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Review

Therapeutic potential of manipulating suicidal erythrocyte death

, MD, , PhD & , MD

Bibliography

  • Lang E, Qadri SM, Lang F. Killing me softly - suicidal erythrocyte death. Int J Biochem Cell Biol 2012;44:1236-43
  • Lang F, Abed M, Lang E, Föller M. Oxidative stress and suicidal erythrocyte death. Antioxid Redox Signal 2014;21:138-53
  • Manodori AB, Barabino GA, Lubin BH, et al. Adherence of phosphatidylserine-exposing erythrocytes to endothelial matrix thrombospondin. Blood 2000;95:1293-300
  • Yang H, Chen YZ, Zhang Y, et al. A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. Nat Commun 2015;6:5717
  • Foller M, Bobbala D, Koka S, et al. Suicide for survival–death of infected erythrocytes as a host mechanism to survive malaria. Cell Physiol Biochem 2009;24:133-40
  • Betal SG, Setty BNY. Phosphatidylserine-positive erythrocytes bind to immobilized and soluble thrombospondin-1 via its heparin-binding domain. Transl Res 2008;152:165-77
  • Walker B, Towhid ST, Schmid E, et al. Dynamic adhesion of eryptotic erythrocytes to immobilized platelets via platelet phosphatidylserine receptors. Am J Physiol Cell Physiol 2014;306:C291-7
  • Vota DM, Crisp RL, Nesse AB, et al. Oxidative stress due to aluminum exposure induces eryptosis which is prevented by erythropoietin. J Cell Biochem 2012;113:1581-9
  • Ghashghaeinia M, Cluitmans JC, Toulany M, et al. Age sensitivity of NFkappaB abundance and programmed cell death in erythrocytes induced by NFkappaB inhibitors. Cell Physiol Biochem 2013;32:801-13
  • Rice L, Alfrey CP. The negative regulation of red cell mass by neocytolysis: physiologic and pathophysiologic manifestations. Cell Physiol Biochem 2005;15:245-50
  • Setty BN, Kulkarni S, Rao AK, et al. Fetal hemoglobin in sickle cell disease: relationship to erythrocyte phosphatidylserine exposure and coagulation activation. Blood 2000;96:1119-24
  • Kaestner L, Bernhardt I. Ion channels in the human red blood cell membrane: their further investigation and physiological relevance. Bioelectrochemistry 2002;55:71-4
  • Lang F, Busch GL, Ritter M, et al. Functional significance of cell volume regulatory mechanisms. Physiol Rev 1998;78:247-306
  • Maellaro E, Leoncini S, Moretti D, et al. Erythrocyte caspase-3 activation and oxidative imbalance in erythrocytes and in plasma of type 2 diabetic patients. Acta Diabetol 2013;50:489-95
  • Owusu BY, Stapley R, Patel RP. Nitric oxide formation versus scavenging: the red blood cell balancing act. J Physiol 2012;590:4993-5000
  • Kahn MJ, Maley JH, Lasker GF, et al. Updated role of nitric oxide in disorders of erythrocyte function. Cardiovasc Hematol Disord Drug Targets 2013;13:83-7
  • Dasgupta T, Fabry ME, Kaul DK. Antisickling property of fetal hemoglobin enhances nitric oxide bioavailability and ameliorates organ oxidative stress in transgenic-knockout sickle mice. Am J Physiol Reg Int Comp Physiol 2010;298:R394-402
  • Salhany JM. The oxidative denitrosylation mechanism and nitric oxide release from human fetal and adult hemoglobin, an experimentally based model simulation study. Blood Cells Mol Dis 2013;50:8-19
