advanced atherosclerosis. New Engl. J Med. (1991) 325:997–1001.
  • MALATINO LS, GRASSI R, STANCANELLI B, et al: Release of immunoreactive endothelin from the heart during percutaneous transluminal coronary angioplasty. Am. Heart J. (1993) 126:700–702.
  • TAHARA A, KOHNO M, YANAGI S, et al.: Circulating immunoreactive endothelin in patients undergoing percutaneous transluminal coronary angioplasty. Metabolism (1992) 40:1235–1237.
  • WANG X, DOUGLAS SA, FEUERSTEIN GZ, OHLSTEIN EH: Temporal expression of ECE-1, ET-1, ET-3, ETA and ETB receptor mRNAs after balloon angioplasty in the rat. J. Cardiovasc. Pharmacol. (1995) 26\(Suppl. 3):S22–S25.
  • WATSCHINGER B, SAYEGH MH, HANCOCK WW, RUSSELL ME: Up-regulation of endothelin-1 mRNA and peptide expression in rat cardiac allografts with rejection and atherosclerosis. Am. PathoL (1995) 146:1065–1072.
  • DOUGLAS SA, VICKERY-CLARK LM, STORER BL, et al.: A role for endogenous endothelin-1 in neointima formation following rat carotid artery balloon angioplasty: antiproliferative effects of the non-peptide endothelin receptor antagonist SB 209670. Circ. Res. (1994) 75:190-197.
  • TRACHTENBERG JD, SUN S, CHOI ET, CALLOW AD, RYAN US: Effect of endothelin-1 infusion on the development of intimal hyperplasia after balloon catheter injury. J. Cardiovasc. Pharmacol. (1993) 22\(Suppl. 8):5355–5359.
  • DOUGLAS SA, MEEK TD, OHLSTEIN EH: Novel receptor antagonists welcome a new era in endothelin biology. Trends Pharmacol. Sci. (1994) 15:313–316.
  • TSUJINO M, HIRATA Y, EGUCHI S, et al.: Nonselective ETA/ETB receptor antagonist blocks proliferation of rat vascular smooth muscle cells after balloon angioplasty. Life Sci. (1995) 56:449–454.
  • HELE DJ, BIRRELL M, BUSH RC, et al.: Selective ETA and mixed ETA/ETB receptor antagonists inhibit balloon catheter-induced smooth muscle cell proliferation in the rat thoracic aorta. Br. J. Pharmacol. (1994) 114:P199.
  • DOUGLAS SA, VICKERY-CLARK LM, LOUDEN C, OHLSTEIN EH: Selective ETA receptor antagonism with BQ-123 is insufficient to inhibit angioplasty induced neointima formation in the rat. Cardiovasc Res (1995) 29:641–646.
  • AZUMA H, HAMASAKI H, NIIMI Y, TERADA T, MATSUBARA 0: Role of endothelin-1 in neointima formation after endothelial removal in rabbit carotid arteries. Am. I Physiol. (1994) 267:H2259–H2267.
  • AZUMA H, HAMASAKI H, SATO J, et al.: Different localization of ETA and ETB receptors in the hyperplastic vascular wall. I Cardiovasc. Pharmacol. (1995) 25:802–809.
  • MORELAND S, JENKINS-WEST T, VALENTINE M, FERRER P: BMS-182874 inhibits intimal lesion formation in balloon-injured rat carotid arteries. I Cardiovasc. Pharmacol. (1995) in press. SURELY NOT!!
  • WESSALE J, ADLER A, NOVOSAD E, et al. Endothelin antagonism reduces neointima formed following balloon injury in the rabbit. I Cardiovasc. Pharmacol. (1995) in press.
  • KOWALA MC, ROSE PM, STEIN PD, et al.: Selective blockade of the endothelin subtype A receptor decreases early atherosclerosis in hamsters fed cholesterol. Am. I Pathol . (1995) 146: 819–826.
  • LOESCH A, BODIN P, BURNSTOCK G: Colocalization of endothelin vasopressin and serotonin in cultured endothelial cells of rabbit aorta. Peptides (1991) 12:1095–1103.
  • BELL L, MADRI JA: Effect of platelet factors on migration of cultured bovine aortic endothelial and smooth muscle cells. Circ. Res. (1989) 65:1057–1065.
  • BONDESSON L, NORDLIND K, EIDEN S, SUNDSTROM E: Inhibiting effects of serotonin antagonists on the migration of mononuclear leukocytes. Immunopharmacol. Immunotoxicol. (1993) 15:243–250.
  • KATZ MF, FARBER HW, DODDS-STITT Z, CRUIKSHANK WW, BEER DJ: Secretion of a novel T-lymphocyte cytokine possessing both chemotactic and growth factor activity by serotonin-stimulated human aortic endothelial cells. Exp. Cell Res. (1994) 212:113–119.
