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Review

The androgen receptor as a therapeutic target in prostate cancer

Pages 65-71 | Published online: 25 Feb 2005

Bibliography

  • KOSARY CL, RIES LAG, MILLER BA, HANKEY BF, HARRASA, EDWARDS BK: SEER Cancer Statistics Review, 1973–1992: Tables and Graphs. National Cancer Institute. NIH Pub. No. 96–2789, Bethesda, MD, USA (1995).
  • FINNISH CANCER REGISTRY: Cancer incidence inFinland 1995. Cancer Soc. Finland, Pub.No. 58, Helsinki, Finland (1997).
  • HANKEY BF, FEUER EJ, CLEGG LX et al.: Cancer surveil-lance series: interpreting trends in prostate cancer-part I: evidence of the effects of screening in recent prostate cancer incidence, mortality, and survival rates. J. Natl Cancer Inst. (1999) 91:1017–1024.
  • GITTES RF: Carcinoma of the prostate. N Engl. J. Med. (1991) 24:324:236–245.
  • •A review on standard treatment of prostate cancer.
  • STEARNS ME, MCGARVEY T: Prostate cancer: therapeutic, diagnostic, and basic studies. Lab. Invest. (1992) 67:540–552.
  • DEKERNION J, BELLDEGRUN A, NAITOH J: Surgical treatment of localized prostate cancer: indications, technique and results. In: New Perspectives in Prostate Cancer. Belldegrun A, Kirby RS, Oliver T (Eds.), Isis Medical Media Ltd., Oxford, UK (1998):185–203.
  • HUGGINS C, HODGES CV: Studies on prostate cancer: the effects of castration, of estrogen, and of androgen injection on serum phosphatases in meatstatic carcinoma of prostate. Cancer Res. (1941) 1:293–297.
  • PALMBERG C, KOIVISTO P, VISAKORPI T, TAMMELA TLJ: PSA decline is an independent prognostic marker in hormonally treated prostate cancer. Eur. Urol. (1999) 36:191–196.
  • KALLIONIEMI O-P, VISAKORPI T: Genetic basis and clonal evolution of human prostate cancer. Adv. Cancer Res. (1996) 68:225–255.
  • ••A comprehensive review of the molecular genetics ofprostate cancer.
  • BEATO M, HERRLICH P, SCHUTZ G: Steroid hormonereceptors: many actors in search of a plot. Cell (1995) 83:851–857.
  • JANNE OA, PALVIMO JJ, KALLIO P, MEHTO M: Androgenreceptor and mechanism of androgen action. Ann. Med. (1993) 25:83–89.
  • KOIVISTO P, KOLMER M, VISAKORPI T, KALLIONIEMI OP:Androgen receptor gene and hormonal therapy failure of prostate cancer. Am. J. Pathol. (1998) 152:1–9.
  • •Review on the AR gene alterations in prostate cancer.
  • SADI MV, BARRACK ER: Image analysis of androgen receptor immunostaining in metastatic prostate cancer. Heterogeneity as a predictor of response to hormonal therapy. Cancer (1993) 71:2574–2580.
  • VAN DER KWAST TH, SCHALKEN J, RUIZEVELD DE WINTER JA et al: Androgen receptors in endocrine-therapy-resistant human prostate cancer. Int. J. Cancer (1991) 48:189–193.
  • VISAKORPI T, HYYTINEN E, KOIVISTO P et al.: In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Nature Genet. (1995) 9:401–406.
  • ••Finding the AR gene amplification in prostate cancer.
  • KOIVISTO P, KONONEN J, PALMBERG C et al.: Androgenreceptor gene amplification: a possible molecular mechanism for failure of androgen deprivation therapy in prostate cancer. Cancer Res. (1997) 57:314–319.
  • VISAKORPI T, KALLIONIEMI A, SYVÄNEN A-C et al:Genetic changes in primary and recurrent prostate cancer by comparative genomic hybridization. Cancer Res. (1995) 55:342–347.
  • •First comprehensive analysis of genetic aberrations in prostate cancer by CGH.
  • NUPPONEN NN, KAKKOLA L, KOIVISTO P, VISAKORPI T: Genetic alterations in hormone-refractory recurrent prostate carcinomas. Am. J Pathol. (1998) 153:141–1488.
  • PALMBERG C, KOIVISTO P, HYYTINEN E et al: Androgen receptor gene amplification in a recurrent prostate cancer after monotherapy with nonsteroidal potent antiandrogen `Casodex' (bicalutamide) with a subsequent favorable response to maximal androgen blockade. Eur. Urol. (1997) 31:216–219.
