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Expert Opinion on Therapeutic Targets Volume 12, 2008 - Issue 8
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Review

Netrin-1 and its receptors in tumour growth promotion

Agnès Bernet Université de Lyon, Apoptosis, Cancer and Development Laboratory, Equipe labellisée ‘La Ligue’, CNRS UMR5238, Centre Léon Bérard, 69008 Lyon, France +33 (0)4 78785128; +33 (0)4 78782887; [email protected]
&
Julien Fitamant Université de Lyon, Apoptosis, Cancer and Development Laboratory, Equipe labellisée ‘La Ligue’, CNRS UMR5238, Centre Léon Bérard, 69008 Lyon, France +33 (0)4 78785128; +33 (0)4 78782887; [email protected]
Pages 995-1007 | Published online: 12 Jul 2008

Bibliography

  • Fearon ER, Cho KR, Nigro JM, et al. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 1990;247(4938):49-56
  • Mehlen P, Thibert C. Dependence receptors: between life and death. Cell Mol Life Sci 2004;61(15):1854-66
  • Rabizadeh S, Oh J, Zhong LT, et al. Induction of apoptosis by the low-affinity NGF receptor. Science 1993;261(5119):345-8
  • Ellerby LM, Hackam AS, Propp SS, et al. Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity. J Neurochem 1999;72(1):185-95
  • Mehlen P, Rabizadeh S, Snipas SJ, et al. The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature 1998;395(6704):801-4
  • Bordeaux MC, Forcet C, Granger L, et al. The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease. EMBO J 2000;19(15):4056-63
  • Llambi F, Causeret F, Bloch-Gallego E, Mehlen P. Netrin-1 acts as a survival factor via its receptors UNC5H and DCC. EMBO J 2001;20(11):2715-22
  • Thibert C, Teillet MA, Lapointe F, et al. Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog. Science 2003;301(5634):843-6
  • Matsunaga E, Tauszig-Delamasure S, Monnier PP, et al. RGM and its receptor neogenin regulate neuronal survival. Nat Cell Biol 2004;6(8):749-55
  • Stupack DG, Puente XS, Boutsaboualoy S, et al. Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J Cell Biol 2001;155(3):459-70
  • Mourali J, Benard A, Lourenco FC, et al. Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage. Mol Cell Biol 2006;26(16):6209-22
  • Tauszig-Delamasure S, Yu LY, Cabrera JR, et al. The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm. Proc Natl Acad Sci USA 2007;104(33):13361-6
  • Barallobre MJ, Pascual M, Del Rio JA, Soriano E. The netrin family of guidance factors: emphasis on netrin-1 signalling. Brain Res Brain Res Rev 2005;49(1):22-47
  • Ishii N, Wadsworth WG, Stern BD, et al. UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans. Neuron 1992;9(5):873-81
  • Arakawa H. Netrin-1 and its receptors in tumorigenesis. Nat Rev Cancer 2004;4(12):978-87
  • Stein E, Zou Y, Poo M, Tessier-Lavigne M. Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation. Science 2001;291(5510):1976-82
  • Yebra M, Montgomery AM, Diaferia GR, et al. Recognition of the neural chemoattractant Netrin-1 by integrins α6β4 and α3β1 regulates epithelial cell adhesion and migration. Dev Cell 2003;5(5):695-707
  • Kruger RP, Lee J, Li W, Guan KL. Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation. J Neurosci 2004;24(48):10826-34
  • Hinck L. The versatile roles of “axon guidance” cues in tissue morphogenesis. Dev Cell 2004;7(6):783-93
  • Hong K, Hinck L, Nishiyama M, et al. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell 1999;97(7):927-41
  • Manitt C, Kennedy TE. Where the rubber meets the road: netrin expression and function in developing and adult nervous systems. Prog Brain Res 2002;137:425-42
  • Conrad S, Genth H, Hofmann F, et al. Neogenin-RGMa signaling at the growth cone is bone morphogenetic protein-independent and involves RhoA, ROCK, and PKC. J Biol Chem 2007;282(22):16423-33
  • Matsunaga E, Nakamura H, Chedotal A. Repulsive guidance molecule plays multiple roles in neuronal differentiation and axon guidance. J Neurosci 2006;26(22):6082-8
