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Review

Emerging drugs for head and neck cancer

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Pages 91-104 | Published online: 02 Mar 2005

Bibliography

  • JEMAL A, MURRAY T, SAMUELS A, GHAFOOR A, WARD E, THUN MJ: Cancer statistics, 2003. CA Cancer. J. (2003) 53(1):5–26.
  • VOKES EE, WEICHSELBAUM RR, LIPPMAN SM, HONG WK: Head and neck cancer. N Eng1.1. Med. (1993) 328(3):184–194.
  • ••A comprehensive and illustrated review ofhead and neck cancer.
  • PIGNON JP, BOURHIS J, DOMENGE C, DESIGNE L: Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. Lancet (2000) 355(9208)949–955.
  • ••Meta-analysis including 63 randomisedtrials (> 10,000 patients) demonstrating only a 4% absolute survival benefit of chemotherapy, in addition to local treatment.
  • VOGL SE, SCHOENFELD DA, KAPLAN BH, LERNER HJ, ENGSTROM PF, HORTON J: A randomized prospective comparison of methotrexate with a combination of methotrexate, bleomycin and cisplatin in head and neck cancer. Cancer (1985) 56(3):432–442.
  • FORASTIERE AA, METCH B, SCHULLER DE et al.: Randomized comparison of cisplatin plus fluorouracil and carboplatin plus fluorouracil versus methotrexate in advanced squamous-cell carcinoma of the head and neck: a Southwest Oncology Group study. I Cirri. Oncol (1992) 10(8):1245–1251.
  • •Southwest Oncology Group study showed that combination chemotherapy with a platinum analogue plus 5-FU resulted in a higher response rate than single-agent MTX, but no improvement in survival.
  • EISENBERGER M, KRASNOW S, ELLENBERG S et al.: A comparison of carboplatin plus methotrexate versus methotrexate alone in patients with recurrent and metastatic head and neck cancer.Oncol (1989) 7(9):1341–1345.
  • HONG WK, SCHAEFER S, ISSELL B et al.: A prospective randomized trial of methotrexate versus cisplatin in the treatment of recurrent squamous cell carcinoma of the head and neck. Cancer (1983) 52(2):206–210.
  • VERMORKEN JB, CATIMEL G, HOEKMAN K et al.: Randomized Phase II trial of methotrexate versus two schedules of paclitaxel in patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN). Proc. Am. Soc. Cirri. Oncol (1998) 17:391a.
  • DECONTI RC, SCHOENFELD D: A randomized prospective comparison of intermittent methotrexate, methotrexate with leucovorin, and a methotrexate combination in head and neck cancer. Cancer (1981) 48(5):1061–1072.
  • TAYLOR SG IV, MCGUIRE WP, HAUCK WW, SHOWEL JL, LAD TE: A randomized comparison of high-dose infusion methotrexate versus standard-dose weekly therapy in head and neck squamous cancer. J. Clin. Oncol (1984) 2(9):1006–1011.
  • HITT R, PAZ-ARES L, HIDALGO M et al.: Phase I/II study of paclitaxelkisplatin as first-line therapy for locally advanced head and neck cancer. Semia Oncol (1997) 24(6, Suppl. 19):519–524.
  • FORASTIERE AA, LEONG T, ROWINSKY E et al: Phase III comparison of high-dose paclitaxel + cisplatin + granulocyte colony-stimulating factor versus low-dose paclitaxel + cisplatin in advanced head and neck cancer: Eastern Cooperative Oncology Group study E1393. I Clin. Oncol (2001) 19(4):1088–1095.
  • JACOBS C, LYMAN G,VELEZ-GARCIA E et al.: A Phase III randomized study comparing cisplatin and fluorouracil as single agents and in combination for advanced squamous cell carcinoma of the head and neck. J. Clin. amyl (1992) 10(2):257–263.
  • •Phase III study that showed which although response rate was improved with the combination of cisplatin and 5-FU as compared with single agents, survival was not improved.
  • VERONESI A, ZAGONEL V, TIRELLI U et al.: High-dose versus low-dose cisplatin in advanced head and neck squamous carcinoma: a randomized study. J. Clin. amyl (1985) 3(8):1105–1108.
