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Review

Eag1 as a cancer target

, MD PhD & , PhD
Pages 837-843 | Published online: 13 Jun 2008

Bibliography

  • DeCoursey TE, Chandy KG, Gupta S, et al. Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis? Nature 1984;307:465-8
  • Villalonga N, Ferreres JC, Argiles JM, et al. Potassium channels are a new target field in anticancer drug design. Recent Patents Anticancer Drug Discov 2007;2:212-23
  • Le Guennec JY, Ouadid-Ahidouch H, Soriani O, et al. Voltage-gated ion channels, new targets in anti-cancer research. Recent Patents Anticancer Drug Discov 2007;2:189-202
  • Stühmer W, Alves F, Hartung F, et al. Potassium channels as tumour markers. FEBS Lett 2006;580:2850-2
  • Felipe A, Vicente R, Villalonga N, et al. Potassium channels: new targets in cancer therapy. Cancer Detect Prev 2006;30:375-85
  • Camacho J. Ether a go-go potassium channels and cancer. Cancer Lett 2006;233:1-9
  • Pardo LA, Contreras-Jurado C, Zientkowska M, et al. Role of voltage-gated potassium channels in cancer. J Membr Biol 2005;205:115-24
  • Kunzelmann K. Ion channels and cancer. J Membr Biol 2005;205:159-73
  • Conti M. Targeting K+ channels for cancer therapy. J Exp Ther Oncol 2004;4:161-66
  • Kaplan WD, Trout WE 3rd. The behavior of four neurological mutants of Drosophila. Genetics 1969;61:399-409
  • Warmke J, Drysdale R, Ganetzky B. A distinct potassium channel polypeptide encoded by the Drosophila eag locus. Science 1991;252:1560-2
  • Zhong Y, Wu CF. Alteration of four identified K+ currents in Drosophila muscle by mutations in eag. Science 1991;252:1562-4
  • Drysdale R, Warmke J, Kreber R, et al. Molecular characterization of eag: a gene affecting potassium channels in Drosophila melanogaster. Genetics 1991;127:497-505
  • Brüggemann A, Pardo LA, Stühmer W, et al. Ether-à-go-go encodes a voltage-gated channel permeable to K+ and Ca2+ and modulated by cAMP. Nature 1993;365:445-8
  • Ganetzky B, Robertson GA, Wilson GF, et al. The eag family of K+ channels in Drosophila and mammals. Ann NY Acad Sci 1999;868:356-69
  • Gutman GA, Chandy KG, Grissmer S, et al. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev 2005;57:473-508
  • Bauer CK, Schwarz JR. Physiology of EAG K+ channels. J Membr Biol 2001;182:1-15
  • Cabral JHM, Lee A, Cohen SL, et al. Crystal structure and functional analysis of the HERG potassium channel N terminus – a eukaryotic PAS domain. Cell 1998;95:649-55
  • Schönherr R, Lober K, Heinemann SH. Inhibition of human ether a go-go potassium channels by Ca(2+)/calmodulin. EMBO J 2000;19:3263-71
  • Jenke M, Sánchez A, Monje F, et al. C-terminal domains implicated in the functional surface expression of potassium channels. EMBO J 2003;22:395-403
  • Wilson GF, Wang Z, Chouinard SW, et al. Interaction of the K channel β subunit, hyperkinetic, with eag family members. J Biol Chem 1998;273:6389-94
  • Piros ET, Shen L, Huang XY. Purification of an EH domain-binding protein from rat brain that modulates the gating of the rat ether-a-go-go channel. J Biol Chem 1999;274:33677-83
  • Schopperle WM, Holmqvist MH, Zhou Y, et al. Slob, a novel protein that interacts with the Slowpoke calcium-dependent potassium channel. Neuron 1998;20:565-73
  • Hoshi N, Takahashi H, Shahidullah M, et al. KCR1, a membrane protein that facilitates functional expression of non-inactivating K+ currents associates with rat EAG voltage-dependent K+ channels. J Biol Chem 1998;273:23080-5
  • Stansfeld CE, Roper J, Ludwig J, et al. Elevation of intracellular calcium by muscarinic receptor activation induces a block of voltage-activated rat ether-a-go-go channels in a stably transfected cell line. Proc Natl Acad Sci USA 1996;93:9910-4
  • Ziechner U, Schönherr R, Born AK, et al. Inhibition of human ether a go-go potassium channels by Ca2+/calmodulin binding to the cytosolic N- and C-termini. FEBS J 2006;273:1074-86
