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Review

Emerging molecular targets in the treatment of bacterial meningitis

Pages 141-152 | Published online: 02 Mar 2005

Bibliography

  • LEIB SL, TAUBER MG: Pathogenesis of bacterial meningitis. Infect. Dis. Cirri North Am. (1999) 13:527–548.
  • DAWSON KG, EMERSON JC, BURNS JL: Fifteen years of experience with bacterial meningitis. Pediatr. Infect. Dis. (1999) 18:816–822.
  • SCHELD WM, KOEDEL U, NATHAN B, PFISTER HW: Pathophysiology of bacterial meningitis: mechanism(s) of neuronal injury. j Infect. Dis. (2002) 186:S225–S233.
  • ••Current review on neuronal injuryassociated with bacterial meningitis.
  • KIM KS: E. colitranslocation of the blood-brain barrier. Infect. Immun. (2001) 69:5217–5222.
  • ••Current review on bacterial translocation ofthe blood-brain barrier.
  • NIZET V, KIM KS, STINS M, JONAS M,NGUYEN D, RUBENS CE: Invasion of brain microvascular endothelial cells by Group B streptococci. Infect. Immun. (1997) 65:5074–5081.
  • BADGER JL, STINS MF, KIM KS: Citrobacter freundli invades and replicates in human brain microvascular endothelial cells. Infect. Immun. (1999) 67:4208–4215.
  • KIM KS, WASS CA, CROSS AS: Blood-brain barrier permeability during the development of experimental bacterial meningitis in the rat. Exp. NeuroL (1997) 45:253–257.
  • STINS ME BADGER JL, KIM KS: Bacterial invasion and transcytosis in transfected human brain microvascular endothelial cells. Microb. Pathog. (2001) 30:19–28.
  • MARRA A, BRIGHAM D: Streptococcus prieumoniae causes experimental meningitis following intranasal and otitis media infections via a nonhematogenous route. Infect. Immun. (2001) 69:7318–7325.
  • DIETZMAN DE, FISCHER GW, SCHOENKNECHT FD: Neonatal Escherichia coil septicemia - bacterial counts in blood. j Pediatr. (1974) 85:128–130.
  • FOTHERGILL LD, WRIGHT J: Influenzalmeningitis: the relation of age incidence to the bactericidal power of blood against the causal organism. j ImmunoL (1933) 24:273.
  • •Seminal paper showing the importance of bactericidal antibodies in protection against H influenzae Type b infection.
  • JODAR L, FEAVERS IM, SALISBURY D, GRANOFF DM: Development of vaccines against meningococcal disease. Lancet (2002) 359:1499–1508.
  • •Current review of meningococcal vaccines.
  • ALEXANDER HE: Experimental basis for treatment of H influertme infections. Am. Dis. Child(1943) 66:160.
  • KIM KS: Efficacy of human immunoglobulin and penicillin G in treatment of experimental Group B streptococcal infection. Pediatr. Res. (1987) 21:289–292.
  • KIM KS, CROSS AS, SADOFF J: Monoclonal antibody to the 0-side chain of Escherichia colilipopolysaccharides enhances the efficacy of cefotaxime against experimental K1 Escherichia coil infection caused by a homologous 0 serotype. Serodiag. Immunotber. Infect. Dis. (1990) 4:95–99.
  • HUANG SH, WASS CA, FU Q, NEMANI PV, STINS M, KIM KS: E. coil invasion of brain microvascular endothelial cells in vivo: molecular cloning and characterization of E. coil invasion gene ibe10. Infect. In-mum. (1995) 63:4470–4475.
  • HUANG SH, CHEN YH, FU Q etal.: Identification and characterization of an E. coil invasion gene locus ibeB required for penetration of brain microvascular endothelial cells. Infect. Immun. (1999) 67:2103–2109.
  • WANG Y, HUANG SH, WASS C, KIM KS: The gene locus yijP contributes to E. coil K1 invasion of brain microvascular endothelial cells. Infect. Immun. (1999) 67:4751–4756.
