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Review

BAFF: B cell survival factor and emerging therapeutic target for autoimmune disorders

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Pages 115-123 | Published online: 02 Mar 2005

Bibliography

  • DAVIDSON A, DIAMOND B: Autoimmune diseases. N Engl. I Med. (2001) 345:340–350.
  • CARSETTI R, KOHLER G, LAMERS MC: Transitional B cells are the target of negative selection in the B cell compartment. I Exp. Med. (1995) 181:2129–2140.
  • SCHNEIDER P, MACKAY F, STEINER Vet al.: BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J. Exp. Med (1999) 189:1747–1756.
  • SHU HB, HU WH, JOHNSON H: TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. Leukoc. Biol. (1999) 65:680–683.
  • MUKHOPADHYAY A, NI J, ZHAI Y, YU GL, AGGARWAL BB: Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase.J. Biol. Chem. (1999) 274:15978–15981.
  • MOORE PA, BELVEDERE O, ORR A et al.: BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science (1999) 285:260–263.
  • GROSS JA, JOHNSTON J, MUDRI S et al: TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature (2000) 404:995–999.
  • •First suggestion that elevated BAFF levels may be linked to autoimmunity, and demonstration that BAFF blockade is efficacious in a model of SLE.
  • LOCKSLEY RM, KILLEEN N, LENARDO The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell (2001) 104:487–501.
  • KARPUSAS M, CACHERO TG, QIAN Fet al: Crystal structure of extracellular hum an BAFF, a TNF family member that stimulates B lymphocytes. J. Ma Biol. (2002) 315:1145–1154.
  • OREN DA, LI Y, VOLOVIK Y et al.: Structural basis of BLyS receptor recognition. Nat. Smuct. Biol. (2002) 9:288–292.
  • LIU Y, XU L, OPALKA N, KAPPLERJ, SHU HB, ZHANG G: Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands. Cell (2002) 108:383–394.
  • HAHNE M, KATAOKA T, SCHROTER M et al.: APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. I Exp. Med. a(1998) 188:1185–1190.
  • NARDELLI B, BELVEDERE O, ROSCHKE V et al.: Synthesis and release of B-lymphocyte stimulator from myeloid cells. Blood(2001) 97:198–204.
  • KELLY K, MANOS E, JENSEN G, NADAULD L, JONES DA: APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death. Cancer Res. (2000) 60:1021–1027.
  • LOPEZ-FRAGA M, FERNANDEZ R, ALBAR JP, HAHNE M: Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase. EMBO Rep. (2001) 2:945–951.
  • THOMPSON JS, SCHNEIDER P, KALLED SL et al.: BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population. I Exp. Med. (2000) 192:129–135.
  • •First demonstration that BAFF blockade results in the loss of peripheral B cells.
  • SHU HB, JOHNSON H: B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1. Proc. Nati Acad. Sci. USA (2000) 97:9156–9161.
  • XIA XZ, TREANOR J, SENALDI G et al: TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation. Exp. Med. (2000) 192:137–143.
  • YAN M, MARSTERS SA, GREWAL IS, WANG H, ASHKENAZI A, DIXIT VM: Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity. Nat. Inman. (2000) 1:37–41.
  • THOMPSON JS, BIXLER SA, QIAN F et al.: BAFF-R, a newly identified TNF receptor that specifically interacts with BAH Science (2001) 293:2108–2111.
  • •First description of the BAFF receptor that is the primary mediator of BAFF survival function.
  • YAN M, BRADY JR, CHAN B et al.: Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency. Cum Biol. (2001) 11:1547–1552.
  • MARSTERS SA, YAN M, prrn PM, HAAS PE, DIXIT VM, ASHKENAZI A: Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Cum Biol. (2000) 10:785–788.
  • •First to show multiple receptors for BAFF which are shared with another TNF ligand, APRIL.
  • WU Y, BRESSETTE D, CARRELL JA et al.: Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS. I Biol. Chem. (2000) 275:35478–35485.
  • RENNERT P, SCHNEIDER P, CACHERO TG et al.: A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth. I Exp. Med. (2000) 192:1677–1684.
  • SMITH CA, FARRAH T, GOODWIN RG: The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell (1994) 76:959–962.
  • NAISMITH JH, SPRANG SR: Tumor necrosis factor receptor superfamily. Inflamm. (1995) 47:1–7.
  • BODMER JL, SCHNEIDER P, TSCHOPP J: The molecular architecture of the TNF superfamily. Trends Biochem. Sci. (2002) 27:19–26.
  • LAABI Y, GRAS MP, BROUET JC, BERGER R, LARSEN CJ, TSAPIS A: The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed. Nucleic Acids Res. (1994) 22:1147–1154.
  • GRAS MP, LAABI Y, LINARES-CRUZ G et al.: BCMAp: an integral membrane protein in the Golgi apparatus of human mature B lymphocytes. mt. Immunol. (1995) 7:1093–1106.
  • VON BULOW GU, BRAM RJ: NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily. Science (1997) 278:138–141.
  • BATTEN M, GROOM J, CACHERO TG et al: BAFF mediates survival of peripheral immature B lymphocytes. I Exp. Med. (2000) 192:1453–1466.
