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Therapeutic targets for the treatment of hepatitis E virus infection

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Bibliography

  • Wong DC, Purcell RH, Sreenivasan MA, et al. Epidemic and endemic hepatitis in India: evidence for a non-A, non-B hepatitis virus aetiology. Lancet 1980;2(8200):876-9
  • Viswanathan R. Infectious hepatitis in Delhi (1955-56): a critical study-epidemiology. 1957. Natl Med J India 2013;26(6):362-77
  • Thomson K, Dvorzak J, Lagu J, et al. Investigation of Hepatitis E Outbreak Among Refugees - Upper Nile, South Sudan, 2012-2013. MMWR Morb Mortal Wkly Rep 2013;62(29):581-6
  • Yugo DM, Meng XJ. Hepatitis E virus: foodborne, waterborne and zoonotic transmission. Int J Environ Res Public Health 2013;10(10):4507-33
  • Pavio N, Meng XJ, Doceul V. Zoonotic origin of hepatitis E. Current opinion in virology 2015;10:34-41
  • Kumar A, Beniwal M, Kar P, et al. Hepatitis E in pregnancy. Int J Gynaecol Obstet 2004;85(3):240-4
  • Yugo DM, Cossaboom CM, Meng XJ. Naturally occurring animal models of human hepatitis E virus infection. ILAR J 2014;55(1):187-99
  • de Niet A, Zaaijer HL, ten Berge I, et al. Chronic hepatitis E after solid organ transplantation. Neth J Med 2012;70(6):261-6
  • Zhu FC, Zhang J, Zhang XF, et al. Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial. Lancet 2010;376(9744):895-902
  • Pischke S, Hardtke S, Bode U, et al. Ribavirin treatment of acute and chronic hepatitis E: a single-centre experience. Liver Int 2013;33(5):722-6
  • Lewis H, Cunningham M, Foster G. Second generation direct antivirals and the way to interferon-free regimens in chronic HCV. Best Pract Res Clin Gastroenterol 2012;26(4):471-85
  • Balayan MS, Andjaparidze AG, Savinskaya SS, et al. Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route. Intervirology 1983;20(1):23-31
  • Reyes GR, Purdy MA, Kim JP, et al. Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis. Science 1990;247(4948):1335-9
  • Smith DB, Simmonds P, Jameel S, et al. Consensus proposals for classification of the family Hepeviridae. J Gen Virol 2014;95(Pt 10):2223-32
  • Okamoto H. Genetic variability and evolution of hepatitis E virus. Virus Res 2007;127(2):216-28
  • Krain LJ, Nelson KE, Labrique AB. Host immune status and response to hepatitis E virus infection. Clin Microbiol Rev 2014;27(1):139-65
  • Bouquet J, Tesse S, Lunazzi A, et al. Close similarity between sequences of hepatitis E virus recovered from humans and swine, France, 2008-2009. Emerg Infect Dis 2011;17(11):2018-25
  • Navaneethan U, Al Mohajer M, Shata MT. Hepatitis E and pregnancy: understanding the pathogenesis. Liver Int 2008;28(9):1190-9
  • Kumar Acharya S, Kumar Sharma P, Singh R, et al. Hepatitis E virus (HEV) infection in patients with cirrhosis is associated with rapid decompensation and death. J Hepatol 2007;46(3):387-94
  • van den Berg B, van der Eijk AA, Pas SD, et al. Guillain-Barre syndrome associated with preceding hepatitis E virus infection. Neurology 2014;82(6):491-7
  • van Eijk JJ, Madden RG, van der Eijk AA, et al. Neuralgic amyotrophy and hepatitis E virus infection. Neurology 2014;82(6):498-503
  • Despierres LA, Kaphan E, Attarian S, et al. Neurologic disorders and hepatitis E, France, 2010. Emerg Infect Dis 2011;17(8):1510-12
  • Izopet J, Kamar N. [Hepatitis E: from zoonotic transmission to chronic infection in immunosuppressed patients]. Med Sci (Paris) 2008;24(12):1023-5
  • Kamar N, Selves J, Mansuy JM, et al. Hepatitis E virus and chronic hepatitis in organ-transplant recipients. N Engl J Med 2008;358(8):811-17
  • Gauss A, Wenzel JJ, Flechtenmacher C, et al. Chronic hepatitis E virus infection in a patient with leukemia and elevated transaminases: a case report. J Med Case Rep 2012;6:334
