Emerging therapeutic targets in asthma: immunomodulatory cytokines and their delivery

Bibliography

• KALINER M: Evolution of asthma treatments. Ann. Al-lergy (1993) 71:300–305.
   PubMedGoogle Scholar
• PRICE J, WELLER PH: Comparison of fluticasone propi-onate and sodium cromoglycate for the treatment of childhood asthma (an open parallel group study). Respir. Med. (1995) 89:363–368.
   PubMed Web of Science ®Google Scholar
• EXPERT PANEL OF THE NATIONAL ASTHMA EDUCATIONPROGRAM CO-ORDINATING COMMITTEE: Guidelines for the Diagnosis and Management of Asthma. J. Allergy Immunol. (1991) 88:427–534.
   Google Scholar
• INTERNATIONAL ASTHMA MANAGEMENT PROJECT: In-ternational Consensus Report on Diagnosis and Treat-ment of Asthma. Eur. Respir. J. (1992) 5:601–641.
   PubMedGoogle Scholar
• BOUSQUET J, AUBER B, BONS J: Comparison of sal-meterol with disodium cromoglycate in the treatment of adult asthma. Ann. Allergy Asthma Immunol. (1996) 176:189–194.
   Google Scholar
• SUISSA S, DENNIS R, ERNST P, SHEEHY O, WOOD-DAUPHINEE S: Effectiveness of the leukotriene recep-tor antagonist zafirlukast for mild-to-moderate asthma. A randomized, double-blind, placebo-controlled trial. Ann. Intern. Med. (1997) 126:177–183.
   PubMed Web of Science ®Google Scholar
• USHAUGHNESSY K, TAYLOR I, O'CONNOR B, O'CON-NELL F, THOMSON H, DOLLERY C: Potent leukotriene D4 receptor antagonist ICI 204, 219 given by the in-haled route inhibits the early but not the late phase of allergen-induced bronchoconstriction. Am. Rev. Respir. Dis. (1993) 147:1431–1435.
   PubMedGoogle Scholar
• BARNES PJ, LIM S: Inhibitory cytokines in asthma. Mol. Med. Today (1998) 4:452–458.
   PubMedGoogle Scholar
• FERREIRA MB, CARLOS AG: Cytokines and asthma. J. In-vest. Clin. Immunol. (1998) 8:141–148.
   Google Scholar
• DEMOLY P, MATHIEU M, CURIEL DT, GODARD PH, BOUSQUET J, MICHEL FB: Gene therapy strategies for asthma. Gene Therap. (1997) 4:507–516.
   PubMedGoogle Scholar
• NORBIATO G, BEVILACQUA M, VAGO T, CLERICI M: Glu-cocorticoids and Th-1, Th-2 type cytokines in rheuma-toid arthritis, osteoarthritis, asthma, atopic dermatitis and AIDS. Clin. Exp. Rheumatol (1997) 15:315–323.
   PubMedGoogle Scholar
• DEL PRETE G: Human Thl and Th2 lymphocytes: their role in the pathophysiology of atopy. Allergy (1992) 47:450–455.
   PubMed Web of Science ®Google Scholar
• ROMAGNANI S: The Thl/Th2 paradigm and allergic dis-orders. Allergy (1998) 53:12–15.
   PubMedGoogle Scholar
• SHER A, GAZZINELLI RT, JANKOVIC D et al: Cytokines as determinants of disease and disease interactions. Braz J. Med. Biol. Res. (1998) 31:85–87.
   PubMedGoogle Scholar
• MOREL PA, ORISS TB: Crossregulation between Thl and Th2 cells. Grit. Rev. Immunol (1998) 18:275–303.
   PubMed Web of Science ®Google Scholar
• DUNNILL M, MASSARELLA G, ANDERSON J: A compari-son of the quantitative anatomy of the bronchi in nor-mal subjects in status asthmaticus, in chronic bronchitis, and in emphysema. Thorax (1969) 24:176–179.
