Emerging therapeutic targets in obesity: new approaches to controlling body weight

Bibliography

• WORLD HEALTH ORGANISATION: Obesity: Preventing and managing the global epidemic. World Health Or-ganisation. Geneva, Switzerland (1998).
   Google Scholar
• •Detailed definition of obesity.
   Google Scholar
• WICKELGREN I: Obesity: How Big a Problem? Science (1998) 280:1364–1367.
   PubMed Web of Science ®Google Scholar
• •Thorough review of obesity: a big problem in US.
   Google Scholar
• TAUBES G: As obesity rates rise, experts struggle to ex-plain why. Science (1998) 280:1367–1368.
   PubMed Web of Science ®Google Scholar
• •Thorough review of why obesity rates rise.
   Google Scholar
• HILL JO, PETERS JC: Environmental Contributions to the Obesity Epidemic. Science (1998) 280:1371–1374.
   PubMed Web of Science ®Google Scholar
• •Thorough review of the involvement of environmental fac-tors in the obesity epidemic.
   Google Scholar
• TROIANO RP, FLEGAL KM: Overweight children andadolescents: description, epidemiology, and demo-graphics [the causes and health consequences of obe-sity in children and adolescents]. Pediatrics (1998) 101 (3S):497–504.
   PubMedGoogle Scholar
• KUCZMARSKI RJ, JONSON CL, FLEGAL KM, CAMPBELL SM:The prevalence of overweight among U.S adults. J. Am. Ass. (1994) 205:205–211.
   Google Scholar
• ROSENBAUM M, LEIBEL RL: The physiology of bodyweight regulation: relevance to the etiology of obesity in children. Pediatrics. (1998) 101(3S):525–539.
   PubMedGoogle Scholar
• WILDING J: Science, medicine, and the future: obesitytreatment. Br. Med. J. (1997) 315:997–1000.
   PubMed Web of Science ®Google Scholar
• POPKIN BM, DOAK CM: The obesity epidemic is aworldwide phenomenon. Nutr. Rev. (1998) 56:106–114.
   PubMed Web of Science ®Google Scholar
• •A special article in which several nationally representative and nationwide surveys are discussed.
   Google Scholar
• PI-SUNYER FX: Medical hazards of obesity. Ann. Intern. Med. (1993) 110:655–660.
   Google Scholar
• JUNG RT: Obesity as a disease. Br. Med. Bull. (1997) 53:307–321.
   PubMed Web of Science ®Google Scholar
• FOOD AND NUTRITION BOARD, INSTITUTE OF MEDI-CINE: Weighing the options: criteria for evaluating weight-management programs. PR Thomas (Ed.), Na-tional Academy Press, Washington, DC, USA (1995).
   Google Scholar
• •The consequence of obesity.
   Google Scholar
• COMUZZIE AG, ALLISON DB: The search for human obesity genes. Science (1998) 280:1374–1377.
   PubMed Web of Science ®Google Scholar
• •Thorough review of the obesity gene.
   Google Scholar
• BJORNTOP P: Disturbances in the regulation of food in-take. Obesity: Anatomic and physiologic-biochemical observations. Adv. Psychosomatic Med. (1972) 7:116–147.
   Google Scholar
• BRAY GA: Endocrine factors in the control of food in-take. Federation Proceedings (1974) 33:1140–1145.
   Google Scholar
• BELFIORE F: Defects in enzyme regulation versus de-fects in enzyme synthesis as a cause of metabolic disor-ders. Enzyme (1980) 25:132–137.
   PubMedGoogle Scholar
• BEREGI LG, HUGON P: The evolution of phenylethyl-amine anorectics. biochemical pharmacology of obe-sity. Curtis-Prior PB (Ed.), Elsevier Science Publishing Company, London (1983):203–242.
   Google Scholar
• DE PEDRO N, PINILLOS ML, VALENCIANO Al, ALONSO-BEDATE M, DELGADO MJ: Inhibitory effect of serotonin on feeding behavior in goldfish: involvement of CRF. Peptides (1998) 19(3):505–511.
   PubMed Web of Science ®Google Scholar
• SIMANSKY KL: Serotonergic control of the organization of feeding and satiety. Behav. Brain Res. (1996) 73 (1-2):37–42.
