Targeting Notch signaling in pancreatic cancer

Bibliography

• Jones S, Zhang X, Parsons DW, Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008;321:1801-6
   PubMed Web of Science ®Google Scholar
• Apelqvist A, Li H, Sommer L, Notch signaling controls pancreatic cell differentiation. Nature 1999;400:877-81
   PubMed Web of Science ®Google Scholar
• Leong KG, Karsan A. Recent insights into the role of Notch signaling in tumorigenesis. Blood 2006;107:2223-33
   PubMed Web of Science ®Google Scholar
• Sjölund J, Manetopoulos C, Stockhausen MT, The Notch pathway in cancer: differentiation gone awry. Eur J Cancer 2005;41:2620-29
   PubMed Web of Science ®Google Scholar
• Wang Z, Zhang Y, Li Y, Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol Cancer Ther 2006;5:483-93
   PubMed Web of Science ®Google Scholar
• Ringel J, Jesnowski R, Moniaux N, Aberrant expression of a disintegrin and metalloproteinase 17/tumor necrosis factor-alpha converting enzyme increases the malignant potential in human pancreatic ductal adenocarcinoma. Cancer Res 2006;66:9045-53
   PubMedGoogle Scholar
• Ristorcelli E, Beraud E, Mathieu S, Essential role of Notch signaling in apoptosis of human pancreatic tumoral cells mediated by exosomal nanoparticles. Int J Cancer 2009;125:1016-26
   PubMed Web of Science ®Google Scholar
• Miyamoto Y, Maitra A, Ghosh B, Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell 2003;3:565-76
   PubMed Web of Science ®Google Scholar
• Jensen J, Heller RS, Funder-Nielsen T, Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes 2000;49:163-76
   PubMed Web of Science ®Google Scholar
• Wang Z, Zhang Y, Banerjee S, Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells. Cancer 2006;106:2503-13
   PubMed Web of Science ®Google Scholar
• Plentz R, Park JS, Rhim AD, Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterol 2009;136:1741-9
   PubMed Web of Science ®Google Scholar
• Kadesch T. Notch signaling: the demise of elegant simplicity. Curr Opin Genet Dev 2004;14:506-12
   PubMed Web of Science ®Google Scholar
• Choi K, Ahn YH, Gibbons DL, Distinct biological roles for the notch ligands Jagged-1 and Jagged-2. J Biol Chem 2009;284:17766-74
   PubMed Web of Science ®Google Scholar
• Tien AC, Rajan A, Bellen HJ. A Notch updated. J Cell Biol 2009;184:621-9
   PubMed Web of Science ®Google Scholar
• Mochizuki S, Okada Y. ADAMs in cancer cell proliferation and progression. Cancer Sci 2007;98:621-8
   PubMed Web of Science ®Google Scholar
• Postina R. A closer look at alpha-secretase. Curr Alzheimer Res 2008;5:179-86
   Google Scholar
• Brou C, Logeat F, Gupta N, A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol Cell 2000;5:207-16
   PubMed Web of Science ®Google Scholar
• Matthews V, Schuster B, Schütze S, Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). J Biol Chem 2003;278:38829-39
   PubMed Web of Science ®Google Scholar
• Kimberly WT, LaVoie MJ, Ostaszewski BL, Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation. J Biol Chem 2002;277:35113-7
   Google Scholar
• Kim SK, Park HJ, Hong HS, ERK1/2 is an endogenous negative regulator of the gamma-secretase activity. FASEB J 2006;20:157-9
   PubMedGoogle Scholar
• Kimberly WT, LaVoie MJ, Ostaszewski BL, gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc Natl Acad Sci USA 2003;100:6382-7
   PubMed Web of Science ®Google Scholar
• Okochi M, Steiner H, Fukumori A, Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. EMBO J 2002;21:5408-16
   PubMed Web of Science ®Google Scholar
• Gupta-Rossi N, Six E, LeBail O, Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor. J Cell Biol 2004;166:73-83
   PubMedGoogle Scholar
• Katho M, Katho M. Notch signaling in gastrointestinal tract. Int J Oncol 2007;30:247-51
   Google Scholar
• Iso T, Kedes L, Hamamori Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol 2003;194:237-55
   PubMed Web of Science ®Google Scholar
• Roy M, Pear WS, Aster JC. The multifaceted role of Notch in cancer. Curr Opin Genet Dev 2007;17:52-9
