Therapeutic targets for overactive bladder other than smooth muscle

Bibliography

• Chapple CR, Khullar V, Gabriel Z, et al. The effects of antimuscarinic treatments in overactive bladder: an update of a systematic review and meta-analysis. Eur Urol 2008;54:543-62
   PubMed Web of Science ®Google Scholar
• Ohlstein EH, Von Keitz A, Michel MC. A multicenter, double-blind, randomized, placebo controlled trial of the beta3-adrenoceptor agonist solabegron for overactive bladder. Eur Urol 2012;62:834-40
   PubMed Web of Science ®Google Scholar
• Chapple CR, Cardozo L, Nitti VW, et al. Mirabegron in overactive bladder: a review of efficacy, safety, and tolerability. Neurourol Urodyn 2014;33:17-30
   PubMed Web of Science ®Google Scholar
• Mangera A, Andersson K-E, Apostolidis A, et al. Contemporary management of lower urinary tract disease with botulinum toxin A: a systematic review of Botox (OnabotulinumtoxinA) and Dysport (AbobotulinumtoxinA). Eur Urol 2011;60:784-95
   PubMed Web of Science ®Google Scholar
• Andersson K-E, Chapple CR, Cardozo L, et al. Pharmacological treatment of overactive bladder: report from the International Consultation on Incontinence. Curr Opin Urol 2009;19:380-97
   PubMed Web of Science ®Google Scholar
• Birder LA, De Groat WC. Mechanisms of disease: involvement of the urothelium in bladder dysfunction. Nat Clin Pract Urol 2007;4:46-54
   PubMedGoogle Scholar
• Sadananda P, Chess-Williams R, BurCher E. Contractile properties of the pig bladder mucosa in response to neurokinin A: a role for myofibroblasts? Br J Pharmacol 2008;153:1465-73
   PubMedGoogle Scholar
• Andersson K-E, Mccloskey KD. Lamina propria: the functional center of the bladder? Neurourol Urodyn 2014;33:9-16
   PubMed Web of Science ®Google Scholar
• Parsons CL. The role of a leaky epithelium and potassium in the generation of bladder symptoms in interstitial cystitis/overactive bladder, urethral syndrome, prostatitis and gynaecological chronic pelvic pain. BJU Int 2011;107:370-5
   PubMed Web of Science ®Google Scholar
• Krege S, Kinzig-Schppers M, Sörgel F, et al. Absorption of intravesically applied drugs: comparison of normal and ileal-augmented rabbit bladder. J Urol 2004;172:2045-50
   PubMed Web of Science ®Google Scholar
• Ochodnicky P, Humphreys S, Eccles R, et al. Expression profiling of G-protein-coupled receptors in human urothelium and related cell lines. BJU Int 2012;110:e293-300
   Google Scholar
• Daher A, De Boer WI, Le Frere-Belda M-A, et al. Growth, differentiation and senescence of normal human urothelium in an organ-like culture. Eur Urol 2004;45:799-805
   PubMedGoogle Scholar
• Kurzrock EA, Lieu DK, De Graffenried LA, et al. Rat urothelium: improved techniques for serial cultivation, expansion, freezing and reconstitution onto acellular matrix. J Urol 2005;173:281-5
   PubMedGoogle Scholar
• Mclatchie LM, Young JS, Fry CH. Regulation of ACh release from guinea pig bladder urothelial cells: potential role in bladder filling sensations. Br J Pharmacol 2014;17:3394-403
   Google Scholar
• Bahadory F, Moore KH, Liu L, et al. Gene expression of muscarinic, tachykinin, and purinergic receptors in porcine bladder: comparison with cultured cells. Front Pharmacol 2013;4:148
   PubMedGoogle Scholar
• Arrighi N, Bodei S, Lucente A, et al. Muscarinic receptors stimulate cell proliferation in the human urothelium-derived cell line UROtsa. Pharmacol Res 2011;64:420-5
   PubMedGoogle Scholar
• Ochodnicky P, Michel-Reher MB, Butter JJ, et al. Bradykinin modulates spontaneous nerve growth factor production and stretch-induced ATP release in human urothelium. Pharmacol Res 2013;70:147-54
   PubMedGoogle Scholar
• Tully BT, Li M, Sun Y, et al. Defects in msucarinic receptor cell signaling in bladder urothelial cancer cell lines. Urology 2009;74:467-73
   PubMedGoogle Scholar
• Chaiyaprasithi B, Mang CF, Kilbinger H, et al. Inhibition of human detrusor contraction by a urothelium derived factor. J Urol 2003;170:1897-0
   PubMed Web of Science ®Google Scholar
• Templeman L, Chapple CR, Chess-Williams R. Urothelium derived inhibitory factor and cross-talk among receptors in the trigone of the bladder of the pig. J Urol 2002;167:742-5
   PubMedGoogle Scholar
• Wuest M, Kaden S, Hakenberg OW, et al. Effect of rilmakalim on detrusor contraction in the presence and absence of urothelium. Naunyn Schmiedebergs Arch Pharmacol 2005;372:203-12
   PubMedGoogle Scholar