  • BODIN P, TRAVO P: Effects of naftidrofuryl on the contraction and proliferation of cultured myocytes evoked by serotonin. I Cardiovasc. Pharmacol. (1990) 16\(Suppl. 3):525–528.
  • SIGAL SL, GELLMAN J, ANDERSON GM, et al.: Potentiation of the vasospastic response to angioplasty by pretreatment with fluoxetine: a study in the atherosclerotic rabbit. Arterioscler. Thromb. (1993) 13:907–914.
  • MASSEY MF, DAVIES MG, SVENDSEN E, et al.: Reduction of experimental vein graft intimal hyperplasia by ketanserin. J. Surg. Res. (1993) 54:530–538.
  • KAUFFMAN RF, BEAN JS, BLOOMQUIST WE, COHEN ML: Vascular serotonin 5-HT2 receptor blockade by LY215840: lack of effect upon neointima formation in balloon-injured rat carotid arteries. J. Pharmacol. Exp. Ther. (1993) 266:450–455.
  • SERRUYS PW, KLEIN W, TUSSEN JP, et al.: Evaluation of ketanserin in the prevention of restenosis after percutaneous transluminal coronary angioplasty. A multicenter randomized double-blind placebo-controlled trial. Circulation (1993) 88:1588–1601.
  • FLETCHER JR: Eicosanoids. Critical agents in the physiological process and cellular injury. Arch. Surg. (1993) 128:1192–1196.
  • VANE JR, BOTTING RM: Pharmacodynamic profile of prostacyclin. Am. I Cardiol. (1995) 75:3A–10A.
  • HEHRLEIN C, SVENSON RH, MCKUSIK AP, et al.: Thermal laser arterial injury and prostacydin administration in dogs: thrombotic and hyperplastic consequences. J. Cardiovasc. Surg. (1992) 33:366–371.
  • VOLKER W, FABER V: Aspirin reduces the growth of medial and neointimal thickenings in balloon-injured rat carotid arteries. Stroke (1990) 21(Suppl. IV):44–45.
  • AUGUST D, TILSON MD: Modification of myointimal response to arterial injury: effects of aspirin and warfarin. Surg. Forum (1980) 31:337–338.
  • CLOWES AW, KARNOVSKY MJ: Failure of certain antiplatelet drugs to affect myointimal thickening following arterial endothelial injury in the rat. Lab. Invest. (1977) 36:452–464.
  • BUSH HL, JAKUBOWSKI JA, SENTIS SI JM, et al.: Neointimal hyperplasia occurring after carotid endarterectomy in a canine model: effect of endothelial seeding vs. perioperative aspirin. J. Vasc. Surg. (1987) 5:118–125.
  • INGERMAN-WOJENSKI CM, SILVER MJ: Model system to study the interaction of platelets with damaged arterial wall. H. Inhibition of smooth muscle cell proliferation by dipyridamole and AH-P719. Exp. MoL PathoL (1988) 48:116–134.
  • SERRUYS PW, RUTSCH W, HEYNDRICKX GR, et al.: Prevention of restenosis after percutane-ous transluminal coronary angioplasty with thromboxane A2 receptor blockade: a randomized, double-blind, placebo-controlled trial. Coronary artery restenosis prevention on repeated throm-boxane-antagonism study (CARPORT). Circulation (1991) 84:1568–1580.
  • HATTORI R, KODAMA K, TAKATSU F, YUI Y, KAWAI C: Randomized trial of a selective inhibitor of thromboxane A2 synthase, (E)-7-phenyl-7-(3-pyridy1)-6- heptenoic acid (CV-4151), for prevention of restenosis after coronary angioplasty. Jap. Circ. J. (1991) 55:324–329.
  • LONGENECKER JP, KILTY LA, JOHNSON LK: Glucocorticoid influence on growth of vascular wall cells in culture. J. Cell PhysioL (1982) 113:197–202.
  • LONGENECKER JP, KILTY LA, JOHNSON LK: Glucocorticoid inhibition of vascular smooth muscle cell proliferation: influence of homologous extracellular matrix and serum mitogens. Cell Biol. (1984) 98:534–540.
  • VOISARD R, SEITZER U, BAUR R, et al.: Corticosteroid agents inhibit proliferation of smooth muscle cells from human atherosclerotic arteries in vitro. Int. I CardioL (1994) 43:257–267.
  • HIROSUMI J, NOMOTO A, OHKUBO Y, et al.: Inflammatory response in cuff-induced atherosclerosis in rabbits. Atherosclerosis (1987) 64:243–254.
  • CHERVU A, MOORE WS, QUINONES-BALDRICH WJ, HENDERSON T: Efficacy of corticos-teroids in suppression of intimal hyperplasia. I Vasc. Surg. (1989) 10:129–134.
  • COLBURN MD, MOORE WS, GALEBERT HA, QUINONES-BALDRICH WJ: Dose responsive suppression of myointimal hyperplasia by dexamethasone. I Vasc. Surg. (1992) 15:510–518.
