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Review

Oxazolidinones: new players in the battle against multi-resistant Gram-positive bacteria

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Pages 43-55 | Published online: 24 Feb 2005

Bibliography

  • HOLMBERG SD, SOLOMON SL, BLAKE PA: Health andeconomic impacts of antimicrobial resistance. Rev. Infect. Dis. (1987) 9:1065–1078.
  • BONTEN MJ, HAYDEN MK, NATHAN C, et al: Epidemi-ology of colonisation of patients and environment with vancomycin-resistant enterococci. Lancet (1996) 348:1615–1619.
  • MARTONE WJ: Spread of vancomycin-resistant entero-cocci: why did it happen in the United States Infect. Control Hosp. Epidemiol. (1998) 19:539–545.
  • RUBIN RJ, HARRINGTON CA, POON A, DIETRICH K, GREENE JA, MOIDUDDIN A: The economic impact of Staphylococcus aureus infections in New York City hospitals. Emerg. Infect. Dis. (1999) 5:9–17.
  • •A review of the costs associated with community- and nosocomially-acquired methicillin-susceptible and -resistant S. aureus infections.
  • WEINGARTEN CM, RYBAK MJ, JAHNS BE, STEVENSON JG, BROWN WJ, LEVINE DP: Resistant Acinetobacter baumannii infection and colonization and antimicro-bial treatment patterns in an urban teaching hospital. Pharmacother. (1999) 19:1080–1085.
  • PALADINO JA: Economic justification of antimicrobial management programs: implications of antimicrobial resistance. Am. J. Health Syst. Pharm. (2000) 57 (Suppl. 2):S10–S12.
  • JONES RN: Impact of changing pathogens and antimi-crobial susceptibility patterns in the treatment of serious infections in hospitalised patients. Am. J. Med. (1996) 1 0 0:3S–12S.
  • PFALLER MA, JONES RN, DOERN GV, KUGLER K. Bacterial pathogens isolated from patients with bloodstream infection: frequencies of occurrence and antimicro-bial susceptibility patterns from the SENTRY antimi-crobial surveillance program (United States and Canada, 1997). Antimicrob. Agents Chemother. (1998) 42:1762–1770.
  • EDMOND MB, WALLACE SE, MCCLISH DK, PFALLER MA, JONES RN, WENZEL RP: Nosocomial bloodstream infections in United States hospitals: a three-year analysis. an. Infect. Dis. (1999) 29:239–244.
  • ••A comprehensive surveillance study presenting incidenceand crude mortality data associated with organisms causing bloodstream infections.
  • SAHM DF, MARSILIO MK, PIAZZA G: Antimicrobial resistance in key bloodstream bacterial isolates: electronic surveillance with the Surveillance Network Database -USA. Clin. Infect. Dis. (1999) 29:259–263.
  • LIVERMORE DM: Antibiotic resistance in staphylococci. Int. J. Antimicrob. Agents (2000) 16 (Suppl.
  • SPINK WW, FERRIS V: Quantitative action of penicillin inhibitor from penicillin-resistant strains of staphylo-cocci. Science (1945) 102:221.
  • Mandell GL, Bennett JE, Dolin R (Eds.), Churchill Livingstone, Philadel-phia, USA (2000):2069–2092.
  • JEVONS MP: Celbenin-resistant staphylococci. Br. Med. J. (1961) 1:124–125.
  • FILE TM: Overview of resistance in the 1990s. Chest (1999) 115 (Suppl. 3):35–85.
  • FRIDKIN SK, EDWARDS JR, PICHETTE SC, et al.: Determi-nants of vancomycin use in adult intensive care units in 41 United States hospitals. Clin. Infect. Dis. (1999) 2 8:1119–1125.
  • LECLERCQ R, DERLOT E, DUVAL J, COURVALIN P: Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium. N Engl. J. Med. (1988) 319:157–161.
  • HIRAMATSU K, HANAKI H, YABUTA K, OGURI T, TENOVER FC: Methicillin -resistantStaphylococcus aureus clinical strain with reduced vancomycin susceptibility. J. Antimicrob. Chemother. (1997) 40:135–136.
  • PLOY MC, GRELAUD C, MARTIN C, DE LUMLEY L, DENIS F:First clinical isolate of vancomycin-intermediate Staphylococcus aureus in a French hospital. Lancet (1998) 351:1212.
  • •Describes the isolation of the first clinical GISA strain worldwide.
