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Meeting Report

Superbugs & Superdrugs: A Focus on Antibacterials – 6th Annual SMi Conference

Pages 191-195 | Published online: 02 Mar 2005

Bibliography

  • DOUGHERTY TJ, BARRETT JF, PUCCI MJ: Microbial genomics and novel antibiotic discovery: new technology to search for new drugs. Curr. Phann. Des. (2002) 8:1119–1135.
  • •A thoughtful review of the process for the identification and validation of novel antibacterial targets generated by bioinformatics-based genomics and their potential for new drug discovery.
  • SUTCLIFFE JA: Antibacterial agents: solutions for the evolving problems of resistance. Bioorg. Med. Chem. Lett. (2003) 13:4159–4161.
  • •Sobering drug resistance statistics for hospital and community pathogens that mitigate against relying solely on generic or soon-to-be generic antibacterials and argue for continuing Sisyphian search for new antibacterials.
  • SHLAES DM: The abandonment of antibacterials: why and wherefore? Curr. Opin. Pharmacol (2003) 3:470–473.
  • PROJAN SJ: Why is big Pharma getting out of antibacterial drug discovery? Curl: Opin. Microbial. (2003) 6:427–430.
  • ZHANEL GG, HOBAN DJ: Ketolides in the treatment of respiratory infections. Expert Opin. Pharmacother (2002) 3:277–297.
  • WALLER AS, CLEMENTS JM: Novel approaches to antimicrobial therapy: peptide deformylase. Curl: Opin. Drug Discov. Dev. (2002) 5:785–792.
  • •An excellent review of peptide deformylase as an antibacterial target.
  • HANSEN JL, MOORE PB, STEITZ TA: Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit. J. Mol Biol. (2003) 330:1061–1075.
  • •First report of anisomycin, chloramphenicol, sparsomycin, blasticidin S, and virginiamycin M bound to the large ribosomal subunit of Haloarcula marismortui at 3 A resolution. Binding sites are shown to overlap with those of peptidyl-tRNA or aminoacyl-tRNA, consistent with competitive inhibition of peptide bond formation.
  • HEBEISEN P, HEINZE-KRAUSS I, ANGEHRN P, HOHL P, PAGE MGP, THEN RL: LI vitro and in vivo properties of Ro 63-9141, a novel broad-spectrum cephalosporin with activity against methicillin-resistant staphylococci. Antimicrob. Agents Chemother. (2001) 45:825–836.
  • RICE LB, BONOMO RA: Beta-lactamases: which ones are clinically important? Drug Resist. Update (2000) 3:178–189.
  • •An excellent review of clinically important 13-lactamases, particularly serine enzymes of Ambler Class A and C. It also discusses the growing importance of metalloenzymes of Ambler Class B.
  • MASCARETTI OA, DANELON GO, LABORDE M, MATA EG, SETTI EL: Recent advances in the chemistry of beta-lactam compounds as selected active-site serine beta-lactamase inhibitors. Curl: Pharm. Dec. (1999) 5:939–953.
  • FARMER TH, DEGNAN BA, PAYNE DJ:Penetration of beta-lactamase inhibitors into the periplasm of Gram-negative bacteria. FEMS Microbiol Lett. (1999) 176:11–15.
  • LI XZ, ZHANG L, SRIKUMAR R, POOLE K: Beta-lactamase inhibitors are substrates for the multidrug efflux pumps of Pseudomonas aerugMosa. Antimicrob. Agents Chemother (1998) 42:399–403.
  • TEDESCO KL, RYBAK MJ: Daptomycin. Pharmacotherapy (2004) 24:41–57.
  • SAFDAR N, ANDES D, CRAIG WA: In vivo pharmacodynamic activity of daptomycin. Antimicrob. Agents Chemother (2004) 48:63–68.
  • LEVY SB: The 2000 Garrod lecture. Factors impacting on the problem of antibiotic resistance. J Antimicrob. Chemother (2002) 49:25–30.
  • ALEKSHUN MN, LEVY SB, MEALY TR, SEATON BA, HEAD JF: The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 A resolution. Nat. Struct. Biol. (2001) 8:710–714.

Websites

  • http://www.datamonitoccom Datamonitor business intelligence website.
  • http://www.merck.com Merck & Co. website.
  • http://www.fda.gov/cder US FDA Center for Drug Evaluation and Research website.
  • http://www.enanta.com Enanta Pharmaceuticals website.
  • http://www. novartis. com Novartis homepage.
  • http://www.vicuron.com Vicuron Pharmaceuticals website.
  • http://www.rib-x.com Rib-X Pharmaceuticals website.
  • http://www.vrtx.com Vertex Pharmaceuticals website.
  • http://www.quorex.com Quorex Pharmaceuticals website.
  • http://www.basileapharma.com Basilea Pharmaceutica AG website.
  • http://www.methylgene.com MethylGene homepage.
  • http://www.cubist.com Cubist Pharmaceuticals website.
  • http://www.paratekpharm.com Paratek Pharmaceuticals website.

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