• Murakami S, Chapple CR, Akino H, et al. The role of the urothelium in mediating bladder responses to isoprenaline. BJU Int 2007;99:669-73
   PubMed Web of Science ®Google Scholar
• Klausner AP, Rourke KF, Miner AS, et al. Potentiation of carbachol-induced detrusor smooth muscle contractions by beta-adrenoceptor activation. Eur J Pharmacol 2009;606:191-8
   PubMedGoogle Scholar
• Hawthorn MH, Chapple CR, Cock M, et al. Urothelium-derived inhibitory factor(s) influences on detrusor muscle contractility in vitro. Br J Pharmacol 2000;129:416-19
   PubMed Web of Science ®Google Scholar
• Michel MC. Do beta-adrenoceptor agonists induce homologous or heterologous desensitization in rat urinary bladder? Naunyn Schmiedebergs Arch Pharmacol 2014;387:215-24
   PubMed Web of Science ®Google Scholar
• Azadzoi KM, Heim VK, Tarcan T, et al. Alteration of urothelial-mediated tone in the ischemic bladder: role of eicosanoids. Neurourol Urodyn 2004;23:258-64
   PubMedGoogle Scholar
• Otsuka A, Shinbo H, Matsumoto R, et al. Expression and functional role of beta-adrenoceptors in the human urinary bladder. Naunyn Schmiedebergs Arch Pharmacol 2008;377:473-81
   PubMed Web of Science ®Google Scholar
• Propping S, Wuest M, Eichhorn B, et al. Role of urothelium on beta3-adrenoceptor mediated relaxation in human detrusor muscle. Neurourol Urodyn 2009;28:870-1
   Web of Science ®Google Scholar
• Masunaga K, Chapple CR, Mckay NG, et al. The beta3-adrenoceptor mediates the inhibitory effects of beta-adrenoceptor agonists via the urothelium in pig bladder dome. Neurourol Urodyn 2010;29:1320-5
   PubMed Web of Science ®Google Scholar
• Kullmann FA, Downs TR, Artim DE, et al. Urothelial beta-3 adrenergic receptors in the rat bladder. Neurourol Urodyn 2011;30:144-50
   PubMed Web of Science ®Google Scholar
• Krause P, Fuhr U, Schnitker J, et al. Pharmacokinetics of intravesical versus oral oxybutynin in healthy adults: results of an open-label, ranodmized, prospective clinical study. J Urol 2013;190:1791-7
   PubMed Web of Science ®Google Scholar
• Michel MC. OnabotulinumtoxinA: how deep shall it go? Eur Urol 2014;65:1125-7
   PubMed Web of Science ®Google Scholar
• Takeda M, Mochizuki T, Yoshiyama M, et al. Sensor mechanism and afferent signal transduction of the urinary bladder: special focus on transient receptor potential ion channels. LUTS 2010;2:51-60
   Google Scholar
• Franken J, Uvin P, De Ridder D, et al. TRP channels in lower urinary tract dysfunction. Br J Pharmacol 2014;171:2537-51
   PubMed Web of Science ®Google Scholar
• Birder LA, Wolf-Johnston AS, Sun Y, et al. Alteration in TRPV1 and muscarinic M3 receptor expression and function in idiopathic overactive bladder urothelial cells. Acta Physiol(Oxf) 2013;207:123-9
   PubMedGoogle Scholar
• Bschleipfer T, Schukowski K, Weidner W, et al. Expression and distribution of cholinergic receptors in the human urothelium. Life Sci 2007;80:2303-7
   PubMed Web of Science ®Google Scholar
• Yoshida M, Masunaga K, Satoji Y, et al. Basic and clinical aspects of non-neuronal acetylcholine: expression of non-neuronal acetylcholine in urothelium and its clinical significance. J Pharmacol Sci 2008;106:193-8
   PubMedGoogle Scholar
• Chopra B, Barrick SR, Meyers S, et al. Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium. J Physiol 2005;562:859-71
   PubMed Web of Science ®Google Scholar
• Yu W, Hill WG. Lack of specificity shown by P2Y6 receptor antibodies. Naunyn Schmiedebergs Arch Pharmacol 2013;386:885-91
   PubMedGoogle Scholar
• Ashton JC, Zheng Y, Darlington C, et al. Cannabinoid CB2 receptor immunolabelling in the healthy brain - still a liver possibility. Naunyn Schmiedebergs Arch Pharmacol 2014;387:301-1
   PubMedGoogle Scholar
• Böhmer T, Pfeiffer N, Gericke A. Three commerical antibodies against alpha1-adrenergic receptor subtypes lack specificity in paraffin-embedded sections of murine tissues. Naunyn Schmiedebergs Arch Pharmacol 2014;387:703-6
   PubMedGoogle Scholar
• Cecyre B, Thomas S, Ptito M, et al. Evaluation of the specificity of antibodies raised against cannabinoid receptor type 2 in the mouse retina. Naunyn Schmiedebergs Arch Pharmacol 2014;387:175-84
   PubMed Web of Science ®Google Scholar
• Talmont F, Mouledous L. Evaluation of commercial antibodies against human sphingosine-1-phosphate receptor 1. Naunyn Schmiedebergs Arch Pharmacol 2014;387:427-31
   PubMedGoogle Scholar
