Targeting mitochondrial function to protect against vision loss

Bibliography

• Tait SW, Green DR. Mitochondria and cell signalling. J Cell Sci. 2012;125(Pt 4):807–815.
   PubMed Web of Science ®Google Scholar
• Liang C, Ahmad K, Sue CM. The broadening spectrum of mitochondrial disease: shifts in the diagnostic paradigm. Biochim Biophys Acta. 2014 Apr;1840(4):1360–1367.
   PubMed Web of Science ®Google Scholar
• Jarrett SG, Lin H, Godley BF, et al. Mitochondrial DNA damage and its potential role in retinal degeneration. Prog Retin Eye Res. 2008;27(6):596–607.
   PubMed Web of Science ®Google Scholar
• Schrier SA, Falk MJ. Mitochondrial disorders and the eye. Curr Opin Ophthalmol. 2011;22(5):325–331.
   PubMed Web of Science ®Google Scholar
• Fraser JA, Biousse V, Newman NJ. The neuro-ophthalmology of mitochondrial disease. Surv Ophthalmol. 2010 Jul–Aug;55(4):299–334.
   PubMed Web of Science ®Google Scholar
• Yu-Wai-Man P, Griffiths PG, Chinnery PF. Mitochondrial optic neuropathies - disease mechanisms and therapeutic strategies. Prog Retin Eye Res. 2011;30(2):81–114.
   PubMed Web of Science ®Google Scholar
• Daruich A, Matet A, Borruat F-X. Macular dystrophy associated with the mitochondrial DNA A3243G mutation: pericentral pigment deposits or atrophy? Report of two cases and review of the literature. BMC Ophthalmol. 2014;14:77.
   PubMed Web of Science ®Google Scholar
• Breuer M, Koopman W, Koene S, et al. The role of mitochondrial OXPHOS dysfunction in the development of neurologic diseases. Neurobiol Dis. 2013;51:27–34.
   PubMed Web of Science ®Google Scholar
• Al-Enezi M, Al-Saleh H, Nasser M. Mitochondrial disorders with significant ophthalmic manifestations. Middle East Afr J Ophthalmol. 2008;15(2):81–86.
   PubMedGoogle Scholar
• Gronlund MA, Honarvar AK, Andersson S, et al. Ophthalmological findings in children and young adults with genetically verified mitochondrial disease. Br J Ophthalmol. 2010 Jan;94(1):121–127.
   PubMed Web of Science ®Google Scholar
• Fortuna F, Barboni P, Liguori R, et al. Visual system involvement in patients with Friedreich’s ataxia. Brain. 2009;132(Pt 1):116–123.
   PubMed Web of Science ®Google Scholar
• Al-Till M, Jarrah NS, Ajlouni KM. Ophthalmologic findings in fifteen patients with Wolfram syndrome. Eur J Ophthalmol. 2002;12(2):84–88.
   PubMed Web of Science ®Google Scholar
• Ross-Cisneros FN, Pan BX, Silva RA, et al. Optic nerve histopathology in a case of Wolfram syndrome: a mitochondrial pattern of axonal loss. Mitochondrion. 2013;13(6):841–845.
   PubMed Web of Science ®Google Scholar
• Johri A, Beal MF. Mitochondrial dysfunction in neurodegenerative diseases. J Pharmacol Exp Ther. 2012;342(3):619–630.
   PubMed Web of Science ®Google Scholar
• Armstrong RA. Visual symptoms in Parkinson’s disease. Parkinsons Dis. 2011;2011:908306.
   PubMed Web of Science ®Google Scholar
• Yu J-G, Feng Y-F, Xiang Y, et al. Retinal nerve fiber layer thickness changes in Parkinson disease: a meta-analysis. PLoS One. 2014;9(1):e85718.
   PubMed Web of Science ®Google Scholar
• Guo L, Duggan J, Cordeiro MF. Alzheimer’s disease and retinal neurodegeneration. Curr Alzheimer Res. 2010;7(1):3–14.
   PubMed Web of Science ®Google Scholar
• Krantic S, Torriglia A. Retina: source of the earliest biomarkers for Alzheimer’s disease? J Alzheimers Dis. 2014;40(2):237–243.