  • HAVLIN KA, KUHN JG, MYERS JW et al.: High-dose cisplatin for locally advanced or metastatic head and neck cancer. A Phase II pilot study. Cancer (1989); 63(3):423–427.
  • FORASTIERE AA, SHANK D, NEUBERG D, TAYLOY SG IV, DECONTI RC, ADAMS G: Final report of a Phase II evaluation of paclitaxel in patients with advanced squamous cell carcinoma of the head and neck: an Eastern Cooperative Oncology Group trial (PA390). Cancer (1998) 82(10:2270–2274.
  • COLEVAS AD, POSNER MR: Docetaxel in head and neck cancer: a review. Am. J. Oncol (1998) 21(5):482–486.
  • HUBER MH, LIPPMAN SM, BENNER SE et al: A Phase II study of ifosfamide in recurrent squamous cell carcinoma of the head and neck. Am. J. Clin. amyl (1996) 19(4):379–382.
  • BUESA JM, FERNANDEZ R, ESTEBAN E et al: Phase II trial of ifosfamide in recurrent and metastatic head and neck cancer. Ann. Oncol (1991) 2(2):151–152.
  • CERVELLINO JC, ARAUJO CE, PIRISI C, FRANCIA A, CERRUTI R: Ifosfamide and mesna for the treatment of advanced squamous cell head and neck cancer. A GETLAC study. Oncology (1991) 48(2):89–92.
  • SANDLER A, SAXMAN S, BANDEALY M et al.: Ifosfamide in the treatment of advanced or recurrent squamous cell carcinoma of the head and neck: a phase II Hoosier Oncology Group trial. Am. J. Clin. Oncol (1998) 21(2):195–197.
  • EISENBERGER M, HORNEDO J, SILVA H, DONEHOWER R, SPAULDING M, VAN ECHO D: Carboplatin (NSC-241-240): an active platinum analog for the treatment of squamous-cell carcinoma of the head and neck. J. Clin. Oncol (1986) 4(10):1506–1509.
  • VOLLING P, SCHRODER M, RAUSCHNING W, ACHTERRATH W, STENNERT E: Carboplatin. The better platinum in head and neck cancer? Arch. Otolaryngol Head Neck Surg. (1989) 115(6):695–698.
  • SHIN DM, LIPPMAN SM: Paclitaxel-based chemotherapy for recurrent and/or metastatic head and neck squamous cell carcinoma: current and future directions. Schuh. amyl (1999) 26(1, Suppl. 2):100–105.
  • •Taxanes emerge as among the most active single agents in HNSCC.
  • VOGL SE, SCHOENFELD DA, KAPLAN BH, LERNER HJ, ENGSTROM PE HORTON J: A randomized prospective comparison of methotrexate with a combination of methotrexate, bleomycin, and cisplatin in head and neck cancer. Cancer (1985) 56(3):432–442.
  • MURPHY B, LI Y, CELLA D et al: Phase II study comparing cisplatin 5-fluorouracil versus cisplatin paclitaxel in metastatic/recurrent head neck cancer. Proc. Am. Soc. Clin. Oncol (2001) 20:224a.
  • HITT R, PAZ-ARES L, HIDALGO M et al.: Phase I/II study of paclitaxelkisplatin as first-line therapy for locally advanced head and neck cancer. Semi]. Oncol (1997) 24:S19–S24.
  • FORASTIERE AA, LEONG T, ROWINSKY E et al.: Phase III comparison of high-dose paclitaxel + cisplatin + granulocyte colony-stimulating factor versus low-dose paclitaxel + cisplatin in advanced head and neck cancer: Eastern Cooperative Oncology Group study E1393. I Clin. Oncol (2001) 19:1088–1095.
  • SHIN DM, GLISSON BS, KHURI FR et al: Phase II trial of paclitaxel, ifosfamide, and cisplatin in patients with recurrent head and neck squamous cell carcinoma../. Oncol (1998) 16(4):1325–1330.
  • SHIN DM, KHURI FR, GLISSON BS et al.: Phase II study of paclitaxel, ifosfamide, and carboplatin in patients with recurrent or metastatic head and neck squamous cell carcinoma. Cancer (2001) 91(7):1316–1323.
  • •The TIC regimen resulted in overall response rates of 59% in metastatic or recurrent disease.
