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Expert Opinion on Therapeutic Targets Volume 6, 2002 - Issue 3
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Miscellaneous

Quorum sensing: an emerging target for antibacterial chemotherapy?

Paul Williams Address for correspondence, Institute of Infections and Immunity, University of Nottingham, Queen’s Medical Centre, Nottingham, NG7 2UH UK, Tel: +44 0115 951 5047;, Fax: +44 0115 984 2396;, E-mail: [email protected] of Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
Pages 257-274 | Published online: 25 Feb 2005

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  • •A DNA microarray is used to gain insights into the repertoire of genes controlled via LuxS in E coll.
  • DELISA ME VALDES JJ, BENTLEY WE: Mapping stress-induced changes in autoinducer AI-2 production in chemostat-cultivated Escherichia coli K-12. j Bacterial (2001) 183:2918–2928.
  • SPERANDIO V, MELLIES JL, NGUYEN W, SHIN S, KAPER JB: Quorum sensing controls expression of the Type III secretion gene transcription and protein secretion in enterohemorrhagic and enteropathogenic Escherichia coll. Proc. Natl. Acad. Sci. USA (1999) 96:15196–15201.
  • DAY WA, MAURELLI AT: Shigella flexneri LuxS quorum sensing system modulates virB expression but is not essential for virulence. Infect. Immun (2001) 69:15–23.
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Websites

  • www.whoindinfectious-disease-repord 192000/intro.htm Report (2000) of the World Health Organization on global problems associated with increasing antimicrobial resistance and to threat to health.
  • www.nottingham.ac.uldquorum This site aims to be a one stop shop' for quorum sensing research. It includes an overview of the field and has links to links to quorum sensing researchers worldwide.

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