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Review

Oestrogen functions in skin and skin appendages

Pages 617-629 | Published online: 10 Jun 2005

Bibliography

  • PAYNE AH, HALES DB: Overview of Steroidogenic Enzymes in the Pathway from Cholesterol to Active Steroid Hormones. Endocr. Rev.(2004) 25:947–970
  • SIMPSON ER: Genetic mutations resulting in estrogen insufficiency in the male. Ma. Endocrinol (1998) 145.55–59
  • LABRIE F: Adrenal androgens and intracrinology. Smith. Reprod. Med. (2004) 22:299–309
  • THORNTON JW: Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions. PNAS (2001) 98:5671–5676
  • THORNTON JW, NEED E, CREWS D: Resurrecting the ancestral steroid receptor origin of estrogen signalling. Science (2003) 301:1714–1717
  • GUSTAFSSON JA: An update on estrogen receptors. &min. Perinatol. (2000) 24:66–69.
  • ENMARK E, PELTO-HUIKKO M, GRANDIEN K et al.: Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern. ./. Clin. Endocrinol Metab. (1997) 82:4258–4265.
  • KUIPER GG, CARLSSON B, GRANDIEN K et al.: Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors a and 0. Endocrinol (1997) 138:863–870.
  • COUSE JF, LINDZEY J, GRANDIEN K, GUSTAFSSON JA, KORACH KS: Tissue distribution and quantitative analysis of estrogen receptor-a (ERa) and estrogen receptor-I3 (ERI3) messenger ribonucleic acid in the wild-type ERa-knockout mouse. Endocrinol (1997) 138:4613–4621.
  • BRANDENBERGER AW, TEE MK, LEE JY, CHAO V, JAFFE RB: Tissue distribution of estrogen receptors alpha (ER-alpha) and beta (ER-beta) mRNA in the midgestational human fetus. I Chit. Endocrinol Metab. (1997) 82:3509–3512.
  • TAYLOR AH, AL- AZZAWI F: Immunolocalisation of oestrogen receptor beta in human tissues. J. Mol. Endocrinol. (2000) 24:145–155.
  • SAUNDERS PTK, MAGUIRE SM, GAUGHAN J, MILLAR MR: Expression of oestrogen receptor beta (ERbeta) in multiple rat tissues visualised by immunohistochemistry. I Enclacrina (1998) 154:R13–R16.
  • THORNTON MJ, TAYLOR AH, MULLIGAN K et al: The distribution of estrogen receptor beta (ERI3) is distinct to that of ER alpha and the androgen receptor in human skin and the pilosebaceous unit. Investig. Dermatol Symp. Proc. (2003) 8:100–103
  • THORNTON MJ, TAYLOR AH, MULLIGAN K et al.: Estrogen receptor beta (ERI3) is the predominant estrogen receptor in human scalp. Exp. Dermatol (2003) 12:181–190
  • PELLETIER G: Localization of androgenand estrogen receptors in rat and primate tissues. Histol Histopathol (2000) 15:1261–1270
  • PELLETIER G AND REN L: Localization of sex steroid receptors in human skin. Histol. Histopathol (2004) 19:629–636
  • KLINGE CM: Estrogen receptor interaction with estrogen response elements. Nucleic Acids Res. (2001) 29:2905–2019
  • PAECH K, WEBB P, KUIPER GG et al.: Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Science (1997) 277:1508–1510.
  • KUSHNER PJ, AGARD DA, GREENE GL et al.: Estrogen receptor pathways to AP-1.J. Steroid Biochem. Mol. Biol. (2000) 74:311–317
  • COWLEY SM, HOARE S, MOSSELMAN S, PARKER MG: Estrogen receptors a and 13 form heterodimers on DNA. I Biol. Chem. (1997) 272:19858–19862.
  • SMITH CL, O'MALLEY BW: Coregulator function: a key to understanding tissue specificity of selective receptor modulators. Endocr. Rev (2004) 25:45–71
  • CONDON JC, JEYASURIA P, FAUST JM, WILSON JW, MENDELSON CR: A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonise progesterone receptor function and contribute to the initiation of parturition. Proc. Natl. Acad. Sci. USA (2003) 100:9518–9523
  • LEVIN ER: Cellular functions of plasma membrane estrogen receptors. Steroids (2002) 67:471–475.
