Targeting disease through novel pathways of apoptosis and autophagy

Bibliography

• Chong ZZ, Li F, Maiese K. Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease. Prog Neurobiol 2005;75:207-46
   PubMed Web of Science ®Google Scholar
• Deretic V, Jiang S, Dupont N. Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation. Trends Cell Biol 2012;22(8):397-406
   PubMed Web of Science ®Google Scholar
• Kerr JF. A histochemical study of hypertrophy and ischaemic injury of rat liver with special reference to changes in lysosomes. J Pathol Bacteriol 1965;90:419-35
   PubMedGoogle Scholar
• Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972;26:239-57
   PubMed Web of Science ®Google Scholar
• Novikoff AB, Beaufay H, De Duve C. Electron microscopy of lysosomerich fractions from rat liver. J Biophys Biochem Cytol 1956;2:179-84
   PubMedGoogle Scholar
• Clark SL Jr. Cellular differentiation in the kidneys of newborn mice studies with the electron microscope. J Biophys Biochem Cytol 1957;3:349-62
   PubMedGoogle Scholar
• Maiese K, Chong ZZ, Shang YC, Novel avenues of drug discovery and biomarkers for diabetes mellitus. J Clin Pharmacol 2011;51:128-52
   PubMed Web of Science ®Google Scholar
• Chong ZZ, Shang YC, Wang S, SIRT1: new avenues of discovery for disorders of oxidative stress. Expert Opin Ther Targets 2012;16:167-78
   PubMed Web of Science ®Google Scholar
• Maiese K, Chong ZZ, Hou J, The vitamin nicotinamide: translating nutrition into clinical care. Molecules 2009;14:3446-85
   PubMed Web of Science ®Google Scholar
• Suzen S, Cihaner SS, Coban T. Synthesis and comparison of antioxidant properties of indole-based melatonin analogue indole amino acid derivatives. Chem Biol Drug Des 2012;79:76-83
   PubMed Web of Science ®Google Scholar
• Yuan H, Wan J, Li L, Therapeutic benefits of the group B3 vitamin nicotinamide in mice with lethal endotoxemia and polymicrobial sepsis. Pharmacol Res 2012;65:328-37
   PubMedGoogle Scholar
• Pearl R. The rate of living. University of London Press; London: 1928
   Google Scholar
• Zengi A, Ercan G, Caglayan O, Increased oxidative DNA damage in lean normoglycemic offspring of type 2 diabetic patients. Exp Clin Endocrinol Diabetes 2011;119:467-71
   PubMed Web of Science ®Google Scholar
• Vendelbo MH, Nair KS. Mitochondrial longevity pathways. Biochim Biophys Acta 2011;1813:634-44
   PubMedGoogle Scholar
• Tupe RS, Tupe SG, Agte VV. Dietary nicotinic acid supplementation improves hepatic zinc uptake and offers hepatoprotection against oxidative damage. Br J Nutr 2011;1-9
   Google Scholar
• Tanno M, Kuno A, Yano T, Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. J Biol Chem 2010;285:8375-82
   PubMed Web of Science ®Google Scholar
• Hou J, Chong ZZ, Shang YC, Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation. Curr Neurovasc Res 2010;7:95-112
   PubMed Web of Science ®Google Scholar
• Jourde-Chiche N, Dou L, Cerini C, Vascular incompetence in dialysis patients-protein-bound uremic toxins and endothelial dysfunction. Semin Dial 2011;24:327-37
   PubMedGoogle Scholar
• Nerurkar PV, Johns LM, Buesa LM, Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation. J Neuroinflammation 2011;8:64
   PubMed Web of Science ®Google Scholar
• Shang YC, Chong ZZ, Hou J, FoxO3a governs early microglial proliferation and employs mitochondrial depolarization with caspase 3, 8, and 9 cleavage during oxidant induced apoptosis. Curr Neurovasc Res 2009;6:223-38
   PubMedGoogle Scholar
