563
Views
27
CrossRef citations to date
0
Altmetric
Reviews

Targeting the anaphase promoting complex: common pathways for viral infection and cancer therapy

, MSc & , PhD
Pages 767-780 | Published online: 05 Mar 2011

Bibliography

  • Peters JM. The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat Rev Mol Cell Biol 2006;7:644-56
  • Vodermaier HC, Gieffers C, Maurer-Stroh S, TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. Curr Biol 2003;13:1459-68
  • Thornton BR, Ng TM, Matyskiela ME, An architectural map of the anaphase-promoting complex. Genes Dev 2006;20:449-60
  • Matyskiela ME, Morgan DO. Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. Mol Cell 2009;34:68-80
  • Pfleger CM, Kirschner MW. The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev 2000;14:655-65
  • Kraft C, Vodermaier HC, Maurer-Stroh S, The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates. Mol Cell 2005;18:543-53
  • Yu H. Cdc20: a WD40 activator for a cell cycle degradation machine. Mol Cell 2007;27:3-16
  • Passmore LA, McCormack EA, Au SW, Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition. EMBO J 2003;22:786-96
  • Carroll CW, Enquist-Newman M, Morgan DO. The APC subunit Doc1 promotes recognition of the substrate destruction box. Curr Biol 2005;15:11-18
  • da Fonseca PC, Kong EH, Zhang Z, Structures of APC/CCdh1 with substrates identify Cdh1 and Apc10 as the D-box co-receptor. Nature 2010: published online 24 November 2010, doi:10.1038/nature09625
  • Thornton BR, Toczyski DP. Securin and B-cyclin/CDK are the only essential targets of the APC. Nat Cell Biol 2003;5:1090-4
  • Reimann JD, Freed E, Hsu JY, Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Cell 2001;105:645-55
  • Guardavaccaro D, Kudo Y, Boulaire J, Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo. Dev Cell 2003;4:799-812
  • Golan A, Yudkovsky Y, Hershko A. The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk. J Biol Chem 2002;277:15552-7
  • Kraft C, Herzog F, Gieffers C, Mitotic regulation of the human anaphase-promoting complex by phosphorylation. EMBO J 2003;22:6598-609
  • Zhou Y, Ching YP, Chun AC, Nuclear localization of the cell cycle regulator CDH1 and its regulation by phosphorylation. J Biol Chem 2003;278:12530-6
  • Jaquenoud M, van Drogen F, Peter M. Cell cycle-dependent nuclear export of Cdh1p may contribute to the inactivation of APC/CCdh1. EMBO J 2002;21:6515-26
  • Oliveira RA, Hamilton RS, Pauli A, Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei. Nat Cell Biol 2010;12:185-92
  • Fang G. Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex. Mol Biol Cell 2002;13:755-66
  • Sudakin V, Chan GK, Yen TJ. Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J Cell Biol 2001;154:925-36
  • Herzog F, Primorac I, Dube P, Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex. Science 2009;323:1477-81
  • Nilsson J, Yekezare M, Minshull J, The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction. Nat Cell Biol 2008;10:1411-20
  • Ge S, Skaar JR, Pagano M. APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation. Cell Cycle 2009;8:167-71
  • Hauf S, Waizenegger IC, Peters JM. Cohesin cleavage by separase required for anaphase and cytokinesis in human cells. Science 2001;293:1320-3
  • Wasch R, Cross FR. APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit. Nature 2002;418:556-62
  • Sigl R, Wandke C, Rauch V, Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis. J Cell Sci 2009;122:4208-17
  • Wei W, Ayad NG, Wan Y, Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature 2004;428:194-8
  • McGarry TJ, Kirschner MW. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 1998;93:1043-53
  • Petersen BO, Wagener C, Marinoni F, Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1. Genes Dev 2000;14:2330-43
  • Bassermann F, Frescas D, Guardavaccaro D, The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. Cell 2008;134:256-67
  • Mocciaro A, Berdougo E, Zeng K, Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair. J Cell Biol 2010;189:631-9
  • Wiebusch L, Hagemeier C. p53- and p21-dependent premature APC/C-Cdh1 activation in G2 is part of the long-term response to genotoxic stress. Oncogene 2010;29:3477-89
  • Hsu JY, Reimann JD, Sorensen CS, E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APCCdh1. Nat Cell Biol 2002;4:358-66
  • Benmaamar R, Pagano M. Involvement of the SCF complex in the control of Cdh1 degradation in S-phase. Cell Cycle 2005;4:1230-2
  • Rape M, Kirschner MW. Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. Nature 2004;432:588-95
  • Listovsky T, Oren YS, Yudkovsky Y, Mammalian Cdh1/Fzr mediates its own degradation. EMBO J 2004;23:1619-26