  • SHIN DM, GLISSON BS, KHURI FR et al.: Phase II study of induction chemotherapy with paclitaxel, ifosfamide, and carboplatin (TIC) for patients with locally advanced squamous cell carcinoma of the head and neck. Cancer (2002) 95(2):322–330.
  • •The TIC regimen resulted in overall response rates of 81% in induction setting.
  • POSNER MR, GLISSON B, FRENETTE G et al: Multicenter Phase I-II trial of docetaxel, cisplatin, and fluorouracil induction chemotherapy for patients with locally advanced squamous cell cancer of the head and neck. I Clin. Oncol (2001) 19(4):1096–1104.
  • •This Phase I - II multi-centre trial showed that induction with docetaxel, cisplatin, and 5-FU resulted in a high major response rate of 93%, including 40% clinical complete response rate. Pathological negative biopsies were confirmed in 92% patients with clinical complete response and 54% patients with partial response or no change.
  • HITT R, LOPEZ-POUSA A, RODRIGUEZ M et al: Phase III study comparing cisplatin and 5-fluoruracil versus cisplatin, 5-fluorouracil and paclitaxel as induction therapy in locally advanced head and neck. Proc. Am. Soc. Clin. Oncol (2003) 22:496.
  • SPITZ MR: Epidemiology and risk factors for head and neck cancer. Semi]. Oncol (1994) 21(3):281–288.
  • LEON X, HITT R, CONSTENLA M et al: A retrospective analysis of the outcome of patients with recurrent or metastatic squamous cell carcinoma of the head and neck who are progressing while on a platinum-based palliative chemotherapy. Proc. Am. Soc. Clin. Oncol. (2003) 22:502.
  • CARPENTER G: Receptors for epidermal growth factor and other polypeptide mitogens. Ann. Rev Biochem. (1987) 56:881–914.
  • REISS M, STASH EB, VELLUCCI VF, ZHOU ZL: Activation of the autocrine transforming growth factor alpha pathway in human squamous carcinoma cells. Cancer Res. (1991) 51(21, Part 1):6254–6262.
  • HOFER DR, SHERWOOD ER, BROMBERG WD, MENDELSOHN J, LEE C, KOZLOWSKI JM: Autonomous growth of androgen-independent human prostatic carcinoma cells: role of transforming growth factor alpha. Cancer Res. (1991) 51(11):2780–2785.
  • NEAL DE, MARSH C, BENNETT MK et al: Epidermal-growth-factor receptors in human bladder cancer: comparison of invasive and superficial tumours. Lancet (1985) 1(8425):366–368.
  • SAINSBURY JR, MALCOLM AJ, APPLETON DR, FARNDON JR, HARRIS AL: Presence of epidermal growth factor receptor as an indicator of poor prognosis in patients with breast cancer. Patna. (1985) 38(11):1225–1228.
  • WALED, ASHCROFT T, MARSH C, GIBSON GJ, HARRIS AL: Epidermal growth factor receptors in non-small cell lung cancer. Br. J. Cancer (1987) 55(5):513–516.
  • GRANDIS JR, TVVEARDY DJ: Elevatedlevels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res. (1993) 53(15):3579–3584.
  • GRANDIS JR, TWEARDY DJ, MELHEM MF: Asynchronous modulation of transforming growth factor alpha and epidermal growth factor receptor protein expression in progression of premalignant lesions to head and neck squamous cell carcinoma. Clin. Cancer. Res. (1998) 4(1):13–20.
  • SHIN DM, RO JY, HONG WK, HITTELMAN WN: Dysregulation of epidermal growth factor receptor expression in premalignant lesions during head and neck tumorigenesis. Cancer Res. (1994) 54(12):3153–3159.
  • KE LD, ADLER-STORTHZ K, CLAYMAN GL, YUNG AW, CHEN Z: Differential expression of epidermal growth factor receptor in human head and neck cancers. Head Neck (1998) 20(4):320–327.
  • GRANDIS JR, MELHEM MF, BARNES EL, TWEARDY DJ: Quantitative immunohistochemical analysis of transforming growth factor-alpha and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck. Cancer (1996) 78(6):1284–1292.
  • HERBST RS, MADDOX AM, ROTHENBERG ML et al: Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors: results of a Phase I trial../. Chit. Oncol (2002) 20(18):3815–3825.
