76
Views
8
CrossRef citations to date
0
Altmetric
Review

Targets for antiageing drugs

Pages 77-82 | Published online: 22 Apr 2005

Bibliography

  • HOLLIDAY R: The close relationship between biological aging and age-associated pathologies in humans. J. Cerontol Biol. Sci. (2004) 59A:543–546.
  • HAYFLICK L: The not-so-close relationship between biological aging and age-associated pathologies in humans. Cerontol Biol. Sci. (2004) 59A:547–550.
  • MASORO EJ: Challenges of biological aging. Springer Publication Co. (1999).
  • •A clear, simple, but exhaustive review of the biological mechanisms of ageing.
  • WEINDRUCH R, SOHAL RJ: Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging. N Eng]. J. Med. (1997) 337:986–994.
  • SHOCK NW: The science of gerontology. In: Proceeding of Seminars 1959–1961. Jeffers EC, Durham NC (Eds), Council on Gerontology, Duke University Press (1962).
  • SHOMALI ME: The use of anti-aging hormones. Melatonin, growth hormone, testosterone, dehydroepiandrosterone: consumer enthusiasm for unproven therapies. Md. Med. J. (1997) 46:181–186.
  • BERGAMINI E, CAVALLINI G, DONATI A, GORI Z: The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases. Int. Biochein. Cell Biol. (2004) 36:2392–2404.
  • •The most recent and exhaustive review on the role of macroautophagy as a cell repair antiageing mechanism. Includes experimental data on the beneficial antiageing effects of life-long stimulation of autophagy.
  • PARENTINI I, CAVALLINI G, DONATI A, GORI Z, BERGAMINI E: The accumulation of dolichol in older tissues satisfies the proposed criteria to be qualified a biomarker of aging. J. Cerontol. Biol. Sci. (2004). In press.
  • VAN REMMEN H, IKENO Y, HAMILTON M et al.: Life-long reduction in MnSOD activity results in an increased DNA damage and higher incidence of cancer but does not accelerate aging. Physic] Cenoinics (2003) 16:29–37.
  • BERGAMINI E, BIZZARRI R, CAVALLINI G et al: Ageing and oxidative stress: a role for dolichol in the antioxidant machinery of cell membranes? J. Alzheimer Dis. (2004) 6:129–135.
  • •This review may help to understand the relevance of lipophylic antioxidants to the process of ageing and their respective roles.
  • TAMBURINI I, QUARTACCI M, IZZO R, BERGAMINI E: Effects of caloric restriction on age-related changes in the phospholipid fatty acid composition of various rat tissues. Aging (2004). In press.
  • YOUDIM KA, DEANS SG: Beneficial effects of thyme oil on age-related changes in phospholipid C20 and C22 polyunsaturated fatty acid composition of various rat tissues. Biochiin. Biophys. Acta (1999) 1438:140–146.
  • HASNIS E, REZNICK AZ: Antioxidants and healthy aging. Isr. Med. Ass. j (2003) 5:368–370.
  • MEYDANI M: Nutrition interventions in aging and age-associated diseases. Ann. N Y Acad. Sci. (2001) 928:226–235.
  • YU BP, KANG CM, HAN JS, KIM DS: Can antioxidant supplementation slow the aging process? Biofactors (1998) 7:93–101.
  • WARD JA: Should antioxidant vitamins be routinely recommended for older people? Drugs Aging (1998) 12:169–175.
  • BERGAMINI E, CAVALLINI G, DONATI A, GORI G: The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically. Biomed. Pharmacother. (2003) 57:203–208.
  • RAVIKUMAR B, VACHER C, BERGER Z et al.: Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington's disease. Nat. Genet. (2004) 36:585–595.
  • •The first experimental evidence showing that stimulation of autophagy may help to prevent neurodegenerative diseases.
  • INGRAM DK, ANSON RIVI, DE CABO R et al: Development of calorie restriction mimeticsas a prolongevitystrategy. Ann. NY Acad. ScL (2004) 1019:412–423.
  • •This review substantiates calorie restriction as an effective antiageing strategy for humans and focuses on identifying compounds that mimic calorie restriction effects.
  • KARP G: In: Cell and Molecular Biology Ord Edn I John Wiley & Sons, NY (2002):572–575.
  • MILLER RA: Gerontology as oncology. Research on aging as the key to the understanding of cancer. Cancer (1991) 68(11 Suppl.):2496–2501.
  • SOHAL RS, AGARWAL S, CANDAS M et al.: Effect of age and calorie restriction on DNA oxidative damage in different tissues of C57BL/6 mice. Mech. Ageing Dev. (1994) 76:215–224.
  • TSAO JL, DUDLEY S, KWOK B et al: Diet, cancer and aging in DNA mismatch repair deficient mice. Carcinogenesis (2002) 23:1807–1810.
  • GEDIK CM, GRANT G, MORRICE PCet al.: Effects of age and dietary restriction on oxidative NA damage, antioxidant protection and DNA repair in rats. Eur. j Nutr. (2004) Epub ahead of print.
  • CAMPANINI C, PETRONINI PG, ALFIERI R, BORGHETTI AF: Decreased expression of heat shock protein 70 A and protein in WI-38 human fibroblasts aging in vitro. Ann. N Y Acad. Li. (1992) 663:442–443.
  • KELLER G, DIMAUGA E, CHEN Q ET AL.: Autophagy, proteasomes, lipofuscin and oxidative stress in the aging brain. Int. J. Biochem. Cell Biol. (2004) 36:2376–2391.