  • BADGER J, WASS C, WEISSMAN S, KIM KS: Application of signature-tagged mutagenesis for the identification of E. coil K1 genes that contribute to invasion of the blood-brain barrier. Infect. hninurt. (2000) 68:5056–5061.
  • HOFFMAN JA, BADGER JL, ZHANG Y,HUANG SH, KIM KS: E. coli K1 aslA contributed to invasion of brain microvascular endothelial cells in vitro and In vivo. Infect. Immun. (2000) 68:5062–5067.
  • KHAN NA, WANG Y, KIM KJ, CHUNG JW, WASS CA, KIM KS: Cytotoxic necrotizing factor-1 contributes to Escherichia coil K1 invasion of the central nervous system. J. Biol. Chem. (2002) 277:15607–15612.
  • WANG Y, KIM KS: Role of OmpA and IbeB in Escherichia coil invasion of brain microvascular endothelial cells in vitro and In vivo. Pediatr. Res. (2002) 51:559–563.
  • RING A, WEISER JN, TUOMANEN El:Pneumococcal trafficking across the blood-brain barrier. Molecular analysis of a novel bi-directional pathway. J. Clin. Invest. (1998) 102:347–360.
  • GREIFFENBERG L, GOEBEL W, KIM KS et al: Interaction of Listeria monacytagenes with human brain microvascular endothelial cells: in 1B-dependent invasion, long-term intracellular growth, and spread from macrophages to endothelial cells. (1998) 66:5260–5267.
  • BRAUN L, GHEBREHI WET B, COSSART P: gClq-R/p32, a Clq-binding protein, is a receptor for the In1B invasion protein of Listeria monacytagenes. EMBO (2000) 19:1458–1466.
  • SHEN Y, NAUJOKAS M, PARK M, IRETON K: In1B-dependent internalization of Listeria is mediated by the met receptor tyrosine kinase. Cell (2000) 103:501–510.
  • UNKMEIR A, LATSCH K, DIETRICH G et al: Fibronectin mediates Opc-dependent internalization of Neisseria meningitidis in human brain microvascular endothelial cells. Mal. Microbial (2002) 46:933–946.
  • PRASADARAO NV, WASS CA, KIM KS: Endothelial cell GlcNAcI31-4G1cNAc epitopes for outer membrane protein A enhance traversal of Escherichia coil across the blood-brain barrier. Infect. Immun. (1996) 64:154–160.
  • PRASADARAO NV, WASS CA, HUANG SH, KIM KS: Identification and characterization of a novel Ibe 1 0 binding protein that contributes to Escherichia coil invasion of brain microvascular endothelial cells. Infect. Immun. (1999) 67:1131–1138.
  • CHUNG JW, KIM KJ, HONG SJ et al: 37 kDa lamina receptor precursor is the receptor for cytotoxic necrotizing factor 1. 102nd General Meeting of American Socio, for Microbiology (2002). Abstract B–51.
  • KHAN NA, CHUNG JW, ELLIOT SJ, KIM KJ, STINS ME KIM KS: Gp96 is a receptor for OmpA in human brain microvascular endothelial cells. 102nd General Meeting of the American Society for Microbiology (2002) . Abstract B–216.
  • STINS ME BADGER JL, KIM KS: Bacterial invasion and transcytosis in transfected human brain microvascular endothelial cells. Microb. Pathog. (2001) 30:19–28.
  • PRASADARAO NV, WASS CA, WEISER JN, STINS ME HUANG SH, KIM KS: Outer membrane protein A of Escherichia coil contributes to invasion of brain microvascular endothelial cells. Infect. Immun. (1996) 64:146–153.
  • REDDY MA, WASS CA, KIM KS, SCHLAEPFER DD, PRASADARAO NV: Involvement of focal adhesion kinases in E. coil invasion of human microvascular endothelial cells. Infect. Immun. (2000) 68:6419–6422.