  • GUPTA AK, MCKENNA WG, WEBER CN et al.: Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction. Clin. Cancer Res. (2002) 8(3):885–892.
  • COHEN EE, ROSEN F, DEKKER A et al: Phase II study of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck. J. Clin. Oncol (2003) 21(10):1980–1987.
  • •ZD1839 was shown to have single-agent activity in recurrent HNSCC with an acceptable toxicity profile.
  • COHEN EE, STENSON K, GUSTIN DM et al: A Phase II study of 250-mg gefitinib monotherapy in recurrent or metastatic squamous cell carcinoma of the head and neck. Proc. Am. Soc. Clin. Oncol (2003) 22:502.
  • INOUE A, SAIJO Y, MAEMONDO M et al.: Severe acute interstitial pneumonia and gefitinib. Lancet (2003) 361(9373):137–139.
  • POLACK VA, SAVAGE DM, BAKER DA et al.: Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinoma with OSI-774: dynamics of receptor inhibition in situ and antitumor effects in athymic mice. J. Pharmcol Exp. Ther. (1999) 291(2):739–748.
  • MOYER JD, BARBACCI EG, IWATA KK et al.: Induction of apoptosis and cell cycle arrest by OSI-774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. (1997) 57(20:4838–4848.
  • HIDALGO M, SIU LL, NEMUNAITIS J et al.: Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. Clin. Oncol. (2001) 19(13):3267–3279.
  • •OSI-774 was shown to be well-tolerated in the Phase I setting, with several patients with advanced solid malignancies demonstrating either antitumour activity or long periods of stable disease.
  • FORERO L, PATNAIK A, HAMMOND LA et al: Phase I, pharmacokinetic and biologic study of OSI-774, a selective epidermal growth factor receptor tyrosine kinase inhibitor in combination with paclitaxel and carboplatin. Proc. Am. Soc. Clin. Oncol. (2002) 21:25b.
  • SOULIERES D, SENZER NN, VOKES EE, HIDALGO M, AGARWALA SS, SIU LL: Multicenter Phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck../. Clin. Oncol (2004) 22(1):77–85.
  • MYERS JN, HOLSINGER FC, BEKELE BN et al.: Targeted molecular therapy for oral cancer with epidermal growth factor receptor blockade: a preliminary report. Arch. Otolaryngol Head Neck Surg. (2002) 128(8):875–879.
  • MURREN JR,PAPADIMITRAKOPOULOU VA, SIZER KC, VAIDYANATHAN S, RAVERA C, ABBRUZZESE J: A Phase I dose-escalating study to evaluate the biological activity and pharmacokinetics of PKI166, a novel tyrosine kinase inhibitor, in patients with advanced cancers. Proc. Am. Soc. Clin. Oncol. (2002) 21:95a.
  • SHIN DM, NEMUNAITIS J, ZINNER RG et al.: A Phase I clinical and biomarker study of CI-1033, a novel pan-erbB tyrosine kinase inhibitor in patients with solid tumors. Proc. Am. Soc. Clin. Oncol. (2001) 20:82a.
  • ZINNER RG, NEMUNAITIS J, DONATO NJ et al: A Phase I clinical and biomarker study of CI-1033 in patients with solid tumors. Proc. AACR-NCI-EORTC Int. Corti 2001. (2001) 566 (Abstract).
  • GARRISON MA, TOLCHER A, MCCREERY H et al: A phase I and pharmacokinetic study of CI-1033, a Pan-ErbB tyrosine kinase inhibitor, given orally on days 1, 8, and 15 every 28 days to patients with solid tumors. Proc. Am. Soc. Oncol. (2002) 20:72a.
  • CIARDIELLO F, DAMIANO V, BIANCO R et al.: Antitumor activity of combined blockade of epidermal growth factor receptor and protein kinase A. .1 Nati Cancer Inst. (1996) 88(23):1770–1776.
  • PREWETT M, ROTHMAN M, WAKSAL H, FELDMAN M, BANDER NH, HICKLIN DJ: Mouse-human chimeric anti-epidermal growth factor receptor antibody C225 inhibits the growth of human renal cell carcinoma xenografts in nude mice. Clin. Cancer Res. (1998) 4(12):2957–2966.
