Targeting the ATF4 pathway in cancer therapy

Bibliography

• Harris AL. Hypoxia–a key regulatory factor in tumour growth. Nat Rev Cancer 2002;2(1):38-47
   PubMed Web of Science ®Google Scholar
• Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005;307(5706):58-62
   PubMed Web of Science ®Google Scholar
• Wouters BG, Koritzinsky M. Hypoxia signalling through mTOR and the unfolded protein response in cancer. Nat Rev Cancer 2008;8(11):851-64
   PubMed Web of Science ®Google Scholar
• Chan DA, Giaccia AJ. Hypoxia, gene expression, and metastasis. Cancer Metastasis Rev 2007;26(2):333-9
   PubMed Web of Science ®Google Scholar
• Bristow RG, Hill RP. Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat Rev Cancer 2008;8(3):180-92
   PubMed Web of Science ®Google Scholar
• Wilson WR, Hay MP. Targeting hypoxia in cancer therapy. Nat Rev Cancer 2011;11(6):393-410
   PubMed Web of Science ®Google Scholar
• Lou Y, McDonald PC, Oloumi A, Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res 2011;71(9):3364-76
   PubMed Web of Science ®Google Scholar
• Harding HP, Novoa I, Zhang Y, Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell 2000;6(5):1099-108
   PubMed Web of Science ®Google Scholar
• McEwen E, Kedersha N, Song B, Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure. J Biol Chem 2005;280(17):16925-33
   PubMedGoogle Scholar
• Garcia MA, Meurs EF, Esteban M. The dsRNA protein kinase PKR: virus and cell control. Biochimie 2007;89(6-7):799-811
   PubMed Web of Science ®Google Scholar
• Sood R, Porter AC, Olsen DA, A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha. Genetics 2000;154(2):787-801
   PubMedGoogle Scholar
• Deng J, Harding HP, Raught B, Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol 2002;12(15):1279-86
   PubMedGoogle Scholar
• Krishnamoorthy T, Pavitt GD, Zhang F, Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide exchange factor eIF2B is required for inhibition of translation initiation. Mol Cell Biol 2001;21(15):5018-30
   PubMedGoogle Scholar
• Wek RC, Jiang HY, Anthony TG. Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans 2006;34(Pt 1):7-11
   PubMed Web of Science ®Google Scholar
• Vattem KM, Wek RC. Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc Natl Acad Sci USA 2004;101(31):11269-74
   PubMed Web of Science ®Google Scholar
• Lu PD, Harding HP, Ron D. Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. J Cell Biol 2004;167(1):27-33
   PubMed Web of Science ®Google Scholar
• Harding HP, Zhang Y, Zeng H, An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 2003;11(3):619-33
   PubMed Web of Science ®Google Scholar
• Yang X, Matsuda K, Bialek P, ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell 2004;117(3):387-98
   PubMed Web of Science ®Google Scholar
• Elefteriou F, Ahn JD, Takeda S, Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 2005;434(7032):514-20
   PubMed Web of Science ®Google Scholar
• Lassot I, Segeral E, Berlioz-Torrent C, ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase. Mol Cell Biol 2001;21(6):2192-202
   PubMedGoogle Scholar
• Ameri K, Lewis CE, Raida M, Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells. Blood 2004;103(5):1876-82
   PubMedGoogle Scholar
• Adams CM. Role of the transcription factor ATF4 in the anabolic actions of insulin and the anti-anabolic actions of glucocorticoids. J Biol Chem 2007;282(23):16744-53
   PubMedGoogle Scholar
• Bi M, Naczki C, Koritzinsky M, ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J 2005;24(19):3470-81
   PubMed Web of Science ®Google Scholar
• Hettmann T, Barton K, Leiden JM. Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor. Dev Biol 2000;222(1):110-23