• Shang YC, Chong ZZ, Hou J, Wnt1, FoxO3a, and NF-kappaB oversee microglial integrity and activation during oxidant stress. Cell Signal 2010;22:1317-29
   PubMedGoogle Scholar
• Poulose SM, Bielinski DF, Carrihill-Knoll K, Exposure to (16)O-particle radiation causes aging-like decrements in rats through increased oxidative stress, inflammation and loss of autophagy. Radiat Res 2011;176:761-9
   PubMedGoogle Scholar
• Chong ZZ, Shang YC, Hou J, Wnt1 neuroprotection translates into improved neurological function during oxidant stress and cerebral ischemia through AKT1 and mitochondrial apoptotic pathways. Oxid Med Cell Longev 2010;3:153-65
   PubMed Web of Science ®Google Scholar
• Raza SS, Khan MM, Ashafaq M, Silymarin protects neurons from oxidative stress associated damages in focal cerebral ischemia: a behavioral, biochemical and immunohistological study in Wistar rats. J Neurol Sci 2011;309:45-54
   PubMedGoogle Scholar
• Hou J, Chong ZZ, Shang YC, FoxO3a governs early and late apoptotic endothelial programs during elevated glucose through mitochondrial and caspase signaling. Mol Cell Endocrinol 2010;321:194-206
   PubMedGoogle Scholar
• Liu Z, Stanojevic V, Brindamour LJ, GLP1-derived nonapeptide GLP1(28-36)amide protects pancreatic beta-cells from glucolipotoxicity. J Endocrinol 2012;213:143-54
   PubMed Web of Science ®Google Scholar
• Cechetti F, Worm PV, Elsner VR, Forced treadmill exercise prevents oxidative stress and memory deficits following chronic cerebral hypoperfusion in the rat. Neurobiol Learn Mem 2012;97:90-6
   PubMed Web of Science ®Google Scholar
• Bailey TJ, Fossum SL, Fimbel SM, The inhibitor of phagocytosis, O-phospho-L-serine, suppresses Muller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina. Exp Eye Res 2010;91:601-12
   PubMedGoogle Scholar
• Chong ZZ, Kang J, Li F, mGluRI targets microglial activation and selectively prevents neuronal cell engulfment through akt and caspase dependent pathways. Curr Neurovasc Res 2005;2:197-211
   PubMedGoogle Scholar
• Koh PO. Nicotinamide attenuates the decrease of astrocytic phosphoprotein PEA-15 in focal cerebral ischemic injury. J Vet Med Sci 2012;74:377-80
   PubMed Web of Science ®Google Scholar
• Maiese K, Chong ZZ, Shang YC. “Sly as a FOXO”: new paths with Forkhead signaling in the brain. Curr Neurovasc Res 2007;4:295-302
   PubMed Web of Science ®Google Scholar
• Aksu U, Demirci C, Ince C. The pathogenesis of acute kidney injury and the toxic triangle of oxygen, reactive oxygen species and nitric oxide. Contrib Nephrol 2011;174:119-28
   PubMed Web of Science ®Google Scholar
• Balan V, Miller GS, Kaplun L, Life span extension and neuronal cell protection by Drosophila nicotinamidase. J Biol Chem 2008;283:27810-19
   PubMed Web of Science ®Google Scholar
• Chong ZZ, Li F, Maiese K. Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways. Cell Signal 2007;19:1150-62
   PubMed Web of Science ®Google Scholar
• Chong ZZ, Hou J, Shang YC, EPO relies upon novel signaling of Wnt1 that requires Akt1, FoxO3a, GSK-3beta, and beta-catenin to foster vascular integrity during experimental diabetes. Curr Neurovasc Res 2011;8:103-20
   PubMed Web of Science ®Google Scholar
• Kook YH, Ka M, Um M. Neuroprotective cytokines repress PUMA induction in the 1-methyl-4-phenylpyridinium (MPP(+)) model of Parkinson's disease. Biochem Biophys Res Commun 2011;411:370-4
   PubMed Web of Science ®Google Scholar
• Ullah N, Lee HY, Naseer MI, Nicotinamide inhibits alkylating agent-induced apoptotic neurodegeneration in the developing rat brain. PLoS One 2011;6:e27093
