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Review

The safety and tolerability of beta blockers in heart failure with reduced ejection fraction: is the current underutilization of this evidence-based therapy justified?

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*Landmark study evaluating the effect of bisoprolol in heart failure with reduced ejection fraction

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*Landmark trial evaluating the effect of metoprolol succinate in heart failure with reduced ejection fraction

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*Landmark trial evaluating the effect of carvedilol in heart failure with reduced ejection fraction

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**Well-designed meta-analysis describing the prevalence of adverse effects with beta blocker use

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**Well-designed meta-analysis describing the prevalence of adverse effects with beta blocker use

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*Well-designed meta-analysis evaluating the prevalence of CNS-related adverse effects from beta blockade

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