   PubMed Web of Science ®Google Scholar
• Nolan JM, Loskutova E, Howard AN, et al. Macular pigment, visual function, and macular disease among subjects with Alzheimer’s disease: an exploratory study. J Alzheimers Dis. 2014;42(4):1191–1202.
   PubMed Web of Science ®Google Scholar
• Siger M, Dziegielewski K, Jasek L, et al. Optical coherence tomography in multiple sclerosis: thickness of the retinal nerve fiber layer as a potential measure of axonal loss and brain atrophy. J Neurol. 2008 Oct;255(10):1555–1560.
   PubMed Web of Science ®Google Scholar
• Michalik A, Martin -J-J, Van Broeckhoven C. Spinocerebellar ataxia type 7 associated with pigmentary retinal dystrophy. Eur J Hum Genet. 2004 Jan;12(1):2–15.
   PubMed Web of Science ®Google Scholar
• Rub U, Brunt ER, Seidel K, et al. Spinocerebellar ataxia type 7 (SCA7): widespread brain damage in an adult-onset patient with progressive visual impairments in comparison with an adult-onset patient without visual impairments. Neuropathol Appl Neurobiol. 2008 Apr;34(2):155–168.
   PubMed Web of Science ®Google Scholar
• Miller RC, Tewari A, Miller JA, et al. Neuro-ophthalmologic features of spinocerebellar ataxia type 7. J Neuroophthalmol. 2009 Sep;29(3):180–186.
   PubMed Web of Science ®Google Scholar
• Han Y, Deng B, Liu M, et al. Clinical and genetic study of a Chinese family with spinocerebellar ataxia type 7. Neurol India. 2010 Jul–Aug;58(4):622–626.
   PubMed Web of Science ®Google Scholar
• Horton LC, Frosch MP, Vangel MG, et al. Spinocerebellar ataxia type 7: clinical course, phenotype-genotype correlations, and neuropathology. Cerebellum. 2013 Apr;12(2):176–193.
   PubMed Web of Science ®Google Scholar
• Andrade LC, Souza GS, Lacerda EM, et al. Influence of retinopathy on the achromatic and chromatic vision of patients with type 2 diabetes. BMC Ophthalmol. 2014;14:104.
   PubMed Web of Science ®Google Scholar
• Catala J, Munoz S. Proliferative diabetic retinopathy and hemovitreous: red flag for blindness. Sci World J. 2008;8:409–410.
   Web of Science ®Google Scholar
• Rodrigues EB, Müller Gonçalves Urias FMP, Badaró E, et al. Diabetes induces changes in neuroretina before retinal vessels: a spectral-domain optical coherence tomography study. Int J Retin Vitr. 2015;1(1):4.
   Google Scholar
• Yang Y, Mao D, Chen X, et al. Decrease in retinal neuronal cells in streptozotocin-induced diabetic mice. Mol Vis. 2012;18:1411–1420.
   PubMed Web of Science ®Google Scholar
• Chen X, Nie C, Gong Y, et al. Peripapillary retinal nerve fiber layer changes in preclinical diabetic retinopathy: a meta-analysis. Plos One. 2015;10(5):e0125919.
   PubMed Web of Science ®Google Scholar
• Glen FC, Crabb DP, Smith ND, et al. Do patients with glaucoma have difficulty recognizing faces? Invest Ophthalmol Vis Sci. 2012 Jun;53(7):3629–3637.
   PubMed Web of Science ®Google Scholar
• Tatham AJ, Weinreb RN, Zangwill LM, et al. Estimated retinal ganglion cell counts in glaucomatous eyes with localized retinal nerve fiber layer defects. Am J Ophthalmol. 2013 Sep;156(3):578–587.e1.
   PubMed Web of Science ®Google Scholar
• Chrysostomou V, Rezania F, Trounce IA, et al. Oxidative stress and mitochondrial dysfunction in glaucoma. Curr Opin Pharmacol. 2013;13(1):12–15.
   PubMed Web of Science ®Google Scholar
• Khandhadia S, Cherry J, Lotery AJ. Age-related macular degeneration. Adv Exp Med Biol. 2012;724:15–36.