  • GIOVANNUCCI E, STAMPFER MJ, KRITHIVAS K et al.: The CAG repeat within the androgen receptor gene and its relationship to prostate cancer. Proc. Natl. Acad. Sci. USA (1997) 94:3320–3323.
  • •An excellent case-control study on association of germ-line CAG repeats in the AR gene with risk of prostate cancer.
  • HAKIMI JM, SCHOENBERG MP, RONDINELLI RH, PIANTA-DOSI S, BARRACK ER: Androgen receptor variants with short glutamine or glycine repeats may identify unique subpopulations of men with prostate cancer. UM. Cancer Res. (1997) 3:1599–1608
  • INGLES SA, ROSS RK, YU MC et al.: Association ofprostate cancer risk with genetic polymorphisms in vitamin D receptor and androgen receptor. J. Natl. Cancer Inst. (1997) 89:166–170.
  • BRATT O, BORG A, KRISTOFFERSSON U, LUNDGREN R, ZHANG QX, OLSSON H: CAG repeat length in the androgen receptor gene is related to age at diagnosis of prostate cancer and response to endocrine therapy, but not to prostate cancer risk. Br. J. Cancer (1999) 81:672–676.
  • CORREA-CERRO L, WOHR G, HAUSSLER J, et al.:(CAG)nCAA and GGN repeats in the human androgen receptor gene are not associated with prostate cancer in a French-German population. Eur. J. Hum. Genet. (1999) 7:357–362.
  • TILLEY WD, BUCHANAN G, HICKEY TE, BENTEL JM: Mutations in the androgen receptor gene are associ-ated with progression of human prostate cancer to androgen independence. Clin. Cancer Res. (1996) 2:277–285.
  • GADDIPATI JP, MCLEOD DG, HEIDENBERG HB et al.:Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers. Cancer Res. (1994) 54:2861–2864.
  • ELO JP, KVIST L, LEINONEN K et al: Mutated humanandrogen receptor gene detected in a prostatic cancer patient is also activated by estradiol. J. Clin. Endocrinol Metab. (1995) 80:3494–3500.
  • SUZUKI H, AKAKURA K, KOMIYA A, AIDA S, AKIMOTO S, SHIMAZAKI J: Codon 877 mutation in the androgen receptor gene in advanced prostate cancer: relation to antiandrogen withdrawal syndrome. Prostate (1996) 29:153–158.
  • SUZUKI H, SATO N, WATABE Y, MASAI M, SEINO S, SHIMAZAKI J: Androgen receptor gene mutations in human prostate cancer. J. Steroid Biochem. Mol. Biol. (1993) 46:759–765.
  • EVANS BAJ, HARPER ME, DANIELLS CE et al. Low incidence of androgen receptor gene mutations in human prostatic tumors using single strand confor-mation polymorphism analysis. Prostate (1996) 28 162–171
  • WATANABE M, USHIJIMA T, SHIRAISHI T et al: Geneticalterations of androgen receptor gene in japanese human prostate cancer. Jpn. J. Clin. Oncol (1997) 27:389–393.
  • RUIZEVELD DE, WINTER JA, JANSSEN PJA et al.:Androgen receptor status in localized and locally progressive hormone refractory human prostate cancer. Am. J. Pathol. (1994) 144:735–746.
  • WALLEN MJ, LINJA M, KAARTINEN K, SCHLEUTKER J, VISAKORPI T: Androgen receptor gene mutations in hormone-refractory prostate cancer. J. Pathol. (1999) 189:559–563.
  • TAPLIN M-E, BUBLEY GJ, SHUSTER TD et al: Mutation ofthe androgen-receptor gene in metastatic androgen-independent prostate cancer. N Engl. J. Med. (1995) 332:1393–1398.
  • TAPLIN ME, BUBLEY GJ, KO YJ et al.: Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist. Cancer Res. (1999) 59:2511–2515.
  • ••Demonstrates the association of flutamide treatment withmutations in codon 877 of the AR gene.
  • ANZICK SL, KONONEN J, WALKER RL et al.: AIB1, asteroid receptor coactivator amplified in breast and ovarian cancer. Science (1997) 277:965–968.
  • LEE SK, ANZICK SL, CHOI JE et al.: A nuclear factor, ASC-2, as a cancer-amplified transcriptional coacti-vator essential for ligand-dependent transactivation by nuclear receptors in vivo. J. Biol. Chem. (1999) 274:34283–34293.
  • HSIAO PW, CHANG C: Isolation and characterization ofARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells. J. Biol. Chem. (1999) 274:22373–22379.
