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Review

Targets for regulating angiogenesis in the ageing endothelium

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Pages 1385-1399 | Published online: 26 Oct 2007

Bibliography

  • NAUMOV GN, AKSLEN LA, FOLKMAN J: Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switch. Cell Cycle (2006) 516:1779-1787.
  • CARMELIET P: Angiogenesis in health and disease. Nat. Med. (2003) 96:653-660.
  • REED MJ, EDELBERG JM: Impaired angiogenesis in the aged. Sci. Aging Knowledge Environ. (2004):PE7.
  • RISAU W: Mechanisms of angiogenesis. Nature (1997) 386:671-674.
  • ASAHARA T, MUROHARA, T, SULLIVAN A et al.: Isolation of putative progenitor endothelial cells for angiogenesis. Science (1997) 275:964-967.
  • SHI Q, RAFII S, WU MH et al.: Evidence for circulating bone marrow-derived endothelial cells. Blood (1998) 92:362-367.
  • FORSYTHE JA, JIANG BH, IYER NV et al.: Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. (1996) 16:4604-4613.
  • TOMANEK RJ, ZHENG W: Role of growth factors in coronary morphogenesis. Tex. Heart Inst. J. (2002) 29:250-254.
  • FERRARA N, GERBER HP, LECOUTER J: The biology of VEGF and its receptors. Nat. Med. (2003) 96:669-676.
  • ASAHARA T, MASUDA H, TAKAHASHI T et al.: Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ. Res. (1999) 853:221-228.
  • SHALABY F, ROSSANT J, YAMAGUCHI TP et al.: Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature (1995) 376:62-66.
  • FONG GH, ROSSANT J, GERTSENSTEIN M et al.: Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature (1995) 376(6535):66-70.
  • PEPPER MS, ROSNOBLET C, DI SANZA C et al.: Synergistic induction of t-PA by vascular endothelial growth factor and basic fibroblast growth factor and localization of t-PA to Weibel-Palade bodies in bovine microvascular endothelial cells. Thromb. Haemost. (2001) 862:702-709.
  • POOLE TJ, FINKELSTEIN EB, COX CM: The role of FGF and VEGF in angioblast induction and migration during vascular development. Dev. Dyn. (2001) 2201:1-17.
  • GERWINS P, SKOLDENBERG E, CLAESSON-WELSH L: Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesis. Crit. Rev. Oncol. Hematol. (2000) 343:185-194.
  • PRESTA M, DELL'ERA P, MITOLA S et al.: Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. Cytokine Growth Factor Rev. (2005) 162:159-178.
  • EDELBERG JM, AIRD WC, WU W et al.: PDGF mediates cardiac microvascular communication. J. Clin. Invest. (1998) 102:837-843.
  • EDELBERG JM, LEE SH, KAUR M et al.: Platelet-derived growth factor-AB limits the extent of myocardial infarction in a rat model: feasibility of restoring impaired angiogenic capacity in the aging heart. Circulation (2002) 105:608-613.
  • D'AMORE PA, ITH SR: Growth factor effects on cells of the vascular wall: a survey. Growth Factors (1993) 8:61-75.
  • MORISADA T, KUBOTA Y, URANO T et al.: Angiopoietins and angiopoietin-like proteins in angiogenesis. Endothelium (2006) 13(2):71-79.
  • SATO TN, QIN Y, KOZAK CA et al.: Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system. Proc. Natl. Acad. Sci. USA (1993) 9020:9355-9358.
  • XAYMARDAN M, ZHENG J, DUIGNAN I et al.: Senescent impairment in synergistic cytokine pathways that provide rapid cardioprotection in the rat heart. J. Exp. Med. (2004) 199:797-804.
  • ZHENG J, CHIN A, DUIGNAN I et al.: Growth factor-mediated reversal of senescent dysfunction of ischemia-induced cardioprotection. Am. J. Physiol. Heart Circ. Physiol. (2006) 290:H525-H530.