   PubMed Web of Science ®Google Scholar
• GERBLICH A, CAMPBELL A, SCHUYLER M: Changes in T-lymphocyte subpopulations after antigenic bronchial provocation in asthmatics. New Engl. J. Med. (1984) 310:1349–1352.
   PubMed Web of Science ®Google Scholar
• GONZALEZ M, DIAZ P, GALLEGUILLOS F, ANCIC P, CROMWELL O, KAY A: Allergen-induced recruitment of bronchoalveolar helper (OKT4) and suppressor (OKT8) cells in asthma: relative increases in OKT8 cells in single early responders compared to those in late responders. Am. Rev. Respir. Dis. (1987) 136:600–604.
   PubMed Web of Science ®Google Scholar
• AZZAWI M, BRADLEY B, JEFFREY P et al.: Identification of activated T lymphocytes and eosinophils in bron-chial biopsies in stable atopic asthmatics. Am. Rev. Respir. Dis. (1990) 142:1407–1413.
   PubMed Web of Science ®Google Scholar
• ROBINSON D, HAMID Q, YING S et al.: Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. New Engl. J. Med. (1992) 326:298–304.
   PubMed Web of Science ®Google Scholar
• •One of the first reports suggesting the pro-inflammatory role of lymphocytes in asthma.
   Google Scholar
• LAI CKW, HO SS, CHAN CHS, LEUNG R, LAI KN: Gene ex-pression of interleukin-3 and granulocyte macro-phage colony-stimulating factor in circulating CD4(+) T cells in acute severe asthma. Clin. Exp. Allergy. (1996) 26:138–146.
   PubMedGoogle Scholar
• BENTLEY A, HAMID Q, ROBINSON D et al.: Prednisolone treatment in asthma: reduction in the numbers of eosi-nophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cyto-kine expression within bronchial mucosa. Am. J. Respir. Grit. Care Med. (1996) 153: 551–556.
   PubMed Web of Science ®Google Scholar
• ROBINSON D, HAMID Q, YING S et al.: Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cells interleukin-4, interleukin-5, and interferon-y cytokine gene expres-sion. Am. Rev. Respir. Dis. (1993) 148:401–406.
   PubMed Web of Science ®Google Scholar
• CARMICHAEL J, PATERSON I, DIAZ P, CROMPTON G, KAY, GRANT K: Glucocorticoid resistance in chronic asthma. Br. Med. J. (1981) 282:1419–1424.
   PubMedGoogle Scholar
• ALVAREZ J, SURS W, LEUNG D, IKLE D, GELFAND E, SZE-FLER S: Steroid-resistant asthma: immunological and pharmacological features. J. Allergy Clin. Immunol (1992) 89:714–719.
   PubMed Web of Science ®Google Scholar
• CORRIGAN C, BROWN P, BARNES N, TSAI J, FREW A, KAY A: Glucocorticoid resistance in chronic asthma. Am. Rev. Respir. Dis. (1991) 144:1026–1032.
   PubMedGoogle Scholar
• LEUNG D, MARTIN R, SZEFLER S et al.: Dysregulation of interleukin 4, interleukin 5, and interferon-y. gene ex-pression in steroid-resistant asthma. J. Exp. Med. (1995) 181:33–40.
   PubMed Web of Science ®Google Scholar
• •Investigation corroborating the relationship between steroid efficacy and helper lymphocyte subsets/activity in asthma.
   Google Scholar
• LEUNG DY, DE CASTRO M, SZEFLER SJ, CHROUSOS GP: Mechanism of glucocorticoid-resistant asthma. Ann. NY Acad. Sci. (1998) 840:735–746.
   PubMed Web of Science ®Google Scholar
• KAM J, SZEFLER S, SURS W, SHER E, LEUNG D: Combina-tion IL-2 and IL-4 reduces glucocorticoid receptor binding affinity and T cell response to glucocorticoids. Immunol (1993) 151:3460–3466.