   PubMedGoogle Scholar
• Troy CM, Akpan N, Jean YY. Regulation of caspases in the nervous system implications for functions in health and disease. Prog Mol Biol Transl Sci 2011;99:265-305
   PubMed Web of Science ®Google Scholar
• Salvesen GS, Riedl SJ. Caspase mechanisms. Adv Exp Med Biol 2008;615:13-23
   PubMed Web of Science ®Google Scholar
• Chong ZZ, Lin SH, Kang JQ, Erythropoietin prevents early and late neuronal demise through modulation of Akt1 and induction of caspase 1, 3, and 8. J Neurosci Res 2003;71:659-69
   PubMed Web of Science ®Google Scholar
• Shang YC, Chong ZZ, Hou J, The forkhead transcription factor FoxO3a controls microglial inflammatory activation and eventual apoptotic injury through caspase 3. Curr Neurovasc Res 2009;6:20-31
   PubMedGoogle Scholar
• Broe M, Shepherd CE, Milward EA, Relationship between DNA fragmentation, morphological changes and neuronal loss in Alzheimer's disease and dementia with Lewy bodies. Acta Neuropathol 2001;101:616-24
   PubMedGoogle Scholar
• Louneva N, Cohen JW, Han LY, Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease. Am J Pathol 2008;173:1488-95
   PubMed Web of Science ®Google Scholar
• Grammas P, Tripathy D, Sanchez A, Brain microvasculature and hypoxia-related proteins in Alzheimer's disease. Int J Clin Exp Pathol 2011;4:616-27
   PubMedGoogle Scholar
• Tatton NA. Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease. Exp Neurol 2000;166:29-43
   PubMed Web of Science ®Google Scholar
• Narula J, Acio ER, Narula N, Annexin-V imaging for noninvasive detection of cardiac allograft rejection. Nat Med 2001;7:1347-52
   PubMed Web of Science ®Google Scholar
• Shang YC, Chong ZZ, Wang S, Erythropoietin and Wnt1 Govern Pathways of mTOR, Apaf-1, and XIAP in Inflammatory Microglia. Curr Neurovasc Res 2011;198:270-85
   PubMed Web of Science ®Google Scholar
• Zhou X, Wang L, Wang M, Emodin-induced microglial apoptosis is associated with TRB3 induction. Immunopharmacol Immunotoxicol 2011;33:594-602
   PubMed Web of Science ®Google Scholar
• Yamada E, Singh R. Mapping autophagy on to your metabolic radar. Diabetes 2012;61:272-80
   PubMed Web of Science ®Google Scholar
• Gumy LF, Tan CL, Fawcett JW. The role of local protein synthesis and degradation in axon regeneration. Exp Neurol 2010;223:28-37
   PubMedGoogle Scholar
• Silva DF, Esteves AR, Oliveira CR, Mitochondria: the common upstream driver of amyloid-beta and tau pathology in Alzheimer's disease. Curr Alzheimer Res 2011;8:563-72
   PubMed Web of Science ®Google Scholar
• Spencer B, Potkar R, Trejo M, Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. J Neurosci 2009;29:13578-88
   PubMed Web of Science ®Google Scholar
• Spilman P, Podlutskaya N, Hart MJ, Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One 2010;5:e9979
   PubMed Web of Science ®Google Scholar
• Jeong JK, Moon MH, Bae BC, Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity. Neurosci Res 2012;73:99-105
   PubMed Web of Science ®Google Scholar
• Xilouri M, Vogiatzi T, Vekrellis K, Aberrant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy. PLoS ONE 2009;4:e5515
   PubMed Web of Science ®Google Scholar
• Qin AP, Liu CF, Qin YY, Autophagy. was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia. Autophagy 2010;6:738-53
   PubMed Web of Science ®Google Scholar
• Baba H, Sakurai M, Abe K, Autophagy-mediated stress response in motor neuron after transient ischemia in rabbits. J Vasc Surg 2009;50:381-7