  • VILLA AE, GUZMAN LA, CHEN W, et al.: Local delivery of dexamethasone for prevention of neointimal proliferation in a rat model of balloon angioplasty. J. Clin. Invest. (1994) 93:1243–1249.
  • MULLER DW, GOLOMB G, GORDON G, LEVY RJ: Site-specific dexamethasone delivery for the prevention of neointimal thickening after vascular stent implantation. Coronary Artery Dis. (1994) 5:435–442.
  • WILCKENS T: Glucocorticoids and immune function: physiological relevance and pathogenic potential of hormonal dysfunction. Trends Pharmacol. Sci. (1995) 16:193–197.
  • LIBBY P, SCHWARTZ D, BROGIE, TANAKA H, CLINTON SK: A cascade model for restenosis. A special case of atherosclerosis progression. Circulation (1992) 86\(suppl 6):11147-II152.
  • STONE GW, RUTHERFORD BD, MCCONAHAY DR, et al.: A randomized trial of corticosteroids for the prevention of restenosis in 102 patients undergoing repeat coronary angioplasty. Cath. Cardiovasc. Dis. (1989) 18:227–231.
  • MCKENNEY PA, CURRIER JW, HAUDENSCHILD LL, HEYMAN D, FAXON DP: Cyclosporin A does not inhibit restenosis in experimental angioplasty. Circulation (1991) 84(Suppl. II):70.
  • JONASSON L, HOLM J, HANSSON GK: Cyclosporin A inhibits smooth muscle proliferation in the vascular response to injury. Proc. Natl. Acad. Sci. USA (1988) 85:2303–2306.
  • FERNS G, REIDY MA, ROSS R: Vascular effects of cydosporin A in vivo and in vitro. Am. J. Pathol. (1990) 137:403–413.
  • REECE AH, WALTON PL: Inhibition of intimal proliferation of rabbit aorta by tidodipine. Thromb. Haemost. (1979) 42:367.
  • BERTRAND ME, ALLAIN H, LABLANCHE JI\4: Results of a randomized trial of tidodipine versus placebo for prevention of acute closure and restenosis after coronary angioplasty (PTCA): the TACT study. Circulation (1990) 111:190.
  • HERRMANN HC, OKADA SS, HOZAKOWSKA E, et al.: Inhibition of smooth muscle cell proliferation and experimental angioplasty restenosis by beta-cyclodextrin tetradecasulfate. Arterioscler. Thromb. (1993) 13:924–931.
  • LETOURNEUR D, LOGEART D, AVRANIOGLOU T, JOZEFONVICZ J: Antiproliferative capac-ity of synthetic dextrans on smooth muscle cell growth: the model of derivatized dextrans as heparin-like polymers. I Biomat. Sci. (1993) 4:431–444.
  • TYRRELL DJ, KILFEATHER S, PAGE CP: Therapeutic uses of heparin beyond its traditional role as an anticoagulant. Trends Pharmacol. Sci. (1995) 16:198–204.
  • CLOWES AW, KARNOVSKY MJ: Suppression by heparin of smooth muscle proliferation in injured arteries. Nature (1977) 265:625–626.
  • BERK BC, GORDON JB, ALEXANDER RW: Pharmacological roles of heparin and glucocorti-coids to prevent restenosis after coronary angioplasty. J. Am. Coll. Cardiol. (1991) 17:111B–117B.
  • CURRIER JW, POW TK, HAUDENSCHILD CC, MINIHAN AC, FAXON DP: Low molecular weight heparin (Enoxaparin) reduces restenosis after iliac angioplasty in the hyper-cholesterolemic rabbit. J. Am. Coll. Cardiol. (1991) 17:118B–125B.
  • OBERHOFF M, HANKE H, HASSENSTEIN S, HANKE S, KANIENZ J: Inhibition of smooth muscle proliferation after experimental balloon angioplasty: comparison of LMWH and unfrac-tionated heparin. Circulation (1991) 84:1180.
  • UNTERBERG C, BUCHWALD AB, NEBENDAHL K, WIEGAND V: Low molecular weight heparin reduces intimal proliferation after coronary stenting. J. Am. Coll. Cardiol. (1992) 19:291A.
  • MORE RS, BRACK MJ, GERSHLICK AC: Heparin after angioplasty: an unresolved issue Eur. Heart J. (1993) 14:1543–1547.
  • FAXON DP, SPIRO T, MINOR S, DOUGLAS J, COTE G: Enoxaparin, a low molecular weight heparin in the prevention of restenosis after angioplasty: result of a double-blind randomized trial. J. Am. Coll. Cardiol. (1991) 19:258A.
  • LEFKOVITS J, PLOW EF, TOPOL EJ: Platelet glycoprotein I1b/Illa receptors in cardiovascular medicine. New Engl. I Med. (1995) 332:1553–1559.