   PubMed Web of Science ®Google Scholar
• NISHIMURA F, NISHIHARA M, TORII K, TAKAHASHI M: Changes in responsiveness to serotonin on rat ven-tromedial hypothalamic neurons after food depriva-tion. Physiol. & Behav. (1996) 60(1):7–12.
   PubMedGoogle Scholar
• •This paper highlights that the hypothalamus is an important region for serotonin action.
   Google Scholar
• ABENHAIM L, MORIDE Y, BRENOT F et al.: Appetite-suppressant drugs and risk of primary pulmonary hy-pertension. New Engl. J. Med. (1996) 335:609–616.
   PubMed Web of Science ®Google Scholar
• BOVETTO S, ROUILLARD C, RICHARD D: Role of CRH inthe effects of 5-HT-receptor agonists on food intake and metabolic rate. Am. J. Physiol. (1996) 271(5):R1231–1238.
   Google Scholar
• DRYDEN S, FRANKISH HM, WANG Q, PICKAVANCE L, WILLIAMS G: The serotonergic agent fluoxetine re-duces neuropeptide Y levels and neuropeptide Y se-cretion in the hypothalamus of lean and obese rats. Neuroscience (1996) 72(2)557–566.
   PubMedGoogle Scholar
• LEIBOWITZ SF: Paraventricular nucleus: a primary site mediating adrenergic stimulation of feeding and drinking. Pharmacol., Biochem. Behav. (1978) 8:163–75.
   PubMed Web of Science ®Google Scholar
• LEIBOWITZ SF, BROWN LL: Histochemical and pharma-cological analysis of catecholaminergic projections to the perifornical hypothalamus in relation feeding in-hibition. Brain Res. (1980) 201:315–345.
   PubMed Web of Science ®Google Scholar
• ANGEL I: Central receptors and recognition sites medi-ating the effects of monoamines and anorectic drugs on feeding behavior. Olin. Neuropharmacol (1990) 13:361–391.
   PubMedGoogle Scholar
• WELLMAN PJ, DAVIES BT: Reversal of cirazoline-induced and phenylpropanolamine-induced anorexia by the alpha-l-receptor antagonist prazosin. Pharma-col., Biochem. Behav. (1992) 42(0:97–100.
   PubMedGoogle Scholar
• LEIBOWITZ SF: Reciprocal hunger-regulating circuits involving alpha-and beta-adrenergic receptors lo-cated, respectively, in the ventromedial and lateral hy-pothalamus. Proc. Natl. Acad. Sci. USA (1970) 67 (2) :1063–1070.
   PubMedGoogle Scholar
• VREE TB, MUSKENS A, TH JM, VAN ROSSUM JM: Somephysico-chemical properties of amphetamine and re-lated drugs. J. Pharm. Pharmacol (1969) 21:774–775.
   PubMed Web of Science ®Google Scholar
• •Detailed description of amphetamine and related drugs.
   Google Scholar
• BRAY G: Pharmacological treatment of obesity. In:Handbook of obesity. Bray GA, Bouchard C, James WPT (Eds.), Marcekl Dekker, New York, USA (1997):953–975.
   Google Scholar
• JACKSON HC, NEEDHAM AM, HUTCHINS LJ, MAZURK-IEWICZ SE, HEAL DJ: Comparison of the effects of sibu-tramine and other monoamine re-uptake inhibitors on food intake in the rats. Br. J. Pharmacol (1997) 121(8)1758–1762.
   PubMedGoogle Scholar
• FURUSE M, MABAYO RT, OKUMURA J: Effects of dietarycholestyramine on the utilization of diets containing medium or long chain triacylglycerols by chicks. Br. Poultry Sci. (1997) 38 (4) :436–438.
   PubMed Web of Science ®Google Scholar
• TATEMOTO K, MUTT V: Isolation of two novel candi-date hormones using a chemical method for finding naturally occurring polypeptides. Nature (1980) 285:417–418.
   PubMed Web of Science ®Google Scholar
• TATEMOTO K, CARLQUIST M, MUTT V: Neuropeptide Y-a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature (1982) 296:659–660.
   PubMed Web of Science ®Google Scholar
• •This paper discusses the role of NPY (A novel brain peptide) in feeding behaviour.
   Google Scholar
• HU Y, BLOOMQUIST BT, CORNFIELD LJ et al: Identifica-tion of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. J. Biol. Chem. (1996) 271:26315–26319.