  • ANTONY SJ: Multidrug-resistant enterococci: the dawnof a new era in resistant pathogens. J Nail Med. Assoc. (1998) 90:537–540.
  • SCHOUTEN MA, HOOGKAMP-KORSTANJE JA, MEIS JF, VOSS A: Prevalence of vancomycin-resistant entero-cocci in Europe. European VRE study group. Eur. Microbiol. Infect. Dis. (2000) 19:816–822.
  • STROUD L, EDWARDS J, DANZING L, CULVER D, GAYNESR: Risk factors for mortality associated with entero-coccal bloodstream infections. Infect. Control Hosp. Epidemiol. (1996) 17:576–580.
  • LINDEN PK, PASCULLE AW, MANEZ, R et al: Differencesin outcomes for patients with bacteremia due to vancomycin-resistant Enterococcus faecium or vancomycin-susceptible E. faecium. Clin. Infect. Dis. (1996) 22:663–670.
  • •A study examining overall morbidity and mortality as they relate to vancomycin resistance in patients with E. faecium bloodstream infections.
  • PAPANICOLAOU GA, MEYERS BR, MEYERS J, et al.: Nosocomial infections with vancomycin-resistant Enterococcus faecium in liver transplant recipients: risk factors for acquisition and mortality. Clin. Infect. Dis. (1996) 23:760–766.
  • MAINOUS MR, LIPSETT PA, O'BRIEN M: Enterococcal bacteremia in a surgical intensive care unit: does vancomycin resistance affect mortality The Johns Hopkins SICU Study Group. Arch. Surg. (1997) 132:76–81.
  • Mandell GL, Bennett JE, Dolin R (Eds.), Churchill Livingstone, Philadel-phia, USA (20003079–3090.
  • EDMOND MB, WENZEL RP, PASCULLE AW: Van comycin-resistant Staphylococcus aureus: perspectives on measures needed for control. Ann. Intern. Med. (1996) 124:329–334.
  • HIRAMATSU K: The emergence of Staphylococcus aureus with reduced susceptibility to vancomycin in Japan. Am. J. Med. (1998) 1 04 (Suppl. 5A):7S–10S.
  • JOHNSON AP: Intermediate vancomycin resistance inStaphylococcus aureus: a major threat or a minor inconvenience J. Antimicrob. Chemother. (1998) 42:289–291.
  • MCMANUS J: Vancomycin resistant staphylococcus reported in Hong Kong. Br. Med. J. (1999) 318:626.
  • ROTUN SS, MCMATH V, SCHOONMAKER DJ, et al.: Staphy-lococcus aureus with reduced susceptibility to vancomycin isolated from a patient with fatal bacteremia. Emerg. Infect. Dis. (1999) 5:147–149.
  • SMITH TL, PEARSON ML, WILCOX KR, et al.: Emergence of vancomycin resistance in Staphylococcus aureus. Glycopeptide-intermediate Staphylococcus aureus working group. N Engl. J. Med. (1999) 340:493–501.
  • RYBAK MJ, AKINS RL: Emergence of methicillin-resistant Staphylococcus aureus with intermediate glycopeptide resistance: clinical significance and treatment options. Drugs (2001) 61:1–7.
  • ••A thorough review of the emergence of glycopeptideresistance in S. aureus and options for treatment of infections caused by such organisms.
  • SCHWALBE RS, STAPLETON JT, GILLIGAN PH: Emergence of vancomycin resistance in coag-ulase-negative staphylococci. N. EngI J. Med. (1987) 316:927–931.
  • RAAD I, ALRAHWAN A, ROLSTON K: Staphylococcus epidermidis: emerging resistance and need for alternative agents. Clin. Infect. Dis. (1998) 26:1182–1187.
  • SIERADZKIK VILLARI P, TOMASZ A: Decreased suscepti-bilities to teicoplanin and vancomycin among coagulase-negative methicillin -resistant clinical isolates of staphylococci. Antimicrob. Agents. Chemother. (1998) 42:100–107.
  • FRIDKIN SK: Vancomycin-intermediate and -resistant Staphylococcus aureus: what the infectious disease specialist needs to know. Clin. Infect. Dis. (2001) 32:108–115.
  • KISLAK JW, RAZAVI LM, DALY AK, FINLAND M: Suscepti-bility of pneumococci to nine antibiotics. Am. J. Med. Sci. (1965) 250:261–268.
