The role of sphingosine-1 phosphate and ceramide-1 phosphate in trafficking of normal stem cells and cancer cells

Bibliography

• Obinata H, Hla T. Sphingosine 1-phosphate in coagulation and inflammation. Semin Immunopathol 2012;34(1):73-91
   PubMed Web of Science ®Google Scholar
• Fyrst H, Saba JD. An update on sphingosine-1-phosphate and other sphingolipid mediators. Nat Chem Biol 2010;6(7):489-97
   PubMed Web of Science ®Google Scholar
• Chalfant CE, Spiegel S. Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. J Cell Sci 2005;118(Pt 20):4605-12
   PubMed Web of Science ®Google Scholar
• Gomez-Munoz A, Gangoiti P, Arana L, et al. New insights on the role of ceramide 1-phosphate in inflammation. Biochim Biophys Acta 2013;1831(6):1060-6
   PubMed Web of Science ®Google Scholar
• Lamour NF, Chalfant CE. Ceramide-1-phosphate: the "missing" link in eicosanoid biosynthesis and inflammation. Mol Interv 2005;5(6):358-67.
   PubMedGoogle Scholar
• Rosen H, Stevens RC, Hanson M, et al. Sphingosine-1-phosphate and its receptors: structure, signaling, and influence. Annu Rev Biochem 2013;82:637-62
   PubMed Web of Science ®Google Scholar
• Kim CH, Wu W, Wysoczynski M, et al. Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: a novel role for bioactive lipids and soluble C5b-C9 as homing factors. Leukemia 2012;26(1):106-16
   Google Scholar
• Hammad SM, Pierce JS, Soodavar F, et al. Blood sphingolipidomics in healthy humans: impact of sample collection methodology. J Lipid Res 2010;51(10):3074-87
   PubMed Web of Science ®Google Scholar
• Pappu R, Schwab SR, Cornelissen I, et al. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science 2007;316(5822):295-8
   PubMed Web of Science ®Google Scholar
• Schwab SR, Pereira JP, Matloubian M, et al. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 2005;309(5741):1735-9
   PubMed Web of Science ®Google Scholar
• Hla T. Immunology. Dietary factors and immunological consequences. Science 2005;309(5741):1682-3
   Google Scholar
• Schneider G, Bryndza E, Abdel-Latif A, et al. Bioactive lipids S1P and C1P are prometastatic factors in human rhabdomyosarcoma, and their tissue levels increase in response to radio/chemotherapy. Mol Cancer Res 2013;11(7):793-807
   Google Scholar
• Kim C, Schneider G, Abdel-Latif A, et al. Ceramide-1-phosphate regulates migration of multipotent stromal cells and endothelial progenitor cells–implications for tissue regeneration. Stem Cells 2013;31(3):500-10
   Google Scholar
• Mizugishi K, Yamashita T, Olivera A, et al. Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol 2005;25(24):11113-21
   PubMed Web of Science ®Google Scholar
• Rivera J, Proia RL, Olivera A. The alliance of sphingosine-1-phosphate and its receptors in immunity. Nat Rev Immunol 2008;8(10):753-63
   PubMed Web of Science ®Google Scholar
• Liu Y, Wada R, Yamashita T, et al. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest 2000;106(8):951-61
   PubMed Web of Science ®Google Scholar
• Ishii I, Friedman B, Ye X, et al. Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3. J Biol Chem 2001;276(36):33697-704
   Web of Science ®Google Scholar
• Ishii I, Ye X, Friedman B, et al. Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3. J Biol Chem 2002;277(28):25152-9
   PubMed Web of Science ®Google Scholar
• Kono M, Mi Y, Liu Y, et al. The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis. J Biol Chem 2004;279(28):29367-73
   PubMed Web of Science ®Google Scholar
• Ishii M, Kikuta J, Shimazu Y, et al. Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo. J Exp Med 2010;207(13):2793-8
   PubMed Web of Science ®Google Scholar
• Sciorra VA, Morris AJ. Roles for lipid phosphate phosphatases in regulation of cellular signaling. Biochim Biophys Acta 2002;1582(1-3):45-51