  • CIARDIELLO F, BIANCO R, DAMIANO V et al.: Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225. Clin. Cancer Res. (1999) 5(4):909–916.
  • BASELGA J, PFISTER D, COOPER MR, COHEN R et al.: Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin.Oncol (2000)18(4):904–914.
  • SHIN DM, DONATO NJ, PEREZ-SOLER R et al: Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer. Clin. Cancer Res. (2001) 7(5):1204–1213.
  • •This Phase Ib study showed that C225, a monoclonal antibody to EGFR, significantly saturates tumour EGFR by immunohistochemistry studies. The article discusses this novel mechanism of cancer therapy in head and neck cancer and other tumours with high EGFR expression.
  • KIES MS, ARQUETTE MA, NABELL L et al.: Final report of the efficacy and safety of the anti-epidermal growth factor antibody Erbitux (IMC-C225), in combination with cisplatin in patients with recurrent squamous cell carcinoma of the head and neck refractory to cisplatin containing chemotherapy. Proc. Am. Soc. Clin. Oncol. (2002) 21:232a.
  • BASELGA J, TRIGO JM, BOURHIS J et al.: Cetuximab plus cisplatin/carboplatin is active in patients with recurrent/ metastatic squamous cell carcinoma of the head and neck progressing on a same dose and schedule platinum-based regimen. Proc. Am. Soc. Clin. Oncol. (2002) 21:226a.
  • BURTNESS BA, LI Y, FLOOD W et al.: Phase III trial comparing cisplatin + placebo to cisplatin + anti-epidermal growth factor antibody C225 in patients with metastatic/ recurrent head and neck cancer. Proc. Am. Soc. Clin. Oncol. (2002) 21:226a.
  • VEGE-VILLEGAS E, AQADA A, MESIA R et al: A Phase I study of cetuximab in combination with cisplatin or carboplatin and 5-fluorouracil in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. Proc. Am. Soc. Clin. Oncol. (2003) 22:502.
  • BONNER J, EZEKIEL M, ROBERT F, MEREDITH R, SPENCER S, WAKSAL H: Continued response following treatment with IMC-C225, an EGFr MoAb, combined with RT in advanced head and neck malignancies. Proc. Am. Soc. Clin. Oncol (2000) 19:4a.
  • PFISTER DG, ALIFF TB, KRAUS DH et al.: Concurrent cetuximab, cisplatin, and concomitant boost radiation therapy for locoregionally advanced, squamous cell head and neck cancer: preliminary evaluation of a new combined-modality paradigm. Proc. Am. Soc. Clin. Oncol (2003) 22:495.
  • WINQUIST E, NABID A, SICHERI D et al.: A Phase I dose escalation study of a humanized monoclonal antibody to EGFR (hR3) in patients with locally advanced squamous cell carcinoma of the head and neck treated with radiotherapy. Proc. Am. Soc. Clin. Oncol. (2002) 21:232a.
  • TEWES M, SCHLEUCHER N, DIRSCH 0 et al.: Results of a Phase I trial of humanized anti epidermal growth factor receptor monoclonal antibody EMD 72000 in patiens with EGFR expressing solid tumors. Proc. Am. Soc. Clin. Oncol. (2002) 21:95a (Abstract 378).
  • BIER H, HOFFMAN T, HAUSER U et al.: Clinical trial with escalating doses of the antiepidermal growth factor receptor humanized monoclonal antibody EMD 72000 in patients with advanced squamous cell carcinoma of the larynx and Hypopharynx. Cancer Chemother. Pharmacol (2001) 47:519–524.
  • SHIN DM, LEE JS, LIPPMAN SM et al: p53 expressions: predicting recurrence and second primary tumors in head and neck squamous cell carcinoma. J. Natl. Cancer Inst. (1996) 88(8):519–529.
  • BOYLE JO, HAKIM J, KOCH W et al: The incidence of p53mutations increases with progression of head and neck cancer. Cancer Res. (1993) 53(19):4477–4480.
  • CABELGUENNE A, BLONS H, DE WAZIERS I et al: p53 alterations predict tumor response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma: a prospective series. J. Chit. Oncol (2000) 18(7):1465–1473.