• Cernecka H, Pradidarcheep W, Lamers WH, et al. Rat beta 3-adrenoceptor protein expression: antibody validation and distribution in rat gastrointestinal and urogenital tissues. Naunyn Schmiedebergs Arch Pharmacol 2014;387:1117-27
   PubMed Web of Science ®Google Scholar
• Mansfield KJ, Liu L, Mitchelson FJ, et al. Muscarinic receptor subtypes in human bladder detrusor and mucosa, studied by radioligand binding and quantitative competitive RT-PCR: changes in ageing. Br J Pharmacol 2005;144:1089-99
   PubMed Web of Science ®Google Scholar
• Braverman AS, Lebed B, Linder M, et al. M2 mediated contractions of human bladder from organ donors is associated with an increase in urothelial muscarinic receptors. Neurourol Urodyn 2007;26:63-70
   Google Scholar
• Anisuzzaman AS, Morishima S, Suzuki F, et al. Assessment of muscarinic receptor subtypes in human and rat lower urinary tract by tissue segment binding assay. J Pharmacol Sci 2008;106:271-9
   PubMedGoogle Scholar
• Nomiya M, Yamaguchi O. A quantitative analysis of mRNA expression of alpha 1 and beta -adrenoceptor subtypes and their functional roles in human normal and obstructed bladders. J Urol 2003;170:649-53
   PubMed Web of Science ®Google Scholar
• Tyagi P, Thomas CA, Yoshimura N, et al. Investigations into the presence of functional beta 1, beta 2 and beta 3-adrenoceptors in urothelium and detrusor of human bladder. Int Braz J Urol 2009;35:76-83
   PubMed Web of Science ®Google Scholar
• Kurizaki Y, Ishizuka O, Imamura T, et al. Relationship between expression of beta 3-adrenoceptor mRNA in bladder mucosa and urodynamic findings in men with lower urinary tract symptoms. Neurourol Urodyn 2013;32:88-91
   PubMed Web of Science ®Google Scholar
• Otsuka A, Kawasaki H, Matsumoto R, et al. Expression of beta -adrenoceptor subtypes in urothelium, interstitial cells and detrusor of the human urinary bladder. Neurourol Urodyn 2013;5:173-80
   Google Scholar
• Kullmann FA, Limberg BJ, Artim DE, et al. Effects of beta 3-adrenergic receptor activation on rat urinary bladder hyperactivity induced by ovariectomy. J Pharmacol Exp Ther 2009;330:704-17
   PubMedGoogle Scholar
• Limberg BJ, Andersson K-E, Kullmann FA, et al. Beta -Adrenergic receptor subtype expression in myocyte and non-myocyte cells in human female bladder. Cell Tissue Res 2010;342:295-306
   PubMed Web of Science ®Google Scholar
• Birder LA, Nealen ML, Kiss S, et al. Beta -Adrenoceptor agonists stimulate endothelial nitric oxide synthase in rat urinary bladder urothelial cells. J Neurosci 2002;22:8063-70
   PubMedGoogle Scholar
• Harmon EB, Porter JM, Porter JE. Beta -Adrenergic receptor activation in immortalized human urothelial cells stimulates inflammatory responses by PKD-independent mechanisms. Cell Commun Signal 2005;3:10
   PubMedGoogle Scholar
• Frazier EP, Peters SLM, Braverman AS, et al. Signal transduction underlying control of urinary bladder smooth muscle tone by muscarinic receptors and beta -adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol 2008;377:449-62
   PubMed Web of Science ®Google Scholar
• Kurizaki Y, Ishizuka O, Imamura T, et al. Relation between expression of alpha1-adrenoceptor mRNAs in bladder mucosa and urodynamic findings in men with lower urinary tract symptoms. Scand J Urol Nephrol 2011;45:15-19
   PubMed Web of Science ®Google Scholar
• Walden PD, Durkin MM, Lepor H, et al. Localization of mRNA and receptor binding sites for the alpha1A-adrenoceptor subtype in the rat, monkey and human urinary bladder and prostate. J Urol 1997;157:1032-8
   PubMed Web of Science ®Google Scholar
• Collins VM, Daly DM, Liaskos M, et al. OnabotulinumtoxinA significantly attenuates bladder afferent nerve firing and inhibits ATP release from the urothelium. BJU Int 2013;112:1018-26
   PubMedGoogle Scholar
• Hanna-Mitchell AT, Wolf-Johnston AS, Barrick SR, et al. Effect of botulinum toxin A on urothelial-release of ATP and expression of SNARE targets within the urothelium. Neurourol Urodyn 2015;34:79-84
   PubMed Web of Science ®Google Scholar
• Azadzoi KM, Radisavljevic ZM, Siroky MB. Effects of ischemia on tachykinin-containing nerves and neurokinin receptors in the rabbit bladder. J Urol 2008;71:979-83
   Google Scholar
• Yokoyama O, Tanaka I, Kusukawa N, et al. Antimuscarinics suppress adenosine triphosphate and prostaglandin E2 release from urothelium with potential improvement in detrusor overactivity in rats with cerebral infarction. J Urol 2011;185:2392-7
   PubMedGoogle Scholar