   PubMedGoogle Scholar
• Wang JY, Xia Q, Chu KT, Severe global cerebral ischemia-induced programmed necrosis of hippocampal CA1 neurons in rat is prevented by 3-methyladenine: a widely used inhibitor of autophagy. J Neuropathol Exp Neurol 2011;70:314-22
   PubMed Web of Science ®Google Scholar
• Canu N, Tufi R, Serafino AL, Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells. J Neurochem 2005;92:1228-42
   PubMed Web of Science ®Google Scholar
• Xue L, Fletcher GC, Tolkovsky AM. Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution. Mol Cell Neurosci 1999;14:180-98
   PubMed Web of Science ®Google Scholar
• Nopparat C, Porter JE, Ebadi M, The mechanism for the neuroprotective effect of melatonin against methamphetamine-induced autophagy. J Pineal Res 2010;49(4):382-9
   PubMed Web of Science ®Google Scholar
• Pattingre S, Tassa A, Qu X, Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005;122:927-39
   PubMed Web of Science ®Google Scholar
• Carayol N, Vakana E, Sassano A, Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells. Proc Natl Acad Sci USA 2010;107:12469-74
   PubMed Web of Science ®Google Scholar
• Luo S, Rubinsztein DC. Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL. Cell Death Differ 2010;17:268-77
   PubMed Web of Science ®Google Scholar
• Maiese K. The many facets of cell injury: angiogenesis to autophagy. Curr Neurovasc Res 2012;9:1-2
   PubMedGoogle Scholar
• McPhee CK, Logan MA, Freeman MR, Activation of autophagy during cell death requires the engulfment receptor Draper. Nature 2010;24465:1093-6
   PubMed Web of Science ®Google Scholar
• Davies SR, Davies ML, Sanders A, Differential expression of the CCN family member WISP-1, WISP-2 and WISP-3 in human colorectal cancer and the prognostic implications. Int J Oncol 2010;36:1129-36
   PubMedGoogle Scholar
• Desnoyers L, Arnott D, Pennica D. WISP-1 binds to decorin and biglycan. J Biol Chem 2001;276:47599-607
   PubMedGoogle Scholar
• Colston JT, de la Rosa SD, Koehler M, Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor. Am J Physiol Heart Circ Physiol 2007;293:H1839-46
   PubMed Web of Science ®Google Scholar
• Wang S, Chong ZZ, Shang YC, Wnt1 inducible signaling pathway protein 1 (WISP1) blocks neurodegeneration through phosphoinositide 3 kinase/Akt1 and apoptotic mitochondrial signaling involving Bad, Bax, Bim, and Bcl-xL. Curr Neurovasc Res 2012;9:20-31
   PubMed Web of Science ®Google Scholar
• Wang S, Chong ZZ, Shang YC, WISP1 (CCN4) autoregulates its expression and nuclear trafficking of beta-catenin during oxidant stress with limited effects upon neuronal autophagy. Curr Neurovasc Res 2012;9:89-99
   Web of Science ®Google Scholar
• Heise RL, Stober V, Cheluvaraju C, Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity. J Biol Chem 2011;286:17435-44
   PubMed Web of Science ®Google Scholar
• French DM, Kaul RJ, D'Souza AL, WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair. Am J Pathol 2004;165:855-67
   PubMedGoogle Scholar
• Macsai CE, Georgiou KR, Foster BK, Microarray expression analysis of genes and pathways involved in growth plate cartilage injury responses and bony repair. Bone 2012;50:1081-91
   PubMed Web of Science ®Google Scholar
• Maiese K, Li F, Chong ZZ, The Wnt signaling pathway: aging gracefully as a protectionist? Pharmacol Ther 2008;118:58-81
   PubMed Web of Science ®Google Scholar
• Noguti J, CF DEM, Hossaka TA, The role of canonical WNT signaling pathway in oral carcinogenesis: a comprehensive review. Anticancer Res 2012;32:873-8