   PubMedGoogle Scholar
• Seo J, Fortuno ES III, Suh JM, Atf4 regulates obesity, glucose homeostasis, and energy expenditure. Diabetes 2009;58(11):2565-73
   PubMed Web of Science ®Google Scholar
• Masuoka HC, Townes TM. Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice. Blood 2002;99(3):736-45
   PubMedGoogle Scholar
• Yoshizawa T, Hinoi E, Jung DY, The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts. J Clin Invest 2009;119(9):2807-17
   PubMed Web of Science ®Google Scholar
• Hara K, Yonezawa K, Weng QP, Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem 1998;273(23):14484-94
   PubMed Web of Science ®Google Scholar
• Nicklin P, Bergman P, Zhang B, Bidirectional transport of amino acids regulates mTOR and autophagy. Cell 2009;136(3):521-34
   PubMed Web of Science ®Google Scholar
• Jin HO, Seo SK, Woo SH, Activating transcription factor 4 and CCAAT/enhancer-binding protein-beta negatively regulate the mammalian target of rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress. Free Radic Biol Med 2009;46(8):1158-67
   PubMedGoogle Scholar
• Jin HO, Seo SK, Woo SH, SP600125 negatively regulates the mammalian target of rapamycin via ATF4-induced Redd1 expression. FEBS Lett 2009;583(1):123-7
   PubMedGoogle Scholar
• Whitney ML, Jefferson LS, Kimball SR. ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression. Biochem Biophys Res Commun 2009;379(2):451-5
   PubMed Web of Science ®Google Scholar
• Ye J, Kumanova M, Hart LS, The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. EMBO J 2010;29(12):2082-96
   PubMed Web of Science ®Google Scholar
• Zhang K, Kaufman RJ. From endoplasmic-reticulum stress to the inflammatory response. Nature 2008;454(7203):455-62
   PubMed Web of Science ®Google Scholar
• Rzymski T, Milani M, Pike L, Regulation of autophagy by ATF4 in response to severe hypoxia. Oncogene 2010;29(31):4424-35
   PubMed Web of Science ®Google Scholar
• Tang X, Lucas JE, Chen JL, Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs. Cancer Res 2012;72(2):491-502
   PubMed Web of Science ®Google Scholar
• Ye J, Mancuso A, Tong X, Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc Natl Acad Sci USA 2012;109(18):6904-9
   PubMed Web of Science ®Google Scholar
• Mazurek S. Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells. Int J Biochem Cell Biol 2011;43(7):969-80
   PubMed Web of Science ®Google Scholar
• Horiguchi M, Koyanagi S, Okamoto A, Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors. Cancer Res 2012;72(2):395-401
   PubMedGoogle Scholar
• Lopez AB, Wang C, Huang CC, A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation. Biochem J 2007;402(1):163-73
   PubMedGoogle Scholar
• Wang Q, Bailey CG, Ng C, Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression. Cancer Res 2011;71(24):7525-36
   PubMed Web of Science ®Google Scholar
• Igarashi T, Izumi H, Uchiumi T, Clock and ATF4 transcription system regulates drug resistance in human cancer cell lines. Oncogene 2007;26(33):4749-60
   PubMed Web of Science ®Google Scholar
• Imming P, Sinning C, Meyer A. Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov 2006;5(10):821-34
   PubMed Web of Science ®Google Scholar
• Stegmaier K, Wong JS, Ross KN, Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma. PLoS Med 2007;4(4):e122
   PubMed Web of Science ®Google Scholar
• Zhang J, Yang PL, Gray NS. Targeting cancer with small molecule kinase inhibitors. Nat Rev Cancer 2009;9(1):28-39
   PubMed Web of Science ®Google Scholar
• Fan CF, Mao XY, Wang EH. Elevated p-CREB-2 (ser 245) expression is potentially associated with carcinogenesis and development of breast carcinoma. Mol Med Report 2012;5(2):357-62