• Lips KS, Wunsch J, Sarghooni S, et al. Acetylcholine and molecular components of its synthesis and release machinery in the urothelium. Eur Urol 2007;51:1042-53
   PubMed Web of Science ®Google Scholar
• Bschleipfer T, Weidner W, Kummer W, et al. Does bladder outlet obstruction alter the non-neuronal cholinergic system of the human urothelium? Life Sci 2012;91:1082-6
   PubMed Web of Science ®Google Scholar
• Burnstock G, Dumsday B, Smythe A. Atropine resistant excitation of the urinary bladder: the possibility of transmission via nerves releasing a purine nucleotide. Br J Pharmacol 1972;44:451-61
   PubMed Web of Science ®Google Scholar
• Smith CP, Gangitano DA, Munoz A, et al. Botulinum toxin type A normalizes alterations in urothelial ATP and NO release induced by chronic spinal cord injury. Neurochem Int 2008;52:1068-75
   PubMed Web of Science ®Google Scholar
• Johansson R, Pandita RK, Poljakovic M, et al. Activity and expression of nitric oxide synthase in the hypertrophied rat bladder and the effect of nitric oxide on bladder smooth muscle growth. J Urol 2002;168:2689-94
   PubMed Web of Science ®Google Scholar
• Andersson MC, Tobin G, Giglio D. Cholinergic nitric oxide release from the urinary bladder mucosa in cyclophosphamide-induced cystitis of the anaesthetized rat. Br J Pharmacol 2008;153:1438-44
   PubMedGoogle Scholar
• Birder LA, Apodaca G, De Groat WC, et al. Adrenergic- and capsaicin-evoked nitric oxide release from urothelium and afferent nerves in urinary bladder. Am J Physiol 1998;275:F226-9
   PubMed Web of Science ®Google Scholar
• Borowsky AD, Bandhuvula P, Kumar A, et al. Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues. J Lipid Res 2012;53:1920-31
   Google Scholar
• Watterson KR, Berg KM, Kapitonov D, et al. Sphingosine-1-phosphate and the immunosuppressant, FTY720-phosphate. regulate detrusor muscle tone. FASEB J 2007;21:2818-28
   PubMedGoogle Scholar
• Aydin M, Downing K, Villegas G, et al. The sphingosine-1-phosphate pathway is upregulated in response to partial urethral obstruction in male rats and activates RhoA/Rho-kinase signalling. BJU Int 2010;106:562-71
   PubMedGoogle Scholar
• Kendig DM, Matsumoto AK, Moreland RS. Sphingosine-1-phosphate induced contraction of bladder smooth muscle. Eur J Pharmacol 2013;720:355-62
   PubMedGoogle Scholar
• Ochodnicky P, Cruz CD, Yoshimura N, et al. Nerve growth factor in bladder dysfunction: contributing factor, biomarker and therapeutic target. Neurourol Urodyn 2011;30:1227-41
   PubMedGoogle Scholar
• Ha US, Park EY, Kim JC. Effect of botulinum toxin on expression of nerve growth factor and transient receptor potential vanilloid 1 in urothelium and detrusor muscle of rats with bladder outlet obstruction-induced detrusor overactivity. Urology 2011;78:721.e1-6
   Google Scholar
• Azadzoi KM, Yalla SV, Siroky MB. Oxidative stress and neurodegeneration in the ischemic overactive bladder. J Urol 2007;178:710-15
   PubMedGoogle Scholar
• Antunes-Lopes T, Cruz CD, Cruz F, et al. Biomarkers in lower urinary tract symptoms/overactive bladder: a critical review. Curr Opin Urol 2014;24:352-7
   PubMed Web of Science ®Google Scholar
• Cheng J-T, Yu B-C, Tong Y-C. Changes of M3-muscarinic receptor protein and mRNA expressions in the bladder urothelium and muscle layer of streptozotocin-induced diabetic rats. Neurosci Lett 2007;423:1-5
   PubMedGoogle Scholar
• Tong Y-C, Cheng J-T. Alterations of M2.3-muscarinic receptor protein and mRNA expression in the bladder of the fructose fed obese rat. J Urol 2007;178:1537-42
   PubMedGoogle Scholar
• Datta SN, Roosen A, Pullen A, et al. Immunohistochemical expression of muscarinic receptors in the urothelium and suburothelium of neurogenic and idiopathic overactive human bladders, and changes with botulinum neurotoxin administration. J Urol 2010;184:2578-85
   PubMed Web of Science ®Google Scholar
• Michel MC, Barendrecht MM. Physiological and pathological regulation of the autonomic control of urinary bladder contractility. Pharmacol Ther 2008;117:297-312
   PubMedGoogle Scholar
• Everaerts W, Sepulveda MR, Gevaert T, et al. Where is TRPV1 expressed in the bladder, do we see the real channel? Naunyn Schmiedebergs Arch Pharmacol 2009;379:421-5
   PubMedGoogle Scholar
• Daly DM, Nucchi L, Liaskos M, et al. Age-related changes in afferent pathways and urothelial function in the male mouse bladder. J Physiol 2014;592:537-49
   PubMedGoogle Scholar