   PubMed Web of Science ®Google Scholar
• Chong ZZ, Shang YC, Maiese K. Vascular injury during elevated glucose can be mitigated by erythropoietin and Wnt signaling. Curr Neurovasc Res 2007;4:194-204
   PubMed Web of Science ®Google Scholar
• Jiang YL, Ning Y, Ma XL, Alteration of the proteome profile of the pancreas in diabetic rats induced by streptozotocin. Int J Mol Med 2011;28:153-60
   PubMedGoogle Scholar
• Fernandez-Martos CM, Gonzalez-Fernandez C, Gonzalez P, Differential expression of wnts after spinal cord contusion injury in adult rats. PLoS One 2011;6:e27000
   PubMedGoogle Scholar
• L'Episcopo F, Tirolo C, Testa N, Reactive astrocytes and Wnt/beta-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Neurobiol Dis 2011;41:508-27
   PubMed Web of Science ®Google Scholar
• Lee G, Goretsky T, Managlia E, Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis. Gastroenterology 2010;139:869-81. 81 e1-9
   PubMedGoogle Scholar
• Marchand A, Atassi F, Gaaya A, The Wnt/beta-catenin pathway is activated during advanced arterial aging in humans. Aging Cell 2011;10:220-32
   PubMed Web of Science ®Google Scholar
• Wexler EM, Rosen E, Lu D, Genome-wide analysis of a wnt1-regulated transcriptional network implicates neurodegenerative pathways. Sci signal 2011;4:ra65
   PubMed Web of Science ®Google Scholar
• Chen JR, Lazarenko OP, Shankar K, A role for ethanol-induced oxidative stress in controlling lineage commitment of mesenchymal stromal cells through inhibition of Wnt/ beta-catenin signaling. J Bone Miner Res 2010;25(5):1117-27
   PubMedGoogle Scholar
• L'Episcopo F, Tirolo C, Testa N, Plasticity of subventricular zone neuroprogenitors in MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) mouse model of Parkinson's disease involves cross talk between inflammatory and Wnt/beta-catenin signaling pathways: functional consequences for neuroprotection and repair. J Neurosci 2012;32:2062-85
   PubMed Web of Science ®Google Scholar
• Shang YC, Chong ZZ, Wang S, Prevention of beta-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL. Aging (Albany NY) 2012;4:187-201
   PubMedGoogle Scholar
• Li F, Chong ZZ, Maiese K. Winding through the WNT pathway during cellular development and demise. Histol Histopathol 2006;21:103-24
   PubMed Web of Science ®Google Scholar
• Liu YL, Yang HP, Zhou XD, The hypomethylation agent bisdemethoxycurcumin acts on the WIF-1 promoter, inhibits the canonical Wnt pathway and induces apoptosis in human non-small-cell lung cancer. Curr Cancer Drug Targets 2011;11(9):1098-110
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wang F, Han L, GABARAPL1 negatively regulates Wnt/beta-catenin signaling by mediating Dvl2 degradation through the autophagy pathway. Cell Physiol Biochem 2011;27:503-12
   PubMedGoogle Scholar
• Su F, Overholtzer M, Besser D, WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. Genes Dev 2002;16:46-57
   PubMed Web of Science ®Google Scholar
• Shanmugam P, Valente AJ, Prabhu SD, Angiotensin-II type 1 receptor and NOX2 mediate TCF/LEF and CREB dependent WISP1 induction and cardiomyocyte hypertrophy. J Mol Cell Cardiol 2011;50:928-38
   PubMedGoogle Scholar
• Reddy VS, Valente AJ, Delafontaine P, Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation. J Cell Physiol 2011;226:3303-15
   PubMedGoogle Scholar
• Venkatesan B, Prabhu SD, Venkatachalam K, WNT1-inducible signaling pathway protein-1 activates diverse cell survival pathways and blocks doxorubicin-induced cardiomyocyte death. Cell Signal 2010;22:809-20