   PubMedGoogle Scholar
• Smith JA, Poteet-Smith CE, Xu Y, Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res 2005;65(3):1027-34
   PubMed Web of Science ®Google Scholar
• Sapkota GP, Cummings L, Newell FS, BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. Biochem J 2007;401(1):29-38
   PubMed Web of Science ®Google Scholar
• Cohen MS, Zhang C, Shokat KM, Taunton J. Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science 2005;308(5726):1318-21
   PubMed Web of Science ®Google Scholar
• Andreani A, Granaiola M, Leoni A, Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors. Eur J Med Chem 2011;46(9):4311-23
   PubMedGoogle Scholar
• Murray AJ. Pharmacological PKA inhibition: all may not be what it seems. Sci Signal 2008;1(22):re4
   PubMed Web of Science ®Google Scholar
• Brudvik KW, Paulsen JE, Aandahl EM, Protein kinase A antagonist inhibits beta-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in Apc(Min/+) mice. Mol Cancer 2011;10:149
   PubMedGoogle Scholar
• Pons J, Evrard-Todeschi N, Bertho G, Transfer-NMR and docking studies identify the binding of the peptide derived from activating transcription factor 4 to protein ubiquitin ligase beta-TrCP. Competition STD-NMR with beta-catenin. Biochemistry 2008;47(1):14-29
   PubMed Web of Science ®Google Scholar
• Wang A, Xu S, Zhang X, Ribosomal protein RPL41 induces rapid degradation of ATF4, a transcription factor critical for tumour cell survival in stress. J Pathol 2011;225(2):285-92
   PubMedGoogle Scholar
• Lassot I, Estrabaud E, Emiliani S, p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain. J Biol Chem 2005;280(50):41537-45
   PubMedGoogle Scholar
• Bowers EM, Yan G, Mukherjee C, Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol 2010;17(5):471-82
   PubMedGoogle Scholar
• Wang H, Blais J, Ron D, Cardozo T. Structural determinants of PERK inhibitor potency and selectivity. Chem Biol Drug Des 2010;76(6):480-95
   PubMed Web of Science ®Google Scholar
• Jammi NV, Whitby LR, Beal PA. Small molecule inhibitors of the RNA-dependent protein kinase. Biochem Biophys Res Commun 2003;308(1):50-7
   PubMedGoogle Scholar
• Shimazawa M, Hara H. Inhibitor of double stranded RNA-dependent protein kinase protects against cell damage induced by ER stress. Neurosci Lett 2006;409(3):192-5
   PubMedGoogle Scholar
• Ingrand S, Barrier L, Lafay-Chebassier C, The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation. FEBS Lett 2007;581(23):4473-8
   PubMedGoogle Scholar
• Zhu PJ, Huang W, Kalikulov D, Suppression of PKR promotes network excitability and enhanced cognition by interferon-gamma-mediated disinhibition. Cell 2011;147(6):1384-96
   PubMedGoogle Scholar
• Bryk R, Wu K, Raimundo BC, Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett 2011;21(13):4108-14
   PubMed Web of Science ®Google Scholar
• Robert F, Williams C, Yan Y, Blocking UV-induced eIF2alpha phosphorylation with small molecule inhibitors of GCN2. Chem Biol Drug Des 2009;74(1):57-67
   PubMedGoogle Scholar
• Rosen MD, Woods CR, Goldberg SD, Discovery of the first known small-molecule inhibitors of heme-regulated eukaryotic initiation factor 2alpha (HRI) kinase. Bioorg Med Chem Lett 2009;19(23):6548-51
   PubMedGoogle Scholar
• Chen T, Ozel D, Qiao Y, Chemical genetics identify eIF2alpha kinase heme-regulated inhibitor as an anticancer target. Nat Chem Biol 2011;7(9):610-16
   PubMed Web of Science ®Google Scholar
• Papandreou I, Denko NC, Olson M, Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood 2011;117(4):1311-14
   PubMed Web of Science ®Google Scholar