• Jang J, Park EY, Seo SI, et al. Effects of intravesical installation of cyclooxygenase-2 inhibitor on the expression of nitric oxid synthase and nerve growth factor in cyclophosphamide-induced overactive bladder. BJU Int 2006;98:435-9
   PubMed Web of Science ®Google Scholar
• Hanna-Mitchell AT, Ruiz GW, Daneshgari F, et al. Impact of diabetes mellitus on bladder uroepithelial cells. Am J Physiol 2013;304:R84-93
   Google Scholar
• Apodaca G, Balestreire E, Birder LA. The uroepithelial-associated sensory web. Kidney Int 2007;72:1057-64
   PubMed Web of Science ®Google Scholar
• Gillespie JI, Van Koeveringe GA, De Wachter SG, et al. On the origins of the sensory output from the bladder: the concept of afferent noise. BJU Int 2009;103:1324-33
   PubMed Web of Science ®Google Scholar
• De Groat WC, Yoshimura N. Changes in afferent activity after spinal cord injury. Neurourol Urodyn 2010;29:63-76
   PubMed Web of Science ®Google Scholar
• Aizawa N, Igawa Y, Andersson K-E, et al. Effects of intravescial instillation of ATP on rat bladder primary afferent activity and its relationship with capsaicin-sensitivity. Neurourol Urodyn 2011;30:163-8
   PubMedGoogle Scholar
• Aizawa N, Wyndaele J-J, Homma Y, et al. Effects of TRPV4 cation channel activation on the primary bladder afferent activities of the rat. Neurourol Urodyn 2012;31:148-55
   PubMed Web of Science ®Google Scholar
• Charrua A, Cruz CD, Jansen K, et al. Co-administration of TRPV4 and TRPV1 antagonists potentiate the effect of each drug in a rat model of cystitis. BJU Int 2014. [ Epub ahead of print]
   Google Scholar
• Wyndaele J-J. Investigating afferent nerve activity from the lower urinary tract: highlighting some basic research techniques and clinical evaluation methods. Neurourol Urodyn 2010;29:56-62
   PubMedGoogle Scholar
• Aizawa N, Homma Y, Igawa Y. Characteristics of lower urinary tract dysfunction and bladder afferent nerve properties in type 2 diabetic Goto-Kakizaki rats. J Urol 2013;189:1580-7
   Google Scholar
• Yoshimura N, Obuchi T, Yokoyama H, et al. Bladder afferent hyperexcitability in bladder pain syndrome/interstitial cystitis. Int J Urol 2014;21(Suppl 1):18-25
   PubMed Web of Science ®Google Scholar
• Patra PB, Thorneloe KS. Enhanced sensitivity to afferent stimulation and impact of overactive bladder therapies in the conscious, spontaneously hypertensive rat. J Pharmacol Exp Ther 2011;338:392-9
   PubMedGoogle Scholar
• Minagawa T, Aizawa N, Igawa Y, et al. The role of transient receptor potential ankyrin (TRPA1) channel in activation of single unit mechanosensitive bladder afferent activities in the rat. Neurourol Urodyn 2014;33:544-9
   PubMedGoogle Scholar
• Tucci P, Bartocci C, Bolle P. Cyclo-oxygenase- and capsaicin-sensitive afferent fibres affect beta-adrenoceptor-evoked response in the rat urinary bladder. Pharmacology 2002;64:57-62
   PubMedGoogle Scholar
• Aizawa N, Igawa Y, Nishizawa O, et al. Effects of CL316,243, a beta3-adrenoceptor agonist, and intravesical prostaglandin E2 on the primary bladder afferent activity of the rat. Neurourol Urodyn 2010;29:771-6
   PubMed Web of Science ®Google Scholar
• Aizawa N, Hedlund P, Homma Y, et al. Inhibitory effect of URB937, a peripherally-restricted inhibitor of fatty acid amide hydrolase, on prostaglandin E2-induced hyperactivity of bladder mechanoafferent nerve fibers in rats. J Urol 2014;191:e138-9
   PubMedGoogle Scholar
• Aizawa N, Homma Y, Igawa Y. Effects of L-arginine, mirabegron, and oxybutynin on the primary bladder afferent nerve activities synchronized with reflex, rhythmic bladder contractions in the rat. Neurourol Urodyn 2014. [ Epub ahead of print]
   Google Scholar
• Ishihama H, Momota Y, Yanase H, et al. Activation of alpha1D adrenergic receptors in the rat urothelium facilitates the micturition reflex. J Urol 2006;175:358-64
   PubMed Web of Science ®Google Scholar
• Yoshiyama M, De Groat WC. Role of spinal alpha1-adrenoceptor subtypes in the bladder reflex in anesthetized rats. Am J Physiol 2001;280:R1414-19
   Google Scholar
• Yokoyama O, Yusup A, Oyama N, et al. Improvement of bladder storage function by alpha1-blocker depends on the suppression of C-fiber afferent activity in rats. Neurourol Urodyn 2006;25:461-7
   PubMed Web of Science ®Google Scholar
• Yokoyama O, Ito H, Aoki Y, et al. Selective alpha1A-blocker improves bladder storage function in rats via suppression of C-fiber afferent activity. World J Urol 2010;28:609-14