  • Abed M, Feger M, Alzoubi K, et al. Sensitization of erythrocytes to suicidal erythrocyte death following water deprivation. Kidney Blood Press Res 2013;37:567-78
  • Abed M, Towhid ST, Feger M, et al. Adhesion of klotho-deficient eryptotic erythrocytes to endothelial cells. Acta Physiol (Oxf) 2013;207:485-93
  • Lang E, Gatidis S, Freise NF, et al. Conjugated bilirubin triggers anemia by inducing erythrocyte death. Hepatology 2015;61:275-84
  • Mahmud H, Ruifrok WP, Westenbrink BD, et al. Suicidal erythrocyte death, eryptosis, as a novel mechanism in heart failure-associated anaemia. Cardiovasc Res 2013;98:37-46
  • Polak-Jonkisz D, Purzyc L. Ca influx versus efflux during eryptosis in uremic erythrocytes. Blood Purif 2012;34:209-10
  • Dmitrieva O, de Lusignan S, Macdougall IC, et al. Association of anaemia in primary care patients with chronic kidney disease: cross sectional study of quality improvement in chronic kidney disease (QICKD) trial data. BMC Nephrol 2013;14:24
  • Yang M, Fox CH, Vassalotti J, et al. Complications of progression of CKD. Adv Chronic Kidney Dis 2011;18:400-5
  • Adamson JW. Hyporesponsiveness to erythropoiesis stimulating agents in chronic kidney disease: the many faces of inflammation. Adv Chronic Kidney Dis 2009;16:76-82
  • Atkinson MA, Furth SL. Anemia in children with chronic kidney disease. Nat Rev Nephrol 2011;7:635-41
  • Attanasio P, Ronco C, Anker SD, et al. Role of iron deficiency and anemia in cardio-renal syndromes. Semin Nephrol 2012;32:57-62
  • Kwack C, Balakrishnan VS. Managing erythropoietin hyporesponsiveness. Semin Dial 2006;19:146-51
  • Abed M, Artunc F, Alzoubi K, et al. Suicidal erythrocyte death in end-stage renal disease. J Mol Med (Berl) 2014;92:871-9
  • Vos FE, Schollum JB, Coulter CV, et al. Red blood cell survival in long-term dialysis patients. Am J Kidney Dis 2011;58:591-8
  • Antonelou MH, Kriebardis AG, Velentzas AD, et al. Oxidative stress-associated shape transformation and membrane proteome remodeling in erythrocytes of end stage renal disease patients on hemodialysis. J Proteomics 2011;74:2441-52
  • Voelkl J, Alzoubi K, Mamar AK, et al. Stimulation of suicidal erythrocyte death by increased extracellular phosphate concentrations. Kidney Blood Press Res 2013;38:42-51
  • Ahmed MS, Langer H, Abed M, et al. The uremic toxin acrolein promotes suicidal erythrocyte death. Kidney Blood Press Res 2013;37:158-67
  • Ahmed MS, Abed M, Voelkl J, et al. Triggering of suicidal erythrocyte death by uremic toxin indoxyl sulfate. BMC Nephrol 2013;14:244
  • Kirk K. Membrane transport in the malaria-infected erythrocyte. Physiol Rev 2001;81:495-537
  • Lew VL, Tiffert T, Ginsburg H. Excess hemoglobin digestion and the osmotic stability of Plasmodium falciparum-infected red blood cells. Blood 2003;101:4189-94
  • Joshi P, Gupta CM. Abnormal membrane phospholipid organization in Plasmodium falciparum-infected human erythrocytes. Br J Haematol 1988;68:255-9
  • Schwartz RS, Olson JA, Raventos-Suarez C, et al. Altered plasma membrane phospholipid organization in Plasmodium falciparum-infected human erythrocytes. Blood 1987;69:401-7
  • Bottger E, Multhoff G, Kun JF, et al. Plasmodium falciparum-infected erythrocytes induce granzyme B by NK cells through expression of host-Hsp70. PLoS ONE 2012;7:e33774
