39
Views
3
CrossRef citations to date
0
Altmetric
Review

Tumour angiogenesis: a novel therapeutic target in patients with malignant disease

&
Pages 155-174 | Published online: 24 Feb 2005

Bibliography

  • O'BYRNE KJ, DALGLEISH AG, BROWNING MJ, et al: The relationship between angiogenesis and the immune response in carcinogenesis and the progression of malignant disease. Eur. J. Cancer (2000) 36(2) :151–169.
  • FOLKMAN J: Clinical applications of research on angiogenesis. N Engl. J. Med. (1995) 333:1757–1763.
  • HARRIS AL: Are angiostatin and endostatin cures for cancer. Lancet (1998) 351:1598–1599.
  • HOLMGREN L, O'REILLY MS, FOLKMAN J: Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppres-sion. Nature Med. (1995) 1:149–153.
  • HANAHAN D, FOLKMAN J: Patterns and emerging mechanisms of the angiogenic switch during tumori-genesis. Cell (1996) 86:353–364.
  • WEINSTAT-SASLOW DL, ZABRENETSKY VS, VAN HK, et al.: Transfection of thrombospondin 1 complementary DNA into human breast carcinoma line reduces primary growth, metastatic potential and angiogene-sis. Cancer Res. (1994) 54:6504–6511.
  • POLVERINI PJ, LEIBOVICH SJ: Induction of neovascu-larization in vivo and endothelial cell proliferation in vitro by tumour associated macrophages. Lab. Invest. (1984) 51:635–642.
  • LEEK RD, LEWIS CE, WHITEHOUSE R, et al.: Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res. (1996) 56:4625–4629.
  • COX G, JONES JL, WALKER RA, STEWARD WP, O'BYRNEKJ: Angiogenesis and non-small cell lung cancer. Lung Cancer (2000) 27:81–100.
  • O'BYRNE KJ, KOUKOURAKIS MI, GIATROMANOLAKI A, et al.: Vascular endothelial growth factor, platelet-derived endothelial cell growth factor and angiogene-sis in non-small cell lung cancer. Br. J Cancer (2000) 82:1427–1432.
  • COX G, STEWARD WP, O'BYRNE KJ: The plasmin cascade and matrix metalloproteinases in non-small cell lung cancer. Thorax (1999) 54:169–179.
  • O'REILLY MS, HOLMGREN L, CHEN C, FOLKMAN J: Angiostatin induces and sustains dormancy of human primary tumours in mice. Nature Med. (1996) 2:689–692.
  • O'REILLY MS, BOEHM T, SHING Y, et al.: Endostatin: anendogenous inhibitor of angiogenesis and tumor growth. Cell (1997) 88:277–285.
  • DHANABAL M, RAMCHANDRAN R, WATERMAN MJ, et al.:Endostatin induces endothelial cell apoptosis. J Chem. (1999) 274:11721–11726.
  • BOEHM T, FOLKMAN J, BROWDER T, O'REILLY MS: Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature (1997) 390:404–407.
  • D'AMATO RJ, LOUGHNAN MS, FLYNN E, FOLKMAN J: Thalidomide is an inhibitor of angiogenesis. Proc. Natl. Acad. ScL USA (1994) 26:4082–4085.
  • KENYON BM, BROWNE F, D'AMATO RJ: Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization. Exp. Eye Res. (1997) 64(6):971–8.
  • CHING LM, BROWNE WL, TCHERNEGOVSKI R, et al.: Interaction of thalidomide, phthalimide analogues of thalidomide and pentoxifylline with the anti-tumour agent 5,6-dimethyxanthenone-4-acetic acid: concomi-tant reduction of serum tumour necrosis factor-alpha and enhancement of anti-tumour activity. Br. J. Cancer (1998) 78:336–343.
  • SINGHAL S, MEHTA J, DESIKAN R, et al.: Antitumoractivity of thalidomide in refractory multiple myeloma. N Engl. J. Med. (1999) 341:1565–1571.
  • EISEN T, BOSHOFF C, MAK I, et al.: Continuous low dose Thalidomide: a Phase II study in advanced melanoma, renal cell, ovarian and breast cancer. Br. J Cancer (2000) 82:812–817.
  • LITTLE RF, WYVILL KM, PLUDA JM, et al.: Activity of thalidomide in AIDS-related Kaposi's sarcoma. J Clin. Oncol. (2000) 18:2593–2602.
  • FINE HA, FIGG WD, JAECKLE K, et al.: Phase II trial of theantiangiogenic agent thalidomide in patients with recurrent high-grade gliomas. j Clin. Oncol. (2000) 18:708–715.
  • INGBER D, FUJITA T, KISHIMOTO S, et al.: Syntheticanalogues of fumagillan that inhibit angiogenesis and suppress tumour growth. Nature (1990) 348:555–557.