  • BALLARD VL, SHARMA A, DUIGNAN I et al.: Vascular tenascin-C regulates cardiac endothelial phenotype and neovascularization. FASEB J. (2006) 20:717-719.
  • PEICHEV M, NAIYER AJ, PEREIRA D et al.: Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors. Blood (2000) 95:952-958.
  • JACKSON KA, MAJKA SM, WANG et al.: Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J. Clin. Invest. (2001) 107:1395-1402.
  • ORLIC D, KAJSTURA J, CHIMENTI S et al.: Transplanted adult bone marrow cells repair myocardial infarcts in mice. Ann. NY Acad. Sci. (2001) 938:221-229.
  • BURGER PE, COETZEE S, MCKEEHAN WL et al.: Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cells. Blood (2002) 100:3527-3535.
  • GUPTA R, KARPATKIN S, BASCH RS: Hematopoiesis and stem cell renewal in long-term bone marrow cultures containing catalase. Blood (2006) 1075:1837-1846.
  • SALVEN P, MUSTJOKI S, ALITALO R et al.: VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells. Blood (2003) 101:168-172.
  • RIBATTI D: The discovery of endothelial progenitor cells. An historical review. Leuk. Res. (2005) 31:439-444.
  • HRISTOV M, ERL W, WEBER PC: Endothelial progenitor cells: mobilization, differentiation, and homing. Arterioscler. Thromb. Vasc. Biol. (2003) 101:168-172.
  • STREHLOW K, WERNER N, BERWEILER J et al.: Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation. Circulation (2003) 107:3059-3065.
  • IWAKURA A, LUEDEMANN C, SHASTRY S et al.: Estrogen-mediated, endothelial nitric oxide synthase-dependent mobilization of bone marrow-derived endothelial progenitor cells contributes to reendothelialization after arterial injury. Circulation (2003) 108:3115-3121.
  • PAPAPETROPOULOS A, GARCIA-CARDENA G, MADRI JA et al.: Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J. Clin. Invest. (1997) 10012:3131-3139.
  • LANTIN-HERMOSO RL, ROSENFELD CR, YUHANNA IS et al.: Estrogen acutely stimulates nitric oxide synthase activity in fetal pulmonary artery endothelium. Am. J. Physiol. (1997) 2731(Part 1):L119-L126.
  • COCKCROFT JR: Exploring vascular benefits of endothelium-derived nitric oxide. Am. J. Hypertens. (2005) 1812(Part 2):S177-S183.
  • LAUFS U, WERNER N, LINK A et al.: Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation (2004) 109:220-226.
  • DIGNAT-GEORGE F, SAMPOL J: Circulating endothelial cells in vascular disorders: new insights into an old concept. Eur. J. Haematol. (2000) 654:215-220.
  • ADAMS V, LENK K, LINKE A et al.: Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia. Arterioscler. Thromb. Vasc. Biol. (2004) 244:684-690.
  • SHINTANI S, MUROHARA T, IKEDA H et al.: Mobilization of endothelial progenitor cells in patients with acute myocardial infarction. Circulation (2001) 103:2776-2779.
  • GILL M, DIAS S, HATTORI K et al.: Vascular trauma induces rapid but transient mobilization of VEGFR2+AC133+ endothelial precursor cells. Circ. Res. (2001) 88:167-174.
  • HEISSIG B, HATTORI K, DIAS S et al.: Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell (2002) 109:625-637.
  • SMADJA DM, BIECHE I, UZAN G et al.: PAR-1 activation on human late endothelial progenitor cells enhances angiogenesis in vitro with upregulation of the SDF-1/CXCR4 system. Arterioscler. Thromb. Vasc. Biol. (2005) 25:2321-2327.
  • TAKAHASHI T, KALKA C, MASUDA H et al.: Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat. Med. (1999) 5:434-438.