  • CENTERS FOR DISEASE CONTROL AND PREVENTION: Defining the public health impact of drug-resistant Streptococcus pneumoniae: report of a working group. Mor. Mortal. Wkly. Rep. (1999) 45:RR–1.
  • DIEKEMA DJ, BRUEGGEMANN AB, DOERN GV: Antimicrobial-drug use and changes in resistance in Streptococcus pneumoniae. Emerg. Infect. Dis. (2000) 6:552–556.
  • THORNSBERRY C, JONES ME, HICKEY ML, MAURIZ Y, KAHN J, SAHM DF: Resistance surveillance of Strepto-coccus pneumoniae, Haemophilus influenzae and Moraxella cararrhalis isolated in the United States, 1997-1998.j Antimicrob. Chemother. (1999) 44:749–759.
  • SAHM DF, JONES ME, HICKEY ML, DIAKUN DR, MANI SV,THORNSBERRY C: Resistance surveillance of Strepto-coccus pneumoniae, Haemophilus influenzae and Moraxella cararrhalis isolated in Asia and Europe,1997-1998.j Antimicrob. Chemother. (2000) 45:457–466.
  • NOVAK R, HENRIQUES B, CHARPENTIER E, NORMARK S,TUOMANEN E. Emergence of vancomycin tolerance in Streptococcus pneumoniae. Nature (1999) 399:590–593.
  • MCCULLERS JA, ENGLISH BK, NOVAK R: Isolation andcharacterization of vancomycin-tolerant Strepto-coccus pneumoniae from the cerebrospinal fluid of a patient who developed recrudescent meningitis. J. Infect. Dis. (2000) 181:369–373.
  • WALLACE MR, MASCOLA JR, OLDFIELD C: Red man syndrome: incidence, etiology and prophylaxis. J. Infect. Dis. (1991) 164:1180–1185.
  • RYBAK MJ, BAILEY EM, WARBASSE LH: Absence of 'redman syndrome' in patients being treated with vancomycin and high-dose teicoplanin. Antimicrob. Agents Chemother. (1992) 36:1204–1207.
  • RYBAK MJ, ALBRECHT LM, BOIKE SC, CHANDRASEKARPH: Nephrotoxicity of vancomycin, alone and with an amin ogly co side. J. Antimicrob. Chemother. (1990) 25:679–687.
  • PESTOTNIK SL, CLASSEN DC, LLOYD JF, BURKE JP:Adverse effects of intravenous vancomycin in hospital patients: attributable costs and excess length of stay. Abstracts of the 35th Infectious Diseases Society of America Annual Meeting. San Francisco, USA (1997) Abstract 376.
  • MARKOWITZ N, QUINN EL, SARAVOLATZ LD. Trimethoprim-sulfamethoxazole compared with vancomycin for the treatment of Staphylococcus aureus infections. Ann. Intern. Med. (1992)117:390–398.
  • HARDY D, AMSTERDAM D, MANDELL LA, ROTSTEIN C:Comparative in vitro activities of ciprofloxacin, gemifloxacin, grepafloxacin, moxifloxacin, ofloxacin, sparfloxacin, trovafloxacin and other antimicrobial agents against bloodstream isolates of Gram-positive cocci. Antimicrob. Agents Chemother. (2000) 44:802–805.
  • HOOGKAMP-KORSTANJE JAA, ROELOFS-WILLEMSE J: Comparative in vitro activity of moxifloxacin against Gram-positive clinical isolates. J. Antimicrob. Chemother. (2000) 45:31–39.
  • DELGADO G, NEUHASER MM, BEARDEN DT, DANZIGER LH: Quinupristin-dalfopristin: an overview. Pharmaco-ther. (2000) 20:1469–1485.
  • ••A comprehensive review of quinupristin-dalfopristin.
  • RUBENSTEIN E, PROKOCIMER P, TALBOT GH: Safety andtolerability of quinupristin/dalfopristin: administra-tion guidelines. J. Antimicrob. Chemother. (1999) 44 (Suppl. A):37–46.
  • MANDLER HD, BLUMBERG EA, FUCHS AE, MOLAVI A, WOOD CA: Arthralgias and myalgias associated with quinupristin/dalfopristin (Synercid) treatment of infections caused by vancomycin-resistant Entero-coccus faecium (VREF). Abstracts of the 36th Infectious Diseases Society of America Annual Meeting. Denver, USA (1998) Abstract 608.