   PubMed Web of Science ®Google Scholar
• Aizawa N, Homma Y, Igawa Y. Effects of silodosin, a selective alpha1A-adrenoceptor antagonist,on the single primary bladder afferent activity of the rat. Eur Urol Suppl 2013;12:e64-5
   Google Scholar
• Kim SE, Ko IG, Hwang L, et al. An animal study to compare the degree of the suppressive effects on the afferent pathways of micturition between tamsulosin and sildenafil. J Biomed Sci 2013;20:81
   PubMedGoogle Scholar
• Aizawa N, Homma Y, Igawa Y. Effect of silodosin, a selective alpha1A-adrenoceptor antagonist on primary bladder afferent activity and bladder microcontractions in rats. Neurourol Urodyn 2013;32:569-71
   Google Scholar
• Aizawa N, Ito H, Sugiyama R, et al. Physiological role of the bladder alpha-1D adrenoceptor in the activation of single-unit primary bladder afferent activity in rats. Neurourol Urodyn 2014;33:734-5
   Google Scholar
• Aizawa N, Homma Y, Igawa Y. Effects of mirabegron, a novel beta3-adrenoceptor agonist, on the primary bladder afferent activity and bladder microcontractions in rats in comparison with those of oxybutynin. Eur Urol 2012;62:1165-73
   PubMed Web of Science ®Google Scholar
• Aizawa N, Hedlund P, Füllhase C, et al. Inhibition of peripheral FAAH depresses activities of bladder mechanosensitive nerve fibers of the rat. J Urol 2014;192:956-63
   PubMed Web of Science ®Google Scholar
• Minagawa T, Aizawa N, Igawa Y, et al. Inhibitory effects of phosphodiesterase 5 inhbitor, tadalafil, on mechanosensitive, bladder afferent nerve activities of the rat, and on acrolein-induced hyperactivity of these nerves. BJU Int 2012;110:E259-66
   Google Scholar
• Xiao Z, Rogers MJ, Shen B, et al. Somatic modulation of spinal reflex bladder activity mediated by nociceptive bladder afferent nerve fibers in cats. Am J Physiol 2014;307:F673-9
   PubMed Web of Science ®Google Scholar
• Nandigama R, Bonitz M, Papadakis T, et al. Muscarinic acetylchoine receptor subtypes expressed by mouse bladder afferent neurons. Neuroscience 2010;168:842-50
   PubMedGoogle Scholar
• Bschleipfer T, Nandigama R, Moeller S, et al. Bladder outlet obstruction influences mRNA expression of cholinergic receptors on sensory neurons in mice. Life Sci 2012;91:1077-81
   PubMedGoogle Scholar
• Daly DM, Chess-Williams R, Chapple C, et al. The inhibitory role of acetylcholine and muscarinic receptors in bladder afferent activity. Eur Urol 2010;58:22-8
   PubMedGoogle Scholar
• Yu Y, De Groat WC. Effects of stimulation of muscarinic receptors on bladder afferent nerves in the in vitro bladder-pelvic afferent nerve preparation of the rat. Brain Res 2010;1361:43-53
   PubMedGoogle Scholar
• Iijima K, De Wachter S, Wyndaele J-J. Effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve. Eur Urol 2007;52:842-9
   PubMed Web of Science ®Google Scholar
• De Laet K, De Wachter S, Wyndaele J-J. Systemic oxybutynin decreases afferent activity of the pelvic nerve of the rat: new insights into the working mechanism of antimuscarinics. Neurourol Urodyn 2006;25:156-61
   PubMed Web of Science ®Google Scholar
• Aizawa N, Ito H, Sugiyama R, et al. Selective inhibitory effect of imidafenacin and 5-hydroxmethyl tolterodine on capsaicin-sensitive C-fibers of the primary bladder mechanosensitive afferent nerves in the rat. J Urol 2014. [ Epub ahead of print]
   Google Scholar
• Aizawa N, Igawa Y, Nishizawa O, et al. Effects of nitric oxide on the primary bladder afferent activities of the rat with and without intravesical acrolein treatment. Eur Urol 2011;59:264-71
   PubMedGoogle Scholar
• Nishiya Y, Yamagata T, Fukuda Y, et al. The anti-overactive bladder activity of KW-7158 is mediated by blocking equilibrative nucleoside transporter-1. Biol Pharm Bull 2014;371:130-6
   Google Scholar
• Kershen RT, Azadzoi KM, Siroky MB. Blood flow, pressure and compliance in the male human bladder. J Urol 2002;168:121-5
   PubMedGoogle Scholar
• Nomiya M, Yamaguchi O, Andersson K-E, et al. The effect of atherosclerosis-induced chronic bladder ischemia on bladder function in the rat. Neurourol Urodyn 2012;31:195-200
   PubMedGoogle Scholar
• Goi Y, Tomiyama Y, Nomiya M, et al. Effects of silodosi, a selective alpha1A-adrenoceptor antagonist, on bladder blood flow and bladder function in a rat model of atherosclerosis induced chronic bladder ischemia without bladder obstruction. J Urol 2013;190:1116-22
   PubMedGoogle Scholar