  • BATES ER, MCGILLEM MJ, MICKELSON JK, PITT B, MANCINI GB: A monoclonal antibody against the platelet glycoprotein I1b/Illa receptor complex prevents platelet aggregation and thrombosis in a canine model of coronary angioplasty. Circulation (1991) 84:2463–2469.
  • ANONYMOUS: Use of monoclonal antibody directed against the platelet glycoprotein 11b/IIIa receptor in high-risk coronary angioplasty. The EPIC investigation. New Engl. I Med. (1994) 330:956–961.
  • TOPOL EJ, CALIFF RM, WEISMAN HF, et al.: Randomized trial of coronary intervention with antibody against platelet 11b/Illa integrin for reduction of clinical restenosis: results at six months. The EPIC Investigators. Lancet (1994) 343:881–886.
  • MATSUNO H, STASSEN JM, VERMYLEN J, DECKMYN H: Inhibition of integrin function by a cyclic RGD-containing peptide prevents neointima formation. Circulation (1994) 90:2203–2206.
  • CHOI ET, ENGEL L, CALLOW AD, et al.: Inhibition of neointimal hyperplasia by blocking alpha V beta 3 integrin with a small peptide antagonist GpenGRGDSPCA. I Vasc. Surg. (1994) 19:125–134.
  • IMURA Y, STASSEN JM, VREYS I, et al.: Synergistic antithrombotic properties of G4120, a RGD-containing synthetic peptide, and argatroban, a synthetic thrombin inhibitor, in a hamster femoral vein platelet-rich thrombus model. Thromb. Haemostas. (1992) 68:336–340.
  • WALTERS TK, GOROG DA, WOOD RF: Thrombin generation following arterial injury is a critical initiating event in the pathogenesis of the proliferative stages of the atherosclerotic process. J. Vasc. Res. (1994) 31:173–177.
  • SAREMBOCK U, GERTZ SD, GIMPLE LW, et al.: Effectiveness of recombinant desulphato-hirudin in reducing restenosis after balloon angioplasty of atherosclerotic femoral arteries in rabbits. Circulation (1991) 84:232–243.
  • RAGOSTA M, GIMPLE LW, GERTZ SD, et al.: Specific factor Xa inhibition reduces restenosis after balloon angioplasty of atherosclerotic femoral arteries in rabbits. Circulation (1994) 89:1262–1271.
  • ASAHARA T, BAUTERS C, PASTORE C, et al.: Local delivery of vascular endothelial growth factor accelerates reendothelialization and attenuates intimal hyperplasia in balloon-injured rat carotid artery. Circulation (1995) 91:2793–2801.
  • HOCH JR, STARK VK, TURNIPSEED WD: The temporal relationship between the development of vein graft intimal hyperplasia and growth factor gene expression.J. Vasc. Surg. (1995) 22:51–58.
  • LINDNER V, GIACHELLI CM, SCHWARTZ SM, REIDY MA: A subpopulation of smooth muscle cells in injured rat arteries express platelet-derived growth factor-I3 chain mRNA. Circ. Res. (1995) 76:951–957.
  • BILDER GE, KASIEWSKI CJ, COSTELLO RJ, HODGE TG, PERRONE MH: Electrode cuff-in-duced changes in DNA and PDGF gene expression in the rat carotid artery. Atherosclerosis (1993) 100:103–112.
  • KRAISS LW, RAINES EW, WILCOX JN, et al.: Regional expression of the platelet-derived growth factor and its receptors in a primate graft model of vessel wall assembly. I Clin. Invest. (1993) 92:338–348.
  • MARMUR JD, POON M, ROSSIKHINA M, TAUBMAN MB: Induction of PDGF-responsive genes in vascular smooth muscle. Implications for the early response to vessel injury. Circulation (1992) 86\(Suppl. 6):11153–11160.
  • MAJESKY MW, GIACHELLI CM, REIDY MA, SCHWARTZ SM: Rat carotid neointimal smooth muscle cells reexpress a developmentally regulated mRNA phenotype during repair of arterial injury. Circ. Res. (1992) 71:759–768.
  • FERNS GA, RAINES EW, SPRUGEL KB, et al.: Inhibition of neointimal smooth muscle accumu-lation after angioplasty by an antibody to PDGF. Science (1991) 253:1129–1132.
  • COSIGNY PM, BARRY JJ, VITALI NJ: Local delivery of an antiproliferative drug with use of hydrogel-coated angioplasty balloons. I Vase. Int. Radio'. (1994) 5:553–560.
  • MUNRO E, PATEL M, CHAN P, et al. : Growth inhibition of human vascular smooth muscle cells by fenofibrate: a possible therapy for restenosis. Cardiovasc. Res. (1994) 28:615–620.
  • KOVALENKO M, GAZIT A, BOHMER A, et al.: Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation. Cancer Res. (1994) 54:6106–6114.
  • TIELL ML, SUSSMAN H, GORDON PB, SAUNDERS RN: Suppression of fibroblast proliferation in vitro and of myointimal hyperplasia in vivo by triazolopyrimidine. Artery (1983) 12:33–50.