   PubMed Web of Science ®Google Scholar
• Moloney DJ, Panin VM, Johnston SH, Fringe is a glycosyltransferase that modifies Notch. Nature 2000;406:369-75
   PubMed Web of Science ®Google Scholar
• Golson ML, Le Lay J, Gao N, Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas. Mech Dev 2009;126:687-99
   Google Scholar
• Xu A, Lei L, Irvine KD. Regions of drosophila notch that contribute to ligand binding and the modulatory influence of Fringe. J Biol Chem 2005;280:30158-65
   PubMedGoogle Scholar
• Gridley T. Notch signaling and inherited disease syndromes. Hum Mol Genet 2003;12(1):R9-13
   Google Scholar
• Vaccari T, Lu H, Kanwar R, Endosomal entry regulates Notch receptor activation in Drosophila melanogaster. J Cell Biol 2008;180:755-62
   PubMed Web of Science ®Google Scholar
• McGill MA, Dho SE, Weinmaster G, Numb regulates post-endocytic trafficking and degradation of Notch-1. J Biol Chem 2009;284:26427-38
   PubMed Web of Science ®Google Scholar
• Shaye DD, Greenwald I. Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans. Nature 2002;420:686-90
   PubMedGoogle Scholar
• Osenkowski P, Ye W, Wang R, Direct and potent regulation of gamma-secretase by its lipid microenvironment. J Biol Chem 2008;283:22529-40
   PubMed Web of Science ®Google Scholar
• Müller P, Crofts JD, Newman BS, SOX9 mediates the retinoic acid-induced HES-1 gene expression in human breast cancer cells. Breast Cancer Res Treat 2009: Published online 26 March 2009, doi: 10.1007/s10549-009-0381-6
   Google Scholar
• Hartman J, Müller P, Foster JS, HES-1 inhibits 17beta-estradiol and heregulin-beta1-mediated upregulation of E2F-1. Oncogene 2004;23:8826-33
   Google Scholar
• Weng AP, Aster JC. Multiple niches for Notch in cancer: context is everything. Curr Opin Genet Dev 2004;14:48-54
   PubMed Web of Science ®Google Scholar
• Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate control and signal integration in development. Science 1999;284:770-6
   PubMed Web of Science ®Google Scholar
• Lammert E, Brown J, Melton DA. Notch gene expression during pancreatic organogenesis. Mech Dev 2000;94:199-203
   PubMed Web of Science ®Google Scholar
• Beres TM, Masui T, Swift GH, PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L. Mol Cell Biol 2006;26:117-30
   PubMedGoogle Scholar
• Nakhai H, Siveke JT, Klein B, Conditional ablation of Notch signaling in pancreatic development. Development 2008;135:2757-65
   Google Scholar
• Kim W, Shin YK, Kim BJ, Egan JM. Notch signaling in pancreatic endocrine cell and diabetes. Biochem Biophys Res Commun 2010;392:247-51
   PubMed Web of Science ®Google Scholar
• Li C, Heidt DG, Dalerba P, Identification of pancreatic cancer stem cells. Cancer Res 2007;67:1030-7
   PubMed Web of Science ®Google Scholar
• Kim SK, Hebrok M. Intercellular signals regulating pancreas development and function. Genes Dev 2001;15:111-27
   PubMed Web of Science ®Google Scholar
• Jensen J. Gene regulatory factors in pancreatic development. DevDyn 2004;229:176-200
   PubMed Web of Science ®Google Scholar
• Habener JF, Kemp DM, Thomas MK. Minireview: transcriptional regulation in pancreatic development. Endocrinology 2005;146:1025-34
   PubMed Web of Science ®Google Scholar
• Radtke F, Raj K. The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer 2003;3:756-67
   PubMed Web of Science ®Google Scholar
• Weng AP, Ferrando AA, Lee W, Activating mutations of NOTCH-1 in human T cell acute lymphoblastic leukemia. Science 2004;306:269-71
   PubMed Web of Science ®Google Scholar
• Sjölund J, Manetopoulos C, Stockhausen MT, The Notch pathway in cancer: differentiation gone awry. Eur J Cancer 2005;41:2620-9
   PubMed Web of Science ®Google Scholar
• Hruban RH, Adsay NV, Albores-Saavedra J, Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol 2001;25:579-86
   PubMed Web of Science ®Google Scholar
• Doucas H, Mann CD, Sutton CD, Expression of nuclear Notch3 in pancreatic adenocarcinomas is associated with adverse clinical features, and correlates with the expression of STAT3 and phosphorylated Akt. J Surg Oncol 2008;97:63-8