  • NADAL A, ROPERO AB, FUENTES E, SORIA B: The plasma membrane estrogen receptor: nuclear or unclear? Trends Pharm. Sci. (2001) 22:597–599
  • ARONICA SM, KRAUS WL, KATZENELLENBOGEN BS: Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription. Proc. Nati Acad. Sci. USA (1994) 91:8517–8521
  • LIEBERHERR M, GROSSE B, KACHKACHE M, BALSAN S: Cell signaling and estrogens in female rat osteoblasts: a possible involvement of unconventional nonnuclear receptors. J. Bone Mineral Res. (1993) 8:1365–1376
  • MARINO M, ACCONCIA F, BRESCIANI F, WEISZ A, TRENTALANCE A: Distinct nongenomic signal transduction pathways controlled by 17beta-estradiol regulate DNA synthesis and cyclin D(1) gene transcription in HepG2 cells. Moi Biol. Cell. (2002) 13:3720–3729.
  • RUSSEL KS, HAYNES MP, SINHA D, CLERISME E, BENDER JR: Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signalling. Proc. Nati Acad. Sci. USA (2000) 97:5930–5935.
  • SHAUL PW: Rapid activation of endothelial nitric oxide synthase by estrogen. Steroids (1999) 64:28–34.
  • PAPPAS TC, GAMETCHU B, WATSON CS: Membrane estrogen receptors identified by multiple antibody labelling and impeded-ligand binding. FASEB J. (1995) 9:404–410.
  • RAZANDI M, PEDRAM A, GREENE GL, LEVIN ER: Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells. Mol. Endocrinol. (1999) 13:307–319
  • BENTEN WPM, STEPHAN C, LIEBERHERR M, WUNDERLICH F: Estradiol signalling via sequestrable surface receptors. Endocrinol (2001) 142:1669–1677.
  • BRINCAT MP: Hormone replacement therapy and the skin. Maturitas (2000) 29:107–117.
  • SATOR PG, SCHMIDT JB, RABE T, ZOUBOULIS CC. Skin aging and sex hormones in women - clinical perspectives for intervention by hormone replacement therapy. Exp. Dermatol. (2004) 13\(Suppl. 4):36–40.
  • SHAH MG, MAIBACH HI. Estrogen and skin. An overview. Am. J. Clin. Dermatol (2001) 2:143–150.
  • THORNTON MJ: The biological actions of estrogens on skin. Exp. Dermatol (2002) 11:487–502.
  • ASHCROFT GS, ASHWORTH JJ: Potential role of estrogens in wound healing. Am. J. Clin. Dermatol (2003) 4:737–743.
  • BOYD AS, MORRIS LF, PHILLIPS CM, MENTER MA: Psoriasis and pregnancy: hormone and immune system interaction. Int. J. Dermatol (1996) 35:169–172.
  • RAYCHAUDHURI SP, NAVARE T, GROSS J, RAYCHAUDHURI SK: Clinical course of psoriasis during pregnancy. Int. Dermatol (2003) 42:518–520.
  • DUNNA SF, FINLAY AY: Psoriasis: improvement during and worsening after pregnancy. BE J. Dermatol (1989) 120:584.
  • TSUKAHARA K, MORIWAKI S, OHUCHI A, FUJIMURA T, TAKEMA Y: Ovariectomy accelerates photoaging of rat skin. Photochem. Photobiol (2001) 73:525–531.
  • WEINSTOCK MA: Epidemiologic investigation of non melanoma skin cancer mortality: the Rhode Island Follow-Back Study. J. Invest. Dermatol (1994) 102:6S–9S.
  • MILLER JG, MAC NEIL S: Gender and cutaneous melanoma. BE J. Dermatol (1997) 136:657–665.
  • UZUKA M, NAKAJIMA K, MORI Y: Estrogen receptor in the mouse skin. Biochem. Biophys. Acta. (1978) 544:329–337.
  • HASSELQUIST MB, GOLDBERG N, SCHROETER A, SPELSBERG TC: Isolation and characterisation of the estrogen receptor in human skin. ./. Clin. Endocrinol Metab. (1980) 50:76–82
  • PUNNONEN R, LOVGRENT, KOUVONEN I: Demonstration of estrogen receptors in the skin. Endocrinol Invest. (1980) 3:217–221.
  • STUMPF WE, SAR M, JOSHI SG: Estrogen target cells in the skin. Experientia (1974) 30:196–198.
  • BIDMON HJ, PITTS JD, SOLOMON HF, BONDI JV, STUMPF WE: Estradiol distribution and penetration in rat skin after topical application, studied by high resolution autoradiography. Histochemistry (1990) 95:43–54.