   PubMed Web of Science ®Google Scholar
• •Report of a novel hypothalamic neuropeptide Y receptor.
   Google Scholar
• SMITH FJ, CAMPFIELD LA, MOSCHERA JA, BAILON PS, BURN P: Feeding inhibition by neuropeptide Y. Nature (1996) 382:307.
   PubMedGoogle Scholar
• •This paper discusses the role of NPY in feeding behaviour.
   Google Scholar
• GERALD C, WALKER MW, CRISCIONE L et al.: A receptor subtype involved in neuropeptide-Y-induced food in-take. Nature (1996) 382:168–173.
   PubMed Web of Science ®Google Scholar
• •This article covers the discovery of a new NPY receptor subtype.
   Google Scholar
• DANIELS AJ, MATTHEWS JE, SLEPETIS R et al.: High-affinity neuropeptide Y receptor antagonists. Proc. Natl. Acad. Sci. USA (1995) 92:9067–9071.
   PubMed Web of Science ®Google Scholar
• •An article on novel antagonists of NPY.
   Google Scholar
• RUDOLF K, EBERLEIN W, ENGEL W et al.: The first highlypotent and selective non-peptide neuropeptide Y Y1 receptor antagonist: BIBP3226. Eur.J. Pharmacol (1995) 271 :R11–R13.
   Google Scholar
• GAL SLC, VALETTE G, ROUBY PE et al.: SR120819A, anorally-active and selective neuropeptide Y Y1 receptor antagonist. FEBS Lett. (1995) 362:192–196.
   PubMedGoogle Scholar
• ZHANG Y, PROENCA R, MAFFEI M, BARONE L, LEOPOLDL, FRIEDMAN JM: Positional cloning of the mouse obese gene and its human homologue. Nature (1994) 372:425–432.
   PubMed Web of Science ®Google Scholar
• •This paper highlights the first cloning of mouse obese gene.
   Google Scholar
• HALAAS JL, GAJIWALA KS, MAFFEI M et al.: Weight reduc-ing effects of the plasma protein encoded by the obese gene. Science (1995) 269:543–546.
   PubMed Web of Science ®Google Scholar
• •An article covering the importance of leptin in reducing food intake.
   Google Scholar
• PELLEYMOUNTER MA, CULLEN MJ, BAKER MB et al.: Ef-fects of the obese gene product on body weight regula-tion in ob/ob mice. Science (1995) 269:540–543.
   PubMed Web of Science ®Google Scholar
• CAMPFIELD LA, SMITH FJ, GUISEZ Y, DEVOS R, BURN P:Recombinant mouse OB protein: evidence for a pe-ripheral signal linking adiposity and central neural networks. Science (1995) 269:546–549.
   PubMed Web of Science ®Google Scholar
• ECKEL LA, LANGHANS W, KAHLER A, CAMPFIELD LA, SMITH FJ, GEARY N: Chronic administration of OB pro-tein decreases food intake by selectively reducing meal size in female rats. Am. J. Physiol. (1998) 275(1):R186–193.
   Google Scholar
• TARTAGLIA LA, DEMBSKI M, WENG X et al.: Identifica-tion and expression cloning of a leptin receptor, OB-R. Cell (1995) 83:1263–1271.
   PubMed Web of Science ®Google Scholar
• •This is the first report which identified the leptin receptor.
   Google Scholar
• MERCER JG, HOGARD N, WILLIAMS LM: Localization ofleptin receptor mRNA and the long form splice variant (0b-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett. (1996) 387:113–116.
   PubMed Web of Science ®Google Scholar
• SCHWARTZ MW, SEELEY RJ, CAMPFIELD LA, BURN P, BASKIN DG: Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest. (1996) 98 (5) :1101–1106.
   PubMed Web of Science ®Google Scholar
• STREAMSON CC, CHUNG WK, WU-PENG S et al.: Pheno-types of mouse diabetes and rat fat due to mutations in the OB (leptin) receptor. Science (1996) 271:994–996.
   PubMedGoogle Scholar
• •This paper discusses the defect of the leptin receptor in mouse diabetes.
   Google Scholar
• SCHAUER E, TRAUTINGER F, KOCK A et al.:Proopiomelanocortin-derived peptides are synthe-sized and released by human keratinocytes. J. Clin. In-vest. (1994) 93(5):2258–2262.