  • GANLY I, ECKHARDT SG, RODRIGUEZ, GI et al: A Phase I study of Onyx-015, an EiB attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer. Clin. Cancer Res. (2000) 6(3):798–806.
  • NEMUNAITIS J, KHURI F, GANLY I et al.: Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer. Clin. OncoL (2001) 19(2):289–298.
  • HEISE C, SAMPSON-JOHANNES A, WILLIAMS A, MCCORMICK F, VON HOFF DD, KIRN DH: ONYX-015, an ElB gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat. Med. (1997) 3(6):639–645.
  • KHURI FR, NEMUNAITIS J, GANLY I et al.: A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer. Nat. Med. (2000) 6(8):879–885.
  • ••This article proposes intratumouralinjection ONYX-015 as an active method for local control in addition to systemic chemotherapy for patients with recurrent head and neck cancer.
  • RUDIN CM, COHEN EE, PAPADIMIRAKOPOULOU VA et al: An attenuated adenovirus, ONYX-015, as mouthwash therapy for premalignant oral dysplasia.Oncol (2003)21:4546–4552.
  • LIU TJ, ZHANG WW, TAYLOR DL, ROTH JA, GOEPFERT H, CLAYMAN GL: Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus. Cancer Res. (1994) 54(14):3662–3667.
  • GOODWIN WJ, ESSER D, CLAYMAN GL, NEMUNAITIS J, YVER A, DREILING LK: Randomized Phase II study of intratumoral injection of two dosing schedules using a replication-deficient adenovirus carrying the p53 gene (AD5CMV-P53) in patients with recurrent/ refractory head and neck cancer. Proc. Am. Soc. Clin. Oncol (1999) 18:445a.
  • CLAYMAN GL, FRANK DK, BRUSO PA, GOEPFERT H: Adenovirus-mediated wild-type p53 gene transfer as a surgical adjuvant in advanced head and neck cancers. Clin. Cancer Res. (1999) 5(7):1715–1722.
  • OLD LJ: Tumor necrosis factor. Science (1985) 230:630–632.
  • SENZER N, MANI S, ROSEMURGY A et al: TNF-erade biologic, an adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene: a Phase I study in patients with solid tumors. ./. Clin. Oncol (2004) 22(4):592–601.
  • GLISSON S, HUBER J, GAUGLER M et al: Smokeless tobacco induced oral cavity tumors in Kentucky have a high incidence of hras mutations. Proc. Am. Soc. Clin. Oncol (1998) 17:399a.
  • HAHN S, KIEL K, BRIGGS M et al: Phase I trial of the farnesyl protein transferase (FPTase) inhibitor L-778123 in combination with radiotherapy. Proc. Am. Soc. Clin. Oncol (2000) 19:231a.
  • HOLDEN S, ECKHARDT SG, FISHERS et al: A Phase I pharmacokinetic (PK) and biologic study of the farnesyl transferase inhibitor (FTI) R115777 and capecitabine in patients (PTS) with advanced solid malignancies. Proc. Am. Soc. Clin. Oncol (2001) 20:80a.
  • KIES MS, CLAYMAN GL, EL-NAGGAR AK et al.: Induction therapy with SCH 66336: a farnesyl transferase inhibitor in squamous cell carcinoma (SCC) of the head and neck. Proc. Am. Soc. Clin. Oncol ( 2001) 20:896 (Abstract).
  • FOLKMAN J: Clinical applications of research on angiogenesis. N Engl. J. Med. (1995) 333(26):1757–1763.
  • ••This seminar discusses the role ofangiogenesis in neoplastic and non-neoplastic diseases.
  • DENHART BC, GUIDI AJ, TOGNAZZI K, DVORAK HF, BROWN LF: Vascular permeability factor/ vascular endothelial growth factor and its receptors in oral and laryngeal squamous cell carcinoma and dysplasia. Lab. Invest. (1997) 77(6):659–664.
  • FONG TAT, SHAWVER LK, SUN L et al: 5U5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res. (1999) 59(1):99–106.
  • ROSEN L, MULAY M, MAYERS A et al: Phase I dose-escalating trial of SU5416, a novel angiogenesis inhibitor in patients with advanced malignancies. Proc. Am. Soc. Chit. Oncol (1999) 18:161a.