  • BULLOUGH WS: Epidermal thickness following oestrone injection in the mouse. Nature (1947): CLIX:101–102.
  • AZZI L, EL-ALFY M, MARTEL C, LABRIE F: Gender differences in mouse skin morphology and specific effects of sex steroids and dehydroepiandrosterone. J. Invest. Dermatol (2005) 124:22–27.
  • MOVERARE S, LINDBERG MK, FAERGEMANN J, GUSTAFSSON JA AND OHLSSON C: Estrogen receptor alpha, but not estrogen receptor beta, is involved in the regulation of the hair follicle cycling as well as the thickness of epidermis in male mice. J. Invest. Dermatol. (2002) 119:1053–1058
  • PUNNONEN R: Effect of castration andperoral estrogen therapy on the skin. Acta. Obstet. Cynecol Land. Suppl. (1972) 21:3–44.
  • URANO R, SAKABE K, SEIKI K, OHKIDO M: Female sex hormone stimulates cultured human keratinocyte proliferation and its RNA- and protein-synthetic activities. Dermatol Sci. (1995) 9:176–184.
  • KANDA N, WATANABE S: 17beta-estradiol stimulates the growth of human keratinocytes by inducing cyclin D2 expression. J. Invest. Dermatol (2004) 123:319–328.
  • VERDIER-SEVRAIN S, YAAR M, CANTATORE J, TRAISH A, GILCHREST BA: Estradiol induces proliferation of keratinocytes via a receptor mediated mechanism. FASEB (2004) 18:1252–1254.
  • KANDA N, WATANABE S: 17beta-estradiol inhibits the production of interferon-induced protein of 10 kDa by human keratinocytes. J. Invest. Dermatol (2003) 120:411–419.
  • KANDA N, WATANABE S: 17beta-estradiol inhibits the production of RANTES in human keratinocytes. I Invest. Dermatol. (2003) 120:420–427.
  • BERTHOIS Y, KATZENELLENBOGEN JA, KATZENELLENBOGEN BS: Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture. Proc. Nati Acad. Sci. USA (1986) 83:2496–2500.
  • KANDA N, WATANABE S: 17beta-estradiol enhances the production of granulocyte-macrophage colony-stimulating factor in human keratinocytes. J. Invest. Dermatol (2004) 123:329–337.
  • MANN A, BREUHAHN K, SCHIRMACHER P, BLESSING M: Keratinocyte-derived granulocyte-macrophage colony stimulating factor accelerates wound healing: Stimulation of keratinocyte proliferation, granulation tissue formation, and vascularization. J. Invest. Dermatol (2001) 117:1382–1390.
  • KANDA N, WATANABE S: 17beta-estradiol inhibits oxidative stress-induced apoptosis in keratinocytes by promoting Bc1-2 expression. J. Invest. Dermatol. (2003) 121:1500–1509.
  • KANDA N, WATANABE S: 17Beta-estradiol inhibits MCP-1 production in human keratinocytes. J. Invest. Dermatol (2003) 120:1058–1066.
  • SMITH QT, ALLISON DJ: Changes of collagen content in skin, femur and uterus of 17-beta-estradiol benzoate-treated rats. Endocrinol (1966) 79:486–492.
  • HENNEMAN DH: Effect of estrogen on in vivo and in vitro collagen biosynthesis and maturation in old and young female guinea pigs. Endocrinol (1968) 83:678–690.
  • SOBEL H, LEE KD, HEWLETT MJ: Effect of estrogen on acid glycosaminoglycans in skin of mice. Biochem. Biophys. Acta. (1965): 101:225–229.
  • BRINCAT M, VERSI E, MONIZ CF, MAGOS A, DE TRAFFORD J, STUDD JW: Skin collagen changes in postmenopausal women receiving different regimens of estrogen therapy. Obstet. Cynecol (1987) 70:123–127.
  • VARILA E, RANTALA I, OIKARINEN A et al: The effect of topical oestradiol on skin collagen of postmenopausal women. BE J. Obstet. Cynaecol. (1995) 102:985–989.
  • SUMINO H, ICHIKAWA S, ABE M, ENDO Y, ISHIKAWA 0, KURABAYASHI M: Effects of aging, menopause, and hormone replacement therapy on forearm skin elasticity in women. I Am. Ceriatr. Soc. (2004) 52:945–949.