  • Ayi K, Giribaldi G, Skorokhod A, et al. 16alpha-bromoepiandrosterone, an antimalarial analogue of the hormone dehydroepiandrosterone, enhances phagocytosis of ring stage parasitized erythrocytes: a novel mechanism for antimalarial activity. Antimicrob Agents Chemother 2002;46:3180-4
  • Turrini F, Ginsburg H, Bussolino F, et al. Phagocytosis of Plasmodium falciparum-infected human red blood cells by human monocytes: involvement of immune and nonimmune determinants and dependence on parasite developmental stage. Blood 1992;80:801-8
  • Sherman IW, Eda S, Winograd E. Erythrocyte aging and malaria. Cell Mol Biol (Noisy-le-grand) 2004;50:159-69
  • Ayi K, Turrini F, Piga A, et al. Enhanced phagocytosis of ring-parasitized mutant erythrocytes: a common mechanism that may explain protection against falciparum malaria in sickle trait and beta-thalassemia trait. Blood 2004;104:3364-71
  • Cappadoro M, Giribaldi G, O’Brien E, et al. Early phagocytosis of glucose-6-phosphate dehydrogenase (G6PD)-deficient erythrocytes parasitized by Plasmodium falciparum may explain malaria protection in G6PD deficiency. Blood 1998;92:2527-34
  • de Jong K, Emerson RK, Butler J, et al. Short survival of phosphatidylserine-exposing red blood cells in murine sickle cell anemia. Blood 2001;98:1577-84
  • Kean LS, Brown LE, Nichols JW, et al. Comparison of mechanisms of anemia in mice with sickle cell disease and beta-thalassemia: peripheral destruction, ineffective erythropoiesis, and phospholipid scramblase-mediated phosphatidylserine exposure. Exp Hematol 2002;30:394-402
  • Kuypers FA, Yuan J, Lewis RA, et al. Membrane phospholipid asymmetry in human thalassemia. Blood 1998;91:3044-51
  • Taylor SM, Fairhurst RM. Malaria parasites and red cell variants: when a house is not a home. Curr Opin Hematol 2014;21:193-200
  • Clark MA, Goheen MM, Fulford A, et al. Host iron status and iron supplementation mediate susceptibility to erythrocytic stage Plasmodium falciparum. Nat Commun 2014;5:4446
  • Jaureguiberry S, Ndour PA, Roussel C, et al. Postartesunate delayed hemolysis is a predictable event related to the lifesaving effect of artemisinins. Blood 2014;124:167-75
  • de Franceschi L, Turrini F, Honczarenko M, et al. In vivo reduction of erythrocyte oxidant stress in a murine model of beta-thalassemia. Haematologica 2004;89:1287-98
  • Vota DM, Maltaneri RE, Wenker SD, et al. Differential erythropoietin action upon cells induced to eryptosis by different agents. Cell Biochem Biophys 2013;65:145-57
  • Dumaswala UJ, Wilson MJ, Wu YL, et al. Glutathione loading prevents free radical injury in red blood cells after storage. Free Radic Res 2000;33:517-29
  • Arnold M, Bissinger R, Lang F. Mitoxantrone-induced suicidal erythrocyte death. Cell Physiol Biochem 2014;34:1756-67
  • Shaik N, Lupescu A, Lang F. Inhibition of suicidal erythrocyte death by probucol. J Cardiovasc Pharmacol 2013;61:120-6
  • Qian EW, Ge DT, Kong SK. Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. J Nat Prod 2012;75:531-7
  • Ben-Hur E, Rywkin S, Rosenthal I, et al. Virus inactivation in red cell concentrates by photosensitization with phthalocyanines: protection of red cells but not of vesicular stomatitis virus with a water-soluble analogue of vitamin E. Transfusion 1995;35:401-6