  • ABE J, ZHOU W, TAKUVVA et al.: A fumagillan derivativeangiogenesis inhibitor, AGM-1470, inhibits activation of cyclin-dependent kinases and phosphorylation of retinoblastoma gene product but not protein tyrosyl phosphorylation or protooncogene expression in vascular endothelial cells. Cancer Res. (1994) 54 :3407–3412.
  • BUDSON AE, KO L, BRASEL C, BISCHOFF: The angiogenesis inhbibitor AGM-1 470 selectively increases E-selectin. Biochem. Biophys. Res. Commun. (1996) 225 (1):141–5.
  • SHIGEMATSU K, YASUHARA H, SHIGEMATSU H, et al.: Anti-angiogenic drug AGM1470 suppresses smooth muscle cell migration induced by endothelial PDGF. Eur.J. Vasc. Endovasc. Surg. (1997) 14:290–298.
  • ISHIKAWA H, SATOH H, KAMMA H, et al.: The effect of TNP-470 on cell proliferation and urokinase-type plasminogen activator and its inhibitor in human lung cancer cell lines. J. Exp. Ther. Oncol. (1996) 1:390-396.
  • FUJIMOTO J, HORI M, ICHIGO S, et al.: Plausible novel therapeutic strategy of uterine endometrial cancer with reduction of basic fibroblast growth factor secretion by progestin and 0-(chloroacetyl-car b am oyl) fumagillol (TNP-470; AGM-1470). Cancer Lett. (1997) 113:187–194.
  • GRIFFITH EC, SU Z, TURK BE, et al.: Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin. Chem. Biol. (1997) 4:461–471.
  • KARAWADA Y, ISHIKURA H, KISHIMOTO T, et al.: Inhibi-tory effects of the antiangiogenic agent TNP-470 on establishment and growth of hematogenous metastasis of human pancreatic carcinoma in SCID beige mice in vivo. Pancreas (1997) 15:251–257.
  • KIDO A, TSUJIUCHI T, MORISHITA T, et al.: Telomerase activity correlates with growth of transplantable osteosarcomas in rats treated with cis-diammine dichloroplatinum or the angiogenesis inhibitor AGM-1470. Jpn. J. Cancer Res. (1998) 89:1074–1081.
  • WATSON JC, SUTANTO-WARD E, OSAKU M, et al.: Importance of timing and length of administration of angiogenesis inhibitor TNP-470 in the treatment of K12/TRb colorectal hepatic metastases in BD-IX rats. Surgery (1999) 126:358–363.
  • KUDELKA AP, LEVY T, VERSCHRAEGEN CF, et al: A Phase I study of TNP-470 administered to patients with advanced squamous cell cancer of the cervix. Clin. Cancer Res. (1997) 3:1501–1505.
  • STADLER WM, KUZEL T, SHAPIRO C, et al.: Multi-institutional study of the angiogenesis inhibitor TNP-470 in metastatic renal carcinoma. J Clin. Oncol (1999) 17:2541.
  • BHARGAVA P, MARSHALL JL, RIZVI N, et al.: APhase land pharmacokinetic study of TNP-470 administered weekly to patients with advanced cancer. an. Cancer Res. (1999) 5:1989–1999.
  • DEZUBE BJ, VON ROENN JH, HOLDEN-WILTSE J, et al.:Fumagillan analog in the treatment of Kaposi's sarcoma: a Phase I AIDS clinical trial group study. AIDS clinical trial group no. 215 team. J Clin. Oncol (1998) 16:1444–1449.
  • OFFODILE R, WALTON T, LEE M, et al: Regression ofmetastatic breast cancer in a patient treated with the anti-angiogenic drug TNP-470. Tumouri (1999) 85:51–53.
  • SCATENA M, ALMEIDA M, CHAISSON ML, et al.: NF-kapp aB mediates av133 integrin-induced endothe-lial cell survival. j Biol. Chem. (1998) 141:1083–1093.
  • SOLDI R, MITOLA S, STRASLY M, et al.: Role ofalphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. EMBO J (1999) 18:882–892.
  • HERMANN P, ARMANT M, BROWN E, et al.: The vitronectin receptor and its associated CD47 molecule mediates proinflammatory cytokine synthesis in human monocytes by interaction with soluble CD23. j Cell Biol. (1999) 1 44 (4):767–775.
  • COLEMAN KR, BRADEN GA, WILLINGHAM, MC, SANE DC: Vitaxin, a humanised monoclonal antibody to the vitronectin receptor (alphavbeta3), reduces neointimal hyperplasia and total vessel area after balloon injury in hypercholesterolemic rabbits. Circ. Res. (1999) 84:1268–1276.
  • STROGARD CM, STUPACK DG, JONCZYK A, et al: Decreased angiogenesis and arthritic disease in rabbits treated with an alphavbeta3 antagonist. J Clin. Invest. (1999) 103:47–54.