  • REDDY MA, PRASADARAO NV, WASS CA, KIM KS: Phosphatidylinositol 3-kinase activation and interaction with focal adhesion kinase in E. colt K1 invasion of human brain microvascular endothelial cells. j Biol. Chem. (2000) 275:36769–36774.
  • DAS A, ASATRYAN L, REDDY MA et al:Differential role of cytosolic phospholipase A2 in the invasion of brain microvascular endothelial cells by Echerichia coil and Listeria monacytagenes. J. Infect. Dis. (2001) 184:732–737.
  • LEBEL MH, FREIJ BJ, SYROGIANNOPOULOS GA et al: Dexamethasone therapy for bacterial meningitis. N Engl. I Med. (1988) 319:964–1014.
  • WALD ER, KAPLAN SL, MASON EO et al.: Dexamethasone therapy for children with bacterial meningitis. Pediatrics (1995) 95:21–28.
  • BRAUN JS, NOVAK R, HERZOG KH, BODNER SM, CLEVELAND JL, TUOMANEN El: Neuroprotection by a caspase inhibitor in acute bacterial meningitis. Nature (1999) 5:298–302.
  • NAU R, SOTO A, BRUCK W: Apoptosis ofneurons in the dentate gyms in humans suffering from bacterial meningitis. Neuropathol. Exp. Neural (1999) 58:265–274.
  • PFISTER HW, FONTANA A, TAUBER MG, TOMASZ, SCHELD WM: Mechanisms of brain injury in bacterial meningitis: workshop summary. Clin. Infect. Dis. (1994) 19:463–479.
  • VAN FURTH AM, ROORD JJ, VAN FURTH R: Roles of proinflammatory and anti-inflammatory cytokines in pathology of bacterial meningitis and effect of adjunctive therapy. Infect. brim= (1996) 64:4883–4890.
  • TAUBER MG, MOSER B: Cytokines and chemokines in meningeal inflammation: biology and clinical implications. Clin. Infect. Dis. (1999) 28:1–12.
  • ZYSK G, BRUCK W, GERBER J, BRUCK Y, PRANGE HW, NAU R: Anti-inflammatory treatment influences neuronal apoptotic cell death in the dentate gyms in experimental pneumococcal meningitis. J. Neurapathol. Exp. Neural (1996) 55:722–728.
  • SAUKKONEN K, SANDE S, GIOFFE C et al: The role of cytokines in the generation of inflammation and tissue damage in experimental Gram-positive meningitis. Exp. Med. (1990) 171:439–448.
  • DIAB A, ABDALLA H, LI HL et al: Neutralization of macrophage inflammatory protein 2 (MIP-2) and MIP-la attenuates neutrophil recruitment in the central nervous system during experimental
  • TUOMANEN El, SAUKKONEN K, SANDE S, CIOFFE C, WRIGHT SD: Reduction of inflammation, tissue damage and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of
  • OSTERGAARD C, YIENG-KOW RV, BENFIELD T, FRIMODT-MOLLER N, ESPERSEN F, LUNDGREN JD: Inhibition of leukocyte entry into the brain by the interleukin-1 (IL-1) levels but increases IL-8 levels in cerebrospinal fluid during experimental pneumococcal meningitis in rabbits. Infect. Lion= (2000) 68:3153–3157.
  • TAUBER MG, BORSCHBERG U, SANDE MA: Influence of granulocytes on Infect. Dis. (1988) 157:456–464.
  • LESSE AJ, MOXON ER, ZWAHLEN A, pleocytosis and Haeinaphilus inhherizae Type b capsule on blood-brain barrier permeability during experimental meningitis in the rat. J. Clin. Invest. (1988) 82:102–109.
  • FISHBEIN DB, PALMER DL, PORTER KM, REED WP: Bacterial meningitis in the absence of CSF pleocytosis. Arch. Intern. Med. (1981) 141:1369–1372.
