Nuclear factor-erythroid 2-related factor 2 as a chemopreventive target in colorectal cancer

Bibliography

• Jemal A, Siegel R, Ward E, Cancer statistics, 2009. CA Cancer J Clin 2009;59:225-49
   PubMed Web of Science ®Google Scholar
• Li W, Kong AN. Molecular mechanisms of Nrf2-mediated antioxidant response. Mol Carcinog 2009;48:91-104
   PubMed Web of Science ®Google Scholar
• Yu S, Kong AN. Targeting carcinogen metabolism by dietary cancer preventive compounds. Curr Cancer Drug Targets 2007;7:416-24
   PubMedGoogle Scholar
• Dinkova-Kostova AT, Talalay P. Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Mol Nutr Food Res 2008;52(Suppl 1):S128-38
   Google Scholar
• Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet 2001;357:539-45
   PubMed Web of Science ®Google Scholar
• Chen C, Kong AN. Dietary chemopreventive compounds and ARE/EpRE signaling. Free Radic Biol Med 2004;36:1505-16
   PubMed Web of Science ®Google Scholar
• Chen C, Kong AN. Dietary cancer-chemopreventive compounds: from signaling and gene expression to pharmacological effects. Trends Pharmacol Sci 2005;26:318-26
   PubMed Web of Science ®Google Scholar
• Anand P, Kunnumakkara AB, Sundaram C, Cancer is a preventable disease that requires major lifestyle changes. Pharm Res 2008;25:2097-116
   PubMed Web of Science ®Google Scholar
• McConnell BB, Yang VW. The role of inflammation in the pathogenesis of colorectal cancer. Curr Colorectal Cancer Rep 2009;5:69-74
   PubMedGoogle Scholar
• Aggarwal BB, Vijayalekshmi RV, Sung B. Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe. Clin Cancer Res 2009;15:425-30
   PubMed Web of Science ®Google Scholar
• Doherty GA, Murray FE. Cyclooxygenase as a target for chemoprevention in colorectal cancer: lost cause or a concept coming of age? Expert Opin Ther Targets 2009;13:209-18
   PubMed Web of Science ®Google Scholar
• Gatof D, Ahnen D. Primary prevention of colorectal cancer: diet and drugs. Gastroenterol Clin North Am 2002;31:587-623, xi
   PubMedGoogle Scholar
• Turini ME, DuBois RN. Primary prevention: phytoprevention and chemoprevention of colorectal cancer. Hematol Oncol Clin North Am 2002;16:811-40
   PubMedGoogle Scholar
• Kumar N, Shibata D, Helm J, Green tea polyphenols in the prevention of colon cancer. Front Biosci 2007;12:2309-15
   PubMed Web of Science ®Google Scholar
• Reid ME, Duffield-Lillico AJ, Sunga A, Selenium supplementation and colorectal adenomas: an analysis of the nutritional prevention of cancer trial. Int J Cancer 2006;118:1777-81
   PubMed Web of Science ®Google Scholar
• Hsu CH, Cheng AL. Clinical studies with curcumin. Adv Exp Med Biol 2007;595:471-80
   PubMed Web of Science ®Google Scholar
• Villegas I, Sanchez-Fidalgo S, Alarcon de la Lastra C. New mechanisms and therapeutic potential of curcumin for colorectal cancer. Mol Nutr Food Res 2008;52:1040-61
   PubMed Web of Science ®Google Scholar
• Half E, Arber N. Colon cancer: preventive agents and the present status of chemoprevention. Expert Opin Pharmacother 2009;10:211-19
   PubMed Web of Science ®Google Scholar
• Chu DZ, Chansky K, Alberts DS, Adenoma recurrences after resection of colorectal carcinoma: results from the Southwest Oncology Group 9041 calcium chemoprevention pilot study. Ann Surg Oncol 2003;10:870-5
   PubMedGoogle Scholar
• Juge N, Mithen RF, Traka M. Molecular basis for chemoprevention by sulforaphane: a comprehensive review. Cell Mol Life Sci 2007;64:1105-27
   PubMed Web of Science ®Google Scholar
• Hatcher H, Planalp R, Cho J, Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci 2008;65:1631-52
