1,612
Views
32
CrossRef citations to date
0
Altmetric
Reviews

Anticonvulsant hypersensitivity syndrome: an update

, BScPhm, , PharmD & , MD
Pages 767-778 | Published online: 14 Jul 2012

Bibliography

  • Knowles SR, Shapiro LE, Shear NH. Anticonvulsant hypersensitivity syndrome: incidence, prevention and management. Drug Saf 1999;21(6):489-501
  • Chaiken BH, Goldberg BI, Segal JP. Dilantin sensitivity; report of a case of hepatitis with jaundice, pyrexia and exfoliative dermatitis. N Engl J Med 1950;242(23):897-8
  • Shear NH, Spielberg SP. Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk. J Clin Invest 1988;82(6):1826-32
  • Gogtay N, Bavdekar S, Kshirsagar N. Anticonvulsant hypersensitivity syndrome: a review. Expert Opin Drug Saf 2005;4:571-81
  • Vittorio CC, Muglia JJ. Anticonvulsant hypersensitivity syndrome. Arch Intern Med 1995;155(21):2285-90
  • Schlienger RG, Shear NH. Antiepileptic drug hypersensitivity syndrome. Epilepsia 1998;39(Suppl 7):S3-7
  • De Vriese AS, Philippe J, Van Renterghem DM, Carbamazepine hypersensitivity syndrome: report of 4 cases and review of the literature. Medicine 1995;74(3):144-51
  • Nagata T, Kawamura N, Motoyama T, A case of hypersensitivity syndrome resembling Langerhans cell histiocytosis during phenobarbital prophylaxis for convulsion. Jpn J Clin Oncol 1992;22(6):421-7
  • Bocquet H, Bagot M, Roujeau J. Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with Eosinophilia and Systemic Symptoms: DRESS). Semin Cutan Med Surg 1996;15:250-7
  • Merritt HH, Putnam TJ. Sodium diphenyl hydantoinate in the treatment of convulsive disorders. JAMA 1938;111:1068-73
  • D'Orazio J. Oxcarbazepine-induced drug reaction with eosinophilia and systemic symptoms (DRESS). Clin Toxicol 2008;46:1093-4
  • Amante MF, Filippini AV, Cejas N, Dress syndrome and fulminant hepatic failure induced by lamotrigine. Ann Hepatol 2009;8(1):75-7
  • Roquin G, Peres M, Lerolle N, First report of lamotrigine-induced drug rash with eosinophilia and systemic symptoms syndrome with pancreatitis. Ann Pharmacother 2010;44(12):1998-2000
  • Amante M, Filippini A, Cejas N, DRESS syndrome and fulminant hepatic failure induced by lamotrigine. Ann Hepatol 2009;8:75-7
  • Maniyar F, Rooney C, Lilly O, Anticonvulsant hypersensitivity syndrome presenting as aseptic meningitis. J Neurol 2009;256:1190-1
  • Fujita Y, Hasegawa M, Nabeshima K, Acute kidney injury caused by zonisamide-induced hypersensitivity syndrome. Intern Med 2010;49:409-13
  • Albayrak F, Cerrah S, Albayrak A, DRESS syndrome with fatal results induced by sodium valproate in a patient with brucellosis and a positive cytoplasmic antineutrophilic cytoplasmic antibody test result. Rheumatol Int 2010; Epub ahead of print
  • Morimoto T, Sato T, Matsuoka A, Trimethoprim-sulfamethoxazole-induced hypersensitivity syndrome associated with reactivation of human herpesvirus-6. Intern Med 2006;45(2):101-5
  • Hicks ME, Smith CL, Stein GE. Trimethoprim/sulfamethoxazole-induced hypersensitivity syndrome. Ann Pharmacother 1997;31(10):1259
  • Prussick R, Shear NH. Dapsone hypersensitivity syndrome. J Am Acad Dermatol 1996;35(2 Pt 2):346-9
  • Knowles SR, Shapiro L, Shear NH. Serious adverse reactions induced by minocycline. Report of 13 patients and review of the literature. Arch Dermatol 1996;132(8):934-9