  • Kenfak-Foguena A, Schoni-Affolter F, Burgisser P, et al. Hepatitis E Virus seroprevalence and chronic infections in patients with HIV, Switzerland. Emerg Infect Dis 2011;17(6):1074-8
  • Ollier L, Tieulie N, Sanderson F, et al. Chronic hepatitis after hepatitis E virus infection in a patient with non-Hodgkin lymphoma taking rituximab. Ann Intern Med 2009;150(6):430-1
  • Tamura A, Shimizu YK, Tanaka T, et al. Persistent infection of hepatitis E virus transmitted by blood transfusion in a patient with T-cell lymphoma. Hepatol Res 2007;37(2):113-20
  • Kamar N, Garrouste C, Haagsma EB, et al. Factors associated with chronic hepatitis in patients with hepatitis E virus infection who have received solid organ transplants. Gastroenterology 2011;140(5):1481-9
  • Crum-Cianflone NF, Curry J, Drobeniuc J, et al. Hepatitis E virus infection in HIV-infected persons. Emerg Infect Dis 2012;18(3):502-6
  • Balayan MS, Fedorova OE, Mikhailov MI, et al. Antibody to hepatitis E virus in HIV-infected individuals and AIDS patients. J Viral Hepat 1997;4(4):279-83
  • Dalton HR, Bendall RP, Keane FE, et al. Persistent carriage of hepatitis E virus in patients with HIV infection. N Engl J Med 2009;361(10):1025-7
  • Kamar N, Izopet J, Tripon S, et al. Ribavirin for chronic hepatitis E virus infection in transplant recipients. N Engl J Med 2014;370(12):1111-20
  • Saravanabalaji S, Tripathy AS, Dhoot RR, et al. Viral load, antibody titers and recombinant open reading frame 2 protein-induced TH1/TH2 cytokines and cellular immune responses in self-limiting and fulminant hepatitis e. Intervirology 2009;52(2):78-85
  • Bose PD, Das BC, Kumar A, et al. High viral load and deregulation of the progesterone receptor signaling pathway: association with hepatitis E-related poor pregnancy outcome. J Hepatol 2011;54(6):1107-13
  • Koonin EV, Gorbalenya AE, Purdy MA, et al. Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses. Proc Natl Acad Sci U S A 1992;89(17):8259-63
  • Graff J, Torian U, Nguyen H, Emerson SU. A bicistronic subgenomic mRNA encodes both the ORF2 and ORF3 proteins of hepatitis E virus. J Virol 2006;80(12):5919-26
  • Cao D, Meng X-J. Molecular biology and replication of hepatitis E virus. Emerg. microbes & infect 2012;1(8):e17
  • Magden J, Takeda N, Li T, et al. Virus-specific mRNA capping enzyme encoded by hepatitis E virus. J Virol 2001;75(14):6249-55
  • Karpe YA, Lole KS. Deubiquitination activity associated with hepatitis E virus putative papain-like cysteine protease. J Gen Virol 2011;92(Pt 9):2088-92
  • Lhomme S, Abravanel F, Dubois M, et al. Characterization of the polyproline region of the hepatitis E virus in immunocompromised patients. J Virol 2014;88(20):12017-25
  • Nan Y, Yu Y, Ma Z, et al. Hepatitis E virus inhibits type I interferon induction by ORF1 products. J Virol 2014;88(20):11924-32
  • Karpe YA, Lole KS. RNA 5’-triphosphatase activity of the hepatitis E virus helicase domain. J Virol 2010;84(18):9637-41
  • Karpe YA, Lole KS. NTPase and 5’ to 3’ RNA duplex-unwinding activities of the hepatitis E virus helicase domain. J Virol 2010;84(7):3595-602
  • Rehman S, Kapur N, Durgapal H, Panda SK. Subcellular localization of hepatitis E virus (HEV) replicase. Virology 2008;370(1):77-92
  • Agrawal S, Gupta D, Panda SK. The 3’ end of hepatitis E virus (HEV) genome binds specifically to the viral RNA-dependent RNA polymerase (RdRp). Virology 2001;282(1):87-101
  • Ansari IH, Nanda SK, Durgapal H, et al. Cloning, sequencing, and expression of the hepatitis E virus (HEV) nonstructural open reading frame 1 (ORF1). J Med Virol 2000;60(3):275-83