   PubMed Web of Science ®Google Scholar
• Aggarwal BB, Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 2006;71:1397-421
   PubMed Web of Science ®Google Scholar
• Aggarwal BB, Van Kuiken ME, Iyer LH, Molecular targets of nutraceuticals derived from dietary spices: potential role in suppression of inflammation and tumorigenesis. Exp Biol Med (Maywood) 2009;234:825-49
   PubMed Web of Science ®Google Scholar
• Khor TO, Yu S, Kong AN. Dietary cancer chemopreventive agents - targeting inflammation and Nrf2 signaling pathway. Planta Med 2008;74:1540-7
   PubMedGoogle Scholar
• Kim J, Cha YN, Surh YJ. A protective role of nuclear erythroid 2-related factor-2 (Nrf2) in inflammatory disorders. Mutat Res 2010;690:12-23
   PubMed Web of Science ®Google Scholar
• Nair S, Li W, Kong AN. Natural dietary anti-cancer chemopreventive compounds: redox-mediated differential signaling mechanisms in cytoprotection of normal cells versus cytotoxicity in tumor cells. Acta Pharmacol Sin 2007;28:459-72
   PubMed Web of Science ®Google Scholar
• Kwak MK, Kensler TW. Targeting NRF2 signaling for cancer chemoprevention. Toxicol Appl Pharmacol 2010;244:66-76
   PubMed Web of Science ®Google Scholar
• Fearon ER. Human cancer syndromes: clues to the origin and nature of cancer. Science 1997;278:1043-50
   PubMed Web of Science ®Google Scholar
• Ahmed FE. Gene-gene, gene-environment & multiple interactions in colorectal cancer. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2006;24:1-101
   PubMedGoogle Scholar
• Half E, Bercovich D, Rozen P. Familial adenomatous polyposis. Orphanet J Rare Dis 2009;4:22
   PubMed Web of Science ®Google Scholar
• Thomas HJ. Familial colorectal cancer. BMJ 1993;307:277-8
   PubMedGoogle Scholar
• Itzkowitz SH, Yio X. Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am J Physiol Gastrointest Liver Physiol 2004;287:G7-17
   PubMed Web of Science ®Google Scholar
• Doll R, Peto R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 1981;66:1191-308
   PubMed Web of Science ®Google Scholar
• Willett WC. Diet, nutrition, and avoidable cancer. Environ Health Perspect 1995;103(Suppl 8):165-70
   PubMedGoogle Scholar
• Garabrant DH, Peters JM, Mack TM, Job activity and colon cancer risk. Am J Epidemiol 1984;119:1005-14
   PubMed Web of Science ®Google Scholar
• Gerhardsson M, Norell SE, Kiviranta H, Sedentary jobs and colon cancer. Am J Epidemiol 1986;123:775-80
   PubMed Web of Science ®Google Scholar
• Thune I, Lund E. Physical activity and risk of colorectal cancer in men and women. Br J Cancer 1996;73:1134-40
   PubMed Web of Science ®Google Scholar
• Colditz GA, Cannuscio CC, Frazier AL. Physical activity and reduced risk of colon cancer: implications for prevention. Cancer Causes Control 1997;8:649-67
   PubMed Web of Science ®Google Scholar
• Satia-Abouta J, Galanko JA, Martin CF, Associations of micronutrients with colon cancer risk in African Americans and whites: results from the North Carolina Colon Cancer Study. Cancer Epidemiol Biomarkers Prev 2003;12:747-54
   PubMedGoogle Scholar
• Tsoi KK, Pau CY, Wu WK, Cigarette smoking and the risk of colorectal cancer: a meta-analysis of prospective cohort studies. Clin Gastroenterol Hepatol 2009;7:682-88 e1-5
   PubMed Web of Science ®Google Scholar
• Liang PS, Chen TY, Giovannucci E. Cigarette smoking and colorectal cancer incidence and mortality: systematic review and meta-analysis. Int J Cancer 2009;124:2406-15
   PubMed Web of Science ®Google Scholar
• Bongaerts BW, van den Brandt PA, Goldbohm RA, Alcohol consumption, type of alcoholic beverage and risk of colorectal cancer at specific subsites. Int J Cancer 2008;123:2411-17