  • Cole KS, Moore JW. Potassium ion current in the squid giant axon: dynamic characteristic. Biophys J 1960;1:1-4
  • Ludwig J, Terlau H, Wunder F, et al. Functional expression of a rat homologue of the voltage gated either a go-go potassium channel reveals differences in selectivity and activation kinetics between the Drosophila channel and its mammalian counterpart. EMBO J 1994;13:4451-8
  • Ludwig J, Weseloh R, Karschin C, et al. Cloning and functional expression of rat eag2, a new member of the ether-a-go-go family of potassium channels and comparison of its distribution with that of eag1. Mol Cell Neurosci 2000;16:59-70
  • Ju M, Wray D. Molecular identification and characterisation of the human eag2 potassium channel. FEBS Lett 2002;524:204-10
  • Schönherr R, Gessner G, Lober K, et al. Functional distinction of human EAG1 and EAG2 potassium channels. FEBS Lett 2002;514:204-8
  • Terlau H, Ludwig J, Steffan R, et al. Extracellular Mg2+ regulates activation of rat eag potassium channel. Pflugers Arch Eur J Physiol 1996;432:301-12
  • Wray D. The roles of intracellular regions in the activation of voltage-dependent potassium channels. Eur Biophys J 2004;33:194-200
  • Napp J, Monje F, Stühmer W, et al. Glycosylation of Eag1 (Kv10.1) potassium channels: intracellular trafficking and functional consequences. J Biol Chem 2005;280:29506-12
  • Bijlenga P, Occhiodoro T, Liu JH, et al. An ether-a-go-go K+ current, ih-eag, contributes to the hyperpolarization of human fusion-competent myoblasts. J Physiol (Lond) 1998;512:317-23
  • Liu JH, Bijlenga P, Fischer-Lougheed J, et al. Role of an inward rectifier K+ current and of hyperpolarization in human myoblast fusion. J Physiol 1998;510:467-76
  • Occhiodoro T, Bernheim L, Liu JH, et al. Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion. FEBS Lett 1998;434:177-82
  • Pardo LA, del Camino D, Sánchez A, et al. Oncogenic potential of EAG K(+) channels. EMBO J 1999;18:5540-7
  • Hemmerlein B, Weseloh RM, Mello de Queiroz F, et al. Overexpression of Eag1 potassium channels in clinical tumours. Mol Cancer 2006;5:41. Published online 5 October 2006, doi:10.1186/1476-4598-5-41
  • Spitzner M, Martins JR, Barro-Soria R, et al. Eag1 and Bestrophin 1 are upregulated in fast growing colonic cancer cells. J Biol Chem 2008
  • Ousingsawat J, Spitzner M, Schreiber R, et al. Upregulation of colonic ion channels in APC (Min/+) mice. Pflugers Arch 2008
  • Ouadid-Ahidouch H, Ahidouch A. K(+) channel expression in human breast cancer cells: involvement in cell cycle regulation and carcinogenesis. J Membr Biol 2008;221:1-6
  • Ouadid-Ahidouch H, Le Bourhis X, Roudbaraki M, et al. Changes in the K+ current-density of MCF-7 cells during progression through the cell cycle: possible involvement of a h-ether.a-gogo K+ channel. Recept Channels 2001;7:345-56
  • Ouadid-Ahidouch H, Van Coppenolle F, Le Bourhis X, et al. Potassium channels in rat prostate epithelial cells. FEBS Lett 1999;459:15-21
  • Meyer R, Schönherr R, Gavrilova-Ruch O, et al. Identification of ether a go-go and calcium-activated potassium channels in human melanoma cells. J Membr Biol 1999;171:107-15
  • Meyer R, Heinemann SH. Characterization of an eag-like potassium channel in human neuroblastoma cells. J Physiol 1998;508:49-56
  • Mello de Queiroz F, Suarez-Kurtz G, Stühmer W, et al. Ether a go-go potassium channel expression in soft tissue sarcoma patients. Mol Cancer 2006;5:42
  • Farias LM, Ocana DB, Diaz L, et al. Ether a go-go potassium channels as human cervical cancer markers. Cancer Res 2004;64:6996-7001
  • Ding XW, Yan JJ, An P, et al. Aberrant expression of ether a go-go potassium channel in colorectal cancer patients and cell lines. World J Gastroenterol 2007;13:1257-61
  • Ousingsawat J, Spitzner M, Puntheeranurak S, et al. Expression of voltage-gated potassium channels in human and mouse colonic carcinoma. Clin Cancer Res 2007;13:824-31