  • Yu VL, Merigan TC, Barriere SL (Eds.), Williams & Wilkins, Baltimore (1998):963–972.
  • IMS Health, Inc. database (2001).
  • SLEE AM, WUONOLA MA, MCRIPLEY RJ, et al.: Oxazolidi-nones, a new class of synthetic antibacterial agents: in vitro and in vivo activities of DuP 105 and DuP 721. Antimicrob. Agents Chemother. (1987) 31:1791–1797.
  • ••Original description of potential clinically relevantoxazolidinones.
  • BARRY A: In vitro evaluation of DuP 105 and DuP 721, two new oxazolidinone antimicrobial agents. Antimi-crob. Agents Chemother. (1988) 32:150–152.
  • BRUMFITT W, HAMILTON-MILLER JMT: In vitro microbiological activities of DuP 105 and DuP 721, novel synthetic oxazolidinones. J. Antimicrob. Chemother. (1988) 21:711–720.
  • DALY JS, ELIOPOULOS GM, REISZNER E, MOELLERING RC: Activity and mechanism of action of DuP 105 and DuP 721, new oxazolidinone compounds. J. Antimi-crob. Chemother. (1988) 21:721–730.
  • NEU HC, NOVELLI A, SAHA G, CHIN N-X: In vitro activi-ties of two oxazolidinone antimicrobial agents, DuP 105 and DuP 721. Antimicrob. Agents Chemother. (1988) 32:580–583.
  • ELIOPOULOS GM, WENNERSTEN CB, GOLD HS, MOELLERING RC: In vitro activities of new oxazolidi-none antimicrobial agents against enterococci. Antimi-crob. Agents Chemother. (1996) 40:1745–1747.
  • KAATZ GW, SEO SM: In vitro activities of oxazolidinone compounds U100592 and U100766 against Staphylo-coccus aureus and Staphylococcus epidermidis. Antimicrob. Agents Chemother. (1996) 40:799–801.
  • MASON EO, LAMBERTH LB, KAPLAN SL: In vitro activi-ties of oxazolidinones U-100592 and U-100766 against penicillin-resistant and cephalosporin-resistant strains of Streptococcus pneumoniae. Antimicrob. Agents Chemother. (1996) 40:1039–1040.
  • ZURENKO GE, YAGI BH, SHAADT RD, et al.: In vitro activities of U-100592 and U-100766, novel oxazolidi-none antibacterial agents. Antimicrob. Agents Chemother. (1996) 40:839–845.
  • JORGENSEN JH, MCELMEEL ML, TRIPPY CW: In vitro activities of the oxazolidinone antibiotics U-100592 and U-100766 against Staphylococcus aureus and coagulase-negative Staphylococcus species. Antimi-crob. Agents Chemother. (1997) 41 :465–467.
  • DRESSER LD, RYBAK MJ: The pharmacologic and bacteriologic properties of oxazolidinones, a new class of synthetic antimicrobials. Pharmacotherapy (1998) 18:456–462.
  • •A review of eperezolid and linezolid.
  • RYBAK MJ, CAPPELLETTY DM, MOLDOVAN T, AESCHLIMANN JR, KAATZ GW: Comparative in vitro activities and postantibiotic effects of the oxazolidi-none compounds eperezolid (PNU-100592) and linezolid (PNU-100766) versus van co my cin against Staphylococcus aureus, coagulase-negative staphylo-cocci, Enterococcus faecalis and Enterococcus faecium. Antimicrob. Agents Chemother. (1998) 42:721–724.
  • NOSKIN GA, SIDDIQUI F, STOSOR V, HACEK D, PETERSON LR: In vitro activities of linezolid against important Gram-positive bacterial pathogens including vancomycin-resistant enterococci. Antimi-crob. Agents Chemother. (1999) 43:2059–2062.
  • VON EIFF C, PETERS G: Comparative in vitro activities of moxifloxacin, trovafloxacin, quinupristin / dalfopristin and linezolid against staphylococci. J. Antimicrob. Chemother. (1999) 43:569–573.
  • JOHNSON AP, WARNER M, LIVERMORE DM: Activity of linezolid against multi-resistant Gram-positive bacteria from diverse hospitals in the United Kingdom. J. Antimicrob. Chemother. (2000) 45:225–230.