  • Ropp SL, Tam AW, Beames B, et al. Expression of the hepatitis E virus ORF1. Arch Virol 2000;145(7):1321-37
  • Suppiah S, Zhou Y, Frey TK. Lack of processing of the expressed ORF1 gene product of hepatitis E virus. J Virol 2011;8:245
  • Perttila J, Spuul P, Ahola T. Early secretory pathway localization and lack of processing for hepatitis E virus replication protein pORF1. J Gen Virol 2013;94(Pt 4):807-16
  • Sehgal D, Thomas S, Chakraborty M, Jameel S. Expression and processing of the Hepatitis E virus ORF1 nonstructural polyprotein. J Virol 2006;3:38
  • Zhang M, Purcell RH, Emerson SU. Identification of the 5’ terminal sequence of the SAR-55 and MEX-14 strains of hepatitis E virus and confirmation that the genome is capped. J Med Virol 2001;65(2):293-5
  • Koonin EV. The phylogeny of RNA-dependent RNA polymerases of positive-strand RNA viruses. J Med Virol 1991;72(Pt 9):2197-206
  • Emerson SU, Nguyen H, Graff J, et al. In vitro replication of hepatitis E virus (HEV) genomes and of an HEV replicon expressing green fluorescent protein. J Virol 2004;78(9):4838-46
  • Graff J, Zhou YH, Torian U, et al. Mutations within potential glycosylation sites in the capsid protein of hepatitis E virus prevent the formation of infectious virus particles. J Virol 2008;82(3):1185-94
  • Surjit M, Jameel S, Lal SK. Cytoplasmic localization of the ORF2 protein of hepatitis E virus is dependent on its ability to undergo retrotranslocation from the endoplasmic reticulum. J Virol 2007;81(7):3339-45
  • Robinson RA, Burgess WH, Emerson SU, et al. Structural characterization of recombinant hepatitis E virus ORF2 proteins in baculovirus-infected insect cells. Protein Expr Purif 1998;12(1):75-84
  • Surjit M, Jameel S, Lal SK. The ORF2 protein of hepatitis E virus binds the 5’ region of viral RNA. J Virol 2004;78(1):320-8
  • Zheng ZZ, Miao J, Zhao M, et al. Role of heat-shock protein 90 in hepatitis E virus capsid trafficking. J Gen Virol 2010;91(Pt 7):1728-36
  • Yu H, Li S, Yang C, et al. Homology model and potential virus-capsid binding site of a putative HEV receptor Grp78. J Mol Model 2011;17(5):987-95
  • Kalia M, Chandra V, Rahman SA, et al. Heparan sulfate proteoglycans are required for cellular binding of the hepatitis E virus ORF2 capsid protein and for viral infection. J Virol 2009;83(24):12714-24
  • Guu TS, Liu Z, Ye Q, et al. Structure of the hepatitis E virus-like particle suggests mechanisms for virus assembly and receptor binding. Proc Natl Acad Sci U S A 2009;106(31):12992-7
  • Wang CY, Miyazaki N, Yamashita T, et al. Crystallization and preliminary X-ray diffraction analysis of recombinant hepatitis E virus-like particle. Acta Crystallogr Sect F Struct Biol Cryst Commun 2008;64(Pt 4):318-22
  • Xing L, Li TC, Mayazaki N, et al. Structure of hepatitis E virion-sized particle reveals an RNA-dependent viral assembly pathway. J Biol Chem 2010;285(43):33175-83
  • Emerson SU, Nguyen H, Torian U, Purcell RH. ORF3 protein of hepatitis E virus is not required for replication, virion assembly, or infection of hepatoma cells in vitro. J Virol 2006;80(21):10457-64
  • Graff J, Nguyen H, Yu C, et al. The open reading frame 3 gene of hepatitis E virus contains a cis-reactive element and encodes a protein required for infection of macaques. J Virol 2005;79(11):6680-9
  • Huang YW, Opriessnig T, Halbur PG, Meng XJ. Initiation at the third in-frame AUG codon of open reading frame 3 of the hepatitis E virus is essential for viral infectivity in vivo. J Virol 2007;81(6):3018-26
  • Zafrullah M, Ozdener MH, Panda SK, Jameel S. The ORF3 protein of hepatitis E virus is a phosphoprotein that associates with the cytoskeleton. J Virol 1997;71(12):9045-53