   PubMed Web of Science ®Google Scholar
• Mao H, Seo SJ, Biswal MR, et al. Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration. Invest Ophthalmol Vis Sci. 2014 Jul;55(7):4613–4627.
   PubMed Web of Science ®Google Scholar
• Savastano MC, Minnella AM, Tamburrino A, et al. Differential vulnerability of retinal layers to early age-related macular degeneration: evidence by SD-OCT segmentation analysis. Invest Ophthalmol Vis Sci. 2014 Jan;55(1):560–566.
   PubMed Web of Science ®Google Scholar
• Smith RA, Hartley RC, Cocheme HM, et al. Mitochondrial pharmacology. Trends in Pharmacol Sci. 2012 Jun;33(6):341–352.
   PubMed Web of Science ®Google Scholar
• Gandhi S, Abramov AY. Mechanism of oxidative stress in neurodegeneration. Oxid Med Cell Longev. 2012;2012:428010.
   PubMed Web of Science ®Google Scholar
• Santos JM, Tewari S, Goldberg AF, et al. Mitochondrial biogenesis and the development of diabetic retinopathy. Free Radic Biol Med. 2011;51(10):1849–1860.
   PubMed Web of Science ®Google Scholar
• Farrar GJ, Chadderton N, Kenna PF, et al. Mitochondrial disorders: aetiologies, models systems, and candidate therapies. Trends Genet. 2013;29(8):488–497.
   PubMed Web of Science ®Google Scholar
• Jarrett SG, Lewin AS, Boulton ME. The importance of mitochondria in age-related and inherited eye disorders. Ophthalmic Res. 2010;44(3):179–190.
   PubMed Web of Science ®Google Scholar
• Carelli V, Ross-Cisneros FN, Sadun AA. Mitochondrial dysfunction as a cause of optic neuropathies. Prog Retin Eye Res. 2004;23(1):53–89.
   PubMed Web of Science ®Google Scholar
• Gueven N. Optic neurodegeneration: time to act. Biol Med. 2014;1(101):2.
   Google Scholar
• Wang L, Dong J, Cull G, et al. Varicosities of intraretinal ganglion cell axons in human and nonhuman primates. Invest Ophthalmol Vis Sci. 2003;44(1):2–9.
   PubMed Web of Science ®Google Scholar
• La Morgia C, Ross-Cisneros FN, Sadun AA, et al. Melanopsin retinal ganglion cells are resistant to neurodegeneration in mitochondrial optic neuropathies. Brain. 2010 Aug;133(Pt 8):2426–2438.
   PubMed Web of Science ®Google Scholar
• Rizzo G, Tozer KR, Tonon C, et al. Secondary post-geniculate involvement in Leber’s hereditary optic neuropathy. Plos One. 2012;7(11):e50230.
   Google Scholar
• Hudson G, Carelli V, Spruijt L, et al. Clinical expression of Leber hereditary optic neuropathy is affected by the mitochondrial DNA-haplogroup background. Am J Hum Genet. 2007 Aug;81(2):228–233.
   PubMed Web of Science ®Google Scholar
• Abu-Amero KK, Jaber M, Hellani A, et al. Genome-wide expression profile of LHON patients with the 11778 mutation. Br J Ophthalmol. 2010 Feb 1;94(2):256–259.
   PubMed Web of Science ®Google Scholar
• Patsi J, Maliniemi P, Pakanen S, et al. LHON/MELAS overlap mutation in ND1 subunit of mitochondrial complex I affects ubiquinone binding as revealed by modeling in Escherichia coli NDH-1. Biochim Biophys Acta. 2012 Feb;1817(2):312–318.
   PubMed Web of Science ®Google Scholar
• Chinnery PF, Hudson G. Mitochondrial genetics. Br Med Bull. 2013;106:135–159.
   PubMed Web of Science ®Google Scholar
• Nakamura M, Yabe I, Sudo A, et al. MERRF/MELAS overlap syndrome: a double pathogenic mutation in mitochondrial tRNA genes. J Med Genet. 2010;47(10):659–664.
