Bibliography
- MCFADDENER JR, GILBERT IA: Asthma. New Engl. J. Med. (1992) 327:1928–1937.
- HOLGATE ST, CHURCH MK, HOWARTH NE et al.: Geneticand environmental influences on airway inflamma-tion in asthma. Int. Arch. Allergy Immunol. (1995) 107:29–33.
- SMITH DH, MALONE DC, LAWSON KA: A national esti-mate of the economic costs of asthma. Am. J. Respir. Grit. Care Med. (1997) 156:787–793.
- AMERICAN LUNG ASSOCIATION: Asthma survey:asthma fact sheet. (1998).
- BURROWS B, MARTINEZ FD, HALONEN M et al.: Associa-tion of asthma with serum IgE levels and skin reactiv-ity to allergens. New Engl. J. Med. (1989) 320:271–277.
- POPP W, ZWICK H, STEYRER K et al.: Sensitization to ae-roallergens depends on environmental factors. Allergy (1989) 44:572–575.
- SEARS M, BURROWS B, FLANNERY EM et al: Relation be-tween airway responsiveness and serum IgE in chil-dren with asthma and in apparently normal children. New Eng]. J. Med. (1991) 325:1067–1071.
- MINOR TE, DICK EC, BAKER JW: Viruses as precipitants of asthmatic attacks in children. Am. Rev. Resp. Dis. (1976) 113: 149–153.
- FERRERI NR, HOWLAND WC, STEVENSON DD et al.: Re-lease of leukotrienes, prostaglandins, and histamine into nasal secretions of aspirin-sensitive asthmatics during reaction to aspirin. Am. Rev. Respir. Dis. (1988) 137:847–854.
- FINNERTY JP, WOOD-BAKER R, THOMSON H et al.: Roleof leukotrienes in exercise-induced asthma. Inhibi-tory effect of ICI 204219, a potent leukotriene D4 re-ceptor antagonist. Am. Rev. Respir. Dis. (1992) 145:746–749.
- VENABLES KM, CHAN-YEUNG M: Occupational asthma.Lancet (1997) 349:1465–1469.
- HOPP RJ, TOWNLEY RE, BIVEN N: The presence of air-way reactivity before the development of asthma. Am. Rev. Respir. Dis. (1990) 141:2-8. NICOLAIDES NC, HOLROYD KJ, EWART SJ et al.: Interleukin-9: a candidate gene for asthma. Proc. Natl. Acad. Sci. USA (1997) 94:13175-13180. Identified IL-9 as a key mediator of airway hyper-responsiveness. LEVITT RC, MITZNER W: Expression of airway hyperac-tivity to acetylcholine as a simple autosomal recessive trait in mice. FASEB (1988) 2:2605–2608.
- NICOLAIDES NC, HOLROYD KJ, EWART SJ et al.: Interleukin-9: a candidate gene for asthma. Proc. Natl. Acad. Sci. USA (1997) 94:13175–13180.
- • Identified IL-9 as a key mediator of airway hyperresponsiveness.
- LEVITT RC, MITZNER W: Expression of airway hyperactivity to acetylcholine as a simple autosomal recessive trait in mice. FASEB J.(1988) 2:2605–2608.
- LEVITT RC, MITZNER W: Autosomal recessive inheri-tance of airway hyperactivity to 5-hydroxytryptamine. Appl. Physic)]. (1989) 67:1125–1132.
- LEVITT RC: Understanding biologic variability in sus-ceptibility to respiratory disease. Pharmacogenetics (1991) 1:94–97.
- LEVITT RC, EWART SL: Genetic susceptibility toatracurium-induced bronchoconstriction. Am. J. Respir. Grit. Care Med. (1995) 151:1537–1542.
- TEMANN UA, GEBA GP, RANKIN JA et al: Expression ofinterleukin-9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bron-chial hyperresponsiveness. J. Exp. Med. (1998) 188:1307–1320.
- •Demonstrates the role of IL-9 in inducing asthmatic-like re-sponses in vivo.
- MCLANE MP, HACKZU A, VANDE RIJN M et al.: Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice. Am. J. Resp. Cell. Mol. Biol. (1998) 19:713–720.
- •Demonstrates the role of IL-9 in inducing asthmatic-like re-sponses in vivo.
- LEVITT RC, MCLANE MP, MACDONALD D et al.: Interleukin-9 pathway in asthma: New therapeutic tar-gets for allergic inflammatory disorders. J. Allergy Clin. Immunol. (1998). (In Press).
- DE SANCTIS G, ITOH A, GREEN FHY et al.: T-lymphocytesregulate genetically determined airway hyperrespon-siveness in mice. Nature Med. 3:460–462.