   PubMed Web of Science ®Google Scholar
• Eastham AM, Spencer H, Soncin F, Epithelial-mesenchymal transition events during human embryonic stem cell differentiation. Cancer Res 2007;67:11254-62
   PubMed Web of Science ®Google Scholar
• Barrallo-Gimeno A, Nieto MA. The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development 2005;132:3151-61
   PubMed Web of Science ®Google Scholar
• von Burstin J, Eser S, Paul MC, E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex. Gastroenterology 2009;137:361-71
   PubMed Web of Science ®Google Scholar
• Sahlgren C, Gustafsson MV, Jin S, Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc Natl Acad Sci USA 2008;105:6392-7
   PubMed Web of Science ®Google Scholar
• Wang Z, Li Y, Kong D, Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. Cancer Res 2009;69:2400-7
   PubMed Web of Science ®Google Scholar
• Hruban RH, Iacobuzio-Donahue C, Wilentz RE, Molecular pathology of pancreatic cancer. Cancer J 2001;7:251-8
   PubMed Web of Science ®Google Scholar
• De La O JP, Murtaugh LC. Notch and Kras in pancreatic cancer: at the crossroads of mutation, differentiation and signaling. Cell Cycle 2009;8:1860-4
   PubMed Web of Science ®Google Scholar
• De La O JP, Emerson LL, Goodman JL, Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc Natl Acad Sci USA 2008;105:18907-12
   PubMed Web of Science ®Google Scholar
• Gansauge S, Gansauge F, Ramadani M, Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis. Cancer Res 1997;57:1634-7
   PubMed Web of Science ®Google Scholar
• D'Souza B, Miyamoto A, Weinmaster G. The many facets of Notch ligands. Oncogene 2008;27:5148-67
   PubMed Web of Science ®Google Scholar
• Fre S, Pallavi SK, Huyghe M, Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc Natl Acad Sci USA 2009;106:6309-14
   PubMed Web of Science ®Google Scholar
• Fitzgerald K, Harrington A, Leder P. Ras pathway signals are required for notch-mediated oncogenesis. Oncogene 2000;19:4191-8
   PubMed Web of Science ®Google Scholar
• Morrow D, Cullen JP, Liu W, Sonic Hedgehog induces Notch target gene expression in vascular smooth muscle cells via VEGF-A. Arterioscler Thromb Vasc Biol 2009;29:1112-8
   PubMed Web of Science ®Google Scholar
• Blokzijl A, Dahlqvist C, Reissmann E, Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. J Cell Biol 2003;163:723-8
   PubMed Web of Science ®Google Scholar
• Morton JP, Lewis BC. Shh signaling and pancreatic cancer: implications for therapy? Cell Cycle 2007;6:1553-7
   PubMed Web of Science ®Google Scholar
• Pasca di Magliano M, Biankin AV, Heiser PW, Common activation of canonical Wnt signaling in pancreatic adenocarcinoma. PLoS One 2007;2:e1155
   PubMedGoogle Scholar
• Simeone DM, Pham T, Logsdon CD. Disruption of TGFbeta signaling pathways in human pancreatic cancer cells. Ann Surg 2000;232:73-80
   Google Scholar
• Weijzen S, Rizzo P, Braid M, Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med 2002;8:979-86
   PubMed Web of Science ®Google Scholar
• Chen Y, Fischer WH, Gill GN. Regulation of the ERBB-2 promoter by RBPJκ and NOTCH. J Biol Chem 1997;272:14110-4
   PubMedGoogle Scholar
• Sarkar FH, Banerjee S, Li Y. Pancreatic cancer: pathogenesis, prevention and treatment. Toxicol Appl Pharmacol 2007;224:326-36
   PubMed Web of Science ®Google Scholar
• Shin HM, Minter LM, Cho OH, Notch-1 augments NF-κB activity by facilitating its nuclear retention. EMBO J 2006;25:129-38
   PubMed Web of Science ®Google Scholar
• Sun Y, Lowther W, Kato K, Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling. Oncogene 2005;24:5365-74
   Google Scholar
• Soares R, Balogh G, Guo S, Evidence for the notch signaling pathway on the role of estrogen in angiogenesis. Mol Endocrinol 2004;18:2333-43
   Google Scholar
• Jögi A, Øra I, Nilsson H, Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype. Proc Natl Acad Sci USA 2002;99:7021-6
   PubMed Web of Science ®Google Scholar