   Google Scholar
• •Details some cellular and molecular mechanisms underlying steroid resistance in asthma.
   Google Scholar
• MORRIS S, MADDEN K, ADAMOVICZ J et al.: Effects of IL-12 on in vivo cytokine expression and Ig isotype selec-tion. J. Immunol (1994) 152:1047–1056.
   PubMed Web of Science ®Google Scholar
• GAVETT SH, O'HEARN DJ, LI XM, HUANG SK, FINKELMANFD, WILLS-KARP M: Interleukin-12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J. Exp. Med. (1995) 182:1527–1536.
   PubMed Web of Science ®Google Scholar
• •Preclinical investigation illustrating the potential therapeutic benefit of IL-12 and IFN-y in asthma.
   Google Scholar
• LACK G, RENZ H, SALOGA J et al.: Nebulized but not par-enteral IFN-y decreases IgE production and normalizes airways function in a murine model of allergen sensiti-zation. J. Immunol. (1994) 152:2546–2554.
   PubMed Web of Science ®Google Scholar
• •Preclinical investigation illustrating the potential therapeutic benefit of IFN-y on asthma.
   Google Scholar
• BONFIELD T, KONSTAN M, BURFEIND P, PANUSKA J, HIL-LIARD J, BERGER M: Normal bronchial epithelial cells constitutively produce the anti-inflammatory cyto-kine interleukin-10, which is downregulated in cystic fibrosis. Am. J. Respir. Cell Mol. Biol. (1995) 13:257–261.
   PubMedGoogle Scholar
• DE WAAL MALEFYT R, ABRAMS J, BENNETT B, FIGDORCG, DE VRIES JE: Interleukin 10 (IL-10) inhibits cytoki-nes synthesis by human monocytes: an auto regula-tory role of IL-10 produced by monocytes. J. Exp. Med. (1991) 179:1209–1220.
   Google Scholar
• MOSMANN TR, MOORE KW: The role of IL-10 in crossregulation of Thl and Th2 responses. Immunol. Today (1991) 12:A49–A53.
   PubMedGoogle Scholar
• DEL PRETE G, DE CARLI M, ALMERIGOGNA F, GIUDIZIMG, BIAGOTTI R, ROMAGNANI S: Human IL-10 is pro-duced by both Type 1 helper (Thl) and Type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. J. Immunol. (1993) 150:353–360.
   PubMed Web of Science ®Google Scholar
• PUNNONEN J, DE WAAL MASLEFYT R, VANVLASSELAE P, GAUCHAT J-F, DE VRIES JE:11-10 and vira111.-10 prevent 11-4-induced IgE synthesis by inhibiting accessory cell function of monocytes. J. Immunol. (1993) 151:1280–1289.
   PubMed Web of Science ®Google Scholar
• TAKANASKI S, NONAKA R, XING Z, O'BYRNE P, DOLOVICH J, JORDANA M: Interleukin 10 inhibits lipopolysaccharide-induced survival and cytokine production by human peripheral blood eosinophils. J. Exp. Med. (1994) 180:711–715.
   PubMed Web of Science ®Google Scholar
• BOGDAN C, VODOVOTZ Y, NATHAN C: Macrophage de-activation by interleukin-10. J. Exp. Med. (1991) 174:1549–1555.
   PubMed Web of Science ®Google Scholar
• BORISH L, AARONS A, RUMBYRT J, CVIETUSA P, NEGRI J, WENZEL S: Interleleukin-10 regulation in normal and asthmatic subjects. J. Allergy Clin. Immunol. (1996) 97:1288–1296.
   PubMed Web of Science ®Google Scholar
• ZUANY-AMORIM C, HAILE S, LEDUC D et al.:Interleukin-10 inhibits antigen-induced cellular re-cruitment into the airways of sensitized mice. J. Clin. Invest. (1995) 95:2644–2651.