   PubMed Web of Science ®Google Scholar
• Huang ML, Becker EM, Whitnall M, et al. Elucidation of the mechanism of mitochondrial iron loading in Friedreich’s ataxia by analysis of a mouse mutant. Proc Natl Acad Sci U S A. 2009;106(38):16381–16386.
   PubMed Web of Science ®Google Scholar
• Newman NJ. Hereditary optic neuropathies: from the mitochondria to the optic nerve. Am J Ophthalmol. 2005;140(3):517–523.
   PubMed Web of Science ®Google Scholar
• Mezghani N, Mnif M, Mkaouar-Rebai E, et al. The mitochondrial ND1 m.3337G>A mutation associated to multiple mitochondrial DNA deletions in a patient with Wolfram syndrome and cardiomyopathy. Biochem Biophys Res Commun. 2011 Jul 29;411(2):247–252.
   PubMed Web of Science ®Google Scholar
• Hilson JB, Merchant SN, Adams JC, et al. Wolfram syndrome: a clinicopathologic correlation. Acta Neuropathol. 2009;118(3):415–428.
   PubMed Web of Science ®Google Scholar
• Simsek E, Simsek T, Tekgul S, et al. Wolfram (DIDMOAD) syndrome: a multidisciplinary clinical study in nine Turkish patients and review of the literature. Acta Paediatr. 2003;92(1):55–61.
   PubMed Web of Science ®Google Scholar
• Bononi A, Missiroli S, Poletti F, et al. Mitochondria-associated membranes (MAMs) as hotspot Ca(2+) signaling units. Adv Exp Med Biol. 2012;740:411–437.
   PubMed Web of Science ®Google Scholar
• Heitz FD, Erb M, Anklin C, et al. Idebenone protects against retinal damage and loss of vision in a mouse model of Leber’s hereditary optic neuropathy. PLoS One. 2012;7(9):e45182.
   PubMed Web of Science ®Google Scholar
• Bababeygy SR, Wang MY, Khaderi KR, et al. Visual improvement with the use of idebenone in the treatment of Wolfram syndrome. J Neuroophthalmol. 2012;32(4):386–389.
   PubMed Web of Science ®Google Scholar
• Schapira AH, Cooper JM, Dexter D, et al. Mitochondrial complex I deficiency in Parkinson’s disease. Lancet. 1989;1(8649):1269.
   PubMed Web of Science ®Google Scholar
• Ferris CF, Marella M, Smerkers B, et al. A phenotypic model recapitulating the neuropathology of Parkinson’s disease. Brain Behav. 2013;3(4):351–366.
   PubMed Web of Science ®Google Scholar
• Reddy PH. Role of mitochondria in neurodegenerative diseases: mitochondria as a therapeutic target in Alzheimer’s disease. CNS Spectr. 2009;14(8 Suppl 7):8–13; discussion 16–8.
   PubMed Web of Science ®Google Scholar
• Koronyo-Hamaoui M, Koronyo Y, Ljubimov AV, et al. Identification of amyloid plaques in retinas from Alzheimer’s patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model. Neuroimage. 2011;54(Suppl 1):S204–S217.
   PubMed Web of Science ®Google Scholar
• Su K, Bourdette D, Forte M. Mitochondrial dysfunction and neurodegeneration in multiple sclerosis. Front Physiol. 2013;4:169.
   PubMed Web of Science ®Google Scholar
• Lassmann H, Van Horssen J, Mahad D. Progressive multiple sclerosis: pathology and pathogenesis. Nat Rev Neurol. 2012 Nov 5;8(11):647–656.
   Web of Science ®Google Scholar
• Palace J. Multiple sclerosis associated with Leber’s hereditary optic neuropathy. J Neurol Sci. 2009;286(1–2):24–27.
   PubMed Web of Science ®Google Scholar
• Pfeffer G, Burke A, Yu-Wai-Man P, et al. Clinical features of MS associated with Leber hereditary optic neuropathy mtDNA mutations. Neurology. 2013;81(24):2073–2081.
   PubMed Web of Science ®Google Scholar
• Su KG, Banker G, Bourdette D, et al. Axonal degeneration in multiple sclerosis: the mitochondrial hypothesis. Curr Neurol Neurosci Rep. 2009;9(5):411–417.