   Google Scholar
• Long J, Darroch P, Wan KF, et al. Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools. Biochem J 2005;391(Pt 1):25-32
   Google Scholar
• Hannun YA, Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol 2008;9(2):139-50
   PubMed Web of Science ®Google Scholar
• Graf C, Zemann B, Rovina P, et al. Neutropenia with impaired immune response to Streptococcus pneumoniae in ceramide kinase-deficient mice. J Immunol 2008;180(5):3457-66
   Google Scholar
• Graf C, Niwa S, Muller M, et al. Wild-type levels of ceramide and ceramide-1-phosphate in the retina of ceramide kinase-like-deficient mice. Biochem Biophys Res Commun 2008;373(1):159-63
   PubMed Web of Science ®Google Scholar
• Brindley DN, Waggoner DW. Mammalian lipid phosphate phosphohydrolases. J Biol Chem 1998;273(38):24281-4
   Google Scholar
• Brindley DN, Pilquil C. Lipid phosphate phosphatases and signaling. J Lipid Res 2009;50(Suppl):S225-30
   PubMed Web of Science ®Google Scholar
• Granado MH, Gangoiti P, Ouro A, et al. Ceramide 1-phosphate (C1P) promotes cell migration Involvement of a specific C1P receptor. Cell Signal 2009;21(3):405-12
   PubMed Web of Science ®Google Scholar
• Ratajczak MZ, Lee H, Wysoczynski M, et al. Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex. Leukemia 2010;24(5):976-85
   Google Scholar
• Kim ES, Kim JS, Kim SG, et al. Sphingosine 1-phosphate regulates matrix metalloproteinase-9 expression and breast cell invasion through S1P3-Galphaq coupling. J Cell Sci 2011;124(Pt 13):2220-30
   Google Scholar
• Bao M, Chen Z, Xu Y, et al. Sphingosine kinase 1 promotes tumour cell migration and invasion via the S1P/EDG1 axis in hepatocellular carcinoma. Liver Int 2012;32(2):331-8
   PubMed Web of Science ®Google Scholar
• Hla T, Venkataraman K, Michaud J. The vascular S1P gradient-cellular sources and biological significance. Biochim Biophys Acta 2008;1781(9):477-82
   Google Scholar
• Bode C, Sensken SC, Peest U, et al. Erythrocytes serve as a reservoir for cellular and extracellular sphingosine 1-phosphate. J Cell Biochem 2010;109(6):1232-43
   Google Scholar
• Ratajczak J, Kucia M, Mierzejewska K, et al. A novel view of paroxysmal nocturnal hemoglobinuria pathogenesis: more motile PNH hematopoietic stem/progenitor cells displace normal HSPCs from their niches in bone marrow due to defective adhesion, enhanced migration and mobilization in response to erythrocyte-released sphingosine-1 phosphate gradient. Leukemia 2012;26(7):1722-5
   Google Scholar
• Taylor JGT, Nolan VG, Mendelsohn L, et al. Chronic hyper-hemolysis in sickle cell anemia: association of vascular complications and mortality with less frequent vasoocclusive pain. PLoS ONE 2008;3(5):e2095
   PubMed Web of Science ®Google Scholar
• Selim S, Sunkara M, Salous AK, et al. Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions. Clin Sci (Lond) 2011;121(12):565-72
   PubMed Web of Science ®Google Scholar
• Yatomi Y, Igarashi Y, Yang L, et al. Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum. J Biochem 1997;121(5):969-73
   PubMed Web of Science ®Google Scholar
• Venkataraman K, Lee YM, Michaud J, et al. Vascular endothelium as a contributor of plasma sphingosine 1-phosphate. Circ Res 2008;102(6):669-76
   PubMed Web of Science ®Google Scholar
• Gomez-Munoz A, Duffy PA, Martin A, et al. Short-chain ceramide-1-phosphates are novel stimulators of DNA synthesis and cell division: antagonism by cell-permeable ceramides. Mol Pharmacol 1995;47(5):833-9
   PubMed Web of Science ®Google Scholar
• Gangoiti P, Bernacchioni C, Donati C, et al. Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts. Biochimie 2012;94(3):597-607
   Google Scholar
• Bertolucci C, Pinotti M, Colognesi I, et al. Circadian rhythms in mouse blood coagulation. J Biol Rhythms 2005;20(3):219-24