  • ASHCROFT GS, GREENWELL-WILD T, HORAN MA, WAHL SM, FERGUSON MW: Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response Am. .1 Path. (1998) 155:1137–1146.
  • HOSOKAWA M, ISHII M, INOUE K, YAO CS, TAKEDA T: Estrogen induces different responses in dermal and lung fibroblasts: special reference to collagen. Connect. Tissue Res. (1981) 9:115–120.
  • HACZYNSKI J, TARKOWSKI R, JARZABEK K et al.: Human cultured skin fibroblasts express estrogen receptor alpha and beta. Int J. Mol. Med. 2002 10:149–153.
  • HACZYNSKI J, TARKOWSKI R, JARZABEK K et al.: Differential effects of estradiol, raloxifene and tamoxifen on estrogen receptor expression in cultured human skin fibroblasts. Int. I Mol. Med. (2004) 13:903–908.
  • PRINS GS, MARMER M, WOODHAM C et al: Estrogen receptor-I3 messenger ribonucleic acid ontogeny in the prostate of normal and neonatally estrogenized rats. Endocrinol. (1998) 139:874–883
  • READ LD, GREENE GL, KATZENELLENBOGEN BS: Regulation of estrogen receptor messenger ribonucleic acid and protein levels in human breast cancer cell lines by sex steroid hormones, their antagonists, and growth factors. Mol. Endocrinol (1989) 3:295–304.
  • SAEGUSA M, OKAYASU I: Changes in expression of estrogen receptors alpha and beta in relation to progesterone receptor and pS2 status in normal and malignant endometrium. fpn. I Cancer Res. (2000) 91:510–518
  • TAKAMA F, KANUMA T, WANG D, KAGAMI I, MIZUNUMA H: Oestrogen receptor beta expression and depth of myometrial invasion in human endometrial cancer. Br. J. Cancer (2001) 84:545–549
  • MULLER-ROVER S, HANDJISKI B, VAN DER VEEN C et al.: Comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages.' Invest. Dermatol (2001) 117:3–15.
  • STENN KS, PAUS R: Controls of hair follicle cycling. Physiol Rev (2001) 81:449–494.
  • OH HS, SMART RC: An estrogen receptorpathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation. Proc. Nati Acad. Li. USA (1996) 93:12525–12530.
  • SMART RC, OH HS, CHANDA S, ROBINETTE CL: Effects of 17-beta-estradiol and ICI 182 780 on hair growth in various strains of mice. J. Invest.Dermatol. Symp. Proc. (1999) 4:285–289.
  • CHANDA S, ROBINETTE CL, COUSE JF, SMART RC: 17beta-estradiol and ICI-182780 regulate the hair follicle cycle in mice through an estrogen receptor-alpha pathway. Am. I Physiol. Endocrinol Metab. (2000) 278:E202–E210.
  • OHNEMUS U, UNALAN M, HANDJISKI B, PAUS R: Topical estrogen accelerates hair regrowth in mice after chemotherapy-induced alopecia by favoring the dystrophic catagen response pathway to damage." Invest. Dermatol (2004) 122:7–13.
  • OHNEMUS U, UENALAN M, CONRAD F et al.: Hair cycle control by estrogens: Catagen induction via ERIalphal is checked by ERIbetal signalling. Endocrinology (2005) 145:1214–1225
  • LYNFIELD YL: Effect of pregnancy on the human hair cycle. I Invest. Dermatol. (1960) 35:323–327.
  • SINCLAIR R: Hair structure and function In: Handbook of Diseases of the Harr and Scalp (1999) Sinclair R, Banfiel C, Dawber R (Eds). New York, Blackwell, Oxford Press.
  • SIMPSON D, CURRAN MP, PERRY CM: Letrozole: a review of its use in postmenopausal women with breast cancer Drugs (2004) 64:1213–1230.
  • KONDO S, HOZUMI Y, ASO K: Organ culture of human scalp hair follicles: effect of testosterone and oestrogen on hair growth. Arch. Dermatol. Res. (1990) 828:442–445.
  • NELSON LD, MESSENGER AG, KAROO ROS, THORNTON MJ: 170-estradiol but not 17a-estradiol inhibits human hair growth in whole follicle organ culture. J. Invest. Dermatol. (2003) 121:821a.
  • CONRAD F, OHNEMUS U, BODO E, BETTERMANN A, PAUS R: Estrogens and human scalp hair growth-still more questions than answers../. Invest. Dermatol (2004) 122:840–842.