  • Tyagi S, Korkaya H, Zafrullah M, et al. The phosphorylated form of the ORF3 protein of hepatitis E virus interacts with its non-glycosylated form of the major capsid protein. ORF2. J Biol Chem 2002;277(25):22759-67
  • Kannan H, Fan S, Patel D, et al. The hepatitis E virus open reading frame 3 product interacts with microtubules and interferes with their dynamics. J Virol 2009;83(13):6375-82
  • Chandra V, Kar-Roy A, Kumari S, et al. The hepatitis E virus ORF3 protein modulates epidermal growth factor receptor trafficking, STAT3 translocation, and the acute-phase response. J Virol 2008;82(14):7100-10
  • Kenney SP, Pudupakam RS, Huang YW, et al. The PSAP motif within the ORF3 protein of an avian strain of the hepatitis E virus is not critical for viral infectivity in vivo but plays a role in virus release. J Virol 2012;86(10):5637-46
  • Takahashi M, Yamada K, Hoshino Y, et al. Monoclonal antibodies raised against the ORF3 protein of hepatitis E virus (HEV) can capture HEV particles in culture supernatant and serum but not those in feces. Arch Virol 2008;153(9):1703-13
  • Nagashima S, Takahashi M, Jirintai et al. A PSAP motif in the ORF3 protein of hepatitis E virus is necessary for virion release from infected cells. J Gen Virol 2011;92(Pt 2):269-78
  • Weissenhorn W, Poudevigne E, Effantin G, Bassereau P. How to get out: ssRNA enveloped viruses and membrane fission. Curr Opin Virol 2013;3(2):159-67
  • Feng Z, Hensley L, McKnight KL, et al. A pathogenic picornavirus acquires an envelope by hijacking cellular membranes. Nature 2013;496(7445):367-71
  • Kar-Roy A, Korkaya H, Oberoi R, et al. The hepatitis E virus open reading frame 3 protein activates ERK through binding and inhibition of the MAPK phosphatase. J Biol Chem 2004;279(27):28345-57
  • Korkaya H, Jameel S, Gupta D, et al. The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK. J Biol Chem 2001;276(45):42389-400
  • Pawson T. Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems. Cell 2004;116(2):191-203
  • Ratra R, Kar-Roy A, Lal SK. The ORF3 protein of hepatitis E virus interacts with hemopexin by means of its 26 amino acid N-terminal hydrophobic domain II. Biochemistry 2008;47(7):1957-69
  • Moin SM, Chandra V, Arya R, Jameel S. The hepatitis E virus ORF3 protein stabilizes HIF-1alpha and enhances HIF-1-mediated transcriptional activity through p300/CBP. Cell Microbiol 2009;11(9):1409-21
  • Ratra R, Kar-Roy A, Lal SK. ORF3 protein of hepatitis E virus interacts with the Bbeta chain of fibrinogen resulting in decreased fibrinogen secretion from HuH-7 cells. J Gen Virol 2009;90(Pt 6):1359-70
  • Moin SM, Panteva M, Jameel S. The hepatitis E virus Orf3 protein protects cells from mitochondrial depolarization and death. J Biol Chem 2007;282(29):21124-33
  • Chandra V, Kalia M, Hajela K, Jameel S. The ORF3 protein of hepatitis E virus delays degradation of activated growth factor receptors by interacting with CIN85 and blocking formation of the Cbl-CIN85 complex. J Virol 2010;84(8):3857-67
  • Tyagi S, Surjit M, Lal SK. The 41-amino-acid C-terminal region of the hepatitis E virus ORF3 protein interacts with bikunin, a kunitz-type serine protease inhibitor. J Virol 2005;79(18):12081-7
  • Tyagi S, Surjit M, Roy AK, et al. The ORF3 protein of hepatitis E virus interacts with liver-specific alpha1-microglobulin and its precursor alpha1-microglobulin/bikunin precursor (AMBP) and expedites their export from the hepatocyte. J Biol Chem 2004;279(28):29308-19
  • Wang C, Guo L, Yu D, et al. HEV-ORF3 Encoding Phosphoprotein Interacts With Hepsin. Hepat Mon 2014;14(1):e13902
  • Geng Y, Yang J, Huang W, et al. Virus host protein interaction network analysis reveals that the HEV ORF3 protein may interrupt the blood coagulation process. PLoS ONE 2013;8(2):e56320