  • LOOMANS CJ, WAN H, DE CROM R et al.: Angiogenic murine endothelial progenitor cells are derived from a myeloid bone marrow fraction and can be identified by endothelial NO synthase expression. Arterioscler. Thromb. Vasc. Biol. (2006) 268:1760-1767.
  • WOO YJ, GRAND TJ, BERRY MF et al.: Stromal cell-derived factor and granulocyte–monocyte colony-stimulating factor form a combined neovasculogenic therapy for ischemic cardiomyopathy. J. Thorac. Cardiovasc. Surg. (2005) 130:321-329.
  • DREXLER H, MEYER GP, WOLLERT KC: Bone-marrow-derived cell transfer after ST-elevation myocardial infarction: lessons from the BOOST trial. Nat. Clin. Pract. Cardiovasc. Med. (2006) 3(Suppl. 1):S65-S68.
  • KALKA C, MASUDA H, TAKAHASHI T et al.: Vascular endothelial growth factor165 gene transfer augments circulating endothelial progenitor cells in human subjects. Circ. Res. (2000) 86:1198-1202.
  • KALKA C, TEHRANI H, LAUDENBERG B: VEGF gene transfer mobilizes endothelial progenitor cells in patients with inoperable coronary disease. Ann. Thorac. Surg. (2000) 70:829-834.
  • HATTORI K, DIAS S, HEISSIG B et al.: Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells. J. Exp. Med. (2001) 193:1005-1014.
  • IWAGURO H, YAMAGUCHI J, KALKA C et al.: Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration. Circulation (2002) 105:732-738.
  • TAKAHASHI T, KALKA C, MASUDA H et al.: Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat. Med. (1999) 54:434-438.
  • YAMAGUCHI J, KUSANO KF, MASUO O et al.: Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation (2003) 107:1322-1328.
  • ASKARI AT, UNZEK S, POPOVIC ZB et al.: Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy. Lancet (2003) 362:697-703.
  • ZIEGELHOEFFER T, FERNANDEZ B, KOSTIN S et al.: Bone marrow-derived cells do not incorporate into the adult growing vasculature. Circ. Res. (2004) 94:230-238.
  • KINNAIRD T, STABILE E, BURNETT MS et al.: Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ. Res. (2004) 94:678-685.
  • KINNAIRD T, STABILE E, BURNETT MS et al.: Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation (2004) 109:1543-1549.
  • URBICH C, AICHER A, HEESCHEN C et al.: Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. J. Mol. Cell. Cardiol. (2005) 39:733-742.
  • ZENGIN E, CHALAJOUR F, GEHLING UM et al.: Vascular wall resident progenitor cells: a source for postnatal vasculogenesis. Development (2006) 133:1543-1551.
  • KORDES C, SAWITZA I, MULLER-MARBACH A et al.: CD133+ hepatic stellate cells are progenitor cells. Biochem. Biophys. Res. Commun. (2007) 352:410-417.
  • MARTINEZ-ESTRADA OM, MUNOZ-SANTOS Y, JULVE J et al.: Human adipose tissue as a source of Flk-1+ cells: new method of differentiation and expansion. Cardiovasc. Res. (2005) 65:328-333.
  • BELTRAMI AP, BARLUCCHI L, TORELLA D et al.: Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell (2003) 114:763-776.
  • ZWAGINGA JJ, DOEVENDANS P: Stem cell-derived angiogenic/vasculogenic cells: possible therapies for tissue repair and tissue engineering Clin. Exp. Pharmacol. Physiol. (2003) 3011:900-908.
  • FAN CL, LI Y, GAO PJ et al.: Differentiation of endothelial progenitor cells from human umbilical cord blood CD 34+ cells in vitro. Acta Pharmacol. Sin. (2003) 243:212-218.
  • LU SJ, FENG Q, CABALLERO S et al.: Generation of functional hemangioblasts from human embryonic stem cells. Nat. Methods (2007) 46:501-509.