  • LIU MW, ROUBIN GS, ROBINSON KA, et al.: Trapidil in preventing restenosis after balloon angioplasty in the atherosclerotic rabbit. Circulation (1990) 81:1089–1093.
  • MULLINS DE, HAMUD F, REIM R, DAVIS HR: Inhibition of PDGF receptor binding and PDGF-stimulated biological activity in vitro and of intimal lesion formation in vivo by 2-bro-momethy1-5-chlorobenzene sulfonylphthalimide. Arteroscler. Thromb. (1994) 14:1047–1055.
  • JAWIEN A, BOWEN-POPE DF, LINDNER V, SCHWARTZ SM, CLOWES AW: Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty. 1 Clin. Invest. (1992) 89:507–511.
  • OKANIOTO S, INDEN M, SETSUDA M, KONISHI T, NAKANO T: Effects of trapidil (tria-zolopyrimidine), a platelet-derived growth factor antagonist, in preventing restenosis after percutaneous transluminal coronary angioplasty. Am. Heart 1 (1992) 123:1439–1444.
  • MARESTA A., BALDUCELLI M, CANTINI L, et al.: Trapidil (triazolopyrimidine), a platelet-de-rived growth factor antagonist, reduces restenosis after percutaneous transluminal coronary angioplasty. Results of the randomized, double-blind STARC study: Studio Trapidil versus Aspirin nella Restenosis Coronarica. Circulation (1994) 90:2710–2715.
  • HANCOCK WW, ADAMS DH, WYNER LR, SAYEGH MH, KARNOVSKY MJ: CD4+ mononu-clear cells induce cytokine expression, vascular smooth muscle cell proliferation, and arterial occlusion after endothelial cell injury. Am. I Pathol. (1994) 145:1008–1014.
  • BROWN SL, LUNDGREN CH, NORDT T, FUJII S: Stimulation of migration of human aortic smooth muscle cells by vitronectin: implications for atherosclerosis. Cardiovasc. Res. (1994) 28:1815–1820.
  • LI Z, ALAVI MZ, MOORE S: The proliferation of neointimal smooth muscle cells cultured from rabbit aortic explants 15 weeks after de-endothelialization by a balloon catheter. Int. I Exp. Pathol. (1994) 75:169–177.
  • NABEL EG, SHUM L, POMPILI VJ, et al.: Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia. Proc. Natl. Acad. Sci. USA (1995) 90:10759–10763.
  • MAJESKY MW, LINDNER V, TWARDZIK DR, SCHWARTZ SM, REIDY MA: Production of transforming growth factor beta 1 during repair of arterial injury. I Clin. Invest. (1991) 88:904–910.
  • MCCAFFREY TA, FALCONE DJ, BORTH W, BRAYTON CF, WEKSLER BB: Fucoidan is a non-coagulant inhibitor of intimal hyperplasia. Biochem. Biophys. Res. Commun. (1992) 184:773–781.
  • BAURIEDEL G, HEIDEMANN P, KLINGEL K, et al.: In situ detection of EGF receptor mRNA in arteriosclerotic lesions in man: implications for the proliferative activity of smooth muscle cells. Z. KardioL (1992) 81:519–524.
  • EPSTEIN SE, SIEGALL, BIRO S, et al.: Cytotoxic effects of a recombinant chimeric toxin on rapidly proliferating vascular smooth muscle cells. Circulation (1991) 84:778–787.
  • PICKERING JG, BACHA PA, WEIR L, et al.: Prevention of smooth muscle outgrowth from human atherosclerotic plaque by a recombinant cytotoxin specific for the epidermal growth factor receptor. I Clin. Invest. (1993) 91:724–729.
  • FU YM, MESRI EA, YU ZX, et al.: Cytotoxic effects of vascular smooth muscles of the chimeric toxin, heparin binding TGF alpha-Pseudomonas exotoxin. Cardiovasc. Res. (1993) 27:1691–1697.
  • FRIESEL RE, MACIAG T: Molecular mechanisms of angiogenesis: fibroblast growth factor signal transduction. FASEB 1 (1995) 9:919–925.
  • REIDY MA, JACKSON CL: Factors controlling growth of arterial cells following injury. ToxicoL PathoL (1990) 18:547–553.
  • LINDNER V, MAJACK RA, REIDY MA: Basic FGF stimulates endothelial regrowth and prolif-eration in denuded arteries. I Clin. Invest. (1990) 85:2004–2008.
  • XIN X, JOHNSON AD, SCOTT-BURDEN T, ENGLER D, CASSCELLS W: The predominant form of fibroblast growth factor receptor expressed by proliferating human arterial smooth muscle cells in culture is type I. Biochem. Biophys. Res. Commun. (1994) 204:557–564.