• Palomero T, Sulis ML, Cortina M, Mutational loss of PTEN induces resistance to NOTCH-1 inhibition in T-cell leukemia. Nat Med 2007;13:1203-10
   PubMed Web of Science ®Google Scholar
• Lee MH, Koria P, Qu J, JNK phosphorylates beta-catenin and regulates adherens junctions. FASEB J 2009;23:3874-83
   Google Scholar
• Tian H, Callahan CA, DuPree KJ, Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad Sci USA 2009;106:4254-9
   PubMed Web of Science ®Google Scholar
• Ingram WJ, McCue KI, Tran TH, Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signaling. Oncogene 2008;27:1489-500
   PubMed Web of Science ®Google Scholar
• Jemal A, Seigel R, Ward E, Cancer statistics. Cancer J Clin 2007;57:43-66
   PubMed Web of Science ®Google Scholar
• Mancuso A, Calabrò F, Sternberg CN. Current therapies and advances in the treatment of pancreatic cancer. Crit Rev Oncol Hematol 2006;58:231-41
   PubMed Web of Science ®Google Scholar
• Borja-Cacho D, Jensen EH, Saluja AK, Molecular targeted therapies for pancreatic cancer. Am J Surg 2008;196:430-41
   Google Scholar
• Pliarchopoulou K, Pectasides D. Pancreatic cancer: current and future treatment strategies. Cancer Treat Rev 2009;35:431-6
   PubMed Web of Science ®Google Scholar
• Novarino I, Chiappin GF, Bertelli A, Phase II study of cisplatin, gemcitabine and 5-fluorouracil in advanced pancreatic cancer. Ann Oncol 2004;15:474-7
   Google Scholar
• Laheru D, Jaffee EM. Immunotherapy for pancreatic cancer – science driving clinical progress. Nat Rev Cancer 2005;5:459-67
   PubMed Web of Science ®Google Scholar
• Cartwright T, Richards DA, Boehm KA. Cancer of the pancreas: are we making progress? A review of studies in the US Oncology Research Network. Cancer Control 2008;15:308-13
   PubMedGoogle Scholar
• Seymour PA, Freude KK, Tran MN, SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci USA 2007;104:1865-70
   PubMed Web of Science ®Google Scholar
• De La O JP, Murtaugh LC. Notch signaling: where pancreatic cancer and differentiation meet? Gastroenterol 2009;136:1499-502
   PubMedGoogle Scholar
• Aiello A, Pandini G, Frasca F, Peroxisomal proliferator-activated receptor-gamma agonists induce partial reversion of epithelial-mesenchymal transition in anaplastic thyroid cancer cells. Endocrinology 2006;147:4463-75
   PubMed Web of Science ®Google Scholar
• Li K, Li Y, Wu W, Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3. J Biol Chem 2008;283:8046-54
   PubMed Web of Science ®Google Scholar
• Shih IeM, Wang TL. Notch signaling, gamma-secretase inhibitors, and cancer therapy. Cancer Res 2007;67:1879-82
   PubMed Web of Science ®Google Scholar
• Stylianou S, Clarke RB, Brennan K. Aberrant activation of notch signaling in human breast cancer. Cancer Res 2006;66:1517-25
   PubMed Web of Science ®Google Scholar
• Paris D, Quadros A, Patel N, Inhibition of angiogenesis and tumor growth by beta and gamma-secretase inhibitors. Eur J Pharmacol 2005;514:1-15
   PubMed Web of Science ®Google Scholar
• Aleksic T, Feller SM. Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells. Cell Commun Signal 2008;6:8-20
   PubMedGoogle Scholar
• Morton JP, Mongeau ME, Klimstra DS, Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proc Natl Acad Sci USA 2007;104:5103-8
   PubMed Web of Science ®Google Scholar
• Olive KP, Jacobetz MA, Davidson CJ, Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009;324:1457-61
   PubMed Web of Science ®Google Scholar
• Mori T, Doi R, Koizumi M, CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer. Mol Cancer Ther 2004;3:29-37
   PubMed Web of Science ®Google Scholar
• Luo Y, Cai J, Xue H, SDF1alpha/CXCR4 signaling stimulates beta-catenin transcriptional activity in rat neural progenitors. Neurosci Lett 2006;398:291-5
   PubMed Web of Science ®Google Scholar
• Benkoël L, Bernard JP, Payan-Defais MJ, Monoclonal antibody 16D10 to the C-terminal domain of the feto-acinar pancreatic protein targets pancreatic neoplastic tissues. Mol Cancer Ther 2009;8:282-91
   Google Scholar