  • Malik A, Bissinger R, Calabro S, et al. Aristolochic acid induced suicidal erythrocyte death. Kidney Blood Press Res 2014;39:408-19
  • Alzoubi K, Calabro S, Bissinger R, et al. Stimulation of suicidal erythrocyte death by artesunate. Cell Physiol Biochem 2014;34:2232-44
  • Gao M, Lau PM, Kong SK. Mitochondrial toxin betulinic acid induces in vitro eryptosis in human red blood cells through membrane permeabilization. Arch Toxicol 2014;88:755-68
  • Jilani K, Lang F. Carmustine-induced phosphatidylserine translocation in the erythrocyte membrane. Toxins (Basel) 2013;5:703-16
  • Lupescu A, Bissinger R, Jilani K, et al. Triggering of suicidal erythrocyte death by celecoxib. Toxins (Basel) 2013;5:1543-54
  • Zhang R, Xiang Y, Ran Q, et al. Involvement of calcium, reactive oxygen species, and ATP in hexavalent chromium-induced damage in red blood cells. Cell Physiol Biochem 2014;34:1780-91
  • Bissinger R, Lupescu A, Zelenak C, et al. Stimulation of eryptosis by cryptotanshinone. Cell Physiol Biochem 2014;34:432-42
  • Abed M, Zoubi KA, Theurer M, et al. Effect of dermaseptin on erythrocytes. Basic Clin Pharmacol Toxicol 2013;113:347-52
  • Bissinger R, Modicano P, Frauenfeld L, et al. Estramustine-induced suicidal erythrocyte death. Cell Physiol Biochem 2013;32:1426-36
  • Gao M, Wong SY, Lau PM, et al. Ferutinin induces in vitro eryptosis/erythroptosis in human erythrocytes through membrane permeabilization and calcium influx. Chem Res Toxicol 2013;26:1218-28
  • Jilani K, Enkel S, Bissinger R, et al. Fluoxetine induced suicidal erythrocyte death. Toxins (Basel) 2013;5:1230-43
  • Zbidah M, Lupescu A, Jilani K, et al. Stimulation of suicidal erythrocyte death by fumagillin. Basic Clin Pharmacol Toxicol 2013;112:346-51
  • Lupescu A, Bissinger R, Warsi J, et al. Stimulation of erythrocyte cell membrane scrambling by gedunin. Cell Physiol Biochem 2014;33:1838-48
  • Jilani K, Qadri SM, Lang F. Geldanamycin-induced phosphatidylserine translocation in the erythrocyte membrane. Cell Physiol Biochem 2013;32:1600-9
  • Lau IP, Chen H, Wang J, et al. In vitro effect of CTAB- and PEG-coated gold nanorods on the induction of eryptosis/erythroptosis in human erythrocytes. Nanotoxicology 2012;6:847-56
  • Zbidah M, Lupescu A, Herrmann T, et al. Effect of honokiol on erythrocytes. Toxicol In Vitro 2013;27:1737-45
  • Jang WH, Lim KM, Kim K, et al. Low level of lead can induce phosphatidylserine exposure and erythrophagocytosis: a new mechanism underlying lead-associated anemia. Toxicol Sci 2011;122:177-84
  • Alzoubi K, Alktifan B, Oswald G, et al. Breakdown of phosphatidylserine asymmetry following treatment of erythrocytes with lumefantrine. Toxins (Basel) 2014;6:650-64
  • Chung SM, Bae ON, Lim KM, et al. Lysophosphatidic acid induces thrombogenic activity through phosphatidylserine exposure and procoagulant microvesicle generation in human erythrocytes. Arterioscler Thromb Vasc Biol 2007;27:414-21
  • Lim KM, Kim S, Noh JY, et al. Low-level mercury can enhance procoagulant activity of erythrocytes: a new contributing factor for mercury-related thrombotic disease. Environ Health Perspect 2010;118:928-35