  • ZAHALSKY AJ, WONG RJ, LIS E et al: Phase II trial of SU5416 in patients with advanced incurable head and neck cancer. Proc. Am. Soc. Clin. Oncol (2002) 21:226a.
  • Bevacizumab. Anti-VEGF monoclonal antibody, avastin, rhumab-VEGF. Drugs R D(2002) 3(1):28–30.
  • GORDON MS, MARGOLIN K, TALPAZ M et al: Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. Clin. Oncol (2001) 19(3):843–850.
  • KABBINAVAR F, HURWITZ HI, FEHRENBACHER L et al: Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J. Clin. Oncol (2003) 21(1):60–65.
  • OIKAWA T, SASAKI T, NAKAMURA M et al: The proteasome is involved in angiogenesis. Biochem. Biophys. Res. Commun. (1998) 246(1):243–248.
  • HIDESHIMA T, RICHARDSON P, CHAUHAN D et al: The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res. (2001) 61(7):3071–3076.
  • SHAH SA, POTTER MW, MCDADE TP et al: 26S Proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer. I Cell. Biochem. (2001) 82(1):110–122.
  • FRANKEL A, MAN S, ELLIOT P, ADAMS J, KERBEL RS: Lack of multicellular drug resistance observed in human ovarian and prostate carcinoma treated with the proteasome inhibitor PS-341. Clin. Cancer. Res. (2000) 6(9):3719–3728.
  • FAN XM, WONG BC, WANG WP et al: Inhibition of proteasome function induced apoptosis in gastric cancer. Int. J. Cancer (2001) 93(4):481–488.
  • AGHAJANIAN C, SOIGNET S, DIZON DS et al: A Phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies. Clin. Cancer Res. (2002) 8(8):2505–2511.
  • •This article discusses PS-341 as the first drug in its class and the Phase I results in patients with various solid tumours.
  • RYAN DP, EDER JP, WINKELMANN J et al.: Pharmacokinetic and pharmacodynamic Phase I study of PS-341 and gemcitabine in patients with advanced solid tumors. Proc. Am. Soc. Clin. Oncol (2002) 21:95a.
  • IQBAL S, LENZ HJ, GROSHEN S et al: Phase I study of PS-341 in combination with 5-FU/LV in solid tumors. Proc. Am. Soc. Clin. Oncol (2002) 21:93 (Abstract 370).
  • THOMAS JP, ARZOOMANIAN R, ALBERTI D et al.: A Phase I and pharmacodynamic study of the proteosome inhibitor PS-341 in combination with doxorubicin. Proc. Am. Soc. Clin. Oncol (2002) 21:93 (Abstract 368).
  • CLARK JW, RYAN D, DEES C et al: Phase I dose-escalation study of the proteasome inhibitor, PS-341, plus irinotecan in patients with advanced solid tumors. Proc. Am. Soc. Clin. Oncol (2002) 21:93 (Abstract 369).
  • MITSIADES N, MITSIADES CS, RICHARDSON PG et al: The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications. Blood (2003) 101(6):2377–2380.
  • LEBOWITZ PF, HARKINS C, CONLEY B et al: Concomitant therapy with proteosome inhibitor, bortezomib and radiation in patients with recurrent or metastatic head and neck squamous cell carcinoma. Proc. Am. Soc. Clin. Oncol (2003) 22:499.
  • LIPPMAN SM, BATSAKIS JG, TOTH BB et al.: Comparison of low-dose isotretinoin with beta carotene to prevent oral carcinonogenesis. N Engl. I Med. (1993) 328(1):15–20.
  • HONG WK, ENDICOTT J, ITRI LM et al.: 13-cis-Retinoic acid in the treatment of oral leukoplakia. N Engl. I Med. (1986) 315(24):1501–1505.
  • ••Landmark study in which 13-th-retinoic acid was shown to be effective in oral premalignant lesions.
  • SHIN DM, RICHARDS TJ, SEIXAS-SILVA JA et al: Phase II trial of bioadjuvant therapy with interferon2a, 13-cis-retinoic acid, and alpha-tocopherol for locally advanced squamous cell carcinoma of the head and neck: long term follow-up. Proc. Am. Soc. Clin. Oncol (2003) 22:496.
