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Review

SGLT2 inhibition: efficacy and safety in type 2 diabetes treatment

Bibliography

  • Papers of special note have been highlighted as either of interest (*) or of considerable interest (**) to readers.

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  • Scheen AJ. Pharmacokinetics, pharmacodynamics and clinical use of SGLT2 inhibitors in patients with type 2 diabetes and chronic kidney disease. Clin Pharmacokinet. 2015;54:691–708.

* Updated review on the efficacy and safety of SGLT2 inhibitors in patients with renal impairment.

  • Vasilakou D, Karagiannis T, Athanasiadou E, et al. Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: a systematic review and meta-analysis. Ann Intern Med. 2013;159:262–274.

* Systematic review summarizing the efficacy and safety of SGLT2 inhibitors in type 2 diabetes.

  • Berhan A, Barker A. Sodium glucose co-transport 2 inhibitors in the treatment of type 2 diabetes mellitus: a meta-analysis of randomized double-blind controlled trials. BMC Endocr Disord. 2013;13:58.
  • Scheen AJ. Pharmacodynamics, efficacy and safety of sodium-glucose co-transporter type 2 (SGLT2) inhibitors for the treatment of type 2 diabetes mellitus. Drugs. 2015;75:33–59.

** Updated review summarizing the current knowledge on SGLT2 inhibitors.

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** Updated position statement where SGLT2 inhibitors are positioned in the algorithm of treatment of type 2 diabetes.

** Landmark study demonstrating that empagliflozin markedly reduces cardiovascular and total mortality in patients with type 2 diabetes and cardiovascular disease, with a good safety profile.

* Exhaustive review on SGLT2 inhibitors for treating type 2 diabetes, including new agents in development.

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* Overview on the impact of SGLT2 inhibitors on body weight as add-on value to the glucose-lowering effect.

  • Scheen AJ, Van Gaal LF. Combating the dual burden: therapeutic targeting of common pathways in obesity and type 2 diabetes. Lancet Diabetes Endocrinol. 2014;2:911–922.
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  • Maliha G, Townsend RR. SGLT2 inhibitors: their potential reduction in blood pressure. J Am Soc Hypertens. 2015;9:48–53.

* Overview on the impact of SGLT2 inhibitors on arterial blood pressure as add-on value to the glucose-lowering effect.

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  • Nicolle LE, Capuano G, Ways K, et al. Effect of canagliflozin, a sodium glucose co-transporter 2 (SGLT2) inhibitor, on bacteriuria and urinary tract infection in subjects with type 2 diabetes enrolled in a 12-week, phase 2 study. Curr Med Res Opin. 2012;28:1167–1171.
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* Discussion about the recent warning after the report of cases of euglycemic ketoacidosis in patients treated with SGLT2 inhibitors.

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