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Review

Emerging therapies for heart failure

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Pages 247-258 | Published online: 24 Feb 2005

Bibliography

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  • ••Comprehensive treatment guidelines andexcellent, up-to-date description of the clinical syndrome of HF from the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.
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  • •Excellent article to increase understanding of the 'malignant' nature of an HF diagnosis compared to a cancer diagnosis.
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  • •Good basic review of the pathways involved in the control of aldosterone secretion from the adrenal gland.
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  • •Comprehensive discussion of how aldosterone levels 'rebound' in HF patients treated chronically with ACE inhibitors.
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  • •First study to demonstrate a positive correlation between plasma aldosterone levels and mortality in HF patients.
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  • ••Detailed description of the EPHESUS trialdesign in which concept will be tested that selective aldosterone blockade (with eplerenone) will reduce mortality in post-MI HF patients.
  • PFEFFER MA: New treasures from old? EPHESUS. Eplerenone PostAMI Heart Failure Efficacy and Survival Study. Cardiovasc. Drugs Ther. (2001) 15:11–13.
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  • MCMAHON EG: Recent studies with eplerenone, a novel selective aldosterone receptor antagonist. Can: Opin. Pharm. (2001) 1:190–196.
  • •Recent summary of pathophysiological effects of aldosterone on the cardiovascular system and predinical data supporting development of the selective aldosterone blocker eplenerone.
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  • •First study to link BNP levels and outcomes in patients with chronic HE
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  • •Early Phase II results with ENBREL in patients with advanced HE
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  • ••First evidence that inhibition of MMPs canreduce LV dilation in HE
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  • ••Excellent recent review on novel strategiesfor regenerating myocardium.
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  • •Good update on myocardial gene therapy with emphasis on current challenges.
  • GRIMES C: Adenovirus FGF angiogenic gene therapy (AGENT) trial. Presented at the Late-Breaking Clinical Trials session of 50th annual American College of Cardiology. Orlando, FL, 19th March 2001.
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  • HE H, MEYER M, MARTIN JL et al.: Effects of mutant and antisense RNA of phospholamban on SR Ca(2+)-ATPase activity and cardiac myocyte contractility. Circulation (1999) 100:974–980.
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  • BRISTOW MR: P-adrenergic receptor blockade in chronic heart failure: Circulation (2000) 101:558–569.
  • ••Excellent recent comprehensive review on13-blockers in HE
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  • ••Exciting new data in dog HF model thatsupports use of the selective aldosterone blocker eplenerone in HF patients.
  • SHAH AS, WHITE DC, EMANI S et al: In vivo ventricular gene delivery of a 13-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction. Circulation (2001) 103:1311–1316.
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  • •Excellent review of the genetic basis for cardiomyopathies in man.

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