   PubMed Web of Science ®Google Scholar
• JOHN M, LIM S, SEYBOLD J et al.: Inhaled corticosteroidsincrease interleukin-10 but reduce macrophage in-flammatory protein-lalpha, granulocyte-macrophage colony-stimulating factor, and interferon-gamma re-lease from alveolar macrophages in asthma. Am. J. Respir. Crit. Care Med. (1998) 157:256–262.
   PubMed Web of Science ®Google Scholar
• HAMID Q, YING S, ROBINSON D, DURHAM S, KAY A: IL-10 mRNA is increased in asthma and co-localized with CD3 and CD68. Am. J. Respir. Crit. Care Med. (1994) 149:A958.
   Google Scholar
• HOBBS K, NEGRI J, KLINNERT M, ROSENWASSER LJ, BORISH L: Interleukin-10 and transforming growth factor-beta promoter polymorphisms in allergies and asthma. Am. J. Respir. Crit. Care Med. (1998)158:1958-62.
   Google Scholar
• OHMORI H, KANDA T, TAKAI T, HIKIDAM: Induction ofantigen-specific IgE response in murine lymphocytes by I1-10. Immunol. Lett. (1995) 47:127–132.
   PubMed Web of Science ®Google Scholar
• MAGNAN A, VAN PEED, BONGRAND P, VERVLOET D: Al-veolar macrophage interleukin (IL)-10 and 11-12 pro-duction in atopic asthmatics. Allergy (1998) 53:1092–1095.
   PubMedGoogle Scholar
• NAKAJIMA H, SANO H, NISHIMURA T, YOSHIDA S, IWA-MOTO I: Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhe-sion molecule 1/lymphocyte function-associated anti-gen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue. J. Exp. Med. (1994) 179:1145–1154.
   PubMed Web of Science ®Google Scholar
• BOGUNIEWICZ M, SCHNEIDER L, MILGROM H et al.:Treatment of steroid-dependent asthma (SDA) with re-combinant interferon-gamma (rIFIsl-y). J. Allergy Clin. Immunol. (1992) 28:288.
   Google Scholar
• LEE SH, KIM KH, LEE SY et al: Clinical efficacy of IFN-y inbronchial asthmatics. Am. J. Resp. Crit. Care Med. (1998) 157:A411.
   Google Scholar
• SCHILLER J, STORER B, PAULNOCK D et al.: A direct comparison of biological response modulation and clinical side-effects by interferon-betaser, interferon-gamma, or the combination of interferon-betaser and gamma in humans. J. Clin. Invest. (1990) 86:1211–1221.
   PubMed Web of Science ®Google Scholar
• MILLER N, VILE R: Targeted vectors for gene therapy. FASEB J (1996) 9:190–199.
   Google Scholar
• CURIEL DT, PILEWSKI JM, ALBELDA SM: Gene therapy approaches for inherited and acquired lung diseases. Am. J. Resp. Cell Mol. Biol. (1996) 14:1–18.
   PubMed Web of Science ®Google Scholar
• ROSENFELD M, SIEGFREID W, YOSHIMURA K et al: Adenovirus-mediated transfer of a recombinant a 1-antitrypsin gene to the lung epithelium in vivo. Science (1991) 252:431–434.
   PubMed Web of Science ®Google Scholar
• MASTRANGELI A, DANIEL C, ROSENFELD M et al: Diver-sity of airway epithelial cell targets for in vivo recombi-nant adenovirus-mediated gene transfer. J. Clin. Invest. (1993) 91:225–234.
   PubMed Web of Science ®Google Scholar
• CRYSTAL R, MCCELVANEY N, ROSENFELD M et al: Ad-ministration of adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis. Nature Genet. (1994) 8:42–51.
   PubMed Web of Science ®Google Scholar
• •Seminal report on the clinical application of gene therapy for the treatment of respiratory defects in patients with cystic fibrosis.