   PubMed Web of Science ®Google Scholar
• Ferrari P, Jenab M, Norat T, Lifetime and baseline alcohol intake and risk of colon and rectal cancers in the European prospective investigation into cancer and nutrition (EPIC). Int J Cancer 2007;121:2065-72
   PubMed Web of Science ®Google Scholar
• Wang C, Miller SM, Egleston BL, Beliefs about the causes of breast and colorectal cancer among women in the general population. Cancer Causes Control 2010;21:99-107
   PubMed Web of Science ®Google Scholar
• Lipkin M, Reddy B, Newmark H, Dietary factors in human colorectal cancer. Annu Rev Nutr 1999;19:545-86
   PubMed Web of Science ®Google Scholar
• Rutter M, Saunders B, Wilkinson K, Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis. Gastroenterology 2004;126:451-9
   PubMed Web of Science ®Google Scholar
• Guyton KZ, Kensler TW. Oxidative mechanisms in carcinogenesis. Br Med Bull 1993;49:523-44
   PubMed Web of Science ®Google Scholar
• D'Odorico A, Bortolan S, Cardin R, Reduced plasma antioxidant concentrations and increased oxidative DNA damage in inflammatory bowel disease. Scand J Gastroenterol 2001;36:1289-94
   PubMed Web of Science ®Google Scholar
• D'Inca R, Cardin R, Benazzato L, Oxidative DNA damage in the mucosa of ulcerative colitis increases with disease duration and dysplasia. Inflamm Bowel Dis 2004;10:23-7
   PubMed Web of Science ®Google Scholar
• Ohshima H, Sawa T, Akaike T. 8-nitroguanine, a product of nitrative DNA damage caused by reactive nitrogen species: formation, occurrence, and implications in inflammation and carcinogenesis. Antioxid Redox Signal 2006;8:1033-45
   PubMed Web of Science ®Google Scholar
• Colotta F, Allavena P, Sica A, Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 2009;30:1073-81
   PubMed Web of Science ®Google Scholar
• Mantovani A, Allavena P, Sica A, Cancer-related inflammation. Nature 2008;454:436-44
   PubMed Web of Science ®Google Scholar
• Moi P, Chan K, Asunis I, Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc Natl Acad Sci USA 1994;91:9926-30
   PubMed Web of Science ®Google Scholar
• Nguyen T, Nioi P, Pickett CB. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem 2009;284:13291-5
   PubMed Web of Science ®Google Scholar
• Rushmore TH, Morton MR, Pickett CB. The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity. J Biol Chem 1991;266:11632-9
   PubMed Web of Science ®Google Scholar
• Keum YS, Owuor ED, Kim BR, Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC). Pharm Res 2003;20:1351-6
   PubMed Web of Science ®Google Scholar
• Balogun E, Hoque M, Gong P, Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem J 2003;371:887-95
   PubMed Web of Science ®Google Scholar
• Li W, Yu SW, Kong AN. Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain. J Biol Chem 2006;281:27251-63
   PubMedGoogle Scholar
• Li W, Thakor N, Xu EY, An internal ribosomal entry site mediates redox-sensitive translation of Nrf2. Nucleic Acids Res 2010;38:778-88
   PubMed Web of Science ®Google Scholar
• Cullinan SB, Diehl JA. PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress. J Biol Chem 2004;279:20108-17
   PubMed Web of Science ®Google Scholar
• Huang HC, Nguyen T, Pickett CB. Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. J Biol Chem 2002;277:42769-74
   PubMed Web of Science ®Google Scholar
• Yu R, Chen C, Mo YY, Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism. J Biol Chem 2000;275:39907-13
   PubMed Web of Science ®Google Scholar
• Lee JM, Hanson JM, Chu WA, Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma cells. J Biol Chem 2001;276:20011-16
