Bibliography
- MANGELSDORF DJ, EVANS PM: The RXR heterodimers and orphan receptors. Cell (1995) 83:841–850.
- KLIEWER SA, MOORE JT, WADE L et al.: An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell (1998) 92:73–82.
- LEHMANN JM, MCKEE DD, WATSON MA, WILLSON TM, MOORE JT, KLIEWER SA: The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. Clin. Invest. (1998) 102:1016–1023.
- BERTILSSON G, HEIDRICH J, SVENSSON K et al.: Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc. Natl. Acad. Sci. USA (1998) 95:12208–12213.
- BLUMBERG B, SABBAGH W Jr, JUGUILON H et al: SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev. (1998) 12:3195–3205.
- XIE W, EVANS RM: Orphan nuclear receptors: the exotics of xenobiotics. J. Biol. Chem. (2001) 276:37739–37742.
- KLIEWER SA, GOODWIN B, WILLSON TM: The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Endocc Rev (2002) 23:687–702.
- •A comprehensive review on PXR and its role in xenobiotic metabolism.
- ZHANG H, LECULYSE E, LIU L et al.: Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation. Arch. Biochem. Biophys. (1999) 368:14–22.
- DOTZLAW H, LEYGUE E, WATSON P, MURPHY LC: The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue. Clin. Cancer Res. (1999) 5:2103–2107.
- JONES SA, MOORE LB, SHENK JL et al: The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Ma Endocrinol (2000) 14:27–39.
- MOORE LB, PARKS DJ, JONES SA et al.: Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. Biol. Chem. (2000) 275:15122–15127.
- STAUDINGER JL, GOODWIN B, JONES SA et al.: The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc. Natl. Acad. Sd. USA (2001) 98:3369–3374.
- XIE W, RADOMINSKA-PANDYA A, SHI Yet al: An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc Natl. Acad. Sd. USA (2001) 98:3375–3380.
- DUSSAULT I, Y00 HD, LIN M et al: Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance. Proc. Natl. Acad. Sci. USA (2003) 100:833–838.
- GOODWIN B, GAUTHIER KC, UMETANI M et aL: Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor. Proc. Natl. Acad. Sci. USA (2003) 100:223–228.
- •This paper describes the fact that bile acid intermediates act as endogenous ligands for PXR.
- DUSSAULT I, LIN M, HOLLISTER K, WANG EH, SYNOLD TW, FORMAN BM: Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR. Biol. Chem. (2001) 276:33309–33312.
- XIE W, BARWICK JL, DOWNES M et al.: Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature (2000) 406:435–439.
- •This paper reports the creation of the 'humanised' hPXR transgenic mice that may aid the development of safer drugs.
- WATKINS RE, WISELY GB, MOORE LB et al: The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science (2001) 292:2329–2333.
- SYN OLD TW, DUSSAULT I, FORMAN BM: The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat. Med. (2001) 7:584–590.
- GILLESPIE DA, VICKERS CR: Pruritus and cholestasis: therapeutic options. Castroenterol Hepatol (1993) 8:168–173.
- CANCADO EL, LEITAO PM, CARRILHO FJ, LAUDANNA AA: Unexpected clinical remission of cholestasis after rifampicin therapy in patients with normal or slightly increased levels of 7-glutamyl transpeptidase. Am.! Castroenterol. (1998) 93:1510–1517.
- BERGINER VM, SALEN G, SHEFER S: Cerebrotendinous xanthomatosis. Neurol. Clin. (1989) 7:55–74.
- ROSEN H, RESHEF A, MAEDA N et al.: Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene. Biol. Chem. (1998) 273:14805–14812.
- REPA JJ, LUND EG, HORTON JD et al.:Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding. J. Biol. Chem. (2000) 275:39685–39692.
- TABB MM, SUN A, ZHOU C et al.: Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR. Biol. Chem. (2003) 278:43919–43927.
- WILLY PJ, UMESONO K, ONG ES, EVANS PM, HEYMAN RA, MANGELSDORF DJ: LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev. (1995) 9:1033–1045.
- PEET DJ, JANOWSKI BA, MANGELSDORF DJ: The LXRs: a new class of oxysterol receptors. Carr: Opin. Genet. Dev. (1998) 8:571–575.