   Google Scholar
• Hoopes PC, McCall CE. The effect or cobra venom factor (CVJ) activation of the complement cascade on leukocyte circadian variation in the rat. Experientia 1977;33(2):224-6
   Google Scholar
• Kim Y, Pallansch M, Carandente F, et al. Circadian and circannual aspects of the complement cascade - new and old results, differing in specificity. Chronobiologia 1980;7(2):189-204
   Google Scholar
• Ratajczak J, Wysoczynski M, Hayek F, et al. Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication. Leukemia 2006;20(9):1487-95
   PubMed Web of Science ®Google Scholar
• Ratajczak MZ. The emerging role of microvesicles in cellular therapies for organ/tissue regeneration. Nephrol Dial Transplant 2011;26(5):1453-6
   Google Scholar
• Brinkmann V, Billich A, Baumruker T, et al. Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. Nat Rev Drug Discov 2010;9(11):883-97
   PubMed Web of Science ®Google Scholar
• Jo E, Sanna MG, Gonzalez-Cabrera PJ, et al. S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. Chem Biol 2005;12(6):703-15
   PubMedGoogle Scholar
• Obinata H, Hla T. Fine-tuning S1P therapeutics. Chem Biol 2012;19(9):1080-2
   Google Scholar
• Gonzalez-Cabrera PJ, Cahalan SM, Nguyen N, et al. S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis. Mol Pharmacol 2012;81(2):166-74
   PubMed Web of Science ®Google Scholar
• Cohen JA, Barkhof F, Comi G, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med 2010;362(5):402-15
   PubMed Web of Science ®Google Scholar
• Bandhuvula P, Honbo N, Wang GY, et al. S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart. Am J Physiol Heart Circ Physiol 2011;300(5):H1753-61
   Web of Science ®Google Scholar
• Liu J, Hsu A, Lee JF, et al. To stay or to leave: Stem cells and progenitor cells navigating the S1P gradient. World J Biol Chem 2011;2: 1 1-13
   Google Scholar
• Bendall LJ, Basnett J. Role of sphingosine 1-phosphate in trafficking and mobilization of hematopoietic stem cells. Curr Opin Hematol 2013;20(4):281-8
   Google Scholar
• Pyne NJ, Pyne S. Sphingosine 1-phosphate and cancer. Nat Rev Cancer 2010;10(7):489-503
   PubMed Web of Science ®Google Scholar
• Yanagawa Y, Masubuchi Y, Chiba K. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats, III. Increase in frequency of CD62L-positive T cells in Peyer's patches by FTY720-induced lymphocyte homing. Immunology 1998;95(4):591-4
   Google Scholar
• Chiba K. FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors. Pharmacol Ther 2005;108(3):308-19
   PubMed Web of Science ®Google Scholar
• Brinkmann V, Cyster JG, Hla T. FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am J Transplant 2004;4(7):1019-25
   PubMed Web of Science ®Google Scholar
• Thangada S, Khanna KM, Blaho VA, et al. Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics. J Exp Med 2010;207(7):1475-83
   PubMed Web of Science ®Google Scholar
• Walzer T, Chiossone L, Chaix J, et al. Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor. Nat Immunol 2007;8(12):1337-44
   PubMed Web of Science ®Google Scholar
• Czeloth N, Bernhardt G, Hofmann F, et al. Sphingosine-1-phosphate mediates migration of mature dendritic cells. J Immunol 2005;175(5):2960-7
   Google Scholar
• Vora KA, Nichols E, Porter G, et al. Sphingosine 1-phosphate receptor agonist FTY720-phosphate causes marginal zone B cell displacement. J Leukoc Biol 2005;78(2):471-80
   Google Scholar
• Chiba K, Yanagawa Y, Masubuchi Y, et al. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. J Immunol 1998;160(10):5037-44
   PubMed Web of Science ®Google Scholar
• Kimura T, Boehmler AM, Seitz G, et al. The sphingosine 1-phosphate receptor agonist FTY720 supports CXCR4-dependent migration and bone marrow homing of human CD34+ progenitor cells. Blood 2004;103(12):4478-86