  • D'ANGELO G, MARTINI JF, IIRI T, et al.: 16K human prolactin inhibits vascular endothelial growth factor-induced activation of ras in capillary endothelial cells. Mol Endocrinol. (1999) 13:692–704.
  • SILLS AK, JR., WILLIAMS JI, TYLER BM, et al: Squalamine inhibits angiogenesis and solid tumour growth in vivo and perturbs embroyonic vasculature. Cancer Res. (1998) 58(13):2784–2792.
  • KAKEJI Y, TEICHER BA: Preclinical studies of the combination of angiogenic inhibitors with cytotoxic agents. Invest. New Drugs (1997) 15:39–48.
  • YAMAMOTO T, TERADA N, NISHIZAWA, PETROW V: Angiostatic activities of medroxyprogesterone acetate and its analogues. Int. J Cancer (1994) 56(3):393–399.
  • HORI Y, HU DE, YASUI K, SMITHER RL, GRESHAM GA, FAN TP: Differential effects of angiostatic steroids and dexamethasone on angiogenesis and cytokine levels in rat sponge implants. Br. J. Pharmacol. 11 8 (7):1584–1591.
  • LIU J, RAZANI B, TANG S, et al: Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells. Angiogenesis inhibitors block vascular endothelial growth factor-induced down-regulation of caveolin-1. J Biol. Chem. (1999) 274:15781–15785.
  • MAJEWSKI S, MARCZAK M, SZMURLO A, et al.: Retinoids,interferon alpha, 1, 25-dihydrox vitamin D3 and their combination inhibit angiogenesis induced by non-HPV-harbouring tumor cell lines RAR alpha mediates the antiangiogenic effect of retinoids. Cancer Lett. (1995) 89:117–124.
  • O'BYRNE KJ, HAN C, MITCHELL K, et al.: Phase II study of liarozole in advanced non-small cell lung cancer. Eur. J. Cancer (1998) 34:1463–1466.
  • YATSUNAMI J, TSURUTA N, FUKUNO Y, et al: Inhibitory effects of roxithromycin on tumor angiogenesis, growth and metastasis of mouse B16 melanoma cells. Clin. Exp. Metastasis (1999) 17:119–124.
  • DE WILT JH, MANUSAMA ER, VAN ETTEN B, et al.: Nitric oxide synthase inhibition results in synergistic anti-tumour activity with mephalan and tumour necrosis factor alpha-based isolated limb perfusion. Br. J. Cancer (2000) 83:1176–1182.
  • ECKHARDT SG, BURRIS HA, ECKARDT JR, et al: A Phase Iclinical and pharmacokinetic study of the angiogene-sis inhibitor, tecogalan sodium. Ann. Oncol. (1996) 7:491–496.
  • LAU DH, XUE L, YOUNG LJ, BURKE PA, CHEUNG AT: Paclitaxel (Taxol): an inhibitor of angiogenesis in a highly vascularised transgenic breast cancer. Cancer Biother. Radiopharm. (1999) 14:31–36.
  • CLEMENTS MK, JONES CB, CUMMING M, DAOUD SS: Antiangiogenic potential of camptothecin and topotecan. Cancer Chemother. Pharmacol (1999) 44 :411–416.
  • O'BYRNE KJ, DOBBS N, PROPPER D, et al.: Vascularendothelial growth factor, platelet counts and renal cell cancer [Research letter]. Lancet (1 9 9 9) 353:1494-1495.
  • COX G, JONES JL, WALKER RA, et al.: Angiogenesis andnon-small cell lung cancer. Lung Cancer (2000) 2781–100.
  • FERRARA N, DAVIS-SMYTH T: The biology of vascular endothelial growth factor. Endoc. Rev. (1997) 18:4–25.
  • WHITTLE C, GILLESPIE K, HARRISON R, MATHIESON PW, HARPER SJ: Heterogeneous vascular endothelial growth factor (VEGF) isoform mRNA and receptor mRNA expression in human glomeruli and the identi-fication of VEGF148 mRNA, a novel truncated splice variant. Clin. Sci. (1999) 97 :303–312.
  • KIM KJ, LI B, WINER J, et al.: Inhibition of vascularendothelial growth factor-induced angiogenesis suppresses tumour growth in viva Nature (1993) 3 62 :841–844.
  • LIN P, SANKAR S, SHAN S, et al: Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor. Cell Growth Differ. (1998) 9(1)49–58.
  • SKOBE M, ROCKWELL P, GOLDSTEIN N, et al.: Halting angiogenesis suppresses carcinoma cell invasion. Nature Med. (1997) 3:1222–1227.
  • GORDON MS, TALPAZ M, MARGOLIN K, et al.: Phase I trialof recombinant humanised monoclonal anti-vascular endothelial growth factor (an ti-VEGF Mab) in patients (pts) with metastatic cancer. Proc. Am. Soc. Chn. Oncol. (1998) 17:210.