  • HENWOOD CJ, LIVERMORE DM, JOHNSON AP, et al: Susceptibility of Gram-positive cocci from 25 UK hospitals to antimicrobial agents including linezolid. Antimicrob. Chemother. (2000) 46:931–940.
  • ASHTEKAR DR, COSTA-PERIERA R, SHRINIVASAN T, IYYER R, VISHVANATHAN N, RITTEL W: Oxazolidinones, anew class of synthetic antituberculosis agent. In vitro and in vivo activities of DuP 721. Diagn. Microbiol. Infect. Dis. (1991) 14:465–471.
  • CYNAMON MH, KLEMENS SP, SHARPE CA, CHASE S: Activities of several novel oxazolidinones against Mycobacterium tuberculosis in a murine model. Antimicrob. Agents Chemother. (1999) 43:1189–1191.
  • CLEMETT D, MARKHAM A: Linezolid. Drugs (2000) 59:815–827.
  • ••A thorough review of linezolid.
  • EUSTICE DC, FELDMAN PA, ZAJAC I, SLEE AM: Mechanism of action of DuP 721: inhibition of an early event during initiation of protein synthesis. Antimi-crob. Agents Chemother. (1988) 32:1218–1222.
  • UN AH, MURRAY RW, VIDMAR TJ, MAROTTI KR: The oxazolidinone eperezolid binds to the 505 ribosomal subunit and competes with binding of chloram-phenicol and lincomycin. Antimicrob. Agents Chemother. (1997) 41:2127–2131.
  • SWANEY SM, AOKI H, GANOZA MC, SHINABARGER DL:The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria. Antimicrob. Agents Chemother. (1998) 42:3251–3255.
  • MATASSOVA NB, RODNINA MV, ENDERMANN R, et al:Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors. RNA (1999) 5:939–946.
  • SHINABARGER DL: Mechanism of action of the oxazolidinone antibacterial agents. Exp. Opin. Invest. Drugs (1999) 8:1195–1202.
  • ZURENKO GE, TODD WM, HAFKIN B, et al.:Development of linezolid-resistant Enterococcus faecium in two compassionate use program patients treated with linezolid. Program and Abstracts of the 39th Intel-science Conference on Antimicrobial Agents and Chemotherapy. San Francisco, USA (1999) Abstract 848.
  • ZURENKO GE: linezolid and beyond. Program and Abstracts of the 40th Intel-science Conference on Antimicro-bial Agents and Chemotherapy. Toronto, Ontario, Canada (2000) Abstract 637.
  • BRICKNER SJ, HUTCHINSON DK, BARBACHYN MR, et al.:Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant Gram-positive bacterial infections. J. Med. Chem. (1996) 39:673–679.
  • Lorian V (Ed.), Williams & Wilkins, Baltimore, USA (1990:432–492.
  • FORD CW, HAMEL JC, WILSON DM, et al.: In vivo activitiesof U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections. Antimicrob. Agents Chemother. (1996) 40:1508–1513.
  • MULAZIMOGLU L, DRENNING SD, YU VL: In vitro activi-ties of two novel oxazolidinones (U100592 and U100766), a new fluoroquinolone (trovafloxacin) and dalfopristin-quinupristin against Staphylococcus aureus and Staphylococcus epidermidis. Antimicrob. Agents Chemother. (1996) 40:2428–2430.
  • BRUSS JB, SMITH LG, DUVALL SE, et al.: Safety andtolerance of linezolid: adverse events reported in Phase III trials. Program and Abstracts of the 40th Intel-sci-ence Conference on Antimicrobial Agents and Chemotherapy. Toronto, Ontario, Canada (2000) Abstract 2236.
  • MARTIN JP, HERBERG JG, SLATTER JG, DUPUIS MJ:Although a novel microtiter-plate assay demonstrates that linezolid (PNU-100766) is a weak, competitive (reversible) monoamine oxidase inhibitor (MAO A), no clinical evidence of MAO A inhibition in clinical trials has been observed. Program and Abstracts of the 38th Intel-science Conference on Antimicrobial Agents and Chemotherapy. San Diego, USA (1998) Abstract A–85.
  • WALKER SE, SHULMAN KI, TAILOR SA, GARDNER D: Tyramine content of previously restricted foods in monoamine oxidase inhibitor diets. J. Clin. Psychophar-macol. (1996) 16:383–388.
  • KLOSS P, XIONG L, SHINABARGER DL, MANKIN AS: Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center. J Mol. Biol. (1999) 294:93–101.