  • CONRAD F, PAUS R: Estrogens and the hair follicle. J. German. Soc. Dermatol (2004) 2:412–423
  • REYNOLDS AJ, JAHODA CA: Cultured dermal papilla cells induce follicle formation and hair growth by transdifferentiation of an adult epidermis. Development (1992) 115:587–593.
  • JAHODA CA: Induction of follicle formation and hair growth by vibrissa dermal papillae implanted into rat ear wounds: vibrissa-type fibres are specified. Development (1992) 115:1103–1109.
  • KIESEWETTER F, ARAI A, SCHELL H: Sex hormones and antiandrogens influence in vitro growth of dermal papilla cells and outer root sheath keratinocytes of human hair follicles. J. Invest. Dermatol (1993) 101:98S–105S
  • LACHGAR S, CHARVERON M, SARRAUTE J, MOURAARD M, GALL Y, BONAFE JL: In vitro main pathways of steroid action in cultured hair follicle cells: vascular approach. J. Invest. Dermatol. Symp. Proc. (1999) 4:290–295.
  • THORNTON MJ, NELSON LD, TAYLOR AH, MULLIGAN KT, AL-AZZAWI F, MESSENGER AG: Human Non-Balding Scalp Dermal Papilla Cells Express Estrogen Receptor beta (ER(3) Protein in vivo and in vitro. In: Hair Science and Technology, D Van Neste (Ed), Skinterface sprl Belgium (2003) pp105–120.
  • NELSON LD, MESSENGER AG, TAYLOR AH, BHARKHADA R, LAING I, THORNTON MJ: Evidence for a glucocorticoid-dependent mechanism for the selective action of estrogen via ERI3 in cultured human scalp dermal papilla cells. J. German Soc. Dermatol. (2004) 2:L1–L5
  • PAUS R, HANDJISKI B, CZARNETZKI BM, EICHMULLER S: Murine model for inducing and manipulating hair follicle regression (catagen): effects of dexamethasone and cyclosporin A. J. Invest. Dermatol (1994) 103:143–147.
  • HOOKER CW, PFEIFFER CA: Effects of sex hormones upon body growth, skin, hair and sebaceous glandsin the rat. Endocrinol (1943) 32:69–76
  • EBLING FJ: Hormonal control and methods of measuring sebaceous gland activity. ./. Invest. Dermatol (1974) 62:161–171.
  • POCHI PE, STRAUSS JS: Endocrinologic control of the development and activity of the human sebaceous gland. ./. Invest. Dermatol (1974) 62:191–201.
  • GILTAY EJ, GOOREN LJG: Effects of sex steroid deprivation/administration on hair growth and skin sebum production in transsexual males and females. ./. Endo. Metab. (2000) 85:2913–2921.
  • GUY R, RIDDEN C, KEALEY T: The improved organ maintenance of the human sebaceous gland: modeling in vitro the effects of epidermal growth factor, androgens, estrogens, 13-cis retinoic acid, and phenol red. J. Invest. Dermatol. (1996) 106:454–460.
  • GUY R, KEALEY T: The organ-maintained human sebaceous gland. Dermatology (1998) 196:16–20.
  • WALES NA, EBLING FJ: The control of the apocrine glands of the rabbit by steroid hormones. I Endocrinol (1971) 51:763–770.
  • OFFIDANI A, CAMPANATI A: Papillary hidradenoma: immunohistochemical analysis of steroid receptor profile with a focus on apocrine differentiation. J. Clin. Pathol (1999) 52:829–832.
  • BISCHITZ PG, SNELL RS: A study of the effect of ovariectomy, estrogen and progesterone on the melanocytes and melanin in the skin of female guinea pigs. Endocrinol (1960) 20: 312–319.
  • KROUMPOUZOS G, COHEN LM: Dermatoses of pregnancy. J. Am. Acad. Dermatol (2001) 45:1–19
  • WADE TR, WADE SL, JONES HE: Skin changes and diseases associated with pregnancy. Obstet. Cynecol. (1978) 52:233–242.
  • BEAS F, VARGAS L, SPADA RP, MERCHAK N: Pseudoprecocious puberty in infants caused by a dermal ointment containing estrogens. J. Pediatr. (1969) 75:127–130.
  • TAYLOR AH, THORNTON MJ, MESSENGER AG, TOBIN DJ: Human epidermal melanocytes express the androgen receptor and both estrogen receptors (ERa) and (ER(3) in situ. J. Invest. Dermatol (2002) 119:801.