  • Ding XW, Luo HS, Jin X, et al. Aberrant expression of Eag1 potassium channels in gastric cancer patients and cell lines. Med Oncol 2007;24:345-50
  • Ding XW, Wang XG, Luo HS, et al. Expression and prognostic roles of Eag1 in resected esophageal squamous cell carcinomas. Dig Dis Sci 2007. Published online 15 December 2007, doi:10.1007/s10620-007-0116-7
  • Smith GAM, Tsui HW, Newell EW, et al. Functional up-regulation of HERG K+ channels in neoplastic hematopoietic cells. J Biol Chem 2002;277:18528-34
  • Patt S, Preussat K, Beetz C, et al. Expression of ether a go-go potassium channels in human gliomas. Neurosci Lett 2004;368:249-53
  • Brüggemann A, Stühmer W, Pardo LA. Mitosis-promoting factor-mediated suppression of a cloned delayed rectifier potassium channel expressed in Xenopus oocytes. Proc Natl Acad Sci USA 1997;94:537-42
  • Pardo LA, Brüggemann A, Camacho J, et al. Cell cycle-related changes in the conducting properties of r-eag K+ channels. J Cell Biol 1998;143:767-75
  • Camacho J, Sánchez A, Stühmer W, et al. Cytoskeletal interactions determine the electrophysiological properties of human EAG potassium channels. Pflugers Arch 2000;441:167-74
  • Borowiec AS, Hague F, Harir N, et al. IGF-1 activates hEAG K(+) channels through an Akt-dependent signaling pathway in breast cancer cells: role in cell proliferation. J Cell Physiol 2007;212:690-701
  • Weber C, Mello de Queiroz F, Downie B, et al. Silencing the activity and proliferative properties of the human Eag1 potassium channel by RNAi. J Biol Chem 2006;281:13033-7
  • Toral C, Mendoza-Garrido ME, Azorin E, et al. Effect of extracellular matrix on adhesion, viability, actin cytoskeleton and K+ currents of cells expressing human ether a go-go channels. Life Sci 2007;81:255-65
  • Gavrilova-Ruch O, Schönherr R, Heinemann SH. Activation of hEAG1 potassium channels by arachidonic acid. Pflugers Arch 2007;453:891-903
  • García-Ferreiro RE, Kerschensteiner D, Major F, et al. Mechanism of block of hEag1 K+ channels by imipramine and astemizole. J Gen Physiol 2004;124:301-17
  • Gavrilova-Ruch O, Schönherr K, Gessner G, et al. Effects of imipramine on ion channels and proliferation of IGR1 melanoma cells. J Membr Biol 2002;188:137-49
  • Suessbrich H, Waldegger S, Lang F, et al. Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole. FEBS Lett 1996;385:77-80
  • Teschemacher AG, Seward EP, Hancox JC, et al. Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline. Br J Pharmacol 1999;128:479-85
  • Sanguinetti MC, Tristani-Firouzi M. hERG potassium channels and cardiac arrhythmia. Nature 2006;440:463-9
  • Xu SZ, Zeng F, Lei M, et al. Generation of functional ion-channel tools by E3 targeting. Nat Biotechnol 2005;23:1289-93
  • Gómez-Varela D, Zwick-Wallasch E, Knötgen H, et al. Monoclonal antibody blockade of the human Eag1 potassium channel function exerts antitumor activity. Cancer Res 2007;67:7343-9
  • Pardo LA, Stühmer W. Eag1: an arising oncological target. Cancer Res 2008;68:1611-3
  • Lindquist M, Edwards IR. Risks of non-sedating antihistamines. Lancet 1997;349:1322
  • Chong CR, Chen X, Shi L, et al. A clinical drug library screen identifies astemizole as an antimalarial agent. Nat Chem Biol 2006;2:415-6
  • Dalton S, Johansen C, Mellemkjaer L, et al. Antidepressant medications and risk for cancer. Epidemiology 2000;11:171-6
  • Basso A, Depiante-Depaoli M, Molina V. Chronic variable stress facilitates tumoral growth: reversal by imipramine administration. Life Sci 1992;50:1789-96
  • Beeton C, Pennington MW, Wulff H, et al. Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases. Mol Pharmacol 2005;67:1369-81
  • Soroceanu L, Gillespie Y, Khazaeli MB, et al. Use of chlorotoxin for targeting of primary brain tumors. Cancer Res 1998;58:4871-9

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