  • RYAN AM, EPPLER DB, HAGLER KE, et al: Preclinical safety evaluation of rhuMAbVEGF, an antiangiogenic humanised monoclonal antibody. Toxkol. Pathol. (1999) 27:78–86.
  • ANGELOV L, SALHIA B, RONCARI L, et al: Inhibition of angiogenesis by blocking activation of the vascular endothelial growth factor receptor 2 leads to decreased growth of neurogenic sarcomas. CancerRes. (1999) 59:5536–5541.
  • FONG TA, SHAWVER LK, SUN L, et al.: SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (flk-1 /KDR) that inhibits tyrosine kinase catalysis, tumor vascularization and growth of multiple tumor types. Cancer Res. (1999) 59:99–106.
  • SHAHEEN RM, DAVIS DW, LIU W et al: Antiangiogenictherapy targeting the tyrosine kinase receptor for vascular endothelial growth factor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis. Cancer Res. (1999) 59:5412–5416.
  • DREVS J, HOFMANN I, HUGENSCHMIDT H, et al.: Effectsof PTK787/ZK 222584, a specific inhibitor of vascular endothelial growth factor receptor tyrosine kinases, on primary tumor, metastasis, vessel density and blood flow in a murine renal cell carcinoma model. Cancer Res. (2000) 60:4819–4824.
  • XU L, YONEDA J, HERRERA C, WOOD J, KILLION JJ, FIDLER IJ: Inhibition of malignant ascites and growth of human ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growth factor receptor tyrosine kinases. Int. J Oncol. (2000) 16:445–454.
  • YANO S, HERBST RS, SHINOHARA H, et al.: Treatment for malignant pleural effusion of human lung adenocarci-noma by inhibition of vascular endothelial growth factor receptor tyrosine kinase phosphorylation. Clin. Cancer Res. (2000) 6:957–965.
  • BRUNS CJ, HARBISON MT, DAVIS DW, et al: Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms. Clin. Cancer Res. (2000) 6:1936–1948.
  • FERRY D, HAMMOND L, RANSON M, et al: Intermittentoral Zd1839 (Iressa), a novel epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) shows evidence of good tolerability and activity: final results from a Phase II trial. Proc. Am. Soc. an. Oncol (2000) Abstract 5E.
  • GLEAVE M, ELHILAH M, FRADET Y, et al. AND THE CANADIAN UROLOGIC ONCOLOGY GROUP: Interferon gamma-113 compared with placebo in metastatic renal cell carcinoma. N Engl. J Med. (1998) 338:1265–1271.
  • MEDICAL RESEARCH COUNCIL RENAL CANCER COLLABORATORS: Interferon -aand survival in metastatic renal carcinoma: early results of a random-ised controlled trial. Lancet (1999) 353:14–17.
  • NEGRIER S, ESCIDIER B, LASSET C, et al FOR THE GROUPEFRANCAIS D'IMMUNOTHERAPIE: Recombinant human interleukin-2, recombinant interferon alpha-2a, or both in metastatic renal-cell carcinoma. N Engl. J Med. (1998) 388:1272–1278.
  • HERNBERG M, PYRHC)NEN S, MUHONEN T: Regimens with or without interferon-a as treatment for metastatic melanoma and renal cell carcinoma: an overview of randomised trials. j immunother. (1999) 22:145–154.
  • GROB JJ, DRENO B, DE LA SALMONIERE P, et al.: Random-ised trial of interferon-a2a as adjuvant therapy in resected primary melanoma thicker than 1.5 mm without clinically detectable node metastases. French Cooperative Group on Melanoma. Lancet (1998) 351:1905–1910.
  • COUGHLIN CM, SALHANY KE, WYSOCKA M, et al: In terleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis. J. Clin. Invest. (1998) 101:1441–1452.
  • LASEK W, FELESZKO W, GOLAB J, et al: Antitumoureffects of the combination immunotherapy with IL-12 and tumour necrosis factor alpha in mice. Cancer Immunol. Immunother. (1997) 45:100–108.
  • COUGHLIN CM, SALHANY KE, GEE MS, et al: Tumor cellresponses to IFN-gamma affect tumorigenicity and response to IL-12 therapy and anti-angiogenesis. Immunity (1998) 9:25–34.
  • SAMANIEGO F, MARKHAM PD, GENEDELMAN R, et al:Vascular endothelial growth factor and basic fibroblast growth factor present in Kaposi's sarcoma (KS) are induced by inflammatory cytokines and synergise to promote vascular permeability and KS lesion development. Am. J. Pathol. (1998)152:1433–1443.
  • COHEN T, NAHARI D, CEREM LW, NEUFELD G, LEVI BZ:Interleukin 6 induces the expression of vascular endothelial growth factor. J. Biol. Chem. (1996) 271:736–41.