  • Zuliani E, Zwahlen H, Gilliet F, Marone C. Vancomycin-induced hypersensitivity reaction with acute renal failure: resolution following cyclosporine treatment. Clin Nephrol 2005;64(2):155-8
  • Gupta AK, Porges AJ. Hypersensitivity syndrome reaction to oral terbinafine. Australas J Dermatol 1998;39(3):171-2
  • Lanzafame M, Rovere P, De Checchi G, Hypersensitivity syndrome (DRESS) and meningoencephalitis associated with nevirapine therapy. Scand J Infect Dis 2001;33(6):475-6
  • Michel F, Navellou JC, Ferraud D, DRESS syndrome in a patient on sulfasalazine for rheumatoid arthritis. Joint Bone Spine 2005;72(1):82-5
  • Ghislain PD, Bodarwe AD, Vanderdonckt O, Drug-induced eosinophilia and multisystemic failure with positive patch-test reaction to spironolactone: DRESS syndrome. Acta Derm Venereol 2004;84(1):65-8
  • Arellano F, Sacristan JA. Allopurinol hypersensitivity syndrome: a review. Ann Pharmacother 1993;27(3):337-43
  • Bhargava P. Anticonvulsant hypersensitivity syndrome study of 60 cases. Indian J Dermatol Venereol Leprol 2001;67:317-19
  • Mahadeva U, Al-Mrayat M, Steer K, Fatal phenytoin hypersensitivity syndrome. Postgrad Med J 1999;75(890):734-6
  • Quinones MD, Valero C, Salcedo M, Phenytoin hypersensitivity syndrome with fatal evolution. Allergy 1999;54(1):83-4
  • Huang YL, Hong HS, Wang ZW, Fatal sodium valproate-induced hypersensitivity syndrome with lichenoid dermatitis and fulminant hepatitis. J Am Acad Dermatol 2003;49(2):316-19
  • Roujeau JC. Clinical heterogeneity of drug hypersensitivity. Toxicology 2005;209(2):123-9
  • Tennis P, Stern RS. Risk of serious cutaneous disorders after initiation of use of phenytoin, carbamazepine, or sodium valproate: a record linkage study. Neurology 1997;49(2):542-6
  • Romero Maldonado N, Sendra Tello J, Raboso Garcia-Baquero E, Harto Castano A. Anticonvulsant hypersensitivity syndrome with fatal outcome. Eur J Dermatol 2002;12(5):503-5
  • Metro G, Pino S, Pellegrini D, Brain radiotherapy during treatment with anticonvulsant therapy as a trigger for toxic epidermal necrolysis. Anticancer Res 2007;27(2):1167-9
  • Aguiar D, Pazo R, Duran I, Toxic epidermal necrolysis in patients receiving anticonvulsants and cranial irradiation: a risk to consider. J Neurooncol 2004;66(3):345-50
  • Bessmertny O, Hatton RC, Gonzalez-Peralta RP. Antiepileptic hypersensitivity syndrome in children. Ann Pharmacother 2001;35(5):533-8
  • Newell BD, Moinfar M, Mancini AJ, Retrospective analysis of 32 pediatric patients with anticonvulsant hypersensitivity syndrome (ACHSS). Pediatr Dermatol 2009;26(5):536-46
  • Levy RM, Bredesen DE. Central nervous system dysfunction in acquired immunodeficiency syndrome. J Acquir Immune Defic Syndr 1988;1(1):41-64
  • Wong MC, Suite ND, Labar DR. Seizures in human immunodeficiency virus infection. Arch Neurol 1990;47(6):640-2
  • Holtzman DM, Kaku DA, So YT. New-onset seizures associated with human immunodeficiency virus infection: causation and clinical features in 100 cases. Am J Med 1989;87(2):173-7
  • Shapiro L, Shear N. Black race may predict increased severe cutaneous adverse reactions in phenytoin hypersensitivity syndrome reactions (abstract). Clin Invest Med 1998;21:S15