  • FISHEL RS, THOURANI V, EISENBERG SJ, et al.: Fibroblast growth factor stimulates angioten-sin converting enzyme expression in vascular smooth muscle cells. Possible mediator of the response to vascular inj ury. 1 Clin. Invest. (1995) 95:377–387.
  • NABEL EG, YANG ZY, PLAUTZ G, et al.: Recombinant fibroblast growth factor-1 promotes intimal hyperplasia and angiogenesis in arteries in vivo. Nature (1993) 362:844–846.
  • SIEGALL CB, EPSTEIN S, SPIER E, et al.: Cytotoxic activity of chimeric proteins composed of acidic fibroblast growth factor and Pseudomonas exotoxin on a variety of cell types. FASEB I (1991) 5:2843–2849.
  • KHORSANDI MJ, FAGIN JA, GIANNELLA-NETO D, FORRESTER JS, CERCEK B: Regulation of insulin-like growth factor-I and its receptor in rat aorta after balloon denudation. Evidence for local bioactivity. I Clin. Invest. (1992) 90:1926–1931.
  • MOORADIAN DL, FERNANDES B, DIGLIO CA, LESTER BR: Angiopeptin (BI1V123014C) inhibits vascular smooth muscle cell migration in vitro through G-protein-mediated pathway and is associated with inhibition of adenylyl cydase and cAlVIP accumulation. I Cardiovasc. Pharma-col. (1995) 25:611–618.
  • BAUTERS C, VAN BELLE E, WERNERT N, et al.: Angiopeptin inhibits oncogene induction in rabbit aorta after balloon denudation. Circulation (1994) 89:2327–2331.
  • FOEGH ML, ASOTRA S, CONTE JV, et al.: Early inhibition of myointimal proliferation by angiopeptin after balloon catheter injury in the rabbit. J. Vasc. Surg. (1994) 19:1084–1091.
  • LUNDERGAN CF, FOEGH ML, VARGAS R, et al.: Inhibition of myointimal proliferation of the rat carotid artery by the peptides, angiopeptin and BIM 23034. Atherosclerosis (1989) 80:49–55.
  • ASOTRA S, FOEGH ML, CONTE JV, CAI BR, RAMWELL PW: Inhibition of 13111-thymidine incorporation by angiopeptin in the aorta of rabbits after balloon angioplasty. Transplant. Proc. (1989) 21:3695–3696.
  • HOWELL M, ADAMS MM, WOLFE MS, FOEGH M, RAMWELL PW: Angiopeptin inhibition of myointimal hyperplasia after balloon angioplasty in large arteries in hypercholesterolaemic rabbits. Clin. Sci. (1993) 85:183–188.
  • HOWELL M, ORSKOV H, FRY STYK J, et al.: Lanreotide, a somatostatin analogue, reduces insulin-like growth factor I accumulation in proliferating aortic tissue in rabbits. A preliminary study. Eur. I Endocrinol. (1994) 130:422–425.
  • SANTOIAN ED, SCHNEIDER JE, GRAVANIS MB, et al.: Angiopeptin inhibits intimal hyperplasia after angioplasty in porcine coronary arteries. Circulation (1993) 88:11–14.
  • MENNANDER A, RAISANEN A, PAAVONEN T, HAYRY P: Chronic rejection in the rat allograft. V. Mechanism of the angiopeptin (B1VI23014C) effect on the generation of allograft atherosclerosis. Transplantation (1993) 55:124–128.
  • GRANT MB, WARGOVICH TJ, ELLIS EA, et al.: Localization of insulin-like growth factor I and inhibition of coronary smooth muscle growth by somatostatin analogues in human coronary smooth muscle cells. A potential treatment for restenosis. Circulation (1994) 89:1511–1517.
  • BORNFELDT KE, RAINES EW, NAKANO T, et al.: Insulin-like growth factor-I and platelet-de-rived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation. J. Clin. Invest. (1994) 93:1266–1274.
  • EMANUELSSON H, BEATT KJ, BAGGER JP, et al.: Long term effects of angiopeptin treatment in coronary angioplasty. Reduction of clinical events but not angiographic restenosis. European angiopeptin study group. Circulation (1995) 91:1689–1696.
  • CHANG MW, BARR E, SELTZER J, et al.: Cytostatic gene therapy for vasculoproliferative disorders with a constitutively active form of the retinoblastoma gene product. Science (1995) 267:518–522.
  • BAURIEDEL G, HEIMERL J, BEINERT T, WELSCH U, HOFLING B: Colchicine antagonizes the activity of human smooth muscle cells cultivated from arteriosclerotic lesions after atherectomy. Coronary Artery Dis. (1994) 5:531–539.
  • TANAKA K, HONDA M, KURANIOCHI T, MORIOKA S: Prominent inhibitory effects of tranilast on migration and proliferation of and collagen synthesis by vascular smooth muscle cells. Atherosclerosis (1994) 107:179–185.