   PubMedGoogle Scholar
• HUANG QH, ENTWISTLE ML, ALVARO JD, DUMAN RS, HRUBY VJ, TATRO JB: Antipyretic role of endogenous melanocortins mediated by central melanocortin re-ceptors during endotoxin-induced fever. J. Neurosci. (1997) 17 (9) :3343–3351.
   PubMedGoogle Scholar
• MOUNTJOY KG, ROBBINS LS, MORTRUD MT, CONE RD:The cloning of a family of genes that encode the mela-nocortin receptors. Science (1992) 257:1248–1251.
   PubMed Web of Science ®Google Scholar
• •The first report to detail the discovery of MC1R and MC2R.
   Google Scholar
• GANTZ I, MIWA H, KONDA Y et al.: Molecular cloning, expression, and gene localization of a fourth melano-cortin receptor. J. Biol. Chem. (1993) 268:15174–15179.
   PubMed Web of Science ®Google Scholar
• •The first paper to outline the cloning of MC4R.
   Google Scholar
• MOUNTJOY KG, MORTRUD MT, LOW MJ, SIMERLY RB, CONE RD: Localization of the melanocortin-4 receptor (MC4R) in neuroendocrine and autonomic control cir-cuits in the brain. Mol. Endocrinol (1994) 8:1298–1308.
   PubMed Web of Science ®Google Scholar
• SEELEY RJ, YAGALOFF KA, FISHER SL et al.: Melanocortinreceptors in leptin effects. Nature (1997) 390:349.
   PubMed Web of Science ®Google Scholar
• •This article explains how MC4R is involved in the action of leptin.
   Google Scholar
• HUSZAR D, LYNCH CA, FAIRCHILD-HUNTRESS V et al: Targeted disruption of the melanocortin-4 receptor re-sults in obesity in mice. Cell (1997) 88:131–141.
   PubMed Web of Science ®Google Scholar
• •First paper to describe MC4R involved in feeding behaviour by using MC4R knock-out mice.
   Google Scholar
• FAN W, BOSTON BA, KESTERSON RA, HRUBY VJ, CONE RD: Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature (1997) 385:165–168.
   PubMed Web of Science ®Google Scholar
• •First report of melanocortin being involved in feeding behaviour.
   Google Scholar
• LU D, WILLARD D, PATEL IR et al.: Agouti protein is an antagonist of the melanocyte-stimulating hormone re-ceptor. Nature (1994) 371:799–802.
   PubMed Web of Science ®Google Scholar
• OLLMANN MM, WILSON BD, YANG Y-K et al.: Agouti-related protein is an endogenous antagonist of the melanocortin-4 receptor in vitro and in vivo. Science (1997) 278:135–138.
   Google Scholar
• •First report that AGRP is an endogenous antagonist of the melanocortin-4 receptor by using transgenic mice.
   Google Scholar
• BULTMAN SJ, MICHAUD EJ, WOYCHIK RP: Molecular characterization of the mouse agouti locus. Cell (1992) 71:1195–1204.
   PubMed Web of Science ®Google Scholar
• •This paper details the first molecular characterisation of the mouse agouti locus.
   Google Scholar
• YANG Y-K, OLLMANN MM, WILSON BD et al: Effects of recombinant agouti-signaling protein on melano-cortin action. Mol Endocrinol. (1997) 11:274–280.
   PubMedGoogle Scholar
• •First description of the human agouti-signalling protein on melanocortin receptors.
   Google Scholar
• SHUTTER JR, GRAHAM M, KINSEY AC, SCULLY S, LeTHY R, STARK KL: Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated on obese and diabetic mutant mice. Gene Dev. (1997) 11:593–602.
   PubMed Web of Science ®Google Scholar
• •This article covers the discovery of AGRP.
   Google Scholar
• MORGAN DGA, ROSSI M, KIM MS et al.: A C-terminal frag-ment of AGRP increases feeding and antagonizes the effects of a-MSH. Endocrinology (1998) 139:4428–4431.
   PubMedGoogle Scholar
• YANG Y-K, DARREN AT, CHRIS JD et al.: Characterization of agouti-related protein binding to melanocortin re-ceptors. Mol. Endocrinol (1999) 13:148–155.