  • FUKUSHI J, MORISAKI T, SHONO T, et al.: Novel biological function of IL-4 and IL-13:formation of tube-like structures by vascular endothelial cells in vitro and angiogenesis in vivo. Biochem. Biophys. Res. CO1711711117. (1999) 250:444–448.
  • FUJIEDA S, SUNAGA H, TSUZUKI H, et al.: IL-10 expres-sion is associated with the expression of platelet-derived endothelial cell growth factor and prognosis in oral and oropharyngeal carcinoma. Cancer Lett. (1999) 136:1–9.
  • JONES MK, ITANI RM, WANG H, et al: Activation of VEGFand Ras genes in gastric mucosa during angiogenic response to ethanol injury. Am. J Physiol (1999) 276:G1345–1355.
  • TANAKA H, NISHIDA K, SUGITA, YOSHIOKA T: Antitumor efficacy of hypothemycin, a new ras-signaling inhibitor. Jpn J Cancer Res. (1999) 90:1139–1145.
  • BIANCO C, TORTORA G, BALDASSARRE G, et al.: 8-chloro-cyclic AMP inhibits autocrine and angiogenic growth factor production in human colorectal and breast cancer. Clin. Cancer Res. (1997) 3:439–444.
  • SAUNDERS MS, SALISBURY AJ, O'BYRNE KJ, et al.: A novel cyclic adenosine monophosphate analog induces hypercalcaemiaviaproductionof1,25-dihydroxyvitamin D in patients with solid tumors. J. Clin. Endocrinol. Metab. (1997) 82:4044–4048.
  • PROPPER DJ, SAUNDERS MS, SALISBURY A, et al.: APhase Istudy of a novel cyclic AMP (cAMP) analogue 8-chloro-cAMP in patients with cancer: toxicity, hormonal and immunological effects. Clin. Cancer Res. (1999) 5:1682–1689.
  • DANESI R, AGEN C, BENELLI U, et al.: Inhibition ofexperimental angiogenesis by the somatostatin analogue octreotide acetate (SMS 201-995). Clin. Cancer Res. (1997) 3:265–272.
  • PATEL PC, BARRIE R, HILL N, et al.: Postreceptor signaltransduction mechanisms involved in octreotide induced inhibition of angiogenesis. Surgery (1994) 116:1148–1152.
  • REUBI J-C, HORISBERGER U, LAISSUE J: High density ofsomatostatin receptors in veins surrounding human cancer tissue: role in tumor-host interaction Int. J Cancer (1994) 56:681–688.
  • PINSKI J, SCHALLY AV, HALMOS G, et al: Effects ofsomatostatin analog RC-160 and bombesin/gastrinre-leasing peptide antagonists on the growth of human small cell and nonsmall cell lung carcinomas in nude mice. Br. J. Cancer (1994) 70:886–892.
  • ALESSANDRO R, MASIERO L, LIOTTA LA, KOHN EC: The role of calcium in the regulation of invasion and angiogenesis. In Vivo (1996)10:153-160.
  • KOHN EC, REED E, SAROSY G, et al: Clinical investiga-tion of a cytostatic calcium influx inhibitor in patients with refractory cancers. Cancer Res. (1999) 56:569–573.
  • BAUER KS, FIGG WD, HAMILTON JM, et al: A pharma-cokinetically guided Phase II study of carboxyamido-triazole in androgen-independent prostate cancer. Clin. Cancer Res. (1999) 5:2324–2329.
  • BROWN P: Matrix metalloproteinase inhibitors. Breast Cancer Res. Treat. (1998) 52:125–136.
  • KONTTINEN YT, AINOLA M, VALLEALA H, et al: Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis. Ann. Rheum. Dis. (1999) 58:691–697.
  • STEWARD WP: Marimastat (BB2516): current status of development. Cancer Chemother. Pharmacol. (1999) 43 (Suppl.):S56–S60.
  • COX G, JONES LJ, WALKER R, O'BYRNE KJ: Matrix metalloproteinase 9 and the epidermal growth factor signal pathway in operable non-small cell lung cancer. Clin. Cancer Res. (2000) 6:2349–2355.
  • MACAULAY VM, O'BYRNE KJ, SAUNDERS MP, et al: Phase I study of intrapleural batimastat (BB-94), a matrix metalloproteinase inhibitor, in the treatment of malignant pleural effusions. Clin. Cancer Res. (1999) 5:513–520.
  • SHALINSKY DR, BREKKEN J, ZOU H, et al.: Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials. Ann. NY Acad. Sci. (1999) 878:236–270.
  • SHALINSKY DR, BREKKEN J, ZOU H, et al: Antitumor efficacy of AG3340 associated with maintenance of minimum effective plasma concentrations and not daily dose, exposure or peak plasma concentrations. Invest. New Drugs. (1999) 16:303–313.