   PubMed Web of Science ®Google Scholar
• Santos JM, Mohammad G, Zhong Q, et al. Diabetic retinopathy, superoxide damage and antioxidants. Curr Pharm Biotechnol. 2011;12(3):352–361.
   PubMed Web of Science ®Google Scholar
• Takahashi H, Goto T, Shoji T, et al. Diabetes-associated retinal nerve fiber damage evaluated with scanning laser polarimetry. Am J Ophthalmol. 2006 Jul;142(1):88–94.
   PubMed Web of Science ®Google Scholar
• Oshitari T, Yamamoto S, Hata N, et al. Mitochondria- and caspase-dependent cell death pathway involved in neuronal degeneration in diabetic retinopathy. Br J Ophthalmol. 2008;92(4):552–556.
   PubMed Web of Science ®Google Scholar
• Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001 Dec 13;414(6865):813–820.
   PubMed Web of Science ®Google Scholar
• Du Y, Miller CM, Kern TS. Hyperglycemia increases mitochondrial superoxide in retina and retinal cells. Free Radic Biol Med. 2003;35(11):1491–1499.
   PubMed Web of Science ®Google Scholar
• Kowluru RA, Kanwar M, Kennedy A. Metabolic memory phenomenon and accumulation of peroxynitrite in retinal capillaries. Exp Diabetes Res. 2007;2007:21976.
   PubMedGoogle Scholar
• Kowluru RA, Mishra M. Oxidative stress, mitochondrial damage and diabetic retinopathy. Biochim Biophys Acta. 2015;1852 (11):2474–2483.
   PubMed Web of Science ®Google Scholar
• Nishikawa T, Edelstein D, Du XL, et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature. 2000;404(6779):787–790.
   PubMed Web of Science ®Google Scholar
• Cedrone C, Mancino R, Cerulli A, et al. Epidemiology of primary glaucoma: prevalence, incidence, and blinding effects. Prog Brain Res. 2008;173:3–14.
   PubMed Web of Science ®Google Scholar
• Guo Y, Chen X, Zhang H, et al. Association of OPA1 polymorphisms with NTG and HTG: a meta-analysis. Plos One. 2012;7(8):e42387.
   Google Scholar
• Osborne NN. Pathogenesis of ganglion “cell death” in glaucoma and neuroprotection: focus on ganglion cell axonal mitochondria. Prog Brain Res. 2008;173:339–352.
   PubMed Web of Science ®Google Scholar
• Zhang M, Maddala R, Rao PV. Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork. Am J Physiol Cell Physiol. 2008 Nov;295(5):C1057–C1070.
   PubMed Web of Science ®Google Scholar
• Buono LM, Foroozan R, Sergott RC, et al. Is normal tension glaucoma actually an unrecognized hereditary optic neuropathy? New evidence from genetic analysis. Curr Opin Ophthalmol. 2002;13(6):362–370.
   PubMedGoogle Scholar
• Bosley TM, Hellani A, Spaeth GL, et al. Down-regulation of OPA1 in patients with primary open angle glaucoma. Mol Vis. 2011;17:1074–1079.
   PubMed Web of Science ®Google Scholar
• He Y, Leung KW, Zhang Y-H, et al. Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants. Invest Ophthalmol Vis Sci. 2008;49(4):1447–1458.
   PubMed Web of Science ®Google Scholar
• Osborne NN. Mitochondria: their role in ganglion cell death and survival in primary open angle glaucoma. Exp Eye Res. 2010;90(6):750–757.
   PubMed Web of Science ®Google Scholar
• Osborne NN, Nunez-Alvarez C, Del Olmo-Aguado S. The effect of visual blue light on mitochondrial function associated with retinal ganglions cells. Exp Eye Res. 2014 Nov;128:8–14.
   PubMed Web of Science ®Google Scholar
• Osborne NN, Lascaratos G, Bron AJ, et al. A hypothesis to suggest that light is a risk factor in glaucoma and the mitochondrial optic neuropathies. Br J Ophthalmol. 2006 Feb;90(2):237–241.