  • Lalic M, Cvejic J, Popovic J, Lamotrigine and valproate pharmacokinetis interactions in epileptic patients. Eur J Drug Metab Pharmacokinet 2009;34:93-9
  • Dreesman A, Hoorens A, Hackimi-Idrissi S. Multiple organ dysfunction syndrome: infection or hypersensitivity reaction? Eur J Emerg Med 2010;17:228-9
  • Schlienger RG, Oh PI, Knowles SR, Shear NH. Quantifying the costs of serious adverse drug reactions to antiepileptic drugs. Epilepsia 1998;39(Suppl 7):S27-32
  • Schlienger RK. Shear, N. Lamotrigine-associted anticonvulsant hypersensitivity syndrome. Neurology 1998;51:1172-5
  • Sierra NM, Garcia B, Marco J, Cross Hypersensitivity syndrome between phenytoin and carbamazepine. Pharm World Sci 2005;27(3):170-4
  • Seitz CS, Pfeuffer P, Raith P, Anticonvulsant hypersensitivity syndrome: cross-reactivity with tricyclic antidepressant agents. Ann Allergy Asthma Immunol 2006;97(5):698-702
  • Spielberg S, Gordon G, Blake D, Anticonvulsant toxicity in vitro: possible role of arene oxides. J Pharmacol Exp Ther 1981;217:386-9
  • Spielberg S, Gordon G, Blake D, Predisposition to phenytoin hepatotoxicity assessed in vitro. N Engl J Med 1981;13:722-7
  • Leeder JS, Riley RJ, Cook VA, Spielberg SP. Human anti-cytochrome P450 antibodies in aromatic anticonvulsant-induced hypersensitivity reactions. J Pharmacol Exp Ther 1992;263:360-7
  • Lu W, Uetrecht J. Possible bioactivation pathways of lamotrigine. Drug Metab Dispos 2007;35:1050-6
  • Maggs J, Naisbitt D, Tettey J, Metabolism of lamtorigine to a reactive arene oxide intermediate. Chem Res Toxicol 2000;13:1075-81
  • Pichler W. Delayed drug hypersensitivity reactions. Ann Intern Med 2003;139:683-93
  • Naisbitt D, Farrell J, Wong G, Characterization of drug-specific T cells in lamotrigine hypersensitivity. J Allergy Clin Immunol 2003;111:1393-403
  • Seishima M, Yamanaka S, Fujisawa T, Reactivation of human herpesvirus (HHV) family members other than HHV-6 in drug-induced hypersensitivity syndrome. Br J Dermatol 2006;155:344-9
  • Wong GAE, Shear NH. Is a drug alone sufficient to cause the drug hypersensitivity syndrome? Arch Dermatol 2004;140(2):226-30
  • Eshki M, Allanore L, Musette P, Twelve-year analysis of severe cases of drug reaction with eosinophilia and systemic symptoms. Arch Dermatol 2009;145:67-72
  • Tohyama M, Hashimoto K, Yasukawa M, Association of human herpesvirus 6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome. Br J Dermatol 2007;157:934-40
  • Shiohara T, Ijima M, Ikezawa Z, The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivation. Br J Dermatol 2007;156:1083-4
  • Hara H, Kobayashi M, Yokoyama A, Drug-induced hypersensitivity syndrome due to carbamazepine associated with reactivation ofhuman herpesvirus 7. Dermatology 2005;211:159-61
  • Saida S, Yoshida A, Tanaka R, A case of drug-induced hypersensitivity syndrome-like symptoms following HHV-6 encephalopathy. Allergol Int 2010;59:83-6
  • Oskay T, Karademir A, Erutrk O. Association of anticonvulsant hypersensitivity syndrome with herpesvirus 6, 7. Epilepsy Res 2006;70:27-40
  • Chang JY, Kim SC. Anticonvulsant hypersensitivity syndrome associated with Epstein-Barr virus reactivation. Yonsei Med J 2007;48(2):317-20
  • Scagni P, Morello M, Ramus MV, Drug-induced hypersensivity syndrome associated with Epstein-Barr virus infection: a pediatric case report. Pediatr Dermatol 2009;26(2):229-31