   PubMedGoogle Scholar
• PRESSE F, SOROKOVSKY I, MAX JP, NICOLAIDIS S, NA-HON JL: Melanin-concentrating hormone is potent an-orectic peptide regulated by food-deprivation and glucopenia in the rat. Neuroscience (1996) 71 (3) 735–745.
   PubMed Web of Science ®Google Scholar
• ROSSI M, CHOI SJ, O'SHEA D, MIYOSHI T, GHATEI MA, BLOOM SR: Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology (1997) 138: 351–355.
   Google Scholar
• QU DQ, LUDWIG, DAVID S et al.: A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature (1996) 380(6570243–247.
   Google Scholar
• SHIMADA M, TRITOS NA, LOWELL BB, FLIER JS, MARATOS-FLIER E: Mice lacking melanin concentrating hormone are hypophagic and lean. Nature (1998) 396:670–673.
   PubMed Web of Science ®Google Scholar
• SMAGIN GN, HOWELL LA, RYAN DH, DE SOUZA EB, HAR-RIS RB: The role of CRF2 receptors in corticotropin-releasing factor-and urocortin-induced anorexia. Neuroreport (1998) 9(7) :1601–1606.
   PubMedGoogle Scholar
• UEHARA Y, SHIMIZU H, OHTANI K, SATO K, MORI M: Hy-pothalamic corticotropin-releasing hormone is a me-diator of the anorexigenic effect of leptin. Diabetes (1998) 47 (6) 890–893.
   PubMed Web of Science ®Google Scholar
• HEINRICHS SC, LAPSANSKY J, BEHAN DP et al.:Corticotropin-releasing factor-binding protein ligand inhibitor blunts excessive weight gain in genetically obese Zucker rats and rats during nicotine with-drawal. Proc. Natl. Acad. Sci. USA (1996) 93(26):15475–15480.
   PubMedGoogle Scholar
• HEINRICHS SC, MENZAGHI F, PICH EM, HAUGER RL, KOOB GF: Corticotropin-releasing factor in the para-ventricular nucleus modulates feeding induced by neuropeptide Y. Brain Res. (1993) 611:18–24.
   PubMed Web of Science ®Google Scholar
• SPINA M, MERLO-PICH E, CHAN RKW et al.: Appetite-suppressing effects of urocortin, a CRF-related neuro-peptide. Science (1996) 273(5280:1561–1564.
   PubMedGoogle Scholar
• •This paper highlights the inhibition of feeding by a new pep-tide, urocortin.
   Google Scholar
• DE PEDRO N, DELGADO MJ, PINILLOS ML, ALONSO-BEDATE M: Alpha-adrenergic and dopaminergic recep-tors are involved in the anorectic effect of corticotropin-releasing factor in goldfish. Life Sciences (1998) 62(19):1801–1808.
   PubMedGoogle Scholar
• GRIGNASCHI G, SIRONI F, SAMANIN R: Stimulation of5-HT2A receptors in the paraventricular hypothala-mus attenuates neuropeptide Y-induced hyperphagia through activation of corticotropin releasing factor. Brain Res. (1996) 708(1-2):173–176.
   PubMedGoogle Scholar
• PRICE ML, CURTIS AL, KIRBY LG, VALENTINO RJ, LUCKI I:Effects of corticotropin-releasing factor on brain sero-tonergic activity. Neuropsychopharmacology (1998) 18(6) 492–502.
   PubMedGoogle Scholar
• HORVATH TL, DIANO S, VAN DEN POL AN: Hypocretin(orexin)-containing neurons make synaptic contact with arcuate nucleus NPY-and POMC-producing cells that express leptin receptors in rat and primate; novel hypothalamic circuit involved in energy homeostasis. Soc. Neurosci. (1998) 24:12.
   Google Scholar
• WOLF G: Orexins: a newly discovered family of hypo-thalamic regulators of food intake. Nutr. Rev. (1998) 56(0:172–3.
   PubMedGoogle Scholar
• SAKURAI T, AMEMIYA A, ISHII M et al.: Orexins andorexin receptor: a family of hypothalamic neuropep-tides and G-protein-coupled receptors that regulate feeding behavior. Cell (1998) 92 (5) :573–585.
   PubMedGoogle Scholar
• •This paper is about the discovery that orexins and the orexin receptor are involved in feeding behaviour.