  • •Reveals the probable site of binding and action of linezolid employing Halobacterium halobium, an archaeon possessing a single copy of the rRNA operon.
  • XIONG L, KLOSS P, DOUTHWAITE S, et al.: Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action. J Bacteriol (2000) 182:5325–5331.
  • ••Establishes the site of action of linezolid and describesadditional mutations conferring linezolid resistance.
  • Hill WE, Dahlberg A, Garrett RA, Moore PR, Schlessinger D, Warner JR (Eds.), American Society for Microbiology, Washington, DC, USA (1990):168–179.
  • FERNANDEZ-MUNOZ R, MONRO RE, TORRES-PINEDO R, VAZQUEZ D: Substrate- and antibiotic-binding sites at the peptidyl-transferase center of Escherichia coli ribosomes. Studies on the chloramphenicol, lincomycin and erythromycin sites. Eur. j Biochem. (1971) 23:185–193.
  • JONES RN, BARRETT MS, ERWIN ME: In vitro activity and spectrum of LY333328, a novel glycopeptide deriva-tive. Antimicrob. Agents Chemother. (1996) 41:488–493.
  • SCHWALBE RS, MCINTOSH AC, QAIYUMI S, et al.: In vitro activity of LY333328, an investigational glycopeptide antibiotic, against enterococci and staphylococci. Antimicrob. Agents Chemother. (1996) 40:2416–2419.
  • SUM PE, SUM PW, PROJAN SJ: Recent developments in tetracycline antibiotics. Curr. Pharm. Res. (1998) 4:119–132.
  • PETERSEN PJ, JACOBUS NV, WEISS WJ, SUM PE, TESTA RT: In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of min o cyclin e (GAR-936). Antimicrob. Agents Chemother. (1999) 43:738–744.
  • GALES AC, JONES RN: Antimicrobial activity and spectrum of the new glycylcycline GAR-936 tested against 1,203 recent clinical bacterial isolates. Diagn. Microbiol. Infect. Dis. (2000) 36:19–36.
  • PROJAN SJ: Preclinical pharmacology of GAR-936, a novel glycylcycline antibacterial agent. Pharmaco-therapy (2000) 20:219S–223S.
  • TALLY FP, DEBRUIN MF: Development of dap tomycin for Gram-positive infections. J Antimicrob. Chemother. (2000) 46:523–526.
  • SNYDMAN DR, JACOBUS NV, MCDERMOTT LA, LONKS JR, BOYCE JM: Comparative in vitro activities of daptomycin and vancomycin against resistant Gram-positive pathogens. Antimicrob. Agents Chemother. (2000) 44:3447–3450.
  • MALATHUM K, COQUE TM, SINGH KV, MURRAY BE: In vitro activities of two ketolides, MIR 3647 and HMR 3004, against Gram-positive bacteria. Antimicrob. Agents Chemother. (1999) 43:930–936.
  • ANDREWS JM, WELLER TMA, ASHBY JP, WALKER RM, WISE R: The in vitro activity of ABT773, a new ketolide antimicrobial agent. J. Antimicrob. Chemother. (2000) 46:1017–1022.
  • JONES RN, HARE RS, SABATELLI FJ: In vitro Gram-positive antimicrobial activity of evernimicin (SCH 27899), a novel oligosaccharide, compared with other antimicrobials: a multicentre international trial. Antimicrob. Chemother. (2001) 47:15–25.
  • AARESTRUP FM: Association between decreased susceptibility to a new antibiotic for treatment of human diseases, everninomicin (SCH 27899) and resistance to an antibiotic used for growth promotion in animals, avilamycin. Microb. Drug Resist. (1998) 4:137–141.
  • GENIN MJ, ALLWINE DA, ANDERSON DJ, et al.: Substituent effects on the antibacterial activity of nitrogen-carbon linked (azolylphenyl)oxazolidinones with expanded activity against the fastidious Gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. J. Med. Chem. (2000) 43:953–970.
  • COTTAGNOUD P, GERBER CM, ACOSTA F, COTTAG-NOUD M, NEFTEL K, TAUBER MG: linezolid against penicillin-sensitive and -resistant pneumococci in the rabbit meningitis model. J. Antimicrob. Chemother. (2000) 46:981–985.

Websites

  • www.fda.gov/cder/foi/labe1/2000/21130161.pdf US Food and Drug Administration approved labelling for linezolid.

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