   PubMed Web of Science ®Google Scholar
• Osborne NN, Li GY, Ji D, et al. Light affects mitochondria to cause apoptosis to cultured cells: possible relevance to ganglion cell death in certain optic neuropathies. J Neuro Chem. 2008 Jun;105(5):2013–2028.
   PubMed Web of Science ®Google Scholar
• Liu Q, Ju W-K, Crowston JG, et al. Oxidative stress is an early event in hydrostatic pressure induced retinal ganglion cell damage. Invest Ophthalmol Vis Sci. 2007;48(10):4580–4589.
   PubMed Web of Science ®Google Scholar
• Lee S, Sheck L, Crowston JG, et al. Impaired complex-I-linked respiration and ATP synthesis in primary open-angle glaucoma patient lymphoblasts. Invest Ophthalmol Vis Sci. 2012;53(4):2431–2437.
   PubMed Web of Science ®Google Scholar
• O’Neill EC, Danesh-Meyer HV, Kong GX, et al. Optic disc evaluation in optic neuropathies: the optic disc assessment project. Ophthalmology. 2011 May;118(5):964–970.
   PubMed Web of Science ®Google Scholar
• Feher J, Kovacs I, Artico M, et al. Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration. Neurobiol Aging. 2006;27(7):983–993.
   PubMed Web of Science ®Google Scholar
• Lin H, Xu H, Liang F-Q, et al. Mitochondrial DNA damage and repair in RPE associated with aging and age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011;52(6):3521–3529.
   PubMed Web of Science ®Google Scholar
• Terluk MR, Kapphahn RJ, Soukup LM, et al. Investigating mitochondria as a target for treating age-related macular degeneration. J Neurosci. 2015;35(18):7304–7311.
   PubMed Web of Science ®Google Scholar
• Dykens JA, Will Y. The significance of mitochondrial toxicity testing in drug development. Drug Discov Today. 2007;12(17–18):777–785.
   PubMed Web of Science ®Google Scholar
• Neustadt J, Pieczenik SR. Medication-induced mitochondrial damage and disease. Mol Nutr Food Res. 2008 Jul;52(7):780–788.
   PubMed Web of Science ®Google Scholar
• Kerrison JB. Optic neuropathies caused by toxins and adverse drug reactions. Ophthalmol Clin North Am. 2004;17(3):481–488; viii.
   PubMedGoogle Scholar
• Zoumalan CI, Agarwal M, Sadun AA. Optical coherence tomography can measure axonal loss in patients with ethambutol-induced optic neuropathy. Graefes Arch Clin Exp Ophthalmol. 2005;243(5):410–416.
   PubMed Web of Science ®Google Scholar
• Nadanaciva S, Bernal A, Aggeler R, et al. Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays. Toxicol In Vitro. 2007;21(5):902–911.
   PubMed Web of Science ®Google Scholar
• Pula JH, Kao AM, Kattah JC. Neuro-ophthalmologic side-effects of systemic medications. Curr Opin Ophthalmol. 2013;24(6):540–549.
   PubMed Web of Science ®Google Scholar
• Kervinen M, Falck A, Hurskainen M, et al. Bilateral optic neuropathy and permanent loss of vision after treatment with amiodarone. J Cardiovasc Pharmacol. 2013;62(4):394–396.
   PubMed Web of Science ®Google Scholar
• Hroudova J, Fisar Z. Activities of respiratory chain complexes and citrate synthase influenced by pharmacologically different antidepressants and mood stabilizers. Neuro Endocrinol Lett. 2010;31(3):336–342.
   PubMed Web of Science ®Google Scholar
• Lloyd MJ, Fraunfelder FW. Drug-induced optic neuropathies. Drugs Today (Barc). 2007;43(11):827–836.
   PubMed Web of Science ®Google Scholar
• Sandoval-Acuna C, Lopez-Alarcon C, Aliaga ME, et al. Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action. Chem Biol Interact. 2012;199(1):18–28.
   PubMed Web of Science ®Google Scholar
• Wang MY, Sadun AA. Drug-related mitochondrial optic neuropathies. J Neuroophthalmol. 2013;33(2):172–178.