  • JEE SH, LEE SY, CHIU HC, CHANG CC, CHEN TY: Effects of estrogen and estrogen receptor in normal human melanocytes. Biochem. Biophys. Res. Commun. (1994) 199:1407–1412.
  • IM S, LEE ES, KIM W et al: Donor specific response of estrogen and progesterone on cultured human melanocytes. J. Korean Med. Sci. (2002) 17:58–64
  • MAEDA K, NAGANUMA M, FUKUDA M, MATSUNAGA J, TOMITA Y: Effect of pituitary and ovarian hormones on human melanocytes in vitro. Pigment Cell Res. (1996) 9:204–212.
  • MCLEOD SD, RANSON M, MASON RS: Effects of estrogens on human melanocytes in vitro. I Steroid Biochem. Mol. Biol. (1994) 49:9–14.
  • SCHLEICHER RL, HITSELBERGER MH, BEATTIE CW: Inhibition of hamster melanoma growth by estrogen. Cancer Res. (1987) 47:453–459.
  • HITSELBERGER MH, SCHLEICHER RL, BEATTIE CW: Effects of estradiol on estrogen receptor, progesterone receptor, and tyrosinase in hamster melanoma transplanted into athymic mice. Cancer Res. (1988) 48:3720–3727.
  • FEUCHT KA, WALKER MJ, DAS GUPTA TK, BEATTIE CW: Effect of 17 beta-estradiol on the growth of estrogen receptor-positive human melanoma in vitro and in athymic mice. Cancer Res. (1988) 48:7093–7101.
  • ZAVA DT, GOLDHIRSCH A: Estrogen receptor in malignant melanoma: fact or artefact?Eur. J. Cancer Chi'. Oncol (1983) 8:1151–1159.
  • RICHARDSON B, PRICE A, WAGNER M, WILLIAMS V et al: Investigation of female survival benefit in metastatic melanoma. Br. I Cancer (1999) 80:2025–2033.
  • KANDA N, WATANABE S: 17 beta-estradiol, progesterone, and dihydrotestosterone suppress the growth of human melanoma by inhibiting interleukin-8 production. J. Invest. Dermatol. (2001) 117:274–283.
  • MIYAZAKI K: Novel approach for evaluation of estrogenic and anti-estrogenic activities of genistein and daidzein using B16 melanoma cells and dendricity assay. Pigment Cell Res. (2004) 17:407–412.
  • MUTHYALA RS, JU YH, SHENG S et al: Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta. Bioorg. Med. Chem. (2004) 12:1559–1567.
  • ROGER P, SAHLA ME, MAKELA S, GUSTAFSSON JA, BALDET P, ROCHEFORT H: Decreased expression of estrogen receptor beta protein in proliferative preinvasive mammary tumors. Cancer Res. (2001) 61:2537–2541
  • SAEGUSA M, OKAYASU I: Changes in expression of estrogen receptors alpha and beta in relation tro progesterone receptor and pS2 status in normal and malignant endometrium. fpn. I Cancer Res. (2000) 91:510–518.
  • TOBIN DJ, BYSTRYN JC: Different populations of melanocytes are present in hair follicles and epidermis. Pigment Cell Res. (1996) 9:304–310.
  • OHUCHI A, OHGUCHI K, TSUJI N et al.: A significant role of aromatase cytochrome P450 on hair re-growth and pigmentation. In: Third Intercontinental Meeting of Hair Research Societies, Japan 2001.
  • NELSON LD, THORNTON MJ, TAYLOR AH, MESSENGER AG, TOBIN DJ: Human scalp hair follicle melanocytes express the androgen receptor and both estrogen receptors (ERa) and (ERB) in situ. J. Invest. Dermatol (2002) 119:521.
  • PRESTON DS, STERN RS: Nonmelanoma cancers of the skin. N. Engl. J. Med. (1992) 327:1649–1662.
  • KARAGAS MR: Occurrence of cutaneous basal cell and squamous cell malignancies among those with a prior history of skin cancer. The Skin Cancer Prevention Study Group../. Invest. Dermatol (1994) 102:10S–13S.
  • BALBIN M, FUEYO A, TESTER AM et al: Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Nat. Genet. (2003) 35:252–257.
  • MATTHEWS J, GUSTAFSSON JA: Estrogen signalling: A subtle balance between ERa and ER13.Mol. Interventions 3:281–292.

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