  • Rajagopalan S, Deitinghoff L, Davis D, et al. Neogenin mediates the action of repulsive guidance molecule. Nat Cell Biol 2004;6(8):756-62
  • Forcet C, Ye X, Granger L, et al. The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation. Proc Natl Acad Sci USA 2001;98(6):3416-21
  • Liu J, Yao F, Wu R, et al. Mediation of the DCC apoptotic signal by DIP13α. J Biol Chem 2002;277(29):26281-5
  • Zimmermann KC, Green DR. How cells die: apoptosis pathways. J Allergy Clin Immunol 2001;108(4 Suppl):S99-103
  • Williams ME, Strickland P, Watanabe K, Hinck L. UNC5H1 induces apoptosis via its juxtamembrane domain through an interaction with NRAGE. J Biol Chem 2003;278(19):17483-90
  • Xie Y. Phosphatidylinositol transfer protein a in netrin-1-induced PLC signaling and neurite outgrowth. Nat Cell Biol 2005;7(11):1124-32
  • Mehlen P, Furne C. Netrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesis. Cell Mol Life Sci 2005;62(22):2599-616
  • Cirulli V, Yebra M. Netrins: beyond the brain. Nat Rev Mol Cell Biol 2007;8(4):296-306
  • Kennedy TE, Wang H, Marshall W, Tessier-Lavigne M. Axon guidance by diffusible chemoattractants: a gradient of netrin protein in the developing spinal cord. J Neurosci 2006;26(34):8866-74
  • Tessier-Lavigne M, Placzek M, Lumsden AG, et al. Chemotropic guidance of developing axons in the mammalian central nervous system. Nature 1988;336(6201):775-8
  • Serafini T, Colamarino SA, Leonardo ED, et al. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell 1996;87(6):1001-14
  • Baker KA, Moore SW, Jarjour AA, Kennedy TE. When a diffusible axon guidance cue stops diffusing: roles for netrins in adhesion and morphogenesis. Curr Opin Neurobiol 2006;16(5):529-34
  • Deiner MS, Kennedy TE, Fazeli A, et al. Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia. Neuron 1997;19(3):575-89
  • Mitchell KJ, Doyle JL, Serafini T, et al. Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons. Neuron 1996;17(2):203-15
  • Winberg ML, Mitchell KJ, Goodman CS. Genetic analysis of the mechanisms controlling target selection: complementary and combinatorial functions of netrins, semaphorins, and IgCAMs. Cell 1998;93(4):581-91
  • Hedgecock EM, Culotti JG, Hall DH. The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron 1990;4(1):61-85
  • Jiang Y, Liu MT, Gershon MD. Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas. Dev Biol 2003;258(2):364-84
  • Liu Y, Stein E, Oliver T, et al. Novel role for netrins in regulating epithelial behavior during lung branching morphogenesis. Curr Biol 2004;14(10):897-905
  • Srinivasan K, Strickland P, Valdes A, et al. Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis. Dev Cell 2003;4(3):371-82
  • De Breuck S, Lardon J, Rooman I, Bouwens L. Netrin-1 expression in fetal and regenerating rat pancreas and its effect on the migration of human pancreatic duct and porcine islet precursor cells. Diabetologia 2003;46(7):926-33
  • Shekarabi M, Moore SW, Tritsch NX, et al. Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion. J Neurosci 2005;25(12):3132-41
  • Dalvin S, Anselmo MA, Prodhan P, et al. Expression of Netrin-1 and its two receptors DCC and UNC5H2 in the developing mouse lung. Gene Expr Patterns 2003;3(3):279-83
  • Strizzi L, Bianco C, Raafat A, et al. Netrin-1 regulates invasion and migration of mouse mammary epithelial cells overexpressing Cripto-1 in vitro and in vivo. J Cell Sci 2005;118(Pt 20):4633-43
  • Serafini T, Kennedy TE, Galko MJ, et al. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 1994;78(3):409-24
  • Kappler J, Franken S, Junghans U, et al. Glycosaminoglycan-binding properties and secondary structure of the C-terminus of netrin-1. Biochem Biophys Res Commun 2000;271(2):287-91
  • Lu X, Le Noble F, Yuan L, et al. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 2004;432(7014):179-86
  • Park KW, Crouse D, Lee M, et al. The axonal attractant netrin-1 is an angiogenic factor. Proc Natl Acad Sci USA 2004;101(46):16210-5