  • SHIBATA J, MURAKAMI K, AOYAGI Y et al.: The induction of apoptosis and inhibition of AP-1 activity by TAC-101 (4-[3,5-bis(trimethylsily0 benzamido] benzoic acid) may result in life prolonging effect in animals bearing metastasizing cancer. Anticancer Res. (2000) 20(5B):3583–3590.
  • RIZVI NA, MARSHALL JL, NESS E et al: Initial clinical trial of oral TAC-101, a novel retinoic acid receptor-alpha selective retinoid, in patients with advanced cancer. Clin. Oncol (2002) 20(16):3522–3532.
  • DUVIC M, HYMES K, HEALD P et al: Bexarotene is effective and safe for treatment of refractory advanced stage cutaneous T-cell lymphoma: multinational Phase II-III trial results. Clin. Oncol (2001) 19(9):2456–2471.
  • SONG JI, LANGO MN, HWANG JD et al.: Abrogation of transforming growth factor-alpha/epidermal growth factor receptor autocrine signaling by an RXR-selective retinoid (LGD1069, Targretin) in head and neck cancer cell lines. Cancer Res. (2001) 61(15):5919–5925.
  • RIZVI NA, MARSHALL JL, DAHUT W et al: A Phase I study of LGD1069 in adults with advanced cancer. Clin. Cancer Res. (1999) 5(7):1658–1664.
  • PAPADIMITRAKOPOULOU V, KHURI FR, LIPPMAN SM et al: Phase I/ II evaluation of Targretin (LDG1069), a novel, RXR-specific retinoid, in patients with recurrent squamous cell carcinoma of the head and neck. Proc. Am. Soc. Clin. Oncol (1998) 17:392a.
  • LIN DT, SUBBARAMAIAH K, SHAH JP, DANNENBERG AJ, BOYLE JO: Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer. Head Neck (2002) 24(8):792–799.
  • MASFERRER JL, LEAHY KM, KOKI AT et al.: Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors. Cancer Res. (2000) 60(5):1306–1311.
  • MESTRE JR, CHAN G, ZHANG F et al: Inhibition of cyclooxygenase-2 expression: an approach to preventing head and neck cancer. Ann. NY Acad. Sci. (1999) 889:62–71.
  • BRESALIER RS: Chemoprevention comes to clinical practice: COX-2 inhibition in familial adenomatous polyposis. Gastroenterology (2000)119(6):1797–1798.
  • REDDY BS, HIROSE Y, LUBET R et al: Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis. Cancer Res. (2000) 60(2):293–297.
  • REDDY BS, RAO CV: Colon cancer: a role for cyclo-oxygenase-2-specific nonsteroidal anti-inflammatory drugs. Drugs Aging (2000) 16(5):329–334.
  • DAVIES G, MARTIN LA, SACKS N, DOWSETT M: Cyclooxygenase-2 (COX-2), aromatase and breast cancer: a possible role for COX-2 inhibitors in breast cancer chemoprevention. Ann. Oncol (2002) 13(5):669–678.
  • BADAWI AF, BADR MZ: Chemoprevention of breast cancer by targeting cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma. mnt..j Oncol (2002) 20(6):1109–1122.
  • HU KQ: Rationale and feasibility of chemoprovention of hepatocellular carcinoma by cyclooxygenase-2 inhibitors. J. Lab. Clin. Med. (2002) 139(4):234–243.
  • PATTON SE, HALL MC, OZEN H: Bladder cancer. Corr. Opin. Oncoi (2002)14(3):265–272.
  • WANG Z, FUENTES CF, SHAPSHAY SM: Antiangiogenic and chemopreventive activities of celecoxib in oral carcinoma cell. Laryngoscope (2002) 112(5):839–843.
  • CHEN Z, ZHANG X, WANG Z et al: A possible interaction between epidermal growth factor receptor and cyclooxygenase-2 mediated pathways in squamous cell carcinoma of the head and neck. Proc. Am. Assoc. Cancer Res. (2003) 44:510a.
  • SHIN DM, WANG ZQ, ZHANG X et al: ZD1839, an epidermal growth factor receptor tyrosine inhibitor, inhibits cell growth synergistically with a cyclooxygenase-2 inhibitor, celecoxib, in squamous cell carcinoma of the head and neck. Proc. Am. Assoc. Cancer Res. (2003) 44:1084a.

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