   Google Scholar
• ZABNER J, COUTURE L, GREGORE R, GRAHAM S, SMITH A, WELSH M: Adenovirus-mediated gene transfer cor-rects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. Cell (1993) 75:207–216.
   PubMed Web of Science ®Google Scholar
• KNOWLES MR, HOHNEKER KW, ZHOU Z et al.: A con-trolled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis. New Engl. J. Med. (1995) 333:823–831.
   PubMed Web of Science ®Google Scholar
• •Seminal report on the clinical application of gene therapy for the treatment of respiratory defects in patients with cystic fibrosis.
   Google Scholar
• SENE C, BOUT A, IMLER JL et al.: Aerosol-mediated deliv-ery of recombinant adenovirus to the airways of non-human primates. Hum. Gene Ther. (1995) 6:1587–1593.
   PubMed Web of Science ®Google Scholar
• YANG Y, NUNES F, BERENCSI K, FURTH E, GONCZOL E, WILSON J: Cellular immunity to viral antigens limits El-deleted adenoviruses for gene therapy. Proc. Natl. Acad. ScL USA (1994) 91:4407–4411.
   PubMed Web of Science ®Google Scholar
• GOLDMAN M, LITZKY L, ENGELHARDT J, WILSON J: Transfer of the CFTR gene to the lung of non-human primates with El-deleted, E2a-defective recombinant adenoviruses: a preclinical toxicology study. Hum. Gene Ther. (1995) 6:839–851.
   PubMed Web of Science ®Google Scholar
• ROSENECKER J, HARMS KH, BERTELE RM et al.: Adenovi-rus infection in cystic fibrosis patients: implications for the use of adenoviral vectors for gene transfer. In-fection (1996) 24:5–8.
   Google Scholar
• TERAMOTO S, BARTLETT JS, MCCARTY D, XIAO X, SAMULSKI RJ, BOUCHER RC: Factors influencing adeno-associated virus-mediated gene transfer to hu-man cystic fibrosis airway epithelium cells: comparison with adenovirus vectors. J. Virol. (1998) 72:8904–8912.
   PubMed Web of Science ®Google Scholar
• FLOTTE T, AFIONE S, CONRAD C et al.: Stable in vivo ex-pression of the cystic fibrosis transmembrane conduc-tance regulator with an adeno-associated virus vector. Proc. Natl. Acad. ScL USA (1993) 90:10613–10617.
   PubMed Web of Science ®Google Scholar
• CANONICO A, CONARY J, MEYRICK B, BRIGHAM K: Aero-sol and intravenous transfection of human a 1-antitrypsin gene to lungs of rabbits. Am. J. Respir. Cell Mol. Biol. (1994) 10:24–29.
   PubMed Web of Science ®Google Scholar
• HUGHS B, KENNELS, LEE R, HUANG L: Monoclonal anti-body targeting of liposomes to mouse lung in vivo. Cancer Res. (1989) 49:6214–6220.
   PubMedGoogle Scholar
• STECENKO AA, WALSH EE, SCHREIER H: Fusion of artifi-cial viral envelopes containing respiratory syncytial virus (RSV) attachment (G) and fusion (F) glycopro-teins with Hep-2-cells. Pharm. Pharmacol. Lett. (1992) 1:127–129.
   Google Scholar
• THOMAS D, MYERS M, WICHERT B, GONZALEZ-ROTHI R: Acute effects of liposome aerosol inhalation on pul-monary function in healthy human volunteers. Chest (1991) 99:1268–1270.
   PubMed Web of Science ®Google Scholar
• TSAN M, WHITE J, SHEPARD B: Lung-specific direct in vivo gene transfer with recombinant plasmid DNA. Am. J. Physic)]. (1995) 268:L1052–L1056.