   PubMed Web of Science ®Google Scholar
• Chong ZZ, Maiese K. The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: diversified control of cell growth, inflammation, and injury. Histol Histopathol 2007;22:1251-67
   PubMed Web of Science ®Google Scholar
• Baryawno N, Sveinbjornsson B, Eksborg S, Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth. Cancer Res 2010;70:266-76
   PubMed Web of Science ®Google Scholar
• Chung CY, Park YL, Song YA, Knockdown of RON Inhibits AP-1 activity and induces apoptosis and cell cycle arrest through the modulation of Akt/FoxO signaling in human colorectal cancer cells. Dig Dis Sci 2012;57:371-80
   PubMedGoogle Scholar
• Fokas E, Yoshimura M, Prevo R, NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity. Radiat Oncol 2012;7:48
   PubMed Web of Science ®Google Scholar
• Janku F, Wheler JJ, Westin SN, PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations. J Clin Oncol 2012;30:777-82
   PubMed Web of Science ®Google Scholar
• Kapoor V, Zaharieva MM, Das SN, Erufosine simultaneously induces apoptosis and autophagy by modulating the Akt-mTOR signaling pathway in oral squamous cell carcinoma. Cancer Lett 2012;319:39-48
   PubMed Web of Science ®Google Scholar
• Le XF, Mao W, Lu Z, Dasatinib induces autophagic cell death in human ovarian cancer. Cancer 2010;116(21):4980-90
   PubMedGoogle Scholar
• Li F, Chong ZZ, Maiese K. Microglial integrity is maintained by erythropoietin through integration of Akt and its substrates of glycogen synthase kinase-3beta, beta-catenin, and nuclear factor-kappaB. Curr Neurovasc Res 2006;3:187-201
   PubMed Web of Science ®Google Scholar
• Case N, Ma M, Sen B, Beta-catenin levels influence rapid mechanical responses in osteoblasts. J Biol Chem 2008;283:29196-205
   PubMedGoogle Scholar
• Nguyen TM, Subramanian IV, Xiao X, Endostatin induces autophagy in endothelial cells by modulating Beclin 1 and beta-catenin levels. J Cell Mol Med 2009;13:3687-98
   PubMed Web of Science ®Google Scholar
• Wang Y, Ding L, Wang X, Pterostilbene simultaneously induces apoptosis, cell cycle arrest and cyto-protective autophagy in breast cancer cells. Am J Transl Res 2012;4:44-51
   PubMed Web of Science ®Google Scholar
• Chong ZZ, Maiese K. Mammalian target of rapamycin signaling in diabetic cardiovascular disease. Cardiovasc Diabetol 2012;11:45
   PubMedGoogle Scholar
• Chong ZZ, Shang YC, Maiese K. Cardiovascular disease and mTOR signaling. Trends Cardiovasc Med 2011;21:151-5
   PubMed Web of Science ®Google Scholar
• Hwang SK, Kim HH. The functions of mTOR in ischemic diseases. BMB Rep 2011;44:506-11
   PubMed Web of Science ®Google Scholar
• Benjamin D, Colombi M, Moroni C, Rapamycin passes the torch: a new generation of mTOR inhibitors. Nat Rev Drug Discov 2011;10:868-80
   PubMed Web of Science ®Google Scholar
• Chong ZZ, Shang YC, Zhang L, Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders. Oxid Med Cell Longev 2010;3:374-91
   PubMed Web of Science ®Google Scholar
• Chen L, Xu B, Liu L, Hydrogen peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells. Lab Invest 2010;90:762-73
   PubMed Web of Science ®Google Scholar
• Chong ZZ, Li F, Maiese K. The pro-survival pathways of mTOR and protein kinase B target glycogen synthase kinase-3beta and nuclear factor-kappaB to foster endogenous microglial cell protection. Int J Mol Med 2007;19:263-72
   PubMedGoogle Scholar
• Choi KC, Kim SH, Ha JY, A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death. J Neurochem 2010;112:366-76