  • KANG HY, YEH S, FUJIMOTO N, CHANG C: Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor. J. Biol. Chem. (1999) 274:8570–8576.
  • FUJIMOTO N, YEH S, KANG HY: Cloning and characteri-zation of androgen receptor coactivator, ARA55, in human prostate. J. Biol. Chem. (1999) 274:8316–8321.
  • YEH S, MIYAMOTO, H., NISHIMURA K et al.: Retinoblas-toma, a tumor suppressor, is a coactivator for the androgen receptor in human prostate cancer DU145 cells. Biochem. Biophys. Res. Commun. (1998) 248:361–367.
  • YEH S, CHANG C: Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. Proc. Natl Acad. Sci. USA (1996) 93:5517–5521.
  • •Cloning the ARA70 gene.
  • MOILANEN AM, KARVONEN U, POUKKA H et al: A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins. J. Biol. Chem. (1999) 274:3700–3704.
  • MOILANEN AM, KARVONEN U, POUKKA H, ANNE OA, PALVIMO JJ: Activation of androgen receptor function by a novel nuclear protein kinase. Mol. Biol. Cell (1998) 9:2527–2543.
  • MOILANEN AM, POUKKA H, KARVONEN U, HAKLI M, ANNE OA, PALVIMO JJ: Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription. Mol. Cell Biol. (1998) 18:5128–5139.
  • MIYAMOTO H, YEH S, WILDING G, CHANG C: Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells. Proc. Natl. Acad Sci. USA (1998) 95:7379–7384.
  • ••Thorough evaluation of the effect of ARA70 expression onactivity of AR.
  • CULIG Z, HOBISCH A, CRONAUER MV et al: Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor. Cancer Res. (1994) 54:5474–5478.
  • •Study on AR activation by different growth factors.
  • KLEIN KA, REITER RE, REDULA J et al.: Progression ofmetastatic human prostate cancer to androgen independence in immunodeficient SCID mice. Nature Med. (1997) 3:402–408.
  • CRAFT N, SHOSTAK Y, CAREY M, SAWYERS CL: A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase. Nature Med. (1999) 5:280–285.
  • ••An excellent study about the cross-talk between ERBB2 andAR pathway.
  • YEH S, UN HK, KANG HY, THIN TH, UN MF, CHANG C: From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells. Proc. Natl. Acad. Sci. USA (1999) 96:5458–5463.
  • •Demonstrates cross-tak between ERBB2 and AR signalling pathways.
  • SLAMON DJ, CLARK GM, WONG SG, LEVIN WJ, ULLRICHA, MCGUIRE WL: Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science (1987) 235:177–182
  • BUBENDORF L, KONONEN J, KOIVISTO P et al.: Survey ofgene amplifications during prostate cancer progres-sion by high-throughout fluorescence in situ hybridi-zation on tissue microarrays. Cancer Res. (1999) 59:803–806.
  • •High througput analysis of gene amplification in prostate cancer.
  • CRAWFORD ED, EISENBERGER MA, MCLEOD DG et al: Acontrolled trial of leuprolide with and without flutamide in prostatic carcinoma. N Engl. J. Med. (1989) 321:419–424.
  • EISENBERGER MA, BLUMENSTEIN BA, CRAWFORD ED et al.: Bilateral orchiectomy with or without flutamide for metastatic prostate cancer. N Engl. J. Med. (1998) 339:1036–1042.
  • •Clinical trial on efficacy of maximal androgen blockade in treatment of prostate cancer.
  • PANTEL, K, ENZMANN T, KOLLERMANN J, CAPRANO J, RIETHMULLER G, KOLLERMANN MW: Immunocyto-chemical monitoring of micrometastatic disease: reduction of prostate cancer cells in bone marrow by androgen deprivation. Int. J. Cancer (1997) 71:521–525.
  • COBLEIGH MA, VOGEL CL, TRIPATHY D et al: Multina-tional study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J. Clin. Oncol (1999) 17:2639–2648.
  • AGUS DB, SCHER HI, HIGGINS B et al.: Response ofprostate cancer to anti-Her-2/neu antibody in androgen-dependent and-independent human xenograft models. Cancer Res. (1999) 59:4761–4764.
  • •A xenograft study on the use of trastuzumab for treatment in prostate cancer.

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