   Google Scholar
• THIM L, NIELSEN PF, JUDGE ME et al.: Purification and characterization of a new hypothalamic satiety pep-tide, cocaine and amphetamine regulated transcript (CART), produced in yeast. FEBS Lett. (1998) 428 (3) 263–268.
   PubMedGoogle Scholar
• •This paper discusses CART, a new peptide involved in feeding.
   Google Scholar
• KRISTENSEN P, JUDGE ME, THIM L et al: Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature (1998) 393:72–76.
   PubMed Web of Science ®Google Scholar
• WOODS SC, CHAVEZ M, PARK CR et al: The evaluation of insulin as a metabolic signal influencing behavior via the brain. Neurosci. Biobehav. Rev. (1996) 20:139–144.
   PubMed Web of Science ®Google Scholar
• FIGLEWICZ DP, SCHWARTZ MW, SEELEY RJ et al: Endo-crine regulation of food intake and body weight.J. Lab. Clin. Med. (1996) 127:328–332.
   PubMed Web of Science ®Google Scholar
• •This is a thorough review about the endocrine regulation of food intake.
   Google Scholar
• SMIT AB, VAN KESTEREN RE, LI KW et al.: Towards un-derstanding the role of insulin in the brain: lessons from insulin-related signaling systems in the inverte-brate brain. Progress Neurobiol (1998) 54(1)35–54.
   PubMedGoogle Scholar
• RODRIGUEZ SA, FERNANDEZ E, MANTECA X, FERNAN-DEZ AG, GONALONS E: CCK is involved in both periph-eral and central mechanisms controlling food intake in chickens. Am. J. Physiol (1997) 272:R334–340.
   Google Scholar
• TRIGAZIS L, ORTTMANN A, ANDERSON GH: Effect of a cholecystokinin-A receptor blocker on protein-induced food intake suppression in rats. Am. J. Physiol. (1997) 272:R1826–1833.
   Google Scholar
• WANK SA: Cholecystokinin receptors. Am. J. Physiol. (1995) 269:G628–646.
   PubMed Web of Science ®Google Scholar
• LIEVERSE RJ, JANSEN JBMJ, MASCLEE AAM, LAMERS CBHW: Satiety effects of a physiological dose of chole-cystokinin in humans. Gut (1995) 36(2):176–179.
   PubMedGoogle Scholar
• BARRACHINA MD, MARTINEZ V, WANG L, WEI JY, TACHE Y: Synergistic interaction between leptin and chole-cystokinin to reduce short-term food intake in lean mice. Proc. Natl. Acad. ScL USA (1997) 94:10455–10460.
   PubMed Web of Science ®Google Scholar
• MORAN TH, KATZ LF, PLATA-SALAMAN CR, SCHWARTZ GJ: Disordered food intake and obesity in rats lacking cholecystokinin A receptor. Am. J. Physiol. (1998) 274:R618–625.
   PubMed Web of Science ®Google Scholar
• TURTON MD, O'SHEA D, GUNN I et al.: A role for glucagon-like peptide-1 in the central regulation of feeding. Nature (1996) 379:69–72.
   PubMed Web of Science ®Google Scholar
• •This paper describes the novel discovery of GLPUs partici-pation in feeding behaviour.
   Google Scholar
• TANG-CHRISTENSEN M, LARSEN P, GOKE R et al.: Central administration of GLP-1(7-36)amide inhibits food and water intake in rats. Am. J. Physiol. (1996) 271:848–856.
   PubMed Web of Science ®Google Scholar
• GOKE R, LARSEN P, MIKKELSEN J, SHEIKH S: Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites. Eur. Neurosci. (1995) 7:2294–2300.
   PubMed Web of Science ®Google Scholar
• WAREMBOURG M, JOLI VET A: Immunocytochemical lo-calization of progesterone receptors in galanin neu-rons in the guinea pig hypothalamus. J. Neuroendocrinol (1993) 5:487–491.
   PubMedGoogle Scholar
• OKADA K, ISHI S, MINAMI S, SUGIHARA H, SHIBASAKI T, WAKABAYASHI I: Intracerebroventricular administra-tion of the growth hormone releasing peptide KP-102 increases food intake in free-feeding rats. Endocrinol-ogy (1996) 137:5155.
   PubMed Web of Science ®Google Scholar
• HAMILTON ME, BOZARTH MA: Feeding elicited by dynorphin(1-13) microinjections into the ventral seg-mental area in rats. Life Sciences (1988) 43(11):941–946.