  • Aihara M, Sugita Y, Takahashi S, Anticonvulsant hypersensitivity syndrome associated with reactivation of cytomegalovirus. Br J Dermatol 2001;144(6):1231-4
  • Asano Y, Kagawa H, Kano Y, Cytomegalovirus disease during severe drug eruptions: report of 2 cases and retrospective study of 18 patients with drug-induced hypersensitivity syndrome. Arch Dermatol 2009;145(9):1030-6
  • Lin D, Tucker MJ, Rieder MJ. Increased adverse drug reactions to antimicrobials and anticonvulsants in patients with HIV infection. Ann Pharmacother 2006;40(9):1594-601
  • Gennis MA, Vemuri R, Burns EA, Familial occurrence of hypersensitivity to phenytoin. Am J Med 1991;91(6):631-4
  • Calligaris L, Stocco G, De Iudicibus S, Carbamazepine hypersensitivity syndrome triggered by a human herpes virus reactivation in a genetically predisposed patient. Int Arch Allergy Immunol 2009;149:173-7
  • Chung W, Hung S, Hong H, Medical genetics: a marker for Stevens-Johnson syndrome. Nature 2004;428:486
  • Man C, Kwan P, Baum L, Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese. Epilepsia 2007;48:1015-18
  • Chung W, Hung S, Chen Y. Genetic predisposition of life-threatening antiepileptic-induced skin reactions. Expert Opin Drug Saf 2010;9:15-21
  • Hung S, Chung W, Jee S, Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenet Genomics 2006;16:297-306
  • Aihara M. Pharmacogenetics of cutaneous adverse drug reactions. J Dermatol 2011;38:246-54
  • Kashiwagi M, Aihara M, Takahashi Y, HLA genotypes in carbamazepine induced severe cutaneous adverse drug response in Japanese patients. J Dermatol 2008;35:683-5
  • McCormack M, Alfirevic A, Bourgeois S, HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med 2011;364:1134-43
  • Hyson C, Sadler M. Cross-sensitivity of skin rashes with antiepileptic drugs. Can J Neurol Sci 1997;24:245-9
  • Arif H, Buchsbaum R, Weintraub D, Comparison and predictors of rash associated with 15 antiepileptic drugs. Neurology 2007;68:1701-9
  • Hirsch L, Arif H, Nahm E, Cross-sensitivity of skin rashes with antiepileptic drug use. Neurology 2008;71:1527-34
  • Murphy J, Mashman J, Miller J, Suppression of carbamazepine-induced skin rash with prednisone. Neurology 1991;41:144-5
  • Son C, Lee C, Roh M, Acute generalized exanthematous pustulosis as a manifestation of carbamazepine hypersensitivity syndrome. J Investig Allergol Clin Immunol 2008;18:461-4
  • Chen Y, Chiu H, Chu C. Drug reaction with eosinophilia and systemic symptoms: a retrospective study of 60 cases. Arch Dermatol 2010;146:1373-9
  • Kano Y, Shiohara T. The variable clinical picture of drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms in relation to the eliciting drug. Immunol Allergy Clin North Am 2009;29:481-501
  • Peyriere H, Dereure O, Breton H, Variability in the clinical pattern of cutaneous side effects of drugs with systemic symptoms: does a DRESS syndrome really exist? Br J Dermatol 2006;155:422-8
  • Morkunas A, Miller M. Anticonvulsant hypersensitivity syndrome. Med Toxicol 1997;13:727-39
  • Zaidi AN. Anticonvulsant hypersensitivity syndrome leading to reversible myocarditis. Can J Clin Pharmacol 2005;12(1):e33-40