   PubMed Web of Science ®Google Scholar
• Balijepalli S, Boyd MR, Ravindranath V. Inhibition of mitochondrial complex I by haloperidol: the role of thiol oxidation. Neuropharmacology. 1999 Apr;38(4):567–577.
   PubMed Web of Science ®Google Scholar
• Fosslien E. Mitochondrial medicine–molecular pathology of defective oxidative phosphorylation. Ann Clin Lab Sci. 2001;31(1):25–67.
   PubMed Web of Science ®Google Scholar
• Simon N, Jolliet P, Morin C, et al. Glucocorticoids decrease cytochrome c oxidase activity of isolated rat kidney mitochondria. FEBS Lett. 1998;435(1):25–28.
   PubMed Web of Science ®Google Scholar
• Moreno-Sanchez R, Bravo C, Vasquez C, et al. Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal anti-inflammatory drugs: study in mitochondria, submitochondrial particles, cells, and whole heart. Biochem Pharmacol. 1999;57(7):743–752.
   PubMed Web of Science ®Google Scholar
• Shulman E, Belakhov V, Wei G, et al. Designer aminoglycosides that selectively inhibit cytoplasmic rather than mitochondrial ribosomes show decreased ototoxicity: a strategy for the treatment of genetic diseases. J Biol Chem. 2014;289(4):2318–2330.
   PubMed Web of Science ®Google Scholar
• Hynes J, Nadanaciva S, Swiss R, et al. A high-throughput dual parameter assay for assessing drug-induced mitochondrial dysfunction provides additional predictivity over two established mitochondrial toxicity assays. Toxicol In Vitro. 2013;27(2):560–569.
   PubMed Web of Science ®Google Scholar
• Lee KK, Fujimoto K, Zhang C, et al. Isoniazid-induced cell death is precipitated by underlying mitochondrial complex I dysfunction in mouse hepatocytes. Free Radic Biol Med. 2013;65:584–594.
   PubMed Web of Science ®Google Scholar
• Javaheri M, Khurana RN, O’Hearn TM, et al. Linezolid-induced optic neuropathy: a mitochondrial disorder? Br J Ophthalmol. 2007;91(1):111–115.
   PubMed Web of Science ®Google Scholar
• Theodossiou TA, Yannakopoulou K, Aggelidou C, et al. Tamoxifen subcellular localization; observation of cell-specific cytotoxicity enhancement by inhibition of mitochondrial ETC complexes I and III. Photochem Photobiol. 2012;88(4):1016–1022.
   PubMed Web of Science ®Google Scholar
• Rana P, Nadanaciva S, Will Y. Mitochondrial membrane potential measurement of H9c2 cells grown in high-glucose and galactose-containing media does not provide additional predictivity towards mitochondrial assessment. Toxicol In Vitro. 2011;25(2):580–587.
   PubMed Web of Science ®Google Scholar
• Casson RJ, Han G, Ebneter A, et al. Glucose-induced temporary visual recovery in primary open-angle glaucoma: a double-blind, randomized study. Ophthalmology. 2014;121(6):1203–1211.
   PubMed Web of Science ®Google Scholar
• Klopstock T, Yu-Wai-Man P, Dimitriadis K, et al. A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy. Brain. 2011 Sep;134(Pt 9):2677–2686.
   PubMed Web of Science ®Google Scholar
• Barboni P, Valentino ML, La Morgia C, et al. Idebenone treatment in patients with OPA1-mutant dominant optic atrophy. Brain. 2013 Feb;136(2):e231.
   Google Scholar
• Kernt M, Arend N, Buerger A, et al. Idebenone prevents human optic nerve head astrocytes from oxidative stress, apoptosis, and senescence by stabilizing BAX/Bcl-2 ratio. J Glaucoma. 2013 Jun–Jul;22(5):404–412.
   PubMed Web of Science ®Google Scholar
• Alam NM, Mills WC, Wong AA, et al. A mitochondrial therapeutic reverses diabetic visual decline. Dis Model Mech. 2015;23:020248.
   Google Scholar
• Gueven N, Faldu D. Therapeutic strategies for Leber’s hereditary optic neuropathy: a current update. Intractable Rare Dis Res. 2013;2(4):130.
   PubMedGoogle Scholar