  • • bacterial meningitis. Infect. Inunun. (1999) 67:2590–2601.
  • LUKES SA, POSNER JB, NIELSEN S, ARMSTRONG D: Bacterial infections of the CNS in neutropenic patients. Neurology (1984) 34:269–275
  • MUSTAFA MM, RAMILO O, OLSEN IUD et al.: Tumor necrosis factor in mediating experimental Haeinaphilus irilluenzae Type b meningitis. I Clin. Invest. (1989) 84:1253–1259.
  • SAUKKONEN K, SANDE S, CIOFFE C et al.: The role of cytokines in the generation of inflammation and tissue damage in experimental Gram-positive meningitis. Exp. Med. (1990) 171:439–448.
  • KORNELISSE RF, SAVELKOUL HFJ, MULDER PHG et al: Interleukin-10 and soluble tumor necrosis factor receptors in cerebrospinal fluid of children with bacterial meningitis. I Infect. Dis. (1996) 173:1498–1502.
  • ICHIYAMA T, HAYASHI T, NISHIKAWA M, FURUKAWA S: Levels of transforming growth factor 131, tumor necrosis factor a, and interleukin 6 in cerebrospinal fluid: association with clinical outcome for children with bacterial meningitis. Clin. Infect. Dis. (1997) 25:328–329.
  • PARIS MM, HICKEY SM, TRUJILLO M, AHMED A, OLSEN K, MCCRACKEN GH Jr: The effect of interleukin-10 on meningeal inflammation in experimental bacterial meningitis. Infect. Dis. (1997) 176:1239–1246.
  • PFISTER HW, FREI K, OTTNAD B, KOEDEL U, TOMASZ A, FONTANA A: Transforming growth factor 32 inhibits cerebrovascular changes and brain edema formation in the tumor necrosis factor a-independent early phase of experimental pneumococcal meningitis. I Exp. Med. (1992) 176:265–268.
  • ZHANG GW, KHAN NA, KIM KJ, STINS M, KIM KS: TGF-I3 increases E. coil K1 adherence, invasion and transcytosis in human brain microvascular endothelial cells. Cell Tissue Res. (2002) 309:281–286.
  • LEIB SL, KIM YS, CHOW LL, SHELDON RA, TAUBER MG: Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to Group B streptococci. I Clin. Invest. (1996) 98:2632-2639. Highlights the role of ROS in neuronal injury associated with experimental Group B streptococcal meningitis.
  • AUER M, PFISTER LA, LEPPERT D, TAUBER MG, LEIB SL: Effects of clinically used antioxidants in experimental pneumococcal meningitis. I Infect. Dis. (2000) 182:347–350.
  • PFISTER KU: Protective effect of the antioxidant N-acetyl-L-cysteine in pneumococcal meningitis in the rat. Neurosci. Lett. (1997) 225:33–36.
  • LOEFFLER JM, RINGER R, HABLUTZEL M, TAUBER MG, LEIB SL: The free radical scavenger a-phenyl-tert-butyl nitrone aggravates hippocampal apoptosis and learning deficits in experimental pneumococcal meningitis. Infect. Dis. (2001) 183:247–252.
  • KOEDEL U, BERNATOWICZ A, PAUL R, FREI K, FONTANA A, PFISTER H: Experimental pneumococcal meningitis: cerebrovascular alterations, brain edema, and meningeal inflammation linked to the production of nitric oxide. Ann. Neural (1995) 37:313–323.
  • LEIB SL, KIM YS, BLACK SM, TUREEN JH, TAUBER MG: Inducible nitric oxide synthase and the effect of aminoguanidine in experimental neonatal meningitis. I Infect. Dis. (1998) 177:692–700.
  • KASTENBAUER S, KOEDEL U, BECKER BF, PFISTER HW: Pneumococcal meningitis in the rat: evaluation of peroxynitrite scavengers for adjunctive therapy. Eur. I Pharinacal. (2002) 449:177–181.
