119
Views
16
CrossRef citations to date
0
Altmetric
Review

Targeting Aurora kinases in ovarian cancer

, , &
Pages 77-85 | Published online: 27 Jan 2006

Bibliography

  • JEMAL A, MURRAY T, WARD E et al.: Cancer statistics, 2005. CA Cancer J. Clin. (2005) 55(1):10-30.
  • CANNISTRA SA: Cancer of the ovary. N. Engl. J. Med. (2004) 351(24):2519-2529.
  • CHEESEMAN IM, DESAI A: Cell division: feeling tense enough? Nature (2004) 428(6978):32-33.
  • TIEN AC, LIN MH, SU LJ et al.: Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model. Mol. Cell Proteomics (2004) 3(1):93-104.
  • GLOVER DM, LEIBOWITZ MH, MCLEAN DA, PARRY H: Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell (1995) 81(1):95-105.
  • GOPALAN G, CHAN CS, DONOVAN PJ: A novel mammalian, mitotic spindle-associated kinase is related to yeast and fly chromosome segregation regulators. J. Cell Biol. (1997) 138(3):643-656.
  • MARUMOTO T, ZHANG D, SAYA H: Aurora-A – a guardian of poles. Nat. Rev. Cancer (2005) 5(1):42-50.
  • CRANE R, GADEA B, LITTLEPAGE L et al.: Aurora A, meiosis and mitosis. Biol. Cell (2004) 96(3):215-229.
  • TATSUKA M, KATAYAMA H, OTA T et al.: Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells. Cancer Res. (1998) 58(21):4811-4816.
  • YOKOYAMA T, GOTA H, IZAWA I et al.: Aurora-B and Rho-kinase/ROCK, the two cleavage furrow kinases, independently regulate the progression of cytokinesis: possible existence of a novel cleavage furrow kinase phosphorylates ezrin/radixin/moesin (ERM). Genes Cells (2005) 10(2):127-137.
  • WHEATLEY SP, HENZING AJ, DODSON H et al.: Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. J. Biol. Chem. (2004) 279(7):5655-5660.
  • PASCREAU G, ARLOT-BONNEMAINS Y, PRIGENT C: Phosphorylation of histone and histone-like proteins by aurora kinases during mitosis. Prog. Cell Cycle Res. (2003) 5:369-374.
  • BEARDMORE VA, AHONEN LJ, GORBSKY GJ, KALLIO MJ: Survivin dynamics increases at centromeres during G2/M phase transition and is regulated by microtubule-attachment and Aurora B kinase activity. J. Cell Sci. (2004) 117(Pt 18):4033-4042.
  • LAMPSON MA, KAPOOR TM: The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments. Nat. Cell Biol. (2005) 7(1):93-98.
  • HONDA R, KORNER R, NIGG EA: Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol. Biol. Cell (2003) 14(8):3325-3341.
  • DITCHFIELD C, JOHNSON VL, TIGHE A et al.: Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J. Cell Biol. (2003) 161(2):267-280.
  • OHI R, SAPRA T, HOWARD J, MITCHISON TJ: Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation. Mol. Biol. Cell (2004) 15(6):2895-2906.
  • LI X, SAKASHITA G, MATSUZAKI H et al.: Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C. J. Biol. Chem. (2004) 279(45):47201-47211.
  • SASAI K, KATAYAMA H, STENOIEN DL et al.: Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. Cell Motil. Cytoskeleton (2004) 59(4):249-263.
  • BISCHOFF JR, ANDERSON L, ZHU Y et al.: A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J. (1998) 17(11):3052-3065.
  • ROYCE ME, XIA W, SAHIN AA et al.: STK15/Aurora-A expression in primary breast tumors is correlated with nuclear grade but not with prognosis. Cancer (2004) 100(1):12-19.
  • GRITSKO TM, COPPOLA D, PACIGA JE et al.: Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer. Clin. Cancer Res. (2003) 9(4):1420-1426.
  • MORENO-BUENO G, SANCHEZ-ESTEVEZ C et al.: Differential gene expression profile in endometrioid and nonendometrioid endometrial carcinoma: STK15 is frequently overexpressed and amplified in nonendometrioid carcinomas. Cancer Res. (2003) 63(18):5697-5702.