  • VOISARD R, DARTSCH PC, SEITZER U, et al.: The in vitro effect of antineoplastic agents on proliferative activity and cytoskeletal components of plaque-derived smooth-muscle cells from human coronary arteries. Coronary Artery Dis. (1993) 4:935–942.
  • CURRIER JW, POW TX, MINIHAN AC, HAUDENSCHILD CC, FAXON DP: Colchicine inhibitsrestenosis after iliac angioplasty in the atherosclerotic rabbit. Circulation (1989) 80\(Suppl. 2):I166.
  • SOLLOTT SJ, CHENG L, PAULY RR, et al.: Taxol inhibits neointimal smooth muscle cell accumulation after angioplasty in the rat. I Clin. Invest. (1995) 95:1869–1876.
  • MURPHY JG, SCHWARTZ RS, EDWARDS WD, CAMRUD AR, KO J: Methotrexate and azathioprine fail to inhibit porcine coronary restenosis. Circulation (1990) 82\(Suppl. 2):I1429.
  • CURRIER JW, KALAN JM, FRANKLIN SM, MEJIAS Y, CODY C: Effects of local infusion of doxorubicin or saline on restenosis following angioplasty in atherosclerotic rabbits. Restenosis Summit (1992) IV:A9.
  • COX DA, ANDERSON PG, ROUBIN GS, CHOU CY, AGRAWAL SK: Local delivery of heparin and methotrexate fails to inhibit in vivo smooth muscle proliferation. Circulation (1991) 84\(Suppl. 2):1171.
  • MULLER DW, TOPOL EJ, ABRANIS GD, GALLAGHER KP, ELLIS SG: Intramural methotrexate therapy for the prevention of the neointimal thickening after balloon angioplasty. I Am. Coll. CardioL (1992) 20:460–466.
  • O'KEEFE JH, Jr., MCCALLISTER BD, BATEMAN TM, et al.: Ineffectiveness of colchicine for the prevention of restenosis after coronary angioplasty. I Am. Coll. CardioL (1992) 19:1597–1600.
  • PASCAL M, SEPULCHRE C, CHAZAN JB, MAJOIE B: Evidence for the inhibition of platelet-derived growth factor induced rat smooth muscle cells DNA synthesis by fenofibric acid at the Go/Gi cell cycle level. Life Sci. (1983) 33:925–933.
  • MUNRO E, PATEL M, CHAN P, et al.: Inhibition of human vascular smooth muscle cell prolif-eration by lovastatin: the role of isoprenoid intermediates of cholesterol synthesis. Eur. I Clin. Invest. (1994) 24:766–772.
  • ROGLER G, LACKNER KJ, SCHMITZ G: Effects of fluvastatin on growth of porcine and human vascular smooth muscle cells in vitro. Am. I CardioL (1995) 76:114A–116A.
  • GELLMAN J, EZEKOWITZ MD, SAREMBOCK IJ, et al.: Effect of lovastatin on intimal hyper-plasia after balloon angioplasty: a study in an atherosclerotic hypercholesterolemic rabbit. I Am. Coll. Cardiol. (1991) 17:251–259.
  • WOLDA SL, GLOMSET JA: Evidence for modification of la min B by a product of mevalonic acid. Biol. Chem. (1988) 263:5997–6000.
  • SAHNI R, MANIET AR, VOCI G, HANKA VS: Prevention of restenosis by lovastatin after successful coronary angioplasty. Am. Heart (1991) 121:1600–1608.
  • WEINTRAUB WS, BOCCUZZI SJ, KLEIN JL, et al.: Lack of effect of lovastatin on restenosis after coronary angioplasty. Lovastatin restenosis trial study group. New Engl. I Med. (1994) 331:1331–1337.
  • YAMAGUCHI H, LEE YJ, DADA H, et al.: Effectiveness of LDL-apheresis in preventing restenosis after percutaneous transluminal coronary angioplasty (PTCA): LDL-apheresis angioplasty restenosis trial (L-ART). Chem. Phys. Lipids (1994) 67:399–403.
  • HARKER LA, KELLY All, HANSON SR, et al.: Interruption of vascular thrombus formation and vascular lesion formation by dietary n-3 fatty acids in fish oil in nonhuman primates. Circulation (1993) 87:1017–1029.
  • FRANZEN D, SCHANNVVELL M, OETTE K, HOPP HW: A prospective, randomized and double-blind trial on the effect of fish oil on the incidence of restenosis following PTCA. Cath. Cardiovasc. Diag. (1993) 28:301–310.
  • LEAF A, JORGENSEN MB, JACOBS AK, et al.: Do fish oils prevent restenosis after coronary angioplasty Circulation (1994) 90:2248–2257.
  • FERNS GA, FORSTER L, STEWART-LEE A, et al.: Probucol inhibits neointimal thickening and macrophage accumulation after balloon injury in the cholesterol-fed rabbit. Proc. Natl. Acad. Sci. USA (1992) 89:11312–11316.