• Pontari MA, Ruggieri MR. Sex differences and role of nitric oxide in blood flow of canine urinary bladder. Am J Physiol 1999;276:R407-13
   Google Scholar
• Hashitani H, Mitsui R, Shimizu Y, et al. Functional and morphological properties of pericytes in suburothelial venules of the mouse bladder. Br J Pharmacol 2012;167:1723-36
   PubMedGoogle Scholar
• Mizuno H, Yamamoto T, Okutsu H, et al. Microcirculation in a rat ischemia-reperfusion model, evaluated by pencil lens charge-coupled device microscopy system. Urology 2010;76:1266. e1-5
   PubMedGoogle Scholar
• Okutsu H, Mastumoto S, Ohtake A, et al. Effect of tamsulosin on bladder blood flow and bladder function in a rat model of bladder over distention/emptying induced bladder overactivity. J Urol 2011;186:2470-7
   PubMedGoogle Scholar
• Levin RM, English M, Barretto M, et al. Normal detrusor is more sensitive than hypertrophied detrusor to in vitro ischemia followed by re-oxygenation. Neurourol Urodyn 2000;19:701-12
   PubMedGoogle Scholar
• Azadzoi KM, Radisavljevic ZM, Golabek T, et al. Oxidative modification of mitochondrial integrity and nerve fiber density in the ischemic overactive bladder. J Urol 2010;183:362-9
   PubMedGoogle Scholar
• Azadzoi KM, Chen BG, Radisavljevic ZM, et al. Molecular reactions and ultrastructural damage in the chronically ischemic bladder. J Urol 2011;186:2115-22
   PubMedGoogle Scholar
• Pessina F, Marazova K, Ninfali P, et al. In vitro neuroprotection by novel antioxidants in guinea-pig urinary bladder subjected to anoxia/reperfusion damage. Naunyn Schmiedebergs Arch Pharmacol 2004;370:521-8
   PubMedGoogle Scholar
• Ishida T, Shimoda N, Sato K, et al. Effects of ischemia on voiding function and nerve growth factor on the rat urinary bladder. Nippon Hinyokika Gakkai Zasshi 1999;90:564-71
   PubMedGoogle Scholar
• Martin SA, Haren MT, Marshall VR, et al. Prevalence and factors associated with uncomplicated storage and voiding lower urinary tract symptoms in community-dwelling Australian men. World J Urol 2011;29:179-84
   PubMed Web of Science ®Google Scholar
• Azadzoi KM, Tarcan T, Siroky MB, et al. Atherosclerosis-induced chronic ischemia causes bladder fibrosis and non-compliance in the rabbit. J Urol 1999;161:1626-35
   PubMed Web of Science ®Google Scholar
• Azadzoi KM, Tarcan T, Kozlowski R, et al. Overactivity and structural changes in the chronically ischemia bladder. J Urol 1999;162:1768-78
   PubMed Web of Science ®Google Scholar
• Nomiya M, Sagawa K, Yazaki J, et al. Increased bladder activity is associated with elevated oxidative stress markers and proinflammatory cytokines in a rat model of atherosclerosis-induced chronic bladder ischemia. Neurourol Urodyn 2012;31:185-9
   PubMedGoogle Scholar
• Sawada N, Nomiya M, Hood B, et al. Protective effect of a beta3-adrenoceptor agonist on bladder function in a rat model of chronic bladder ischemia. Eur Urol 2013;64:664-71
   PubMed Web of Science ®Google Scholar
• Nomiya M, Burmeister DM, Sawada N, et al. Prophylactic effect of tadalafil on bladder function in a rat model of chronic bladder ischemia. J Urol 2013;189:754-61
   PubMedGoogle Scholar
• Nomiya M, Yamaguchi O, Akaihata H, et al. Progressive vascular damage may lead to bladder underactivity in rats. J Urol 2014;191:1462-9
   PubMedGoogle Scholar
• Lee W-C, Chien C-T, Yu H-J, et al. Bladder dysfunction in rats with metabolic syndrome induced by long-term fructose feeding. J Urol 2008;179:2470-6
   PubMed Web of Science ®Google Scholar
• Shenfeld OZ, Meir KS, Yutkin V, et al. Do atherosclerosis and chronic bladder ischemia really play a role in detrusor dysfunction of old age? Urology 2005;65:181-4
   PubMedGoogle Scholar
• Bschleipfer T, Dannenmaier AK, Illig C, et al. Systemic atherosclerosis causes detrusor overactivity - functional and morphological changes in hyperlipoproteinemic apoE-/-/LDLR-/- mice. J Urol 2015;193:345-51
   PubMedGoogle Scholar
• Lin W-Y, Mannikarottu A, Li S, et al. Correlation of in vivo bladder flow measurements with tissue hypoxia. World J Urol 2011;29:165-70
   PubMedGoogle Scholar
• Koritsiadis G, Stravodimos K, Koutatellis G, et al. Immunohistochemical estimation of hypoxia in human obstructed bladder and correlation with clinical variables. BJU Int 2008;102:28-332
   PubMedGoogle Scholar
• Greenland JE, Brading AF. The effect of bladder outflow obstruction on detrusor blood flow changes during the voiding cycle in conscious pigs. J Urol 2001;165:245-8