   Google Scholar
• Seitz G, Boehmler AM, Kanz L, Mohle R. The role of sphingosine 1-phosphate receptors in the trafficking of hematopoietic progenitor cells. Ann N Y Acad Sci 2005;1044:84-9
   PubMed Web of Science ®Google Scholar
• Juarez JG, Harun N, Thien M, et al. Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice. Blood 2012;119(3):707-16
   Google Scholar
• Massberg S, Schaerli P, Knezevic-Maramica I, et al. Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell 2007;131(5):994-1008
   PubMed Web of Science ®Google Scholar
• Weichand B, Weis N, Weigert A, et al. Apoptotic cells enhance sphingosine-1-phosphate receptor 1 dependent macrophage migration. Eur J Immunol 2013; doi: 10.1002/eji.201343441
   Google Scholar
• Petit I, Szyper-Kravitz M, Nagler A, et al. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol 2002;3(7):687-94
   PubMed Web of Science ®Google Scholar
• Greenbaum AM, Link DC. Mechanisms of G-CSF-mediated hematopoietic stem and progenitor mobilization. Leukemia 2011;25(2):211-17
   Google Scholar
• Aiuti A, Webb IJ, Bleul C, et al. The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. J Exp Med 1997;185(1):111-20
   PubMed Web of Science ®Google Scholar
• Ratajczak MZ, Serwin K, Schneider G. Innate immunity derived factors as external modulators of the CXCL12-CXCR4 axis and their role in stem cell homing and mobilization. Theranostics 2013;3(1):3-10
   Google Scholar
• Kozuka T, Ishimaru F, Fujii K, et al. Plasma stromal cell-derived factor-1 during granulocyte colony-stimulating factor-induced peripheral blood stem cell mobilization. Bone Marrow Transplant 2003;31(8):651-4
   Google Scholar
• Golan K, Vagima Y, Ludin A, et al. S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release. Blood 2012;119(11):2478-88
   Google Scholar
• Ratajczak MZ, Borkowska S, Ratajczak J. An emerging link in stem cell mobilization between activation of the complement cascade and the chemotactic gradient of sphingosine-1-phosphate. Prostaglandins Other Lipid Mediat 2013;104-105:122-9
   Google Scholar
• Schraufstatter IU, Trieu K, Sikora L, et al. Complement c3a and c5a induce different signal transduction cascades in endothelial cells. J Immunol 2002;169(4):2102-10
   PubMed Web of Science ®Google Scholar
• Mierzejewska K, Kucia M, Ratajczak J, Ratajczak MZ. Novel Evidence That Hematopoietic Stem/Progenitor Cells (HSPCs) Are Mobilized During Hemolysis in an Erythrocyte Lysis-Derived, Sphingosine-1-Phosphate (S1P)-Dependent manner—the Crucial Involvement of Complement Cascade (CC) Activation and Attenuation of CXCR4 Retention Signaling Blood. ASH Annual Meeting Abstracts. 2012
   Google Scholar
• Ratajczak MZ, Kim CH, Abdel-Latif A, et al. A novel perspective on stem cell homing and mobilization: review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients. Leukemia 2012;26(1):63-72
   Google Scholar
• Arana L, Ordonez M, Ouro A, et al. Ceramide 1-phosphate induces macrophage chemoattractant protein-1 release: involvement in ceramide 1-phosphate-stimulated cell migration. Am J Physiol Endocrinol Metab 2013;304(11):E1213-26
   PubMed Web of Science ®Google Scholar
• Ortiz LA, Gambelli F, McBride Cet al. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci USA 2003;100(14):8407-11
   PubMed Web of Science ®Google Scholar
• Minguell JJ, Erices A. Mesenchymal stem cells and the treatment of cardiac disease. Exp Biol Med (Maywood) 2006;231(1):39-49
   Google Scholar
• Ratajczak MZ, Liu R, Ratajczak J, et al. The role of pluripotent embryonic-like stem cells residing in adult tissues in regeneration and longevity. Differentiation 2011;81(3):153-61
   Google Scholar
• Wojakowski W, Kucia M, Liu R, et al. Circulating very small embryonic-like stem cells in cardiovascular disease. J Cardiovasc Transl Res 2011;4(2):138-44