  • Gieffers C, Peters BH, Kramer ER, Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. Proc Natl Acad Sci USA 1999;96:11317-22
  • Wirth KG, Ricci R, Gimenez-Abian JF, Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation. Genes Dev 2004;18:88-98
  • Almeida A, Bolanos JP, Moreno S. Cdh1/Hct1-APC is essential for the survival of postmitotic neurons. J Neurosci 2005;25:8115-21
  • Konishi Y, Stegmuller J, Matsuda T, Cdh1-APC controls axonal growth and patterning in the mammalian brain. Science 2004;303:1026-30
  • van Roessel P, Elliott DA, Robinson IM, Independent regulation of synaptic size and activity by the anaphase-promoting complex. Cell 2004;119:707-18
  • Juo P, Kaplan JM. The anaphase-promoting complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans. Curr Biol 2004;14:2057-62
  • Yang Y, Kim AH, Yamada T, A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science 2009;326:575-8
  • Kim AH, Puram SV, Bilimoria PM, A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Cell 2009;136:322-36
  • Herrero-Mendez A, Almeida A, Fernandez E, The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1. Nat Cell Biol 2009;11:747-52
  • Almeida A, Bolanos JP, Moncada S. E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation. Proc Natl Acad Sci USA 2010;107:738-41
  • Colombo SL, Palacios-Callender M, Frakich N, Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes. Proc Natl Acad Sci USA 2010;107:18868-73
  • Newsholme P, Curi R, Pithon Curi TC, Glutamine metabolism by lymphocytes, macrophages, and neutrophils: its importance in health and disease. J Nutr Biochem 1999;10:316-24
  • Lobo C, Ruiz-Bellido MA, Aledo JC, Inhibition of glutaminase expression by antisense mRNA decreases growth and tumourigenicity of tumour cells. Biochem J 2000;348:257-61
  • Turnell AS, Stewart GS, Grand RJ, The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression. Nature 2005;438(7068):690-5
  • Teodoro JG, Heilman DW, Parker AE, The viral protein Apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53. Genes Dev 2004;18:1952-7
  • Heilman DW, Teodoro JG, Green MR. Apoptin nucleocytoplasmic shuttling is required for cell type-specific localization, apoptosis, and recruitment of the anaphase-promoting complex/cyclosome to PML bodies. J Virol 2006;80:7535-45
  • Rohn JL, Zhang YH, Aalbers RI, A tumor-specific kinase activity regulates the viral death protein Apoptin. J Biol Chem 2002;277:50820-7
  • Maddika S, Wiechec E, Ande SR, Interaction with PI3-kinase contributes to the cytotoxic activity of apoptin. Oncogene 2008;27:3060-5
  • Jiang J, Cole D, Westwood N, Crucial roles for protein kinase C isoforms in tumor-specific killing by apoptin. Cancer Res 2010;70:7242-52
  • Marcellus RC, Lavoie JN, Boivin D, The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis. J Virol 1998;72:7144-53
  • Li S, Brignole C, Marcellus R, The adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit. J Virol 2009;83:8340-52
  • Kornitzer D, Sharf R, Kleinberger T. Adenovirus E4orf4 protein induces PP2A-dependent growth arrest in Saccharomyces cerevisiae and interacts with the anaphase-promoting complex/cyclosome. J Cell Biol 2001;154:331-44
  • Mui MZ, Roopchand DE, Gentry MS, Adenovirus protein E4orf4 induces premature APCCdc20 activation in Saccharomyces cerevisiae by a protein phosphatase 2A-dependent mechanism. J Virol 2010;84:4798-809
  • Liu B, Hong S, Tang Z, HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule. Proc Natl Acad Sci USA 2005;102:63-8
  • Kuo YL, Giam CZ. Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence. EMBO J 2006;25:1741-52
  • Merling R, Chen C, Hong S, HTLV-1 Tax mutants that do not induce G1 arrest are disabled in activating the anaphase promoting complex. Retrovirology 2007;4:35
  • Rajasekaran SA, Christiansen JJ, Schmid I, Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability. Mol Cancer Ther 2008;7:2142-51
  • Bellanger S, Blachon S, Mechali F, High-risk but not low-risk HPV E2 proteins bind to the APC activators Cdh1 and Cdc20 and cause genomic instability. Cell Cycle 2005;4:1608-15
  • Patel D, McCance DJ. Compromised spindle assembly checkpoint due to altered expression of Ubch10 and Cdc20 in HPV16 E6- and E7-expressing keratinocytes. J Virol 2010;84:10956-64
  • Noris E, Zannetti C, Demurtas A, Cell cycle arrest by human cytomegalovirus 86-kDa IE2 protein resembles premature senescence. J Virol 2002;76:12135-48
  • Wiebusch L, Bach M, Uecker R, Human cytomegalovirus inactivates the G0/G1-APC/C ubiquitin ligase by Cdh1 dissociation. Cell Cycle 2005;4:1435-9