   PubMed Web of Science ®Google Scholar
• Shen G, Kong AN. Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters. Biopharm Drug Dispos 2009;30:345-55
   PubMed Web of Science ®Google Scholar
• Xu C, Li CY, Kong AN. Induction of phase I, II and III drug metabolism/transport by xenobiotics. Arch Pharm Res 2005;28:249-68
   PubMed Web of Science ®Google Scholar
• Rushmore TH, Kong AN. Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes. Curr Drug Metab 2002;3:481-90
   PubMed Web of Science ®Google Scholar
• Bock KW, Kohle C. UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects. Methods Enzymol 2005;400:57-75
   PubMed Web of Science ®Google Scholar
• Khor TO, Huang MT, Kwon KH, Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis. Cancer Res 2006;66:11580-4
   PubMed Web of Science ®Google Scholar
• Osburn WO, Karim B, Dolan PM, Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment. Int J Cancer 2007;121:1883-91
   PubMedGoogle Scholar
• Khor TO, Huang MT, Prawan A, Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer. Cancer Prev Res (Phila Pa) 2008;1:187-91
   PubMed Web of Science ®Google Scholar
• Yuan JH, Li YQ, Yang XY. Protective effects of epigallocatechin gallate on colon preneoplastic lesions induced by 2-amino-3-methylimidazo[4,5-f ] quinoline in mice. Mol Med 2008;14:590-8
   PubMed Web of Science ®Google Scholar
• Yuan JH, Li YQ, Yang XY. Inhibition of epigallocatechin gallate on orthotopic colon cancer by upregulating the Nrf2-UGT1A signal pathway in nude mice. Pharmacology 2007;80:269-78
   PubMed Web of Science ®Google Scholar
• Chen C, Yu R, Owuor ED, Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death. Arch Pharm Res 2000;23:605-12
   PubMed Web of Science ®Google Scholar
• Shen G, Xu C, Hu R, Comparison of (-)-epigallocatechin-3-gallate elicited liver and small intestine gene expression profiles between C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice. Pharm Res 2005;22:1805-20
   PubMed Web of Science ®Google Scholar
• Zhang ZM, Yang XY, Yuan JH, Modulation of NRF2 and UGT1A expression by epigallocatechin-3-gallate in colon cancer cells and BALB/c mice. Chin Med J (Engl) 2009;122:1660-5
   PubMed Web of Science ®Google Scholar
• Kassie F, Uhl M, Rabot S, Chemoprevention of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-induced colonic and hepatic preneoplastic lesions in the F344 rat by cruciferous vegetables administered simultaneously with the carcinogen. Carcinogenesis 2003;24:255-61
   PubMed Web of Science ®Google Scholar
• Uhl M, Kassie F, Rabot S, Effect of common Brassica vegetables (Brussels sprouts and red cabbage) on the development of preneoplastic lesions induced by 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in liver and colon of Fischer 344 rats. J Chromatogr B Analyt Technol Biomed Life Sci 2004;802:225-30
   PubMedGoogle Scholar
• Chung FL, Conaway CC, Rao CV, Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate. Carcinogenesis 2000;21:2287-91
   PubMed Web of Science ®Google Scholar
• Shen G, Khor TO, Hu R, Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse. Cancer Res 2007;67:9937-44
   PubMed Web of Science ®Google Scholar
• Myzak MC, Dashwood WM, Orner GA, Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. Faseb J 2006;20:506-8
   PubMed Web of Science ®Google Scholar
• Hu R, Khor TO, Shen G, Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable. Carcinogenesis 2006;27:2038-46
   PubMed Web of Science ®Google Scholar
