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Review

The clinical application of monoclonal antibody therapies in renal transplantation

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Pages 23-37 | Published online: 02 Mar 2005

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  • ••The first trial using alemtuzumab intransplantation and introducing the concept that depletional therapy can Induce prope tolerance.
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  • ••The only trial to investigate the isolatedeffects of depletion in man.
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  • ••Pivotal trial with anti-IL-2R monoclonalantibodies and first important study using a humanised monoclonal antibodies.
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  • •A good example of extended monoclonal antibody use suggesting applications other than induction therapy.
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  • •First concerted effort to develop a costimulatory blockade monoclonal antibody for transplantation. Subsequent results of this trial will be closely watched.
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  • •The most definitive result from a preclinical anti-rejection trial using only monoclonal antibody therapy.
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Websites

  • http://www.ama-assn.org/ama/pub/article/ 4781–4661.html AMA-USAN website. Accessed (2004).
  • http://www.immunetolerance.org/research/ solidorgan/trials/sachsl.html Immune Tolerance Network website. Accessed (2004).
  • http://www.immunetolerance.org/eXpress/ research/ 192003-1/vincenti.html Immune Tolerance Network Newsletter, Vol. 1 Number 1, July 2003. Accessed (2004).

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