   Google Scholar
• Herrera MB, Fonsato V, Gatti S, et al. Human liver stem cell-derived microvesicles accelerate hepatic regeneration in hepatectomized rats. J Cell Mol Med 2010;14(6B):1605-18
   PubMed Web of Science ®Google Scholar
• Baglio SR, Pegtel DM, Baldini N. Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy. Front Physiol 2012;3:359
   PubMed Web of Science ®Google Scholar
• Kimura A, Ohmori T, Kashiwakura Y, et al. Antagonism of sphingosine 1-phosphate receptor-2 enhances migration of neural progenitor cells toward an area of brain. Stroke 2008;39(12):3411-17
   Google Scholar
• Karapetyan AV, Klyachkin YM, Selim S, et al. Bioactive lipids and cationic antimicrobial peptides as new potential regulators for trafficking of bone marrow-derived stem cells in patients with acute myocardial infarction. Stem Cells Dev 2013;22(11):1645-56
   Google Scholar
• Quint P, Ruan M, Pederson L, et al. Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathways. J Biol Chem 2013;288(8):5398-406
   PubMed Web of Science ®Google Scholar
• Niwa S, Graf C, Bornancin F. Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro. Microvasc Res 2009;77(3):389-93
   Google Scholar
• Peranteau WH, Endo M, Adibe OO, et al. CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation. Blood 2006;108(13):4268-74
   Google Scholar
• Moon H, Chon J, Joo J, et al. FTY720 preserved islet beta-cell mass by inhibiting apoptosis and increasing survival of beta-cells in db/db mice. Diabetes Metab Res Rev 2013;29(1):19-24
   Google Scholar
• Ieronimakis N, Pantoja M, Hays AL, et al. Increased sphingosine-1-phosphate improves muscle regeneration in acutely injured mdx mice. Skelet Muscle 2013;3(1):20
   PubMedGoogle Scholar
• Leong WI, Saba JD. S1P metabolism in cancer and other pathological conditions. Biochimie 2010;92(6):716-23
   PubMed Web of Science ®Google Scholar
• Van Brocklyn J, Letterle C, Snyder P, Prior T. Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: role of ERK MAP kinase and phosphatidylinositol 3-kinase beta. Cancer Lett 2002;181(2):195-204
   Google Scholar
• Bergelin N, Blom T, Heikkila J, et al. Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2. Endocrinology 2009;150(5):2055-63
   Google Scholar
• Visentin B, Vekich JA, Sibbald BJ, et al. Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell 2006;9(3):225-38
   PubMed Web of Science ®Google Scholar
• Yoon CM, Hong BS, Moon HG, et al. Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways. Blood 2008;112(4):1129-38
   Google Scholar
• Li MH, Sanchez T, Yamase H, et al. S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor. Cancer Lett 2009;276(2):171-9
   Google Scholar
• Yamashita H, Kitayama J, Shida D, et al. Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation. J Surg Res 2006;130(1):80-7
   Web of Science ®Google Scholar
• Jankowski K, Kucia M, Wysoczynski M, et al. Both hepatocyte growth factor (HGF) and stromal-derived factor-1 regulate the metastatic behavior of human rhabdomyosarcoma cells, but only HGF enhances their resistance to radiochemotherapy. Cancer Res 2003;63(22):7926-35
   Google Scholar
• O'Brien N, Jones ST, Williams DG, et al. Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies. J Lipid Res 2009;50(11):2245-57
   Google Scholar
• Davis MD, Clemens JJ, Macdonald TL, Lynch KR. Sphingosine 1-phosphate analogs as receptor antagonists. J Biol Chem 2005;280(11):9833-41
   PubMed Web of Science ®Google Scholar
• Brinkmann V. Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology. Pharmacol Ther 2007;115(1):84-105
   PubMed Web of Science ®Google Scholar
• Simanshu DK, Kamlekar RK, Wijesinghe DS, et al. Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids. Nature 2013;7463):463-7
   Google Scholar