   PubMed Web of Science ®Google Scholar
• Wu X, Reiter CE, Antonetti DA, Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner. J Biol Chem 2004;279:9167-75
   PubMedGoogle Scholar
• Kim J, Jung Y, Sun H, Erythropoietin mediated bone formation is regulated by mTOR signaling. J Cell Biochem 2012;113:220-8
   PubMed Web of Science ®Google Scholar
• Chong ZZ, Li F, Maiese K. Attempted cell cycle induction in post-mitotic neurons occurs in early and late apoptotic programs through Rb, E2F1, and caspase 3. Curr Neurovasc Res 2006;3:25-39
   PubMedGoogle Scholar
• Yu Y, Ren QG, Zhang ZH, Phospho-Rb mediating cell cycle reentry induces early apoptosis following oxygen-glucose deprivation in rat cortical neurons. Neurochem Res 2012;37:503-11
   PubMedGoogle Scholar
• Bhaskar K, Miller M, Chludzinski A, The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events. Mol Neurodegener 2009;4:14
   PubMed Web of Science ®Google Scholar
• Pastor MD, Garcia-Yebenes I, Fradejas N, mTOR/S6 kinase pathway contributes to astrocyte survival during ischemia. J Biol Chem 2009;284:22067-78
   PubMed Web of Science ®Google Scholar
• Zhang D, Contu R, Latronico MV, MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest 2010;120:2805-16
   PubMed Web of Science ®Google Scholar
• Dormond O, Madsen JC, Briscoe DM. The effects of mTOR-Akt interactions on anti-apoptotic signaling in vascular endothelial cells. J Biol Chem 2007;282:23679-86
   PubMed Web of Science ®Google Scholar
• Thedieck K, Polak P, Kim ML, PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. PLoS One 2007;2:e1217
   PubMed Web of Science ®Google Scholar
• Nascimento EB, Snel M, Guigas B, Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1. Cell Signal 2010;22:961-7
   PubMed Web of Science ®Google Scholar
• Yu L, McPhee CK, Zheng L, Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature 2010;465:942-6
   PubMed Web of Science ®Google Scholar
• Schips TG, Wietelmann A, Hohn K, FoxO3 induces reversible cardiac atrophy and autophagy in a transgenic mouse model. Cardiovasc Res 2011;91:587-97
   PubMed Web of Science ®Google Scholar
• Jaber N, Dou Z, Chen JS, Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function. Proc Natl Acad Sci USA 2012;109:2003-8
   PubMed Web of Science ®Google Scholar
• Ogura Y, Iemitsu M, Naito H, Single bout of running exercise changes LC3-II expression in rat cardiac muscle. Biochem Biophys Res Commun 2011;414:756-60
   PubMedGoogle Scholar
• Maiese K, Chong ZZ, Shang YC, Rogue proliferation versus restorative protection: where do we draw the line for Wnt and forkhead signaling? Expert Opin Ther Targets 2008;12:905-16
   PubMed Web of Science ®Google Scholar
• Yeo W, Gautier J. Early neural cell death: dying to become neurons. Dev Biol 2004;274:233-44
   PubMedGoogle Scholar
• Wang RH, Kim HS, Xiao C, Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. J Clin Invest 2011;121:4477-90
   PubMed Web of Science ®Google Scholar
• Lafay-Chebassier C, Perault-Pochat MC, Page G, The immunosuppressant rapamycin exacerbates neurotoxicity of Abeta peptide. J Neurosci Res 2006;84:1323-34
   PubMedGoogle Scholar
• Hernandez G, Lal H, Fidalgo M, A novel cardioprotective p38-MAPK/mTOR pathway. Exp Cell Res 2011;317:2938-49
   PubMed Web of Science ®Google Scholar
• Sinha SS, Pham MX, Vagelos RH, Effect of rapamycin therapy on coronary artery physiology early after cardiac transplantation. Am Heart J 2008;155:889; e1-6
   PubMedGoogle Scholar