  • KWAK MK, WAKABAYASHI N, GREENLAW JL, YAMAMOTO M, KENSLER TW: Antioxidants enhance mammalian proteasome expression through the Keap 1 -Nrf2 signaling pathway. Mol. Cell. Biol. (2003) 23:8786–8794.
  • ADAMS J, KAUFMANN M: Developmentof the proteasome inhibitor Velcade (Bortezomib) Cancer Invest. (2004) 22:304–311.
  • MCNAUGHT KS, PERL DP, BROWNELL AL, OLANOW CW: Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann. Neurol (2004) 56:149–162.
  • CUERVO AM, DICE JF: Age-related decline in chaperone mediated autophagy. J.Biol. Chem. (2000) 275:31505–31513.
  • WANG CW, KLIONSKY DJ: The molecular mechanism of autophagy. Mol Med. (2003) 9:65–76.
  • KANAZAWA T, TANEIKE I, AKAISHI R et al.: Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes. Biol. Chem. (2004) 279:8452–8459.
  • SALMINEN A, VIHKO V: Autophagic response to strenuous exercise in mouse skeletal muscle fibers. Virchows Arch. B Cell. Biol. Ina Mol Pathol (1984) 45:97–106.
  • SALAS M, TUCHWEBER B, KOUROUNAKIS P: Liver ultrastructure during acute stress. Pathol. Res. Pract. (1980) 167:217–233.
  • BERGAMINI E, DEL ROSO A, FIERABRACCI V et al: A new method for the investigation of endocrine-regulated autophagy and protein degradation in rat liver. Exp. Mol Pathol. (1993) 59:13–22.
  • •This paper describes how to induce macrophagy by the administration of antilipolytic drugs.
  • DONATI A, CAVALLINI G, CARRESI C et al: Antiaging effects of antilipolytic drugs. Exp. Gerontol. (2004) 39:1061–1067.
  • BLUEHER M, KAHN BB, KAHN CR: Extended longevity in mice lacking the insulin receptor in the adipose tissue. Science (2003) 299:572–574.
  • COUZIN J: Research on aging: gene links calorie deprivation and long life in rodents. Science (2004) 304:1731.
  • WEISBURGER JH: Antimutagens, anticarcinogens, and effective worldwide cancer prevention. Environ. Pathol. Toxicol. Oncol (1999) 18:85–93.
  • DAVIDSON LA, NGUYEN DV, HOKANSON RM et al: Chemopreventive n -3 Polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat. Cancer Res. (2004) 64:6797–6803.
  • MARGOLIS S: The Johns Hopkins Medical Guide after 50. Rebus, NY (2002).
  • HURSTING SD, LAVIGNE JA, BERRIGAN D, PERKINS SN, BARRETT JC: Calorie restriction, aging, and cancer prevention: mechanisms of action andapplicability to humans. Ann. Rev. Med. (2003) 54:131–152.
  • •This review describes the key biological mechanisms underlying many of the beneficial effects of calorie restriction, with a particular focus on the insulin-like growth factor-1 pathway.
  • GRUNE T, JUNG T, MERKER K, DAVIES KJ: Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease. Int. .1 Biochem. Cell Biol. (2004) 36:2519–2530.
  • ANDERSEN JK: Oxidative stress in neurodegeneration: cause or consequence? Nat. Med. (2004) 10(Suppl.):518–525.
  • MITCHISON HM, LIM MJ, COOPER JD: Selectivity and types of cell death in the neuronal ceroid lipofuscinoses Brain. Pathol. (2004) 14:86–96.
  • HUANG X, MOIR RD, TANZI RE, BUSH Al, ROGERS JT: Redox-active metals, oxidative stress, and Alzheimer's disease pathology. Ann. N Y Acad. ScL (2004) 1012:153–163.
  • •The redox interactions between Abeta, APP and metals are discussed, and shown to be at the heart of a pathological positive feedback system, wherein Abeta amyloidosis and oxidative stress promote each other.
  • STEVENS A, LOWE J: Pathology (2nd Edn). Mosby, NY (2000).
  • PALLOTTINI V, MARINO M, CAVALLINI G, BERGAMINI E, TRENTALANCE A: Age-related changes of isoprenoid biosynthesis in rat liver and brain. Biogerontology (2003) 4:371–378.
  • PALLOTTINI V, PASCOLINI A, CAVALLINI G et al.: ROS influence on HMGCoA reductase: a study of the key enzyme of cholesterologenesis. Proceedings SIF Congress. Pisa, October (2004).
  • THOLSTRUP T, HELLGREN LI, PETERSEN M et al.: A solid dietary fat containing fish oil redistributes lipoprotein subclasses without increasing oxidative stress in men. J. Nutr. (2004) 134:1051–1057.
  • BAVEELAR FJ, BEYNEN AC: Severity of atherosclerosis in parrots in relation to intake of alpha-linolenic acid. Avian Dis. (2003) 47:566–577.
  • HIRAFUJI M, MACHIDA T, HAMAUE N, MINAMI M: Cardiovascular protective effects of n-3 polyunsaturated fatty acids with special emphasis on docosahexaenoic acid. J. Phannacol Sci. (2003) 92:308–316.
  • KROMHOUT D, BOSSCHIETER EB, DE LEZENNE COULANDER C: The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N Engl. J. Med. (1985) 312:1205–1209.
  • MUNTEANU A, ZINGG JM, AZZI A: Anti-atherosclerotic effects of vitamin E - myth or reality?' Cell Mol. Biol. (2004) 8:59–76.
  • NAPOLI C, WILLIAMS-IGNARRO S, DE NIGRIS F et al: Long-term combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice. Proc. Natl. Acad. Sci. USA (2004) 101:8797–8802.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.