  • Arankalle VA, Chadha MS, Chobe LP, et al. Cross-challenge studies in rhesus monkeys employing different Indian isolates of hepatitis E virus. J Med Virol 1995;46(4):358-63
  • Purcell RH, Emerson SU. Animal models of hepatitis A and E. ILAR J 2001;42(2):161-77
  • Meng XJ, Purcell RH, Halbur PG, et al. A novel virus in swine is closely related to the human hepatitis E virus. Proc Natl Acad Sci U S A 1997;94(18):9860-5
  • Halbur PG, Kasorndorkbua C, Gilbert C, et al. Comparative pathogenesis of infection of pigs with hepatitis E viruses recovered from a pig and a human. J Clin Microbiol 2001;39(3):918-23
  • Meng XJ. Hepatitis E virus: animal reservoirs and zoonotic risk. Vet Microbiol 2010;140(3-4):256-65
  • Haqshenas G, Shivaprasad HL, Woolcock PR, et al. Genetic identification and characterization of a novel virus related to human hepatitis E virus from chickens with hepatitis-splenomegaly syndrome in the United States. J Gen Virol 2001;82(Pt 10):2449-62
  • Marek A, Bilic I, Prokofieva I, Hess M. Phylogenetic analysis of avian hepatitis E virus samples from European and Australian chicken flocks supports the existence of a different genus within the Hepeviridae comprising at least three different genotypes. Vet Microbiol 2010;145(1-2):54-61
  • Huang FF, Sun ZF, Emerson SU, et al. Determination and analysis of the complete genomic sequence of avian hepatitis E virus (avian HEV) and attempts to infect rhesus monkeys with avian HEV. J Gen Virol 2004;85(Pt 6):1609-18
  • Meng XJ SH, Payne CJ. Hepatitis E virus infections. 13 edition. Blackwell Publishing Press; Ames, Iowa: 2008
  • Johne R, Heckel G, Plenge-Bonig A, et al. Novel hepatitis E virus genotype in Norway rats. Germany. Emerg Infect Dis 2010;16(9):1452-5
  • Purcell RH, Engle RE, Rood MP, et al. Hepatitis E virus in rats, Los Angeles, California, USA. Emerg Infect Dis 2011;17(12):2216-22
  • Raj VS, Smits SL, Pas SD, et al. Novel hepatitis E virus in ferrets, the Netherlands. Emerg Infect Dis 2012;18(8):1369-70
  • Zhao C, Ma Z, Harrison TJ, et al. A novel genotype of hepatitis E virus prevalent among farmed rabbits in China. J Med Virol 2009;81(8):1371-9
  • Cossaboom CM, Cordoba L, Dryman BA, Meng XJ. Hepatitis E virus in rabbits, Virginia, USA. Emerg Infect Dis 2011;17(11):2047-9
  • Cossaboom CM, Cordoba L, Sanford BJ, et al. Cross-species infection of pigs with a novel rabbit, but not rat, strain of hepatitis E virus isolated in the United States. J Gen Virol 2012;93(Pt 8):1687-95
  • Liu P, Bu QN, Wang L, et al. Transmission of hepatitis E virus from rabbits to cynomolgus macaques. Emerg Infect Dis 2013;19(4):559-65
  • Xia J, Liu L, Wang L, et al. Experimental infection of pregnant rabbits with hepatitis E virus demonstrating high mortality and vertical transmission. J Viral Hepat 2015;10.1111/jvh.12406
  • Tanaka T, Takahashi M, Takahashi H, et al. Development and characterization of a genotype 4 hepatitis E virus cell culture system using a HE-JF5/15F strain recovered from a fulminant hepatitis patient. J Clin Microbiol 2009;47(6):1906-10
  • Tanaka T, Takahashi M, Kusano E, Okamoto H. Development and evaluation of an efficient cell-culture system for Hepatitis E virus. J Gen Virol 2007;88(Pt 3):903-11
  • Shukla P, Nguyen HT, Faulk K, et al. Adaptation of a genotype 3 hepatitis E virus to efficient growth in cell culture depends on an inserted human gene segment acquired by recombination. J Virol 2012;86(10):5697-707
  • Debing Y, Emerson SU, Wang Y, et al. Ribavirin inhibits in vitro hepatitis E virus replication through depletion of cellular GTP pools and is moderately synergistic with alpha interferon. Antimicrob Agents Chemother 2014;58(1):267-73