- ROBINSON DS, HAMID Q, YING S et al.: Predominant T112-like bronchoalveolar T-lymphocyte population in atopic asthma. New Engl. J. Med. (1992) 326:289–304.
- ••Identifies the association of Th2 lymphocytes with atopicasthma.
- HOLROYD KJ, MARTINATI LC, TRABETTI E et al.: Asthmaand Bronchial hyperresponsiveness linked to the XY long arm pseudoautosomal region. Genomics (1998) 52:33–235.
- GRASSO L, HUANG M, SULLIVAN CD et al.: Molecularanalysis of human interleukin-9 receptor transcripts in peripheral blood mononuclear cells: Identification of a splice variant encoding for a nonfunctional cell surface receptor. J. Biol. Chem. (1998) 273:24016–24024.
- BOUSHEY HA, HOLTZMAN MJ, SHELLER JR et al: Bron-chial hyperreactivity. Am. Rev. Respir. Dis. (1980) 121:389–413.
- GERBLICH AA, SALIK H, SCHUYLER MR: Dynamic T-cell changes in peripheral blood and bronchoalveolar lavage after antigen provocation in asthmatics. Am. Rev. Respir. Dis. (1991) 143:533–539.
- KALINER MA, BLENNERHASSETT J, AUSTEN KF: Bron-chial asthma. In: Text Book of Immunopathology Grune & Stratton, New York, USA (1976):387–401.
- HOLGATE S: Mediator and cytokine mechanisms in asthma. Thorax (1993) 48:103–109.
- DUGAS B, RENAULD JC, PENE J et al.: Interleukin-9 po-tentiates the interleukin-4 induced immunoglobulin (IgG, IgM, and IgE) production by normal human B lymphocytes. Eur. J. Immunol (1993) 23:1687–1692.
- MCKENZIE GJ, EMSON CL, BELL SE et al: Impaired devel-opment of Th2 cells in IL-13-deficient mice. Immunity (1998) 9:423–432.
- WARDLAW AJ, DUNNETTE S, GLEICH GJ: Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperre-activity. Am. Rev. Respir. Dis. (1988) 137:62–69.
- KNIGHT DA, STEWART GA, THOMPSON PJ: The respira-tory epithelium and airway smooth muscle homeosta-sis: Its relevance to asthma. Clin. Exp. Allergy (1994) 24:698–706.
- OLSZEWSKA-PAZDRAK B, CASOLA A, SAITO et al.: Cell-specific expression of RANTES, MCP-1, and MIP-lalpha by lower airway epithelial cells and eosino-phils infected with respiratory syncytial virus. J. Vim]. (1998) 72:4756–4764.
- MARSH DG, MEYERS DA, BIAS WB et al.: The epidemiol-ogy and genetics of atopic allergy. New Engl. J. Med. (1982) 305:1551–1559.
- DANIELS SE, BHATTACHARRYA S, JAMES A et al.: Agenome-wide search for quantitative trait loci underly-ing asthma. Nature (1996) 383:247–250.
- THE COLLABORATIVE STUDY ON THE GENETICS OF ASTHMA: A genome-wide search for asthma suscepti-bility loci in ethnically diverse populations. Nature Genet. (1997) 15:389–392.
- OBER C, COX NJ, ABNEY M et al: Genome-wide searchfor asthma susceptibility loci in a founder population. Hum. Mol. Genet. (1998) 7:1393–1398.
- MEYERS DA, POSTMA DS, PANHUYSEN CIM et al: Evi-dence for a locus regulating total serum IgE levels map-ping to chromosome 5. Genomics (1994) 23:464–470.
- MARSH DG, NEELY JD, BREAZEALE DR et al.: Linkage analysis of IL-4 and other chromosome 5q31.1 mark-ers and total serum immunoglobulin E concentra-tions. Science (1994) 264:1152–1156.
- BARNES KC, NEELY JD, DUFFY DL et al.: Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: evidence from Afro-Caribbean and Caucasian populations. Genomics (1996) 37:41–50.
- POSTMA DS, BLEECKER ER, AMELUNG PJ et al.: Genetic susceptibility to asthma-bronchial hyperresponsive-ness coinherited with a major gene for atopy. NewEngl. J. Med. (1995) 333:894–900.
- ROSENWASSER LJ, KLEMM DJ, DRESBACK JK et al.: Pro-moter polymorphisms in the chromosome 5 gene cluster in asthma and atopy. Clin. Exp. Allergy (1995) 25:74–78.
- MITSUYASU H, IZUHARA K, MAO XQ: Ile50Val variant of IL-4R alpha upregulates IgE synthesis and associates with atopic asthma. Nature Genet. (1998) 19:119–120.
- DRAZEN JM, ARM JP, AUSTEN KF: Sorting out the cytoki-nes of asthma. J. Exp. Med. (1996) 183:1–5.