  • Engelkamp D. Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation. Mech Dev 2002;118(1-2):191-7
  • Larrivee B, Freitas C, Trombe M, et al. Activation of the UNC5B receptor by netrin-1 inhibits sprouting angiogenesis. Genes Dev 2007;21(19):2433-47
  • Bouvree K, Larrivee B, Lv X, et al. Netrin-1 inhibits sprouting angiogenesis in developing avian embryos. Dev Biol 2008;318(1):172-83
  • Leonardo ED, Hinck L, Masu M, et al. Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature 1997;386(6627):833-8
  • Wilson BD, Ii M, Park KW, et al. Netrins promote developmental and therapeutic angiogenesis. Science 2006;313(5787):640-4
  • Navankasattusas S, Whitehead KJ, Suli A, et al. The netrin receptor UNC5B promotes angiogenesis in specific vascular beds. Development 2008;135(4):659-67
  • Mazelin L, Bernet A, Bonod-Bidaud C, et al. Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature 2004;431(7004):80-4
  • Lee HK, Seo IA, Seo E, et al. Netrin-1 induces proliferation of Schwann cells through Unc5b receptor. Biochem Biophys Res Commun 2007;362(4):1057-62
  • Moon C, Kim H, Ahn M, et al. Enhanced expression of netrin-1 protein in the sciatic nerves of Lewis rats with experimental autoimmune neuritis: possible role of the netrin-1/DCC binding pathway in an autoimmune PNS disorder. J Neuroimmunol 2006;172(1-2):66-72
  • Ly NP, Komatsuzaki K, Fraser IP, et al. Netrin-1 inhibits leukocyte migration in vitro and in vivo. Proc Natl Acad Sci USA 2005;102(41):14729-34
  • Reeves WB, Kwon O, Ramesh G. Netrin-1 is an early biomarker of acute kidney injury. Am J Physiol Renal Physiol 2008;294(4):F731-8
  • Forcet C, Stein E, Pays L, et al. Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation. Nature 2002;417(6887):443-7
  • Ren XR, Ming GL, Xie Y, et al. Focal adhesion kinase in netrin-1 signaling. Nat Neurosci 2004;7(11):1204-12
  • Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996;87(2):159-70
  • Shibata D, Reale MA, Lavin P, et al. The DCC protein and prognosis in colorectal cancer. N Engl J Med 1996;335(23):1727-32
  • Saito M, Yamaguchi A, Goi T, et al. Expression of DCC protein in colorectal tumors and its relationship to tumor progression and metastasis. Oncology 1999;56(2):134-41
  • Saw RP, Koorey D, Painter D, et al. p53, DCC and thymidylate synthase as predictors of survival after resection of hepatic metastases from colorectal cancer. Br J Surg 2002;89(11):1409-15
  • Barratt PL, Seymour MT, Stenning SP, et al. DNA markers predicting benefit from adjuvant fluorouracil in patients with colon cancer: a molecular study. Lancet 2002;360(9343):1381-91
  • Carethers JM, Hawn MT, Greenson JK, et al. Prognostic significance of allelic lost at chromosome 18q21 for stage II colorectal cancer. Gastroenterology 1998;114(6):1188-95
  • Fazeli A, Dickinson SL, Hermiston ML, et al. Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature 1997;386(6627):796-804
  • Huerta S, Srivatsan ES, Venkatasan N, Livingston EH. Human colon cancer cells deficient in DCC produce abnormal transcripts in progression of carcinogenesis. Dig Dis Sci 2001;46(9):1884-91
  • Tanaka K, Oshimura M, Kikuchi R, et al. Suppression of tumorigenicity in human colon carcinoma cells by introduction of normal chromosome 5 or 18. Nature 1991;349(6307):340-2
  • Klingelhutz AJ, Smith PP, Garrett LR, McDougall JK. Alteration of the DCC tumor-suppressor gene in tumorigenic HPV-18 immortalized human keratinocytes transformed by nitrosomethylurea. Oncogene 1993;8(1):95-9
  • Velcich A, Corner G, Palumbo L, Augenlicht L. Altered phenotype of HT29 colonic adenocarcinoma cells following expression of the DCC gene. Oncogene 1999;18(16):2599-606
  • Kato H, Zhou Y, Asanoma K, et al. Suppressed tumorigenicity of human endometrial cancer cells by the restored expression of the DCC gene. Br J Cancer 2000;82(2):459-66