• McMahon M, Itoh K, Yamamoto M, The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. Cancer Res 2001;61:3299-307
   PubMed Web of Science ®Google Scholar
• McWalter GK, Higgins LG, McLellan LI, Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates. J Nutr 2004;134:3499S-506S
   PubMed Web of Science ®Google Scholar
• Hu R, Xu C, Shen G, Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice. Cancer Lett 2006;243:170-92
   PubMed Web of Science ®Google Scholar
• Hu R, Xu C, Shen G, Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray. Life Sci 2006;79:1944-55
   PubMed Web of Science ®Google Scholar
• Sharma RA, Ireson CR, Verschoyle RD, Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels. Clin Cancer Res 2001;7:1452-8
   PubMed Web of Science ®Google Scholar
• Iqbal M, Sharma SD, Okazaki Y, Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity. Pharmacol Toxicol 2003;92:33-8
   PubMedGoogle Scholar
• Ye SF, Hou ZQ, Zhong LM, Effect of curcumin on the induction of glutathione S-transferases and NADP(H): quinone oxidoreductase and its possible mechanism of action. Yao Xue Xue Bao 2007;42:376-80
   PubMedGoogle Scholar
• Shen G, Xu C, Hu R, Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin. Mol Cancer Ther 2006;5:39-51
   PubMed Web of Science ®Google Scholar
• Volate SR, Davenport DM, Muga SJ, Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin). Carcinogenesis 2005;26:1450-6
   PubMed Web of Science ®Google Scholar
• Seow A, Yuan JM, Sun CL, Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study. Carcinogenesis 2002;23:2055-61
   PubMed Web of Science ®Google Scholar
• Brusewitz G, Cameron BD, Chasseaud LF, The metabolism of benzyl isothiocyanate and its cysteine conjugate. Biochem J 1977;162:99-107
   PubMed Web of Science ®Google Scholar
• Jiao D, Ho CT, Foiles P, Identification and quantification of the N-acetylcysteine conjugate of allyl isothiocyanate in human urine after ingestion of mustard. Cancer Epidemiol Biomarkers Prev 1994;3:487-92
   PubMed Web of Science ®Google Scholar
• Skjelbred CF, Saebo M, Hjartaker A, Meat, vegetables and genetic polymorphisms and the risk of colorectal carcinomas and adenomas. BMC Cancer 2007;7:228
   PubMedGoogle Scholar
• Yeh CC, Hsieh LL, Tang R, Vegetable/fruit, smoking, glutathione S-transferase polymorphisms and risk for colorectal cancer in Taiwan. World J Gastroenterol 2005;11:1473-80
   PubMed Web of Science ®Google Scholar
• Cotton SC, Sharp L, Little J, Glutathione S-transferase polymorphisms and colorectal cancer: a HuGE review. Am J Epidemiol 2000;151:7-32
   PubMed Web of Science ®Google Scholar
• Pool-Zobel B, Veeriah S, Bohmer FD. Modulation of xenobiotic metabolising enzymes by anticarcinogens – focus on glutathione S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesis. Mutat Res 2005;591:74-92
   PubMed Web of Science ®Google Scholar
• Tang KS, Chiu HF, Chen HH, Link between colorectal cancer and polymorphisms in the uridine-diphosphoglucuronosyltransferase 1A7 and 1A1 genes. World J Gastroenterol 2005;11:3250-4
   PubMed Web of Science ®Google Scholar
• Dixit V, Mak TW. NF-kappaB signaling. Many roads lead to madrid. Cell 2002;111:615-19
   PubMedGoogle Scholar
• Pomerantz JL, Baltimore D. Two pathways to NF-kappaB. Mol Cell 2002;10:693-5
   PubMed Web of Science ®Google Scholar
• Wada T, Penninger JM. Mitogen-activated protein kinases in apoptosis regulation. Oncogene 2004;23:2838-49
   PubMed Web of Science ®Google Scholar
• Li W, Khor TO, Xu C, Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis. Biochem Pharmacol 2008;76:1485-9
   PubMed Web of Science ®Google Scholar