  • Tran K, Mahr JA, Choi J, Accumulation of substrates of the anaphase-promoting complex (APC) during human cytomegalovirus infection is associated with the phosphorylation of Cdh1 and the dissociation and relocalization of APC subunits. J Virol 2008;82:529-37
  • Tran K, Kamil JP, Coen DM, Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1. J Virol 2010;84:10832-43
  • Tran K, Mahr JA, Spector DH. Proteasome subunits relocalize during human cytomegalovirus infection, and proteasome activity is necessary for efficient viral gene transcription. J Virol 2010;84:3079-93
  • Mo M, Fleming SB, Mercer AA. The Orf virus cell cycle regulator, PACR, competes with subunit 11 of the anaphase promoting complex for incorporation into the complex. J Gen Virol 2010;91:3010-5
  • Mo M, Fleming SB, Mercer AA. Cell cycle deregulation by a poxvirus partial mimic of anaphase-promoting complex subunit 11. Proc Natl Acad Sci USA 2009;106:19527-32
  • Weaver BA, Cleveland DW. Decoding the links between mitosis, cancer, and chemotherapy: the mitotic checkpoint, adaptation, and cell death. Cancer Cell 2005;8:7-12
  • Brito DA, Rieder CL. Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint. Curr Biol 2006;16:1194-200
  • Andersen JL, Johnson CE, Freel CD, Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2. EMBO J 2009;28:3216-27
  • Allan LA, Clarke PR. Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis. Mol Cell 2007;26:301-10
  • Terrano DT, Upreti M, Chambers TC. Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis. Mol Cell Biol 2010;30:640-56
  • Toh WH, Nam SY, Sabapathy K. An essential role for p73 in regulating mitotic cell death. Cell Death Differ 2010;17:787-800
  • Huang HC, Shi J, Orth JD, Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell 2009;16:347-58
  • Li M, York JP, Zhang P. Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos. Mol Cell Biol 2007;27:3481-8
  • Garcia-Higuera I, Manchado E, Dubus P, Genomic stability and tumour suppression by the APC/C cofactor Cdh1. Nat Cell Biol 2008;10:802-11
  • Davoli T, Denchi EL, de Lange T. Persistent telomere damage induces bypass of mitosis and tetraploidy. Cell 2010;141:81-93
  • Engelbert D, Schnerch D, Baumgarten A, The ubiquitin ligase APC(Cdh1) is required to maintain genome integrity in primary human cells. Oncogene 2008;27:907-17
  • Jacobs H, Richter D, Venkatesh T, Completion of mitosis requires neither fzr/rap nor fzr2, a male germline-specific Drosophila Cdh1 homolog. Curr Biol 2002;12:1435-41
  • Kidokoro T, Tanikawa C, Furukawa Y, CDC20, a potential cancer therapeutic target, is negatively regulated by p53. Oncogene 2008;27:1562-71
  • Baumgarten AJ, Felthaus J, Wasch R. Strong inducible knockdown of APC/CCdc20 does not cause mitotic arrest in human somatic cells. Cell Cycle 2009;8:643-6
  • Wolthuis R, Clay-Farrace L, van Zon W, Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A. Mol Cell 2008;30:290-302
  • Wang Q, Moyret-Lalle C, Couzon F, Alterations of anaphase-promoting complex genes in human colon cancer cells. Oncogene 2003;22:1486-90
  • Park KH, Choi SE, Eom M, Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships. Breast Cancer Res 2005;7:R238-47
  • Banerjee T, Nath S, Roychoudhury S. DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling. Nucleic Acids Res 2009;37:2688-98
  • Song MS, Song SJ, Ayad NG, The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nat Cell Biol 2004;6:129-37
  • Fujita T, Liu W, Doihara H, An in vivo study of Cdh1/APC in breast cancer formation. Int J Cancer 2009;125:826-36
  • Fujita T, Liu W, Doihara H, Dissection of the APCCdh1-Skp2 cascade in breast cancer. Clin Cancer Res 2008;14:1966-75
  • Fujita T, Liu W, Doihara H, Regulation of Skp2-p27 axis by the Cdh1/anaphase-promoting complex pathway in colorectal tumorigenesis. Am J Pathol 2008;173:217-28
  • Lehman NL, Tibshirani R, Hsu JY, Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors. Am J Pathol 2007;170:1793-805
  • Luo J, Emanuele MJ, Li D, A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell 2009;137:835-48
  • Karnoub AE, Weinberg RA. Ras oncogenes: split personalities. Nat Rev Mol Cell Biol 2008;9:517-31
  • Silva JM, Marran K, Parker JS, Profiling essential genes in human mammary cells by multiplex RNAi screening. Science 2008;319:617-20
  • Quasthoff S, Hartung HP. Chemotherapy-induced peripheral neuropathy. J Neurol 2002;249:9-17
  • Zeng X, Sigoillot F, Gaur S, Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell 2010;18:382-95
  • Li S, Szymborski A, Miron MJ, The adenovirus E4orf4 protein induces growth arrest and mitotic catastrophe in H1299 human lung carcinoma cells. Oncogene 2009;28:390-400

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.