  • Arima M, Kanoh T, Yamasaki A, Eosinophilic myocarditis associated with toxicodermia caused by phenobarbital. Jpn Circ J 1998;62(2):132-5
  • deMello DE, Liapis H, Jureidini S, Cardiac localization of eosinophil-granule major basic protein in acute necrotizing myocarditis. N Engl J Med 1990;323(22):1542-5
  • Arsenovic N, Sheehan L, Clark D, Fatal carbamazepine induced fulminant eosinophilic (hypersensitivity) myocarditis: emphasis on anatomical and histological characteristics, mechanisms and genetics of drug hypersensitivity and differential diagnosis. J Forensic Leg Med 2010;17(2):57-61
  • Bourgeois GP, Cafardi JA, Groysman V, A review of DRESS-associated myocarditis. J Am Acad Dermatol 2011; Epub ahead of print
  • Do-Pham G, Charachon A, Duong T, Drug reaction with eosinophilia and systemic symptoms and severe involvement of digestive tract: description of two cases. Br J Dermatol 2011;165:207-9
  • Balatsinou C, Milano A, Caldarella M, Eosinophilic esophagitis is a component of the anticonvulsant hypersensitivity syndrome: description of two cases. Dig Liver Dis 2008;40:145-8
  • Pereira de Silva N, Piquioni P, Kochen S, Saidon P. Risk factors associated with DRESS syndrome produced by aromatic and non-aromatic antipiletic drugs. Eur J Clin Pharmacol 2011;67(5):463-70
  • Ito S, Shioda M, Sasaki K, Agranulocytosis following phenytoin-induced hypersensitivity syndrome. Brain Dev 2009;31:449-51
  • Gupta A, Eggo M, Uetrecht J, Drug-induced hypothyroidism: the thyroid as a target organ in hypersensitivity reactions to anticonvulsants and sulfonamides. Clin Pharmacol Ther 1992;51:56-67
  • Brown R, Rother K, Artman H, Minocycline-induced drug hypersensitivity syndrome followed by multiple autoimmune sequelae. Arch Dermatol 2009;145:63-6
  • Aota N, Hirahara K, Yea K. Systemic lupus erythematosus presenting with Kikuchi-Fujimoto's disease as a long-term sequela of drug-induced hypersensitivity syndrome. Dermatology 2009;218:275-7
  • Cacoub P, Musette P, Descamps V, The DRESS syndrome: a literature review. Am J Med 2011;124:588-97
  • Neuman M, Malkiewicz I, Shear N. A novel lymphocyte toxicity assay to assess drug hypersensitivity syndromes. Clin Biochem 2000;33:517-24
  • Elzagallaai A, Knowles S, Rieder M, Patch testing for the diagnosis of anticonvulsant hypersensivity syndrome: a systematic review. Drug Saf 2009;32:391-408
  • Elzagallaai AA, Knowles SR, Rieder MJ, In vitro testing for the diagnosis of anticonvulsant hypersensitivity syndrome: a systematic review. Mol Diagn Ther 2009;13(5):313-30
  • Bavdekar S, Muranjan M, Gogtay N, Anticonvulsant hypersensitivity syndrome: lymphocyte toxicity assay for the confirmation of diagnosis and risk assessment. Ann Pharmacother 2004;38:1648-50
  • Wu Y, Sanderson J, Farrell J, Activation of T cells by carbamazepine and carbamazepine metabolites. J Allergy Clin Immunol 2006;118:233-41
  • Beeler A, Engler O, Gerber B, Pichler W. Long-lasting reactivity and high frequency of drug-specific T cells after severe systemic drug hypersensitivity reactions. J Allergy Clin Immunol 2006;117:455-62
  • Allam J, Paus T, Reichel C, DRESS syndrome associated with carbamazepine and phenytoin. Eur J Dermatol 2004;14:339-42
