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Meeting Report

B cells and autoimmunity 2004: new concepts and therapeutic perspectives

, &
Pages 195-200 | Published online: 22 Apr 2005

Bibliography

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  • ••In anti-DNA heavy chain transgenicmice, autoreactive B cells often coexpress lambdal and a kappa chain that prevents autoreactivity. The authors propose that such isotypically included cells have a feature that may lead to self-tolerance.
  • WARDEMANN H, HAMMERSEN J, NUSSENZWEIG MC: Human autoantibody silencing by immunoglobulin light chains. J. Exp. Med. (2004) 200(2):191–199.
  • CARROLL MC: Opinion: a protective role for innate immunity in systemic lupus erythematosus. Nat. Rev Immunol. (2004) 4(10):825–831.
  • •This review argues that complement provides protection against autoreactivity by facilitating the rapid removal of apoptotic debris to circumvent an autoimmune response.
  • MARTIN DA, ELKON KB: Mechanisms of apoptosis. Rheum. Dis. Clin. North Am. (2004) 30(3)441-454,vii.
  • VIGLIANTI GA, LAU CM, HANLEY TM et al.: Activation of autoreactive B cells by CpG dsDNA. Immunity (2003) 19(6):837–847.
  • •This work implicates hypomethylated CpG motifs as ligand elements necessary for the initiation of systemic autoimmune disease.
  • PEEVA E, MICHAEL D, CLEARY J et al.: Prolactin modulates the naive B cell repertoire. J. Clin. Invest. (2003) 111(2):275–283.
  • ZOUALI M, SARMAY G: B lymphocyte signalling pathways in systemic autoimmunity: implications for pathogenesis and treatment. Arthritis Rheumatism (2004) 50:2730–2741.
  • •A thorough review of abnormalities of signalling pathways in autoimmunity.
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  • OKAZAKI T, TANAKA Y, NISHIO R et al.: Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice. Nat. Med. (2003) 9(12):1477–1483.
  • ••Mice deficient in the programmedcell death-1 (PD-1) immunoinhibitory coreceptor develop autoimmune dilated cardiomyopathy. This work suggests that autoantibodies against cardiac troponin I, a heart-specific 30-kDa protein, are responsible for heart dysfunction and dilatation by chronic stimulation of Ca2'.
  • NG LG, SUTHERLAND AP, NEWTON R et al.: B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J. Immunol (2004) 173(2):807–817.
  • •These studies reveal that BAFF-R is Important not only for splenic B cell maturation, but is the major mediator of BAFF-dependent costimulatory responses in peripheral B and T cells.
  • FAVA RA, NOTIDIS E, HUNT J et al: A role for the lymphotoxin/LIGHT axis in the pathogenesis of murine collagen-induced arthritis. J. Immunol (2003) 171(1):115–126.
  • MOSER B, WOLF M, WALZ A, LOETSCHER P: Chemokines: multiple levels of leukocyte migration control. Trends Immunol (2004) 25(2):75–84.
  • BALABANIAN K, COUDERC J, BOUCHET-DELBOS L et al: Role of the chemokine stromal cell-derived factor 1 in autoantibody production and nephritis in murine lupus. I Immunol (2003) 170(6):3392–3400.
  • HOYER BF, MOSER K, HAUSER AE et al.: Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W mice. Exp Med. (2004) 199(11):1577–1584.
  • ••This paper shows that 40% of(auto)antibody-secreting cells in the spleens of NZB x NZW Fl are nondividing, long-lived plasma cells with a half-life of over 6 months, suggesting that long-lived, autoreactive plasma cells are a relevant target for therapy for autoimmune diseases.
  • KAZKAZ H, ISENBERG D: Anti B cell therapy (rltuximab) in the treatment of autoimmune diseases. Curr. Opin. Pharmacol (2004) 4(4):398–402.
  • TAKEMURA S, KLIMIUK PA, BRAUN A, GORONZY JJ, WEYAND CM: T cell activation in rheumatoid synovium is B cell dependent. Immunol (2001) 167(8):4710–4718
  • •This article shows the central role of B cells in synovial inflammation and identifies them as excellent targets for immunosuppressive therapy.
  • NICOLO D, MONESTIER M: Antiphospholipid antibodies and atherosclerosis. Clin. Immunol (2004) 112(2):l83–l89.
  • •The authors propose that some antiphospholipid antibodies may exhibit a beneficial role in atherosclerosis.

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