  • HSU BL, HARLESS SM, LINDSLEY RC, HILBERT DM, CANCRO MP: Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators. J. Immunol (2002) 168:5993–5996.
  • •Using RNA analysis, a differential pattern of expression of the three BAFF receptors during B cell development is demonstrated.
  • ROLINK AG, TSCHOPP J, SCHNEIDER P, MELCHERS F: BAFF is a survival and maturation factor for mouse B cells. Ear: I Immunol (2002) 32:2004–2010.
  • MACKAY F, WOODCOCK SA, LAWTON P et al.: Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J. Exp. Med. (1999) 190:1697–1710.
  • DO RK, HATADA E, LEE H, TOURIGNY MR, HILBERT D, CHEN-KIANG S: Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response. J. Exp. Med. (2000) 192:953–964.
  • AMANNA IJ, CLISE-DWYER K, NASHOLD FE, HOAG KA, HAYES CE: Cutting edge: A/WySnJ transitional B cells overexpress the chromosome 15 proapoptotic Blk gene and succumb to premature apoptosis. I Immunol (2001) 167:6069–6072.
  • SCHIEMANN B, GOMMERMAN JL, VORA K et al.: An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science (2001) 293:2111–2114.
  • •First description of BAFF knockout mice and demonstration that BAFF is essential for B cell development.
  • GROSS JA, DILLON SR, MUDRI S et al.: TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease: impaired B cell maturation in mice lacking BLyS. Immunity (2001) 15:289–302.
  • XU S, LAM KP: B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses. Mol. Biol. (2001) 21:4067–4074.
  • YAN M, WANG H, CHAN B et al.: Activation and accumulation of B cells in TACI-deficient mice. Nat. Immun. (2001) 2:638–643.
  • MILLER DJ, HAYES CE: Phenotypic and genetic characterization of a unique B lymphocyte deficiency in strain A/WySnJ mice. Eur. I Immunol. (1991) 21:1123–1130.
  • LITINSKIY MB, NARDELLI B, HILBERT DM et al.: DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat. Inman. (2002) 3:822–829.
  • ZENG D, LEE MK, TUNG J, BRENDOLAN A, STROBER S: Cutting edge: a role for CD1 in the pathogenesis of lupus in NZB/NZW mice. J. Immunol. (2000) 164:5000–5004.
  • GRIMALDI CM, MICHAEL DJ, DIAMOND B, CARSETTI R, KOHLER G, LAMERS MC: Cutting edge: expansion and activation of a population of autoreactive marginal zone B cells in a model of estrogen-induced lupus. J. Immunol. (2001) 167:1886–1890.
  • LI Y, LI H, WEIGERT M: Autoreactive B cells in the marginal zone that express dual receptors. J. Exp. Med. (2002) 195:181–188.
  • GROOM J, KALLED SL, CUTLER AH et al.: Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome. Clin. Invest. (2002) 109:59–68.
  • •Demonstrates a link between BAFF and SS.
  • ZHANG J, ROSCHKE V, BAKER KP et al.: Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus. Immunol. (2001) 166:6–10.
  • •The first description of elevated levels of BAFF in the sera of SLE patients and in the synovial fluid of RA patients.
  • CHEEMA GS, ROSCHKE V, HILBERT DM, STOHL W: Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases. Arthritic Rheum. (2001) 44:1313–1319.
  • BRIONES J, TIMMERMAN JM, HILBERT DM, LEVY R: BLyS and BLyS receptor expression in non-Hodgkin's lymphoma. Exp. Hematol. (2002) 30:135–141.
  • NOVAK AJ, BRAM RJ, KAY NE, JELINEK DF: Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukemia cells: a mechanism for survival. Blood(2002) 100:2973–2979.
  • HUARD B, SCHNEIDER P, MAURI D, TSCHOPP J, FRENCH LE: T cell costimulation by the TNF ligand BAFF. Immunol. (2001) 167:6225–6231.
  • WANG H, MARSTERS SA, BAKER T et al.: TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice. Nat. Immun. (2001) 2:632–637.
  • •The first demonstration that BAFF blockade is efficacious in a mouse arthritis model.
  • LAABI Y, GRAS MP, CARBONNEL F et al.: A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma. EMBO (1992) 11:3897–3904.
  • HATZOGLOU A, ROUSSEL J, BOURGEADE MF et al.: TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase. Immunol. (2000) 165:1322–1330.
  • YE H, ARRON JR, LAMOTHE B et al.: Distinct molecular mechanism for initiating TRAF6 signalling. Nature (2002) 418:443–447.
  • GRUMONT RJ, ROURKE IJ, O'REILLY LA et al.: B lymphocytes differentially use the Rel and nuclear factor kappaBl (NF-kappaBl) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells. Exp. Med. (1998) 187:663–674.
  • STRASSER A, WHITTINGHAM S, VAUX DL et al.: Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc. Natl. Acad. Sci. USA (1991) 88:8661–8665.
  • CARIAPPA A, PILLAI S: Antigen-dependent B-cell development. Curt: Opin. Immunol. (2002) 14:241–249.
  • WANG L, WOODCOCKS, LIU Z-Y, KALLED SL: The role of BAFF in B cell biology and autoimmunity. In: Immune Disorders. London (2002):SMI.
  • YU G, BOONE T, DELANEY J et al: APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Nat. Immun. (2000) 1:252–256.
  • FARRELL RJ: Crohn's disease: not all anti-TNFs are the same! Inflamm. Bowel Dis. (2002) 8:232–233.

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