  • TANAKA E, HASHIMOTO Y, ITO T et al.: The clinical significance of Aurora-A/STK15/BTAK expression in human esophageal squamous cell carcinoma. Clin. Cancer Res. (2005) 11(5):1827-1834.
  • KAMADA K, YAMADA Y, HIRAO T et al.: Amplification/overexpression of Aurora-A in human gastric carcinoma: potential role in differentiated type gastric carcinogenesis. Oncol. Rep. (2004) 12(3):593-599.
  • LI D, ZHU J, FIROZI PF et al.: Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer. Clin. Cancer Res. (2003) 9(3):991-997.
  • JENG YM, PENG SY, LIN CY, HSU HC: Overexpression and amplification of Aurora-A in hepatocellular carcinoma. Clin. Cancer Res. (2004) 10(6):2065-2071.
  • FRAIZER GC, DIAZ MF, LEE IL et al.: Aurora-A/STK15/BTAK enhances chromosomal instability in bladder cancer cells. Int. J. Oncol. (2004) 25(6):1631-1639.
  • BUSCHHORN HM, KLEIN RR, CHAMBERS SM et al.: Aurora-A over-expression in high-grade PIN lesions and prostate cancer. Prostate (2005) 64(4):341-346.
  • KLEIN A, REICHARDT W, JUNG V et al.: Overexpression and amplification of STK15 in human gliomas. Int. J. Oncol. (2004) 25(6):1789-1794.
  • SORRENTINO R, LIBERTINI S, PALLANTE PL et al.: Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation. J. Clin. Endocrinol. Metab. (2005) 90(2):928-935.
  • KEEN N, TAYLOR S: Aurora-kinase inhibitors as anticancer agents. Nat. Rev. Cancer (2004) 4(12):927-936.
  • MERALDI P, HONDA R, NIGG EA: Aurora kinases link chromosome segregation and cell division to cancer susceptibility. Curr. Opin. Genet. Dev. (2004) 14(1):29-36.
  • FUJITA Y, SAKAKURA C, SHIMOMURA K et al.: Chromosome arm 20q gains and other genomic alterations in esophageal squamous cell carcinoma, as analyzed by comparative genomic hybridization and fluorescence in situ hybridization. Hepatogastroenterology (2003) 50(54):1857-1863.
  • GOEPFERT TM, ADIGUN YE, ZHONG L et al.: Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis. Cancer Res. (2002) 62(14):4115-4122.
  • KATAYAMA H, BRINKLEY WR, SEN S: The Aurora kinases: role in cell transformation and tumorigenesis. Cancer Metastasis Rev. (2003) 22(4):451-464.
  • TATSUKA M, SATO S, KITAJIMA S et al.: Overexpression of Aurora-A potentiates HRAS-mediated oncogenic transformation and is implicated in oral carcinogenesis. Oncogene (2005) 24(6):1122-1127.
  • YANG H, OU CC, FELDMAN RI et al.: Aurora-A kinase regulates telomerase activity through c-Myc in human ovarian and breast epithelial cells. Cancer Res. (2004) 64(2):463-467.
  • DU J, HANNON GJ: The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1. Nucleic Acids Res. (2002) 30(24):5465-5475.
  • MERALDI P, HONDA R, NIGG EA: Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. EMBO J. (2002) 21(4):483-492.
  • KATAYAMA H, SASAI K, KAWAI H et al.: Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat. Genet. (2004) 36(1):55-62.
  • YU X, MINTER-DYKHOUSE K, MALUREANU L et al.: Chfr is required for tumor suppression and Aurora A regulation. Nat. Genet. (2005) 37(4):401-406.
  • ZHANG D, HIROTA T, MARUMOTO T et al.: Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models. Oncogene (2004) 23(54):8720-8730.
  • ANAND S, PENRHYN-LOWE S, VENKITARAMAN AR: AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell (2003) 3(1):51-62.
  • OTA T, SUTO S, KATAYAMA H et al.: Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes to chromosome number instability. Cancer Res. (2002) 62(18):5168-5177.