  • MUROHARA T: Therapeutic vasculogenesis using human cord blood-derived endothelial progenitors. Trends Cardiovasc. Med. (2001) 118:303-307.
  • ZHANG L, YANG R, HAN ZC: Transplantation of umbilical cord blood-derived endothelial progenitor cells: a promising method of therapeutic revascularisation. Eur. J. Haematol. (2006) 761:1-8.
  • EDELBERG JM, REED MJ: Aging and angiogenesis. Front. Biosci. (2003) 8:S1199-1209.
  • WANG H, KEISER JA, OLSZEWSKI B et al.: Delayed angiogenesis in aging rats and therapeutic effect of adenoviral gene transfer of VEGF. Int. J. Mol. Med. (2004) 13:581-587.
  • REED MJ, CORSA AC, KUDRAVI SA et al.: A deficit in collagenase activity contributes to impaired migration of aged microvascular endothelial cells. J. Cell Biochem. (2000) 77:116-126.
  • ARTHUR WT, VERNON RB, SAGE EH et al.: Growth factors reverse the impaired sprouting of microvessels from aged mice. Microvasc. Res. (1998) 55:260-270.
  • KANG DH, ANDERSON S, KIM YG et al.: Impaired angiogenesis in the aging kidney: vascular endothelial growth factor and thrombospondin-1 in renal disease. Am. J. Kidney Dis. (2001) 37:601-611.
  • KALARIA RN: The role of cerebral ischemia in Alzheimer's disease. Neurobiol. Aging (2000) 212:321-330.
  • BACH MH, SADOUN E, REED MJ: Defects in activation of nitric oxide synthases occur during delayed angiogenesis in aging. Mech. Ageing Dev. (2005) 1264:467-473.
  • HULLEY S, GRADY D, BUSH T et al.: Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and estrogen/progestin replacement study HERS research group. JAMA (1998) 2807:605-613.
  • ROSSOUW JE, ANDERSON GL, PRENTICE RL et al.: Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial. JAMA (2002) 2883:321-333.
  • WASSERTHEIL-SMOLLER S, HENDRIX SL, LIMACHER M et al.: Effect of estrogen plus progestin on stroke in postmenopausal women: the women's health initiative: a randomized trial. JAMA (2003) 28920:2673-2684.
  • RIVARD A, BERTHOU-SOULIE L, PRINCIPE N et al.: Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity. J. Biol. Chem. (2000) 275:29643-29647.
  • GREB RR, MAIER I, WALLWIENER D et al.: Vascular endothelial growth factor A (VEGF-A) mRNA expression levels decrease after menopause in normal breast tissue but not in breast cancer lesions. Br. J. Cancer (1999) 81:225-231.
  • RIVARD A, FABRE JE, SILVER M et al.: Age-dependent impairment of angiogenesis. Circulation (1999) 99:111-120.
  • SWIFT ME, KLEINMAN HK, DIPIETRO LA: Impaired wound repair and delayed angiogenesis in aged mice. Lab. Invest. (1999) 79:479-447.
  • POLA R, APRAHAMIAN TR, BOSCH-MARCE M et al.: Age-dependent VEGF expression and intraneural neovascularization during regeneration of peripheral nerves. Neurobiol. Aging (2004) 25:1361-1368.
  • ZHU WH, IURLARO M, MACINTYRE A et al.: The mouse aorta model: influence of genetic background and aging on bFGF- and VEGF-induced angiogenic sprouting. Angiogenesis (2003) 6:193-199.
  • PHILLIPS GD, STONE AM: PDGF-BB induced chemotaxis is impaired in aged capillary endothelial cells. Mech. Ageing Dev. (1994) 73:189-196.
  • DING YH, LI J, ZHOU Y et al.: Cerebral angiogenesis and expression of angiogenic factors in aging rats after exercise. Curr. Neurovasc. Res. (2006) 3:15-23.
  • HILL JM, ZALOS G, HALCOX JP et al.: Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N. Engl. J. Med. (2003) 348:593-600.