  • KOEDEL U, WINKLER E ANGELE B, FONTANA A, PFISTER H-W: Meningitis-associated central nervous system complications are mediated by the activation of poly (ADP-ribose) polymerase. I Cereb. Blood Flow Metab. (2002) 22:39–49.
  • PAUL R, LORENZI S, KOEDEL U et al.: Matrix metalloproteinases contribute to the blood-brain barrier disruption during bacterial meningitis. Ann. Neural (1998) 44:592–600.
  • LEPPERT D, LEIB SL, GRYGAR C, MILLER KM: Matrix metalloproteinase (MMP)-8 and MIV1P-9 in cerebrospinal fluid during bacterial meningitis: association with blood-brain barrier damage and neurological sequelae. Clin. Infect. Dis. (2000) 31:80–84.
  • LEIB SL, CLEMENTS JM, LINDBERG RLP et al.: Inhibition of matrix metalloproteinases and tumor necrosis factor-a converting enzyme as adjuvant therapy in pneumococcal meningitis. Brain (2001) 124:1734–1742.
  • •Highlights the roles of 1VEVIP and TACE in neuronal injury associated with experimental pneumococcal meningitis.
  • KIESEIER BC, PAUL R, KOEDEL U et al: Differential expression of matrix metalloproteinases in bacterial meningitis. Brain (1999) 122:1579–1587.
  • LEIB SL, LEPPERT D, CLEMENTS J, TAUBER MG: Matrix metalloproteinases contribute to brain damage in experimental pneumococcal meningitis. Infect. Immun. (2000) 68:615–620.
  • BOGDAN I, LEIB SL, BERGERON M, CHOW L, TAUBER MG: Tumor necrosis factor-a contributes to apoptosis in hippocampal neurons during experimental Group B streptococcal meningitis. I Infect. Dis. (1997) 176:693–697.
  • SPRANGER M, SCHWAB S, KREMPIEN S, WINTERHOLLER M, STEINER T: Excess glutamate levels in the cerebrospinal fluid predict clinical outcome of bacterial meningitis. Arch. Neural. (1996) 53:992–996.
  • PERRY VL, YOUNG RSK, AQUILA WJ, DURING MJ: Effect of experimental Escherichia coil meningitis on concentrations of excitatory and inhibitory amino acids in the rabbit brain: in viva microdialysis study. Pediatr Res. (1993) 34:187–198.
  • LEIB SL, KIM YS, FERRIERO DM, TAUBER MG: Neuroprotective effect of excitatory amino acid antagonist kynurenic acid in experimental bacterial meningitis. Infect. Dis. (1996) 173:166–171.
  • •Highlights the role of excitatory amino acids in neuronal injury associated with experimental Group B streptococcal meningitis.
  • PFISTER LA, TUREEN JH, SHAW S et al.: Endothelin inhibition improves cerebral blood flow and is neuroprotective in pneumococcal meningitis. Ann. Neural. (2000) 47:329–335.
  • KOEDEL U, GORRIZ C, LORENZL S, PFISTER HW: Increased endothelin levels in cerebrospinal fluid samples from adults with bacterial meningitis. Chi]. Infect. Dis. (1997) 25:329–330.
  • HOFFMANN O, KEILWORTH N, BILLE MB etal.: Triptans reduce the inflammatory response in bacterial meningitis. j Cereb. Blood Flaw Metab. (2002) 22:988–996.
  • KOEDEL U, BAYERLEIN I, PAUL R, SPORER B, PFISTER HW: Pharmacologic interference with NF-1c13 activation attenuates central nervous system complications in experimental pneumococcal meningitis. j Infect. Dis. (2000) 182:1437–45.
  • KOEDEL U, WINKLER F, ANGELE B, FONTANA A, FLAVELL RA, PFISTER H-W: Role of caspase-1 in experimental pneumococcal meningitis: evidence from pharmacologic caspase inhibition and caspase-l-deficient mice. Ann. Neural (2001) 51:319–329.

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