   PubMedGoogle Scholar
• SALAMONE JD, MAHAN K, ROGERS S: Ventrolateral stri-atal dopamine depletions impair feeding and food handling in rats. Pharmacol. Biochem. Behav. (1993) 44 (3):605–610.
   PubMedGoogle Scholar
• LIN L, YORK DA: Chronic ingestion of dietary fat is aprerequisite for inhibition of feeding by enterostatin. Am. J. Physiol (1998) 275(2 Pt. 2):R619–623.
   Google Scholar
• LIVERSE RJ, JANSEN JBMJ, VAN DE ZWAN A et al.: Bombe-sin reduces food intake in lean man by a cholecystokinin-independent mechanism. J. Clin. En-docrinol Metab. (1993) 76:1459–1498.
   Google Scholar
• BECK B, NICOLAS JP, BURLET C: Neurotensin decreases with fasting in the ventromedian nucleus of obese Zucker rats. Metab. Clin. Exp. (1995) 44 (8):972–975.
   PubMedGoogle Scholar
• LUTZ TA, ROSSI R, ALTHAUS J, DEL PRETE E, SCHARRER E: Evidence for a physiological role of central calcitonin gene-related peptide(CGRI) receptors in the control of food intake in rats. Neurosci. Lett. (1997) 230(3):159–162.
   PubMedGoogle Scholar
• YEN TT: Beta-agonists as anti-obesity, antidiabetic and nutrient partitioning agents. Obes. Res. (1995) 3 (suppl.):531S–536S.
   Google Scholar
• WIDEN E, LEHTO M, KANNINEN T, WALSTON J, SHULDINER AR, GROOP LC: Association of a polymor-phism in the 63-adrenergic-receptor gene with fea-tures of the insulin resistance syndrome in Finns. New Engl. J. Med. (1995) 51:333–348.
   Google Scholar
• CLEMENT K, VAISSE C, MANNING ST et al.: Genetic varia-tion in the 03-adrenergic receptor and an increased ca-pacity to gain weight in patients with morbid obesity. New Engl. J. Med. (1995) 4:333–352.
   Google Scholar
• CONNACHER AA, BENNET WM, JUNG RT: Clinical stud-ies with the 0-adrenoceptor agonist BRL.26830A. Am. J. Nutr. (1992) 55:2585–2615.
   Google Scholar
• CONNACHER AA, MITCHELL PEG, JUNG RT: Weight loss in obese subjects on a restricted diet given BRL 26830A. A new atypical 6-adrenoceptor agonist. Br. Med. J. (1988) 26:1217–1220.
   Google Scholar
• LOOKENE A, SKOTTOVA N, OLIVECRONA G: Interac-tions of lipoprotein lipase with the active-site inhibi-tor tetrahydrolipstatin (Orlistat). Eur.j Biochem. (1994) 222(2)395–403.
   PubMedGoogle Scholar
• GURA T: Uncoupling Proteins Provide New Clue to Obesity's Causes. Science (1998) 280:1369–1370.
   PubMedGoogle Scholar
• •This is a thorough review of uncoupling proteins.
   Google Scholar
• FLEURY CJ, NEVEROVA M, COLLINS S et al.: Uncoupling protein-2: a novel gene linked to obesity and hyperin-sulinemia. Nature Genet. (1997) 15:269–272.
   PubMed Web of Science ®Google Scholar
• BOSS O, BOBBIONI-HARSCH E, ASSIMACOPOULOS-JEANNET F et al. Uncoupling protein-3 expression in skelet al muscle and free fatty acids in obesity. Lancet (1998) 351 (9120) 1933
   PubMedGoogle Scholar
• GUERRA C, KOZA RA, YAMASHITA H, WALSH K, KOZAK LP: Emergence of brown adipocytes in white fat in mice is under genetic control: Effects on body weight and adiposity. J. Clin. Invest. (1998) 102 (2) :412–420.
   PubMed Web of Science ®Google Scholar
• NAGASE I, YOSHIDA T, KUMAMOTO K et al: Expression of uncoupling protein in skelet al muscle and white fat of obese mice treated with thermogenic beta 3-adrenergic agonist. j Clin. Invest. (1996) 97 (12) : 2898–2904.
   Google Scholar