  • Aouam K, Romdhane F, Loussaief C, Hypersensitivity syndrome induced by anticonvulsants: possible cross-reactivity between carbamazepine and lamotrigine. J Clin Pharmacol 2009;49:1488-91
  • Voltolini S, Dignardi D, Minale P, Phenobarbital-induced DiHS and ceftriaxone hypersensitivity reaction: a case of multiple drug allergy. Eur Ann Allergy Clin Immunol 2009;41:62-3
  • Ben Salem S, Slim R, Denguezli M, A recurrent drug rash with eosinophilia and systemic symptoms. Pediatr Dermatol 2007;24:666-8
  • Gaig P, Garcia-Orega P, Baltasar M, Drug neosensitization during anticonvulsant hypersensitivity syndrome. J Investig Allergol Clin Immunol 2006;16:321-6
  • Stewart MG, Duncan NO III, Franklin DJ, Head and neck manifestations of erythema multiforme in children. Otolaryngol Head Neck Surg 1994;111(3 Pt 1):236-42
  • Um SJ, Lee SK, Kim YH, Clinical features of drug-induced hypersensitivity syndrome in 38 patients. J Investig allergol Clin Immunol 2010;20(7):556-62
  • Lens S, Crespo G, Carrion J, Severe acute hepatitis in the DRESS syndrome: report of two cases. Ann Hepatol 2010;9:198-201
  • Valeyrie-Allanore L, Wolkenstein P, Brochard L, Open trial of ciclosporin treatment for Stevens-Johnson syndrome and toxic epidermal necrolysis. Br J Dermatol 2010;163(4):847-53
  • Harman KE, Morris SD, Higgins EM. Persistent anticonvulsant hypersensitivity syndrome responding to ciclosporin. Clin Exp Dermatol 2003;28(4):364-5
  • Fischer M, Fiedler E, Marsch WC, Antitumour necrosis factor-alpha antibodies (infliximab) in the treatment of a patient with toxic epidermal necrolysis. Br J Dermatol 2002;146(4):707-9
  • Okumura A, Tsuge I, Kamachi Y, Transient hypogammaglobulinemia after antiepileptic drug hypersensitivity. Pediatr Neurol 2007;36(5):342-4
  • Mostella J, Pieroni R, Jones R, Finch CK. Anticonvulsant hypersensitivity syndrome: treatment with corticosteroids and intravenous immunoglobulin. South Med J 2004;97(3):319-21
  • Straussberg R, Harel L, Ben-Amitai D, Carbamazepine-induced Stevens-Johnson syndrome treated with IV steroids and IVIG. Pediatr Neurol 2000;22(3):231-3
  • Prais D, Straussberg R, Amir J, Treatment of anticonvulsant hypersensitivity syndrome with intravenous immunoglobulins and corticosteroids. J Child Neurol 2006;21(5):380-4
  • Dredge DC, Parsons EC, Carter LP, Anticonvulsant hypersensitivity syndrome treated with intravenous immunoglobulin. Pediatr Neurol 2010;43(1):65-9
  • Cumbo-Nacheli G, Weinberger J, Alkhalil M, Anticonvulsant hypersensitivity syndrome: is there a role for immunomodulation? Epilepsia 2008;49(12):2108-12
  • Egan CA, Grant WJ, Morris SE, Plasmapheresis as an adjunct treatment in toxic epidermal necrolysis. J Am Acad Dermatol 1999;40(3):458-61
  • Chaidemenos GC, Chrysomallis F, Sombolos K, Plasmapheresis in toxic epidermal necrolysis. Int J Dermatol 1997;36(3):218-21
  • Smith H, Newton R. Adverse reactions to carbamazepine managed by desensitisation. Lancet 1985;1(8431):753
  • Eames P. Adverse reactions to carbamazepine managed by desensitisation. Lancet 1989;1(8636):509-10
  • Watts D, Bird J. Oxcarbazepine sensitivity treated by desensitisation. J Neurol Neurosurg Psychiatry 1991;54(4):376
  • Butte MJ, Dodson B, Dioun A. Pentobarbital desensitization in a 3-month-old child. Allergy Asthma Proc 2004;25(4):225-7

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.