  • GILBERTSON-BEADLING S, POWERS EA, STAMP-COLE M, et al: The tetracycline analogs minocycline and doxycycline inhibit angiogenesis in vitro by a non-metalloproteinase-dependent mechanism. Cancer Chemother. Pharmacol. (1995) 36:418–424.
  • STUART R, HAWKINS P, MCCULLOCH T, et al.: A random-ised double-blind placebo-controlled study of marimastat in patients with inoperable gastric adenocarcinoma. Proc. Am. Soc. Clin. Oncol (2000) 19. Abstract 929.
  • TEICHER BA, DUPUIS NP, ROBINSON MF, et al.: Antiangiogenic treatment (TNP-470/minocycline) increases tissue levels of anticancer drugs in mice bearing Lewis lung carcinoma. Oncol. Res. (1995) 7:237–243.
  • TEICHER BA, HOLDEN SA, DUPUIS NP, et al.: Potentiation of cytotoxic therapies by TNP470 and minocycline in mice bearing EMT-6 mammary carcinoma. Breast Cancer Res. Treat. (1995) 36:227–236.
  • HERBST RS, TAKEUCHI H, TEICHER BA: Paclitaxel/carboplatin administration along with antiangiogenic therapy in non-small cell lung and breast carcinoma models. Cancer Chemother. Pharmacol. (1998) 41:497–450.
  • SATOH H, ISHIKAWA H, FUJIMOTO M, et al.: Combined effects of TNP-470 and Tax ol in human non-small cell lung cancer cell lines. AntiCancer Res. (19 9 8) 18:1027-1030.
  • SZEPESHAZI K, LAPIS K, SCHALLY AV: Effect of combina-tion treatment with analogs of luteinizing hormone-releasing hormone (LI-1-RH) or somatostatin and 5-fluorouracil on pancreatic cancer in hamsters. Int. J Cancer (1991) 49:260–266.
  • THOMAS F, BOURGEOIS E, POUPON MF: Additive inhibi-tory effects of cyclophosphamide (CPM) and of a somatostatin analogue lanreotide (Ian) on the growth of a small cell lung cancer (SCLC) xenograft. Proc. Am. Assoc. Clin. Oncol. (1992) 11. Abstract 1036.
  • WECKBECKER G, RAULF F, TOLCSVAI L, BRUNS C: Potentiation of the anti-proliferative effects of anti-cancer drugs by octreotide in vitro and in vivo. Digestion (1996) 57 (Suppl. 0:22–28.
  • BRUNS CJ, SOLORZANO CC, HARBISON MT, et al.: Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res. (2000) 60:2926–2935.
  • KLEMENT G, BARUCHEL S, RAK J, et al: Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regres-sion without overt toxicity. J. Clin. Invest. (2000) 105 (8):R15–24.
  • HANNINEN EL, KIRCHNER H, ATZPODIEN J: Interleuken-2 based home therapy of metastatic renal cell carcinoma: risks and benefits in 215 consecutive single institution patients. J. Urol (1996) 155:19–25.
  • GASPARINI G: The rationale and future potential of angiogenesis inhibitors in neoplasia. Drugs (1999) 58:17–38.
  • HUANG X, MOLEMA G, KING S, et al.: Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature. Science (1997) 275:547–550.
  • TSUNODA S, OHIZUMI I, MATSUI J, et al: Specific binding of IM-23 antibody to tumour vascular endothelium in mice, rats and human cancer tissue: a novel drug carrier for cancer targeting therapy. Br]. Cancer (1999) 81:1155–1161.
  • KONG H-L, CRYSTAL RG: Gene therapy strategies for tumor antiangiogenesis. J. Natl. Cancer Inst. (1998) 90:273–284.
  • LAU KKW, BICKNELL R: Antiangiogenic gene therapy. Gene Ther. (1999) 6:1793–1795.
  • MILLAUER B, SHAWVER LK, PLATE KH, et al: Glioblas-toma growth inhibited in vivo by a dominant-negative flk-1 mutant. Nature (1994) 367:576–579.
  • SALEH M, STACKER SA, WILKS AF, et al: Inhibition of growth of C6 glioma cells in vivo by expression of an tisense vascular endothelial growth factor sequence. Cancer Res. (1996) 56:393–401.
  • IM SA, GOMEZ-MANZANO, FUEYO J, et al.: Antiangio-genesis treatment for gliomas: transfer of antisense-vascular endothelial growth factor inhibits tumor growth in vivo. Cancer Res. (1999) 59:895–900.
  • LIN P, SANKA S, SHAN S, et al: Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor. Cell. Growth Diff (1998) 9:49–58.