  • Munoz C, Alzoubi K, Jacobi J, et al. Effect of miltefosine on erythrocytes. Toxicol In Vitro 2013;27:1913-19
  • Jacobi J, Lang E, Bissinger R, et al. Stimulation of erythrocyte cell membrane scrambling by mitotane. Cell Physiol Biochem 2014;33:1516-26
  • Frauenfeld L, Alzoubi K, Abed M, et al. Stimulation of erythrocyte cell membrane scrambling by mushroom tyrosinase. Toxins (Basel) 2014;6:1096-108
  • Noh JY, Park JS, Lim KM, et al. A naphthoquinone derivative can induce anemia through phosphatidylserine exposure-mediated erythrophagocytosis. J Pharmacol Exp Ther 2010;333:414-20
  • Arnold M, Lang E, Modicano P, et al. Effect of nitazoxanide on erythrocytes. Basic Clin Pharmacol Toxicol 2014;114:421-6
  • Lupescu A, Bissinger R, Herrmann T, et al. Induction of suicidal erythrocyte death by novobiocin. Cell Physiol Biochem 2014;33:670-80
  • Malik A, Bissinger R, Jilani K, et al. Stimulation of erythrocyte cell membrane scrambling by nystatin. Basic Clin Pharmacol Toxicol 2015;116:47-52
  • Tesoriere L, Attanzio A, Allegra M, et al. Oxysterol mixture in hypercholesterolemia-relevant proportion causes oxidative stress-dependent eryptosis. Cell Physiol Biochem 2014;34:1075-89
  • Lupescu A, Jilani K, Zbidah M, et al. Patulin-induced suicidal erythrocyte death. Cell Physiol Biochem 2013;32:291-9
  • Alzoubi K, Honisch S, Abed M, et al. Triggering of suicidal erythrocyte death by penta-O-galloyl-beta-D-glucose. Toxins (Basel) 2014;6:54-65
  • Abed M, Towhid ST, Pakladok T, et al. Effect of bacterial peptidoglycan on erythrocyte death and adhesion to endothelial cells. Int J Med Microbiol 2013;303:182-9
  • Bissinger R, Fischer S, Jilani K, et al. Stimulation of erythrocyte death by phloretin. Cell Physiol Biochem 2014;34:2256-65
  • Noh JY, Lim KM, Bae ON, et al. Procoagulant and prothrombotic activation of human erythrocytes by phosphatidic acid. Am J Physiol Heart Circ Physiol 2010;299:H347-55
  • Gao M, Cheung KL, Lau IP, et al. Polyphyllin D induces apoptosis in human erythrocytes through Ca(2)(+) rise and membrane permeabilization. Arch Toxicol 2012;86:741-52
  • Oswald G, Alzoubi K, Abed M, et al. Stimulation of suicidal erythrocyte death by ribavirin. Basic Clin Pharmacol Toxicol 2014;114:311-17
  • Bissinger R, Malik A, Jilani K, et al. Triggering of erythrocyte cell membrane scrambling by salinomycin. Basic Clin Pharmacol Toxicol 2014;115:396-402
  • Lupescu A, Bissinger R, Jilani K, et al. In vitro induction of erythrocyte phosphatidylserine translocation by the natural naphthoquinone shikonin. Toxins (Basel) 2014;6:1559-74
  • Abed M, Herrmann T, Alzoubi K, et al. Tannic Acid induced suicidal erythrocyte death. Cell Physiol Biochem 2013;32:1106-16
  • Lang E, Modicano P, Arnold M, et al. Effect of thioridazine on erythrocytes. Toxins (Basel) 2013;5:1918-31
  • Theurer M, Shaik N, Lang F. Stimulation of suicidal erythrocyte death by trans-cinnamaldehyde. Phytomedicine 2013;20:1119-23
  • Jilani K, Lupescu A, Zbidah M, et al. Withaferin A-stimulated Ca2+ entry, ceramide formation and suicidal death of erythrocytes. Toxicol In Vitro 2013;27:52-8
  • Jilani K, Lang F. Ca(2+)-dependent suicidal erythrocyte death following zearalenone exposure. Arch Toxicol 2013;87:1821-8

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