  • VASA M, FICHTLSCHERER S, AICHER A et al.: Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ. Res. (2001) 89:E1-E7.
  • HEISS C, KEYMEL S, NIESLER U et al.: Impaired progenitor cell activity in age-related endothelial dysfunction. J. Am. Coll. Cardiol. (2005) 459:1441-1448.
  • SHIMADA T, TAKESHITA Y, MUROHARA T et al.: Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse. Circulation (2004) 1109:1148-1155.
  • ASHCROFT GS, HORAN MA, FERGUSON MW: The effects of ageing on cutaneous wound healing in mammals. J. Anat. (1995) 187:1-26.
  • LI A, FROEHLICH J, GALIS ZS, LAKATTA, EG: Increased expression of matrix metalloproteinases: structure, function and biochemistry. Hypertension (1999) 33:116-123.
  • KOIKE T, VERNON R, GOODEN M, SADOUN E, REED M: Inhibited angiogenesis in aging: a role for TIMP2. J. Gerontol. A Biol. Sci. Med. Sci. (2003) 58:B798-B805.
  • LERI A, MALHOTRA A, LIEW CC et al.: Telomerase activity in rat cardiac myocytes is age and gender dependent. J. Mol. Cell. Cardiol. (2000) 32:385-390.
  • FRANCO S, SEGURA I, RIESE HH et al.: Decreased B16F10 melanoma growth and impaired vascularization in telomerase-deficient mice with critically short telomeres. Cancer Res. (2002) 62:552-559.
  • HERBIG U, SEDIVY JM: Regulation of growth arrest in senescence: telomere damage is not the end of the story. Mech. Ageing Dev. (2006) 127:16-24.
  • MARTIN I, GROTEWIEL MS: Oxidative damage and age-related functional declines. Mech. Ageing Dev. (2006) 127:411-423.
  • KAMMINGA LM, DE HAAN G: Cellular memory and hematopoietic stem cell memory. Stem Cells (2006) 24:1143-1149.
  • ANVERSA P, ROTA M, URBANEK K et al.: Myocardial aging – a stem cell problem. Basic Res. Cardiol. (2005) 100:482-493.
  • TORELLA D, ROTA M, NURZYNSKA D et al.: Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circ. Res. (2004) 94:514-524.
  • YLA-HERTTUALA S, RISSANEN TT, VAJANTO I et al.: Vascular endothelial growth factors: biology and current status of clinical applications in cardiovascular medicine. J. Am. Coll. Cardiol. (2007) 4910:1015-1026.
  • GRINES C, RUBANYI GM, KLEIMAN NS et al.: Angiogenic gene therapy with adenovirus 5 fibroblast growth factor-4 Ad5FGF-4: a new option for the treatment of coronary artery disease. Am. J. Cardiol. (2003) 929B:N24-N31.
  • ROSSOUW JE: Effect of postmenopausal hormone therapy on cardiovascular risk. J. Hypertens. Suppl. (2002) 202:S62-S65.
  • KEECH CA, SASHEGYI A, BARRETT-CONNOR E: Year-by-year analysis of cardiovascular events in the multiple outcomes of raloxifene evaluation MORE trial. Curr. Med. Res. Opin. (2005) 1:135-140.
  • RAY PS, MAULIK G, CORDIS GA et al.: The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury. Free Radic. Biol. Med. (1999) 271-272:160-169.
  • SATO M, MAULIK N, DAS DK: Cardioprotection with alcohol: role of both alcohol and polyphenolic antioxidants. Ann. NY Acad. Sci. (2002) 957:122-135.
  • KLINGE CM, BLANKENSHIP KA, RISINGER KE et al.: Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors α and β in endothelial cells. J. Biol. Chem. (2005) 2809:7460-7468.
  • SPYRIDOPOULOS I, HAENDELER J, URBICH C et al.: Statins enhance migratory capacity by upregulation of the telomere repeat-binding factor TRF2 in endothelial progenitor cells. Circulation (2004) 110:3136-3142.