- CORRY DB, FOLKESSON HG, WARNOCK ML et al: Inter-leukin 4, but not Interleukin 5 or eosinophils, is re-quired in a murine model of acute airway hyperreactivity. J. Exp. Med. (1996) 183:109–117.
- HOGAN SP, MATTHAEI KI, YOUNG JM et al: A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5. J. Immunol (1998) 161: 1501–1509.
- DOULL I, LAWRENCE S, WATSON M et al.: Allelic associa-tion of makers on chromosome 5q and llq with atopy and bronchial hyperresponsiveness. Am. J. Respir. Grit. Care Med. (1996) 153:1280–1284.
- EMERY I, LIANCE M, DERIAUD E et al.: Characterizationof T-cell immune responses of Echinococcus multilocularis-infected C57BL/6J mice. Parasite Immu-nol. (1996) 9:463–72.
- HULTNER L, DRUEZ C, MOELLER J et al.: Mast cell growth-enhancing activity (MEA) is structurally re-lated and functionally identical to a novel mouse T-cell growth factor p40/TCGF III (interleukin 9). Eur. 1 Im-munol. (1990) 20:1413–1416.
- DEMOULIN JB, RENAULD JC: Interleukin-9 and its recep-tor: an overview of structure and function. Int. Rev. Im-munol (1998) 16:345–364.
- •Reviews biological activities of IL-9 on inflammatory cells.
- UYTTENHOVE C, SIMPSON R, VAN SNICK J: Functional and structural characterization of P40, a mouse glyco-protein with T cell growth factor activity. Proc. Nati Acad. Sci. USA (1988) 85:6934–6938.
- VAN SNICK J, GOETHALS A, RENAULD JC et al: Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40). J. Exp. Med. (1989) 169:363–368.
- GESSNER A, BLUM ROLLINGHOFF M: Differential regula-tion of IL-9-expression after infection with Leishma-nia major in susceptible and resistant mice. Immunobiol (1993) 189:419–435.
- JEANNIN P, LECOANET S, DELNESTE Y et al.: IgE versus IgG4 production can be differentially regulated by IL-Immunol (1998) 160:3555–3561.
- LEMOLI RM, FOGLI M, FORTUNA A et al.: Interleukin-11 (IL-11) and IL-9 counteract the inhibitory activity of transforming growth factor beta 3 (TGF-b3) on human primitive hematopoietic progenitor cells. Haemato-logica (1994) 80:5–12.
- DONG Q, LOUAHED J, VINK A et al.: Interleukin-9 in-duces chemokine expression in lung epithelial cells and baseline airway eosinophilia in transgenic mice. (In Preparation).
- PILEWSKI JM, ALBELDA SM: Cell adhesion molecules inasthma: homing activation and airway remodeling. Am. J. Resp. Cell. Mol. Biol. (1995) 12:1–3.
- GONZALO JA, LLOYD CM, WEND et al.: The coordinated action of CC chemokines in the lung orchestrates aller-gic inflammation and airway hyperresponsiveness. Exp. Med. (1998) 188:157–167.
- RABB H, MARTIN JG: An emerging paradigm shift on the role of leukocyte adhesion molecules. J. Clin. Invest. (1997) 100:2937–2938.
- HENDERSON WR, CHI EY, ALBERT RK et al. Blockade of CD49d (a4 integrin) on intrapulmonary but not circu-lating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma. J. Clin. Invest. (1997) 100:3083–3092.
- New clues to asthma therapies. Science (1997)276:1643–1646.
- RENZ H, ENSSLE K, LAUFFER L et al: Inhibition ofallergen-induced IgE and IgG1 production by soluble IL-4 receptor (sIL-4R). Int. Arch. Allergy Immunol (1995) 106:46–54.
- EGAN RW, ATHWAHL D, CHOU CC et al.: Inhibition of pulmonary eosinophilia and hyperreactivity by anti-bodies to interleukin-5. Int. Arch. Allergy Immunol. (1995) 107:321–322.
- WILLS-KARP M, LUYIMBAZI J, XU X et al.: Interleukin-13: central mediator of allergic asthma. Science (1998) 282:2258–2261.
- GRUNIG G, WARNOCK M, WAKIL AE et al.: Requirementfor IL-13 independently of IL-4 in experimental asthma. Science (1998) 282:2261–2263.
- GRUNEWALD SM, WERTHMANN A, SCHNARR B et al.: Anantagonistic IL-4 mutant prevents Type I allergy in the mouse: inhibition of the IL-4111-13 receptor system completely abrogates humoral immune response to allergen and development of allergic symptoms in vivo. J. Immunol. (1998) 160:4004–4009.