  • Kenney SP, Meng XJ. The Lysine Residues within the Human Ribosomal Protein S17 (RPS17) Sequence Naturally Inserted into the Viral Nonstructural Protein of a Unique Strain of Hepatitis E Virus are Important for Enhanced Virus Replication. J Virol 2015;89(7):3793-803
  • Nguyen HT, Shukla P, Torian U, et al. Hepatitis E virus genotype 1 infection of swine kidney cells in vitro is inhibited at multiple levels. J Virol 2014;88(2):868-77
  • Zhou Y, Emerson SU. P. 302 Heat shock cognate protein 70 may mediate the entry of hepatitis E virus into host cells. J Clin Virol 2006;36(Suppl 2):S155
  • Kapur N, Thakral D, Durgapal H, Panda SK. Hepatitis E virus enters liver cells through receptor-dependent clathrin-mediated endocytosis. J Viral Hepat 2012;19(6):436-48
  • Wang LH, Rothberg KG, Anderson RG. Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation. J Cell Biol 1993;123(5):1107-17
  • Emerson SU, Nguyen HT, Torian U, et al. An essential RNA element resides in a central region of hepatitis E virus ORF2. J Gen Virol 2013;94(Pt 7):1468-76
  • Cao D, Huang YW, Meng XJ. The nucleotides on the stem-loop RNA structure in the junction region of the hepatitis E virus genome are critical for virus replication. J Virol 2010;84(24):13040-4
  • Graff J, Nguyen H, Kasorndorkbua C, et al. In vitro and in vivo mutational analysis of the 3’-terminal regions of hepatitis e virus genomes and replicons. J Virol 2005;79(2):1017-26
  • Huang F, Hua X, Yang S, et al. Effective inhibition of hepatitis E virus replication in A549 cells and piglets by RNA interference (RNAi) targeting RNA-dependent RNA polymerase. Antiviral Res 2009;83(3):274-81
  • Kumar A, Panda SK, Durgapal H, et al. Inhibition of Hepatitis E virus replication using short hairpin RNA (shRNA). Antiviral Res 2010;85(3):541-50
  • Lindner HA, Fotouhi-Ardakani N, Lytvyn V, et al. The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme. J Virol 2005;79(24):15199-208
  • Frias-Staheli N, Giannakopoulos NV, Kikkert M, et al. Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses. Cell Host Microbe 2007;2(6):404-16
  • Adams J, Kauffman M. Development of the proteasome inhibitor Velcade (Bortezomib). Cancer Invest 2004;22(2):304-11
  • Karpe YA, Meng XJ. Hepatitis E virus replication requires an active ubiquitin-proteasome system. J Virol 2012;86(10):5948-52
  • Xu L, Zhou X, Peppelenbosch MP, Pan Q. Inhibition of hepatitis E virus replication by proteasome inhibitor is nonspecific. Arch Virol 2015;160(2):435-9
  • Surjit M, Varshney B, Lal SK. The ORF2 glycoprotein of hepatitis E virus inhibits cellular NF-kappaB activity by blocking ubiquitination mediated proteasomal degradation of IkappaBalpha in human hepatoma cells. BMC Biochem 2012;13:7
  • Lee CM, Kumar V, Riley RI, Morgan ET. Metabolism and action of proteasome inhibitors in primary human hepatocytes. Drug Metab Dispos 2010;38(12):2166-72
  • Nagashima S, Takahashi M, Jirintai S, et al. Tumour susceptibility gene 101 and the vacuolar protein sorting pathway are required for the release of hepatitis E virions. J Gen Virol 2011;92(Pt 12):2838-48
  • Freed EO. Viral late domains. J Virol 2002;76(10):4679-87
  • Tavassoli A, Lu Q, Gam J, et al. Inhibition of HIV budding by a genetically selected cyclic peptide targeting the Gag-TSG101 interaction. ACS Chem Biol 2008;3(12):757-64
  • Yamada K, Takahashi M, Hoshino Y, et al. ORF3 protein of hepatitis E virus is essential for virion release from infected cells. J Gen Virol 2009;90(Pt 8):1880-91
  • Ahmad I, Holla RP, Jameel S. Molecular virology of hepatitis E virus. Virus Res 2011;161(1):47-58
  • Zuker M. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res 2003;31(13):3406-15

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