  • Rodrigues S, De Wever O, Bruyneel E, et al. Opposing roles of netrin-1 and the dependence receptor DCC in cancer cell invasion, tumor growth and metastasis. Oncogene 2007;26(38):5615-25
  • Shin SK, Nagasaka T, Jung BH, et al. Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. Gastroenterology 2007;133(6):1849-57
  • Uchino S, Tsuda H, Noguchi M, et al. Frequent loss of heterozygosity at the DCC locus in gastric cancer. Cancer Res 1992;52(11):3099-102
  • Fang DC, Jass JR, Wang DX. Loss of heterozygosity and loss of expression of the DCC gene in gastric cancer. J Clin Pathol 1998;51(8):593-6
  • Yoshida Y, Itoh F, Endo T, et al. Decreased DCC mRNA expression in human gastric cancers is clinicopathologically significant. Int J Cancer 1998;79(6):634-9
  • Latil A, Chene L, Cochant-Priollet B, et al. Quantification of expression of netrins, slits and their receptors in human prostate tumors. Int J Cancer 2003;103(3):306-15
  • Imamura T, Arima T, Kato H, et al. Chromosomal deletions and K-ras gene mutations in human endometrial carcinomas. Int J Cancer 1992;51(1):47-52
  • Gima T, Kato H, Honda T, et al. DCC gene alteration in human endometrial carcinomas. Int J Cancer 1994;57(4):480-5
  • Saegusa M, Hashimura M, Hara A, Okayasu I. Loss of expression of the gene deleted in colon carcinoma (DCC) is closely related to histologic differentiation and lymph node metastasis in endometrial carcinoma. Cancer 1999;85(2):453-64
  • Saegusa M, Machida D, Okayasu I. Loss of DCC gene expression during ovarian tumorigenesis: relation to tumour differentiation and progression. Br J Cancer 2000;82(3):571-8
  • Dolan K, Garde J, Gosney J, et al. Allelotype analysis of oesophageal adenocarcinoma: loss of heterozygosity occurs at multiple sites. Br J Cancer 1998;78(7):950-7
  • Thompson AM, Morris RG, Wallace M, et al. Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer. Br J Cancer 1993;68(1):64-8
  • Strohmeyer D, Langenhof S, Ackermann R, et al. Analysis of the DCC tumor suppressor gene in testicular germ cell tumors: mutations and loss of expression. J Urol 1997;157(5):1973-6
  • Reyes-Mugica M, Rieger-Christ K, Ohgaki H, et al. Loss of DCC expression and glioma progression. Cancer Res 1997;57(3):382-6
  • Reyes-Mugica M, Lin P, Yokota J, Reale MA. Status of deleted in colorectal cancer gene expression correlates with neuroblastoma metastasis. Lab Invest 1998;78(6):669-75
  • Miyake K, Inokuchi K, Nomura T. Expression of the DCC gene in human hematological malignancies. Leuk Lymphoma 1994;16(1-2):13-8
  • Carvalho AL, Chuang A, Jiang WW, et al. Deleted in colorectal cancer is a putative conditional tumor-suppressor gene inactivated by promoter hypermethylation in head and neck squamous cell carcinoma. Cancer Res 2006;66(19):9401-7
  • Thiebault K, Mazelin L, Pays L, et al. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. Proc Natl Acad Sci USA 2003;100(7):4173-8
  • Bernet A, Mazelin L, Coissieux MM, et al. Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies. Gastroenterology 2007;133(6):1840-8
  • Grady WM. Making the case for DCC and UNC5C as tumor-suppressor genes in the colon. Gastroenterology 2007;133(6):2045-9
  • Fitamant J, Guenebeaud C, Coissieux MM, et al. Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer. Proc Natl Acad Sci USA 2008;105(12):4850-5
  • Meyerhardt JA, Caca K, Eckstrand BC, et al. Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. Cell Growth Differ 1999;10(1):35-42
  • Link BC, Reichelt U, Schreiber M, et al. Prognostic implications of netrin-1 expression and its receptors in patients with adenocarcinoma of the pancreas. Ann Surg Oncol 2007;14(9):2591-9
  • Llambi F, Lourenco FC, Gozuacik D, et al. The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase. EMBO J 2005;24(6):1192-201
  • Inbal B, Cohen O, Polak-Charcon S, et al. DAP kinase links the control of apoptosis to metastasis. Nature 1997;390(6656):180-4

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