  • SCHNEIDER JE, BERK BC, GRAVANIS MB, et al.: Probucol decreases neointimal formation in a swine model of coronary artery balloon injury. A possible role for antioxidants in restenosis. Circulation (1993) 88:628–637.
  • BAUMANN DS, DOBLAS M, SCHONFELD G, SICARD GA, DAUGHERTY A: Probucol reduces the cellularity of aortic intimal thickening at anastomotic regions adjacent to prosthetic grafts in cholesterol-fed rabbits. Arterioscler. Thromb. (1994) 14:162–167.
  • NUNES GL, SGOUTAS DS, REDDEN RA, et al.: Combination of vitamins C and E alters the response to coronary balloon injury in the pig. Arterioscler. Thromb. Vas c. Biol. (1995) 15:156–165.
  • LAFONT AM, CHAI YC, CORNHILL JF, et al.: Effect of alpha-tocopherol on restenosis after angioplasty in a model of experimental atherosclerosis. I Clin. Invest. (1995) 95:1018–1025.
  • KONNEH MK, RUTHERFORD C, LI SR, ANGGARD EE, FERNS GA: Vitamin E inhibits the intimal response to balloon catheter injury in the carotid artery of the cholesterol-fed rat. Atherosclerosis (1995) 113:29–39.
  • YUE TL, WANG X, GU JL, RUFFOLO RR, Jr., FEUERSTEIN GZ: Carvedilol, a new vasodilating beta-adrenoceptor blocker, inhibits oxidation of low-density lipoproteins by vascular smooth muscle cells and prevents leukocyte adhesion to smooth muscle cells. I Pharmacol. Exp. Ther. (1995) 273:1442–1449.
  • SETSUDA M, INDEN M, HIRAOKA N, et al.: Probucol therapy in the prevention of restenosis after successful percutaneous transluminal coronary angioplasty. Clin. Ther. (1993) 15:374–382.
  • DEMAIO SJ, KING SB, III, LEMBO NJ, et al.: Vitamin E supplementation, plasma lipids and the incidence of restenosis after percutaneous transluminal coronary angioplasty (PTCA). I Am. Coll. Nutr. (1992) 11:68–73.
  • FAXON DP: Effect of high dose angiotensin-converting enzyme inhibition on restenosis: final results of the MARCATOR study, a multicenter, double-blind, placebo-controlled trial of cilazapril. I Am. Coll. Cardiol. (1995) 25:362–369.
  • DESMET W, VROLIX M, DE SCHREERDER I, et al.: Angiotensin-converting enzyme inhibition with fosinopril sodium in the prevention of restenosis after coronary angioplasty. Circulation (1994) 89:385–392.
  • KAUL U, CHANDRA S, BAHL VK, SHARMA S, WASIR HS: Enalamil for prevention of restenosis after coronary angioplasty. Indian Heart I (1993) 45:469–473.
  • LIANG P, PARDEE AB: Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science (1992) 257:967–971.
  • LIANG P, PARDEE AB: Recent advances in differential display. Curr. Opin. Immnnol. (1995) 7:274–280.
  • SIMONS M, EDELMAN ER, DE KEYSER it, LANGER R, ROSENBERG RD: Antisense c-myboligonudeotides inhibit intimal arterial smooth muscle accumulation in vivo. Nature (1992) 359:67–70.
  • BURGESS TL, FISHER EF, ROSS SL, et al.: The antiproliferative activity of c-myb and c-myc antisense oligonudeotides in smooth muscle cells is caused by a nonantisense mechanism. Proc. Natl. Acad. Sci. USA (1995) 92:4051–4055.
  • VILLA AE, GUZMAN LA, POPTIC EJ, et al.: Effects of antisense c-myb oligonucleotides on vascular smooth muscle cell proliferation and response to vessel wall injury. Circ. Res. (1995) 76:505–513.
  • MORISHITA R, GIBBONS GH, KANEDA Y, OGIHARA T, DZAU VJ: Pharmacokinetics of antisense oligodeoxyribonucleotides (cyclin BI and CDC 2 kinase) in the vessel wall in vivo: enhanced therapeutic utility for restenosis of HVJ-liposome delivery. Gene (1994) 149:13–19.
  • SHI Y, FARD A, GALE° A et al.: Transcatheter delivery of c-myc antisense oligomers redues neointimal formation in a porcine model of coronary artery balloon injury. Circulation (1994) 90:944–951.
  • BENNETT MR, ANGLIN S, MCEWAN JR, et al.: Inhibition of vascular smooth muscle cell proliferation in vitro and in vivo by c-myc antisense oligodeoxynucleotides. I Clin. Invest. (1994) 93:820–828.
  • GUZMAN RJ, HIRSCHOWITZ EA, BRODY SL, et al.: In vivo suppression of injury-induced vascular smooth muscle accumulation using adenovirus mediated transfer of the herpes simplex virus thymidine kinase gene. Proc. Natl. Acad. Sci. USA (1994) 91:10732–10736.

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