  • GUO N, KRUTZSCH HC, INMAN JK, ROBERTS DD: Thrombospondin 1 and Type I repeat peptides of thrombospondin I specifically induce apoptosis of endothelial cells. Cancer Res. (1997) 57:1735–1742.
  • CLAESSON-WELSH L, WELSH M, ITO N, et al: Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin binding motif RGD. Proc. Natl. Acad. Sci. USA (1988) 95:5579–5583.
  • TANAKA T, CAO Y, FOLKMAN J, FINE HA: Viral vector-targeted antiangiogenic gene therapy utilising an angiostatin complementary DNA. Cancer Res. (1998) 58:3362–3369.
  • TANAKA T, MANOME Y, WEN P, et al: Viral vector mediated transduction of a modified platelet factor 4 cDNA inhibits angiogenesis and tumor growth. Nature Med. (1997) 3:437–442.
  • BLEZINGER P, WANG J, GONDO M, et al.: Systemic inhibi-tion of tumor growth and tumor metastases by intramuscular administration of the endostatin gene. Nature Biotechnol. (1999) 17:343–348.
  • LIN P, BUXTON JA, ACHESON A, et al: Antiangiogenic gene therapy targets the endothelial-specific receptor tyrosine kinase tie2. Proc. Natl. Acad. Sci. USA (1998) 95:8829–8834.
  • LIU Y, THOR A, SHTIVELMAN Y et al: Systemic gene delivery expand the repertoire of effective antiangio-genic agents. J. Biol. Chem. (1999) 274:13338–13344.
  • BERGERS G, JAVAHERIAN K, LO KM, et al: Effects of angiogenesis inhibitors on multistage carcinogenesis. Science (1999) 284:808–812.
  • TANAKA Y, KAWAMATA H, FUJIMOTO K, OYASU R: Angiogenesis inhibitor TNP-470 suppresses tumorige-nesis in rat urinary bladder. j Uroi. (1997) 157:683–688.
  • FOTSIS T, PEPPER MS, MONTESANO R, et al.: Phytoestro-gens and inhibition of angiogenesis. Baillieres Clin. Endocrinol. Metab. (1998) 12:649–666.
  • ZHOU JR, GUGGER ET, TANAKA et al.: Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumour angiogenesis in mice. J. Nutr. (1999) 129:1628–1635.
  • TATSUTA M, IISHI H, BABA M, et al: Attenuation by genistein of sodium chloride enhanced gastric carcinogen esis induced by N-methyl-N'-nitro-N--nitrosoguanidine in Wister rats. Int. J. Cancer (1999) 80:396–399.
  • HUANG M-T, LOU Y-R, MAW et al.: Inhibitory effects of dietary curcumin on forestomach, duodenal and colon carcinogenesis in mice. Cancer Res. (1994) 54:5841–5887.
  • ARBISER JL, KLAUBER N, ROHAN R, et al: Cur cumin is an in vivo inhibitor of angiogenesis. Mol. Med. (1998) 4:376–383.
  • CASTONGUAY A, RIOUX N: Inhibition of lung tumorige-nesis by sulindac: comparison of 2 experimental protocols. Carcinogenesis (1997) 18:491–496.
  • PERKINS TM, SHKLAR G: Delay in hamster buccal pouch carcinogenesis by aspirin and indomethacin. Oral Surg. (1982) 53:170–178.
  • MCCORMICK DL, MADIGAN MJ, MOON RC: Modulation of rat mammary carcinogenesis by indomethacin. Cancer Res. (1985) 45:1803–1808.
  • SAMAHA HS, KELLOFF GJ, STEELE V: Modulation of apoptosis by sulindac, curcumin, phenylethy1-3-methylcaffeate and 6-phenylhexyl isocyanate: apoptotic index as a biomarker in colon cancer chemoprevention and promotion. Cancer Res. (1997) 57:1301–1305.
  • GIARDIELLO FM, HAMILTON SR, KRUSH AJ, et al: Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N Engl. J. Med. (1993) 328:1313–1316.
  • STEINBACH G, LYNCH PM, PHILLIPS RK, et al: The effect of celecoxib, a cyclooygenase-2 inhibitor, in familial adenomatous polyposis. N. Engl. J. Med. (2000) 342(26)1946–1952.
  • THUN MJ, NAMBOODIN MM, HEATH CW, JR.: Aspirin use and reduced risk of fatal colon cancer. N Engl. J Med. (1991) 325:1593–1596.
  • GIOVANNUCCI E, EGAN KM, HUNTER DJ, et al: Aspirin and the risk of colorectal cancer in women. N Engl. J. Med. (1995) 333:609–614.
  • FUNKHOUSER EM, SHARP PH: Aspirin and reduced risk of esophageal carcinoma. Cancer (1995) 76:1116–1119.
  • TSUJI M, KAWANO S, TSUJI S, SAWAOKA H, HORI M, DUBOIS RN: Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell (1998) 94(2):271.