• Lee ES, Yoon CH, Kim YS, Bae YS. The double-strand RNA-dependent protein kinase PKR plays a significant role in a sustained ER stress-induced apoptosis. FEBS Lett 2007;581(22):4325-32
   PubMedGoogle Scholar
• Acharya P, Chen JJ, Correia MA. Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone. Mol Pharmacol 2010;77(4):575-92
   PubMed Web of Science ®Google Scholar
• Cullinan SB, Zhang D, Hannink M, Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol 2003;23(20):7198-209
   PubMed Web of Science ®Google Scholar
• Novoa I, Zeng H, Harding HP, Ron D. Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha. J Cell Biol 2001;153(5):1011-22
   PubMed Web of Science ®Google Scholar
• Jousse C, Oyadomari S, Novoa I, Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells. J Cell Biol 2003;163(4):767-75
   PubMedGoogle Scholar
• Tsaytler P, Harding HP, Ron D, Bertolotti A. Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis. Science 2011;332(6025):91-4
   PubMed Web of Science ®Google Scholar
• Kim R, Emi M, Tanabe K, Murakami S. Role of the unfolded protein response in cell death. Apoptosis 2006;11(1):5-13
   PubMed Web of Science ®Google Scholar
• Rabinowitz JD, White E. Autophagy and metabolism. Science 2010;330(6009):1344-8
   PubMed Web of Science ®Google Scholar
• Rouschop KM, van den Beucken T, Dubois L, The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. J Clin Invest 2009
   PubMedGoogle Scholar
• McAfee Q, Zhang Z, Samanta A, Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. Proc Natl Acad Sci USA 2012;109(21):8253-8
   PubMed Web of Science ®Google Scholar
• Miller S, Tavshanjian B, Oleksy A, Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34. Science 2010;327(5973):1638-42
   PubMed Web of Science ®Google Scholar
• Claessen JH, Kundrat L, Ploegh HL. Protein quality control in the ER: balancing the ubiquitin checkbook. Trends Cell Biol 2012;22(1):22-32
   PubMedGoogle Scholar
• Ma Y, Hendershot LM. Herp is dually regulated by both the endoplasmic reticulum stress-specific branch of the unfolded protein response and a branch that is shared with other cellular stress pathways. J Biol Chem 2004;279(14):13792-9
   PubMedGoogle Scholar
• Obeng EA, Carlson LM, Gutman DM, Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood 2006;107(12):4907-16
   PubMed Web of Science ®Google Scholar
• Fels DR, Ye J, Segan AT, Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways. Cancer Res 2008;68(22):9323-30
   PubMedGoogle Scholar
• Milani M, Rzymski T, Mellor HR, The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib. Cancer Res 2009;69(10):4415-23
   PubMed Web of Science ®Google Scholar
• Siu F, Bain PJ, LeBlanc-Chaffin R, ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene. J Biol Chem 2002;277(27):24120-7
   PubMedGoogle Scholar
• Chen H, Pan YX, Dudenhausen EE, Kilberg MS. Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient-responsive basic region/leucine zipper transcription factors as well as localized histone acetylation. J Biol Chem 2004;279(49):50829-39
   PubMedGoogle Scholar
• Gutierrez JA, Pan YX, Koroniak L, An inhibitor of human asparagine synthetase suppresses proliferation of an L-asparaginase-resistant leukemia cell line. Chem Biol 2006;13(12):1339-47
   PubMedGoogle Scholar
• Rapisarda A, Hollingshead M, Uranchimeg B, Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition. Mol Cancer Ther 2009;8(7):1867-77
   PubMedGoogle Scholar
• Wang J, Foehrenbacher A, Su J, The 2-nitroimidazole EF5 is a biomarker for oxidoreductases that activate the bioreductive prodrug CEN-209 under hypoxia. Clin Cancer Res 2012;18(6):1684-95
   PubMed Web of Science ®Google Scholar