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- ••Comprehensive treatment guidelines andexcellent, up-to-date description of the clinical syndrome of HF from the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.
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- •Excellent article to increase understanding of the 'malignant' nature of an HF diagnosis compared to a cancer diagnosis.
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- •Good basic review of the pathways involved in the control of aldosterone secretion from the adrenal gland.
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- •Comprehensive discussion of how aldosterone levels 'rebound' in HF patients treated chronically with ACE inhibitors.
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- •First study to demonstrate a positive correlation between plasma aldosterone levels and mortality in HF patients.
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- WEBER MA: Vasopeptidase inhibitors. Lancet (2001) 358:1535-1532. Excellent up-to-date review on vasopeptidase inhibitors currently in clinical development for hypertension and HE
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- ••Detailed description of the EPHESUS trialdesign in which concept will be tested that selective aldosterone blockade (with eplerenone) will reduce mortality in post-MI HF patients.
- PFEFFER MA: New treasures from old? EPHESUS. Eplerenone PostAMI Heart Failure Efficacy and Survival Study. Cardiovasc. Drugs Ther. (2001) 15:11–13.
- SPERTUS JA, TOOLEY J, JONES P et al.: Expanding the outcomes in clinical trials of heart failure: the quality of life and economic components of EPHESUS (EPlerenone's neuroHormonal Efficacy and SUrvival Study). Am. Heart j (2002) 143:636–642.
- MCMAHON EG: Recent studies with eplerenone, a novel selective aldosterone receptor antagonist. Can: Opin. Pharm. (2001) 1:190–196.
- •Recent summary of pathophysiological effects of aldosterone on the cardiovascular system and predinical data supporting development of the selective aldosterone blocker eplenerone.
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- PITT B, RONIKER B: Eplerenone, a novel selective aldosterone receptor antagonist (SARA): Dose finding study in patients with heart failure. I Am. Coll. Cardio. (1999) 33 (Suppl. A):188A–189A.
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- •First study to link BNP levels and outcomes in patients with chronic HE
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- •Early Phase II results with ENBREL in patients with advanced HE
- MCMURRAY J, PFEFFER MA: New therapeutic options in congestive heart failure. Part II. Circulation (2002) 105:2223–2228.
- FELDMAN AM, LI YY, MCTIERNAN CF: Matrix metalloproteinases in pathophysiology and treatment of heart failure. Lancet (2001) 357:654–655.
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- CHANCEY AL, BROWER GL, PETERSON JT, JANICKI JS: Effects of matrix metalloproteinase inhibition on ventricular remodeling due to volume overload. Circulation (2002) 105:1983–1988.
- SPINALE FG, COKER ML, KROMBACH SR et al.: Matrix metalloproteinase inhibition during the development of congestive heart failure. Effects on left ventricular dimensions and function. Circ. Res. (1999) 85:364–376.
- ••First evidence that inhibition of MMPs canreduce LV dilation in HE
- HAGEGE AA, VILQUIN JT, BRUNEVAL P MENASCHE: Regeneration of the myocardium. A new role in the treatment of ischemic heart disease? Hypertension (2001) 86:616–621.
- ••Excellent recent review on novel strategiesfor regenerating myocardium.
- JAIN M, DERSIMONIAN H, BRENNER DA et al.: Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Circulation (2001) 103:1920–1927.
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- MENASCHE P, HAGEGE AA, SCORSIN M et al.: Myoblast transplantation for heart failure. Lancet (2001) 357:279–280.
- ISNER JM: Myocardial gene therapy. Nature (2002) 415:234–239.
- •Good update on myocardial gene therapy with emphasis on current challenges.
- GRIMES C: Adenovirus FGF angiogenic gene therapy (AGENT) trial. Presented at the Late-Breaking Clinical Trials session of 50th annual American College of Cardiology. Orlando, FL, 19th March 2001.
- MIYAMOTO M, DEL MONTE F, SCHMIDT U et al.: Adenoviral gene transfer of SERCA2a improves left ventricular function in aortic-banded rats in transition to heart failure. Proc. Nati Acad. Sci. USA (2000) 97:793–798.
- HE H, MEYER M, MARTIN JL et al.: Effects of mutant and antisense RNA of phospholamban on SR Ca(2+)-ATPase activity and cardiac myocyte contractility. Circulation (1999) 100:974–980.
- MAURICE JP, HATA JA, SHAH AS et al.: Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary 132-adrenergic receptor gene delivery. J. Clio. Invest. (1999) 104:21–29.
- OLIVETTI G, ABBI R, QUAINT F et al: Apoptosis in the failing human heart. N. Engl. J. Med. (1997) 336:1131–1141.
- KIRSHENBAUM LA, DE MOISSAC D: The bc1-2 gene product prevents programmed cell death of ventricular myocytes. Circulation (1997) 96:1580–1585.
- MATSUI T, LI L, DEL MONTE F et al: Adenoviral gene transfer of activated PI 3-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes M vitro. Circulation (1999) 100:2373–2379.
- BRISTOW MR: P-adrenergic receptor blockade in chronic heart failure: Circulation (2000) 101:558–569.
- ••Excellent recent comprehensive review on13-blockers in HE
- PACKER M, O'CONNOR CM, GHALI JK et al.: Effect of amlodipine on morbidity and mortality in patients with severe heart failure. New Engl. J. Med. 335:1107-1114.
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- LINDSEY ML, GANNON J, AIKAWA M et al: Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction. Circulation (2002) 105:753–758.
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- ••Exciting new data in dog HF model thatsupports use of the selective aldosterone blocker eplenerone in HF patients.
- SHAH AS, WHITE DC, EMANI S et al: In vivo ventricular gene delivery of a 13-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction. Circulation (2001) 103:1311–1316.
- SEIDMAN JG, SEIDMAN C: The genetic basis for cardiac hypertrophy: from mutation identification to mechanistic paradigms. Cell (2001) 104:557–567.
- •Excellent review of the genetic basis for cardiomyopathies in man.