   Google Scholar
• KNOWLES MR, NOONE PG, HOHNEKER K et al.: A double-blind, placebo controlled, dose ranging study to evaluate the safety and biologicalal efficacy of the lipid-DNA complex GR213487B in the nasal epithe-lium of adult patients with cystic fibrosis. Hum. Gene Ther. (1998) 9:249–269.
   PubMed Web of Science ®Google Scholar
• CHOW YH, O'BRODOVICH H, PLUMB J et al.: Develop-ment of an epithelium-specific expression set with hu-man DNA regulatory elements for transgene expression in lung airways. Proc. Natl. Acad. Sci. USA (1997) 94:14695–1470.
   PubMedGoogle Scholar
• ISGAARD J, CARLSSON L, ISAKSSON O, JANSSON J: Pulsa-tile intravenous growth hormone (GI-1) infusion to hy-pophysectomized rats increases insulin-like growth factor I messenger ribonucleic acid in skelet al tissues more effectively than continuous Gil infusion. Endo-crinology (1988) 123:2605–2610.
   PubMed Web of Science ®Google Scholar
• WOLF E, KAHNT E, EHRLEIN J, HERMANNS W, BREM G, WANKE R: Effects of long-term elevated serum levels of growth hormone on life expectancy of mice: lessons learned from transgenic animal models. Mech. Ageing Dev. (1993) 68:71–87.
   PubMedGoogle Scholar
• RIDDELL S: T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients. Nature Med. (1996) 2:216–223.
   PubMed Web of Science ®Google Scholar
• RIVERA V, CLACKSON T, NATESAN S et al.: A humanized system for pharmacological control of gene expres-sion. Nature Med. (1996) 2:1028–1032.
   PubMed Web of Science ®Google Scholar
• WANG Y, O'MALLEY JR, TSAI SY, O'MALLEY BW: A regula-tory system for use in gene transfer. Proc. Natl. Acad. Sci. USA (1994) 91:8180–8184.
   PubMed Web of Science ®Google Scholar
• SCHMITZ M, BAEUERLE P: The p65 subunit is responsi-ble for the strong transcription activating potential of NF-kappa B. EMBO J (1991) 10:3805–3817.
   PubMed Web of Science ®Google Scholar
• CHEN J, ZHENG X, BROWN E, SCHREIBER S: Identifica-tion of an 11 kDa FKBP12-rapamycin binding domain within the 289-kDa FKBP-rapamycin-associated pro-tein and characterization of a critical serine residue. Proc. Natl. Acad. Sci. USA (1995) 92:4947–4951.
   PubMed Web of Science ®Google Scholar
• POMERANTZ J, SHARP P, PABO C: Structure-based de-sign of transcription factors. Science (1995) 267:93–96.
   PubMed Web of Science ®Google Scholar
• STANDAERT R, GALAT A, VERDINE G, SCHREIBER S: Mo-lecular cloning and overexpression of the human FK506-binding protein FKBP. Nature (1990) 346:671–674.
   PubMed Web of Science ®Google Scholar
• DHAWAN J, RANDO T, ELSON S, BUJARD H, BLAU H:Tetracycline-regulated gene expression following di-rect gene transfer into mouse skelet al muscle. Som. Cell Molec. Genet. (1995) 21:233–240.
   PubMedGoogle Scholar
• MAGARI SR, RIVERA VM, IULIUCCI JD, GILMAN M, CERA-SOLI JR F: Pharmacological control of a humanized gene therapy system implanted into nude mice. J. Clin. Invest. (1997) 100:2865–2872.
   PubMedGoogle Scholar
• GRANGER D, CROMWELL J, CHEN S et al.: Prolongation of renal allograft survival in a large animal model by oral rapamycin monotherapy. Transplantation (1995) 59:183–186.
   PubMedGoogle Scholar
• BELSHAW P, SCHOEPFER J, LIU K, MORRISON K, SCHREI-BER S: Rational design of orthogonal receptor-ligand combinations. Angew. Chem. Int. Ed. Eng. (1995) 34:2129–2132.
   Google Scholar