• Banning A, Florian S, Deubel S, GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells. Antioxid Redox Signal 2008;10:1491-500
   PubMed Web of Science ®Google Scholar
• Kang ES, Kim GH, Kim HJ, Nrf2 regulates curcumin-induced aldose reductase expression indirectly via nuclear factor-kappaB. Pharmacol Res 2008;58:15-21
   PubMed Web of Science ®Google Scholar
• Chen XL, Dodd G, Thomas S, Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression. Am J Physiol Heart Circ Physiol 2006;290:H1862-70
   PubMed Web of Science ®Google Scholar
• Zhang X, Chen X, Song H, Activation of the Nrf2/antioxidant response pathway increases IL-8 expression. Eur J Immunol 2005;35:3258-67
   PubMed Web of Science ®Google Scholar
• Nair S, Doh ST, Chan JY, Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis. Br J Cancer 2008;99:2070-82
   PubMed Web of Science ®Google Scholar
• Svehlikova V, Wang S, Jakubikova J, Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells. Carcinogenesis 2004;25:1629-37
   PubMed Web of Science ®Google Scholar
• Jakubikova J, Sedlak J, Mithen R, Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells. Biochem Pharmacol 2005;69:1543-52
   PubMed Web of Science ®Google Scholar
• Yuan X, Xu C, Pan Z, Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells. Mol Carcinog 2006;45:841-50
   PubMed Web of Science ®Google Scholar
• Shen G, Hebbar V, Nair S, Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein. J Biol Chem 2004;279:23052-60
   PubMed Web of Science ®Google Scholar
• Murakami A, Song M, Ohigashi H. Phenethyl isothiocyanate suppresses receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis by blocking activation of ERK1/2 and p38 MAPK in RAW264.7 macrophages. Biofactors 2007;30:1-11
   PubMed Web of Science ®Google Scholar
• de Sousa RR, Queiroz KC, Souza AC, Phosphoprotein levels, MAPK activities and NFkappaB expression are affected by fisetin. J Enzyme Inhib Med Chem 2007;22:439-44
   PubMed Web of Science ®Google Scholar
• Lin W, Wu RT, Wu T, Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway. Biochem Pharmacol 2008;76:967-73
   PubMed Web of Science ®Google Scholar
• Liu H, Dinkova-Kostova AT, Talalay P. Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles. Proc Natl Acad Sci USA 2008;105:15926-31
   PubMed Web of Science ®Google Scholar
• Wang H, Khor TO, Saw CL, Role of nrf2 in suppressing LPS-induced inflammation in mouse peritoneal macrophages by polyunsaturated Fatty acids docosahexaenoic Acid and eicosapentaenoic Acid. Mol Pharm 2010;7:2185-93
   PubMedGoogle Scholar
• Bosetti C, Gallus S, La Vecchia C. Aspirin and cancer risk: an updated quantitative review to 2005. Cancer Causes Control 2006;17:871-88
   PubMedGoogle Scholar
• Bertagnolli MM, Eagle CJ, Zauber AG, Celecoxib for the prevention of sporadic colorectal adenomas. N Engl J Med 2006;355:873-84
   PubMed Web of Science ®Google Scholar
• Bertagnolli MM, Eagle CJ, Zauber AG, Five-year efficacy and safety analysis of the Adenoma Prevention with Celecoxib Trial. Cancer Prev Res (Phila Pa) 2009;2:310-21
   PubMed Web of Science ®Google Scholar
• Mantovani A. Cancer: inflaming metastasis. Nature 2009;457:36-7
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70
   PubMed Web of Science ®Google Scholar
• Garg A, Aggarwal BB. Nuclear transcription factor-kappaB as a target for cancer drug development. Leukemia 2002;16:1053-68
   PubMed Web of Science ®Google Scholar
• Sethi G, Sung B, Aggarwal BB. Nuclear factor-kappaB activation: from bench to bedside. Exp Biol Med (Maywood) 2008;233:21-31
   PubMed Web of Science ®Google Scholar