  • INTERNATIONAL INTERFERON-a HEPATOCELLULAR CARCINOMA STUDY GROUP: Effect of interferon-a on progression of cirrhosis to hepatocellular carcinoma: a retrospective cohort study. Lancet (1 9 9 8) 351:1535-1539.
  • GAGLIARDI AR, HENNIG B, COLLINS DC: Antiestrogens inhibit endothelial cell growth stimulated by angiogenic growth factors. AntiCancer Res. (1996) 16:1101–1106.
  • LINDNER DJ, BORDEN EC: Effects of tamoxifen and interferon-I3 or the combination on tumor-induced angiogenesis. Int. J Cancer (1997) 71:456–461.
  • HADDOCK G, HARRISON DJ, CARTER DC: The effect of the somatostatin analogue SMS 201-995 on experi-mental pancreatic carcinogenesis in the Syrian golden hamster. Carcinogenesis (1991) 12:1103–1107.
  • SZENDE B, JUHASZ E, LAPIS K, SCHALLY AV: Inhibition of two-step urinary bladder carcinogenesis by the somatostatin analogue RC-160. Urol. Res. (1992) 20:383–386.
  • FISHER B, CONSTANTINO JP, WICKERHAM DL, et al: Tamoxifen for the prevention of breast cancer: report of the national surgical adjuvant breast and bowel project P-1 study. J. Natl. Cancer Inst. (1998) 90:1371–1388.
  • JORDAN VC, MORROW M: Tamoxifen, raloxifene and the prevention of breast cancer. Endocr. Rev. (1999) 20:253–278.
  • LEVER AF, HOLE DJ, GILLIS CR, et al: Do inhibitors of angiotensin-I-converting enzyme protect against risk of cancer Lancet (1998) 352:179–84.
  • GATELY S, TWARDOWSKI P, STACK MS, et al: The mechanism of cancer mediated conversion of plasmi-nogen to the angiogenesis inhibitor angiostatin. Proc. Natl. Acad. ScI USA (1997) 94:10868–10872.
  • VOLPERT OV, WARD WF, LINGEN MW, et al: Captopril inhibits angiogenesis and slows the growth of experi-mental tumors in rats. J. Clin. Invest. (1996) 98:671–679.
  • JONES M, PHILLIP T, PALMER P, et al. The impact of interleukin-2 on survival in renal cancer: a multivariate analysis. Cancer Biother. (1993) 8:275–288.
  • BRAYBROOKE J, O'BYRNE KJ, PROPPER DJ, et al.: APhase II study of razoxane, an anti-angiogenic topoisomerase II inhibitor, in renal cell cancer. Clin. Cancer Res. (2001) 6:4697–4704.
  • BICKNELL R, HARRIS AL: Mechanisms and therapeutic implications of angiogenesis. CUIT. Opin. Oncol (1996) 8:60–65.
  • DELORME S, KNOPP MV: Non-invasive vascular imaging: assessing tumour vascularity. Eur. Radio]. (1998) 8:517–527.
  • VAN DIJKE CF, BRASCH RC, ROBERTS TP, et al.Mammary carcinoma model: correlation of macromolecular contrast-enhanced MR imaging characterizations of tumor microvasculature and histologic capillary density. Radiology (1996) 198 (3):813–818.
  • STOMPER PC, WINSTON JS, HERMAN S, et al.: Angiogene-sis and dynamic MR imaging gadolinium enhance-ment of malignant and benign breast lesions. Breast Cancer Res. Treat. (1997) 45:39–46.
  • BRASCH R, PHAM C, SHAMES D, et al.: Assessing tumor angiogenesis using macromolecular MR imaging contrast media. J. Magn. Reson. Imaging (1997) 7:68–74.
  • CREW J, O'BRIEN T, BICKNELL R, et al.: Urinary vascular endothelial growth factor and its correlation with bladder cancer recurrence rates. J. Urol. (1999) 161: 799–804.
  • DIRIX LY, VERMEULEN PB, PAWINSKI A, et al.: Elevated levels of the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients. Br. J. Cancer (1997) 76:238–243.
  • O'BRIEN TS, SMITH K, CRANSTON D, et al.: Urinary basic fibroblast growth factor in patients with bladder cancer and benign prostatic hypertrophy. Br. J. Urol (1995) 76:311–314.
  • STEPHENS RW, PEDERSEN AN, NIELSEN HJ, et al.: ELISA determination of soluble urokinase receptor in blood from healthy donors and cancer patients. Clin. Chem. (1997) 43:1868–1876.
  • KOCH AE, HALLORAN MM, HASKELL CJ, et al.: Angiogene-sis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1. Nature (1995) 376 :517–519.
  • BROCK TA, DVORAK HF, SENGER DR: Tumour secreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothe-lial cells. Am. J. Pathol. (1991) 138:213–221.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.