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Review

Endocannabinoids Part I: Molecular basis of endocannabinoid formation, action and inactivation and development of selective inhibitors

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Pages 241-265 | Published online: 25 Feb 2005

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  • •First report of an inhibitor of anandamide transport across the membrane.
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  • •First report that CBI receptors are positively linked to endocannabinoid uptake via NO.
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  • •First evidence for the effect of NO on the anandamide membrane transporter.
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  • •First evidence that anandamide can be oxidised by lipoxy-genases in intact cells.
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  • •First report of CB1-selective ligands.
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  • •First report of inhibitors of the anandamide membrane transporter selective vs. VR1 receptors.
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  • •First report of a CBI receptor ligand extremely selective vs. both CB2 and VR1 receptors.
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