- CHINETTI G, LESTAVEL S, BOCHER Vet al.: PPAR-a and PPAR-y activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat. Med. (2001) 7:53–58.
- LAFFITTE BA, JOSEPH SB, WALCZAK R et al.: Autoregulation of the human liver X receptor a promoter. Mol. Cell. Biol. (2001) 21:7558–7568.
- JOSEPH SB, MCKILLIGIN E, PEI L et al.:Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc. Nati Acad. Sci. USA (2002) 99:7604–7609.
- •This paper provides evidence that LXR ligands could be used as atheroprotective agents.
- TANGIRALA RK, BISCHOFF ED, JOSEPH SB et al.: Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc. Nati Acad. St". USA (2002) 99:11896–11901.
- MILLATT LJ, BOCHER V, FRUCHART JC, STAELS B: Liver X receptors and the control of cholesterol homeostasis: potential therapeutic targets for the treatment of atherosclerosis. Biochim. Biophys. Acta (2003) 1631:107–118.
- PEET DJ, TURLEY SD, MAW et al.: Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR a. Cell (1998) 93:693–704.
- REPA JJ, TURLEY SD, LOBACCARO JAet al.: Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science (2000) 289:1524–1529.
- JOSEPH SB, CASTRILLO A, LAFFITTE BA, MANGELSDORF DJ, TONTONOZ P: Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat. Med. (2003) 9:213–219.
- ZAGHINI I, LANDRIERJF, GROBER Jet al.: Sterol regulatory element-binding protein- lc is responsible for cholesterol regulation of ileal bile acid-binding protein gene M vivo. Possible involvement of liver-X-receptor. Biol. Chem. (2002) 277:1324–1331.
- SCHULTZ JR, TU H, LUK A et al.: Role of LXRa in control of lipogenesis. Genes Dev. (2000) 14:2831–2838.
- CHISHOLM JW, HONG J, MILLS SA, LAWN PM: The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. Lipid Res. (2003) 44:2039–2048.
- JANOWSKI BA, GROGAN MJ, JONES SA et al.: Structural requirements of ligands for the oxysterol liver X receptors LXRa and LXRP. Proc. Nati Acad. Sci. USA (1999) 96:266–271.
- SPARROW CP, BAFFIC J, LAM MH et al.: A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux. J. Biol. Chem. (2002) 277:10021–10027.
- KANEKO E, MATSUDA M, YAMADA Y, TACHIBANA Y, SHIM OMURA I, MAKISHIMA M: Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist. Biol. Chem. (2003) 278:36091–36098.
- BRAMLETT KS, HOUCK KA, BORCHERT KM et al.: A natural product ligand of the oxysterol receptor, liver X receptor. Pharmacol. Exp. The]: (2003) 307:291–296.
- FARNEGARDH M, BONN T, SUN S et al.: The three-dimensional structure of the liver X receptor 13 reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands. J. Biol. Chem. (2003) 278:38821–38828.
- YOSHIKAWA T, SHIMANO H, YAHAGI N et al.: Polyunsaturated fatty acids suppress sterol regulatory element-binding protein lc promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements. Biol. Chem. (2002) 277:1705–1711.
- SONG C, HIIPAKKA RA, LIAO S: Auto-oxidized cholesterol sulfates are antagonistic ligands of liver X receptors: implications for the development and treatment of atherosclerosis. Steroids (2001) 66:473–479.
- FORMAN BM, RUAN B, CHEN J, SCHROEPFER GJ Jr, EVANS RM: The orphan nuclear receptor LXRa is positively and negatively regulated by distinct products of mevalonate metabolism. Proc. Nati Acad. Sci USA (1997) 94:10588–10593.
- XIE W, YEUH ME RADOMINSKA-PANDYA A et al.: Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. Proc. Nati Acad. St". USA (2003) 100:4150–4155.
- •Evidence showing that activation of PXR is sufficient to promote bilirubin detoxification.
- MUSCAT GE, WAGNER BL, HOU J et al.: Regulation of cholesterol homeostasis and lipid metabolism in skeletal muscle by liver X receptors. Biol. Chem. (2002) 277:40722–40728.