  • TANNER MM, GRENMAN S, KOUL A et al.: Frequent amplification of chromosomal region 20q12-q13 in ovarian cancer. Clin. Cancer Res. (2000) 6(5):1833-1839.
  • CHUNG CM, MAN C, JIN Y et al.: Amplification and overexpression of aurora kinase A (AURKA) in immortalized human ovarian epithelial (HOSE) cells. Mol. Carcinog. (2005) 43(3):165-174.
  • HU W, KAVANAGH JJ, DEAVER M et al.: Frequent overexpression of STK15/Aurora-A/BTAK and chromosomal instability in tumorigenic cell cultures derived from human ovarian cancer. Oncol. Res. (2005) 15(1):49-57.
  • LANDEN CN, IMMANENI A, DEAVER MT et al.: Overexpression of the centrosomal protein aurora-A kinase is associated with poor prognosis in epithelial ovarian cancer patients. J. Clin. Oncol. (Meeting Abstracts) (2005) 23(16 Suppl.):5039.
  • ROJANALA S, HAN H, MUNOZ RM et al.: The mitotic serine threonine kinase, Aurora-2, is a potential target for drug development in human pancreatic cancer. Mol. Cancer Ther. (2004) 3(4):451-457.
  • MORTLOCK A, KEEN NJ, JUNG FH et al.: Progress in the development of selective inhibitors of Aurora kinases. Curr. Top. Med. Chem. (2005) 5(2):199-213.
  • WARNER SL, MUNOZ RM, KOLLER E et al.: The comparison of aurora A and aurora B as therapeutic targets using antisense oligonucleotides. The 2005 Proceedings of the AACR 96th Annual Meeting, Anaheim, USA (2005) Abstract 591.
  • CAI K, YANG G, ROSEN D et al.: Expression of STK15/BTAK is required for sustained tumor growth through maintenance of genetic stability of cancer cells. The 2005 Proceedings of the AACR 96th Annual Meeting, Anaheim, USA (2005) Abstract 127.
  • MORTLOCK AA, KEEN NJ, JUNG FH et al.: Progress in the development of selective inhibitors of aurora kinases. Curr. Top. Med. Chem. (2005) 5(8):807-821.
  • FANCELLI D, BERTA D, BINDI S et al.: Potent and selective aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition. J. Med. Chem. (2005) 48(8):3080-3084.
  • YANG H, BURKE T, DEMPSEY J et al.: Mitotic requirement for aurora A kinase is bypassed in the absence of aurora B kinase. FEBS Lett. (2005) 579(16):3385-3391.
  • GADEA BB, RUDERMAN JV: Aurora kinase inhibitor ZM447439 blocks chromosome-induced spindle assembly, the completion of chromosome condensation, and the establishment of the spindle integrity checkpoint in Xenopus egg extracts. Mol. Biol. Cell (2005) 16(3):1305-1318.
  • HAUF S, COLE RW, LATERRA S et al.: The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J. Cell. Biol. (2003) 161(2):281-294.
  • SESSA F, MAPELLI M, CIFERRI C et al.: Mechanism of Aurora B Activation by INCENP and Inhibition by Hesperadin. Mol. Cell (2005) 18(3):379-391.
  • HARRINGTON EA, BEBBINGTON D, MOORE J et al.: VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat. Med. (2004) 10(3):262-267.
  • CHEETHAM GM, KNEGTEL RM, COLL JT et al.: Crystal structure of aurora-2, an oncogenic serine/threonine kinase. J. Biol. Chem. (2002) 277(45):42419-42422.
  • HATA T, FURUKAWA T, SUNAMURA M et al.: RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells. Cancer Res. (2005) 65(7):2899-2905.
  • NAIR J, TSE N, KEEN N, SCHWARTZ G: A Novel Aurora B kinase inhibitor with potent anticancer activity either as a single agent or in combination with chemotherapy. JCO ASCO Annual Meeting Proceedings (2004) 22(14S):9568.
  • WARNER SL, BEARSS DJ, HAN H, VON HOFF DD: Targeting Aurora-2 kinase in cancer. Mol. Cancer Ther. (2003) 2(6):589-595.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.