   PubMedGoogle Scholar
• Gabella G, Uvelius B. Structural changes in the rat bladder after acute outlet obstruction. Scand J Urol Nephrol Suppl 1999;201:32-7
   PubMedGoogle Scholar
• Okutsu H, Matsumoto S, Hanai T, et al. Effects of tamsulosin on bladder blood flow and bladder function in rats with bladder outlet obstruction. Urology 2010;75:235-40
   PubMedGoogle Scholar
• Mine S, Yamamoto T, Mizuno H, et al. Effect of tamsulosin on bladder microcirculation in rat model of bladder outlet obstruction using pencil lens charge-coupled device mircoscopy system. Urology 2013;81:155-9
   PubMedGoogle Scholar
• Inoue S, Saito M, Tsounapi P, et al. Effect of silodosin on detrusor overactivity in the male spontaneously hypertensive rat. BJU Int 2012;110:E118-24
   Google Scholar
• Mitterberger M, Pallwein L, Gradl J, et al. Persistent detrusor overactivity after transurethral resection of the prostate is associated with reduced perfusion of the urinary bladder. BJU Int 2007;99:831-5
   PubMedGoogle Scholar
• Edwards G, Feletou M, Weston AH. Endothelium-derived hyperpolarising factors and associated pathways: a synopsis. Pflügers Arch 2010;459:863-79
   PubMed Web of Science ®Google Scholar
• Fovaeus M, Fujiwara M, Högestätt ED, et al. A non-nitrergic smooth muscle relaxant factor released from rat urinary bladder by muscarinic receptor stimulation. J Urol 1999;161:649-53
   PubMedGoogle Scholar
• Barendrecht MM, Chichester P, Michel MC, et al. Effect of short-term outlet obstruction on rat bladder nerve density and contractility. Auton Autacoid Pharmacol 2007;27:47-54
   PubMedGoogle Scholar
• Frias B, Charrua A, Avelino A, et al. Transient receptor potential vanilloid 1 mediates nerve growth factor-induced bladder hyperactivity and noxious input. BJU Int 2012;110:E422-8
   PubMedGoogle Scholar
• Rapp DE, Lyon MB, Bales GT, et al. A role for the P2X receptor in urinary tract physiology and in the pathophysiology of urinary dysfunction. Eur Urol 2005;48:303-8
   PubMed Web of Science ®Google Scholar
• Frazier EP, Mathy M-J, Peters SLM, et al. Does cyclic AMP mediate rat urinary bladder relaxation by isoproterenol? J Pharmacol Exp Ther 2005;313:260-7
   PubMed Web of Science ®Google Scholar
• Gillespie JI. The actions of sodium nitroprusside and the phosphodiesterase inhibitor dipyridamole on phasic activity in the isolated guinea-pig bladder. BJU Int 2004;93:851-8
   Google Scholar
• Liu S-H, Lin-Shiau S-Y. Enhancement by nitric oxide of neurogenic contraction in the mouse urinary bladder. Naunyn Schmiedebergs Arch Pharmacol 1997;356:850-1
   PubMedGoogle Scholar
• Lee JG, Coplen D, Macarak E, et al. Comarative studies on the ontogeny and autonomic responses of the fetal calf bladder at different stages of development: involvement of nitric oxide on field stimulated relaxation. J Urol 1994;151:1096-101
   PubMedGoogle Scholar
• Hernandez M, Recio P, Barahona MV, et al. Pre-junctional alpha2-adrenoceptors modulation of the nitrergic transmission in the pig urinary bladder neck. Neurourol Urodyn 2007;26:578-83
   PubMedGoogle Scholar
• Sand C, Michel MC. Bradykinin contracts rat urinary blader largely independent of phospholipase C. J Pharmacol Exp Ther 2014;348:25-31
   PubMedGoogle Scholar
• Yu Y, De Groat WC. Nitric oxide modulates bladder afferent nerve activity in the in vitro urinary bladder-pelvic nerve preparation from rats with cyclophosphamide induced cystitis. Brain Res 2013;1490:83-94
   PubMedGoogle Scholar
• Michel MC, Vrydag W. Alpha1-, alpha2- and beta-adrenoceptors in the urinary bladder, urethra and prostate. Br J Pharmacol 2006;147:S88-S119
   PubMed Web of Science ®Google Scholar
• Kuo H-C, Liu H-T, Chuang Y-C, et al. Pilot study of liposome-encapsulated onabotulinumtoxinA for patients with overactive bladder: a single-center study. Eur Urol 2014;65:1117-24
   PubMed Web of Science ®Google Scholar
• Madersbacher H, Knoll M. Intravesical application of oxybutynin: mode of action controlling detrusor hyperreflexia. Preliminary results. Eur Urol 1995;28:340-4
   PubMedGoogle Scholar
• Andersson K-E. Antimuscarinic mechanisms and the overactive detrusor: an update. Eur UroL 2011;59:377-86
   PubMed Web of Science ®Google Scholar
• Yokoyama O, Yusup A, Miwa Y, et al. Effects of tolterodine on an overactive bladder depend on suppression of C-fiber bladder afferent activity in rats. J Urol 2005;174:2032-6
   PubMed Web of Science ®Google Scholar