  • KUREISHI Y, LUO Z, SHIOJIMA I et al.: The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat. Med. (2000) 6:1004-1010.
  • GERBER HP, MCMURTREY A, KOWALSKI J et al.: Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J. Biol. Chem. (1998) 273:30336-30343.
  • EDELBERG JM, TANG L, HATTORI K et al.: Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function. Circ. Res. (2002) 90:E89-E93.
  • KLIBANSKY DA, CHIN A, DUIGNAN IJ et al.: Synergistic targeting with bone marrow-derived cells and PDGF improves diabetic vascular function. Am. J. Physiol. Heart Circ. Physiol. (2006) 290:H1387-H1392.
  • STRAUER BE, BREHM M, ZEUS T et al.: Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation (2002) 106:1913-1918.
  • ASSMUS B, SCHACHINGER V, TEUPE C et al.: Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction TOPCARE-AMI. Circulation (2002) 106:3009-3017.
  • WOLLERT KC, MEYER GP, LOTZ J et al.: Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet (2004) 364:141-148.
  • BRITTEN MB, ABOLMAALI ND, ASSMUS B et al.: Infarct remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction TOPCARE-AMI: mechanistic insights from serial contrast-enhanced magnetic resonance imaging. Circulation (2003) 108:2212-2218.
  • SCHACHINGER V, ASSMUS B, BRITTEN MB et al.: Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI trial. J. Am. Coll. Cardiol. (2004) 448:1690-1699.
  • MEYER GP, WOLLERT KC, DREXLER H: Stem cell therapy: a new perspective in the treatment of patients with acute myocardial infarction. Eur. J. Med. Res. (2006) 1110:439-446.
  • POMPILIO G, CANNATA A, PECCATORI F et al.: Autologous peripheral blood stem cell transplantation for myocardial regeneration: a novel strategy for cell collection and surgical injection. Ann. Thorac. Surg. (2004) 785:1808-1812.
  • STAMM C, KLEINE HD, CHOI YH et al.: Intramyocardial delivery of CD133+ bone marrow cells and coronary artery bypass grafting for chronic ischemic heart disease: safety and efficacy studies. J. Thorac. Cardiovasc. Surg. (2007) 1333:717-725.
  • BAUMGARTNER I, PIECZEK A, MANOR O et al.: Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. Circulation (1998) 97:1114-1123.
  • ISNER JM, PIECZEK A, SCHAINFELD R et al.: Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb. Lancet (1996) 348:370-374.
  • LOSORDO DW, VALE PR, ISNER JM: Gene therapy for myocardial angiogenesis. Am. Heart J. (1999) 138:S132-S141.
  • SYMES JF, LOSORDO DW, VALE PR et al.: Gene therapy with vascular endothelial growth factor for inoperable coronary artery disease. Ann. Thorac. Surg. (1999) 68:830-837.
  • XU HX, LI GS, JIANG H et al.: Implantation of BM cells transfected with phVEGF165 enhances functional improvement of the infarcted heart. Cytotherapy (2004) 6:204-211.
  • POWELL TM, PAUL JD, HILL JM et al.: Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease. Arterioscler. Thromb. Vasc. Biol. (2005) 252:296-301.
  • OZBARAN M, OMAY SB, NALBANTGIL S et al.: Autologous peripheral stem cell transplantation in patients with congestive heart failure due to ischemic heart disease. Eur. J. Cardiothorac. Surg. (2004) 253:3423-3450.
  • KANG HJ, KIM HS, ZHANG SY et al.: Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial. Lancet (2004) 3639411:751-756.
  • POMPILIO G, CANNATA A, PECCATORI F et al.: Autologous peripheral blood stem cell transplantation for myocardial regeneration: a novel strategy for cell collection and surgical injection. Ann. Thorac. Surg. (2004) 785:1808-1812.

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